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All Journal Dental Journal (Majalah Kedokteran Gigi) Padjadjaran Journal of Dentistry Indonesian Journal of Dental Medicine Indonesian Journal of Prosthodontics

Nike Hendrijantini

Department Of Prosthodontic, Faculty Of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia

Author-ID : 597153

Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

Published : 9 Documents Claim Missing Document

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Articles

Stem Cells Approach for Implant Therapy in Diabetes Model Kuntjoro, Mefina; Hendrijantini, Nike; Agustono, Bambang; Salim, Sherman
Indonesian Journal of Prosthodontic Special Issue 2021
Publisher : Indonesia Prosthodontic Association

Objective of Investigation: Dental implant osseointegration in patients with hyperglycemic conditions was reported to be delayed so the restoration procedure must be postponed. Mesenchymal Stem Cells (MSCs) is a tissue engineering material that has the potential to treat various systemic diseases. Human Umbilical Cord Mesenchymal Stem Cells (hUCMSCs) is proven to improve bone microenvironment and have osteogenic potential. Their excellent capability can be a new approach for osseointegration acceleration. The purpose of this study was to determine the capability of hUCMSCs to accelerate dentalimplant osseointegration in hyperglycemic condition through angiogenesis and osteoblastogenesis. Experimental methods used: 28 Wistar rats were injected intraperitoneally with Streptozotocin 20mg/kg body weight for 5 days in a row to make the diabetic model. The treatment was carried out after fasting blood sugar levels 300 mg/dl and waited 5 days for the glycation period. The source of stem cell is human umbilical cord which has been isolated and cultured until passage 6. The experimental animals were divided into 4 groups, namely the 2-week implant group (K1), the 4-week implant group (K2), the 2-week implant + hUCMSCs group (P1) and the 4-week implant + hUCMSCs group (P2). The variables examined were BIC (Bone Implant Contact), VEGF and Runx2 expression. Data were analyzed using Analysis of Variance (ANOVA). Result : BIC, VEGF and Runx2 expresssion was higher in treatment groups compared with control groups. The highest expression of VEGF and Runx2 occurred in the P1 and decreased in the P2 group. While for BIC in groups P1 and P2 remained high to maintain osseointegration. Conclusion : With the limitation of this study, stem cells was proven to accelerate the osseointegration of dental implants through osteoblastogenesis and angiogenesis in diabetes model.

Front teeth replacement with implant-supported crowns: A case report K.K., Michael Josef; Hendrijantini, Nike; A, Maretaningtias Dwi; W, Wiwik Herawati
Indonesian Journal of Prosthodontic Vol 2, No 1 (2021): June 2021
Publisher : Indonesia Prosthodontic Association

The use of dental implants to support fixed or removable restoration is widely used as treatment modality. The advantages are increased retention, chewing ability, and easy access to oral hygiene procedures. A missing tooth that needs to be replaced completely can be restored using an implant-supported crown. The aim of this study is to rehabilitate maxillary partial edentulous with implant supported crown. A 56-year-old female patient came to the clinic, wanted to replace partial edentulous after extraction of 11 and 21, needed fixed restoration in order to eat and chew well, and expected high aesthetic result as well. This patient had experienced using removable partial denture to replace her lost teeth . Patient wanted to have implant treatment with fixed restoration because she felt that her partial denture did not fit anymore, so the prosthodontic treatment option was using implant-supported crowns. Implant supported crown can be an option to replace partial edentulous.

The effect of combined Moringa oleifera and demineralized freeze-dried bovine bone xenograft on the amount of osteoblast and osteoclast in the healing of tooth extraction socket of Cavia cobaya Rostiny Rostiny; Eha Djulaeha; Nike Hendrijantini; Agus Pudijanto
Dental Journal (Majalah Kedokteran Gigi) Vol. 49 No. 1 (2016): March 2016
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Alveolar bone has an important role in providing support to teeth and dentures. Loss of support caused by alveolar resorption will cause functional and aesthetic problems. Preservation socket using bone graft is one way to maintain the dimensions of the alveolar bone. Moringa oleifera leaf can increase the activity of bone graft in the formation of new bone. Purpose: This study was aimed to evaluate the effect of combined Moringa oleivera leaf extract and demineralized freeze-dried bovine bone xenograft (DFDBBX) towards the formation of osteoblasts and osteoclasts in the tooth extraction sockets of cavia cobaya. Method: This study used 28 cavia cobayas divided into four groups. The combination of Moringa oleifera leaf extract and DFDBBX was inducted into the sockets of lower incisor tooth with certain dose in each group, ointment 1 containing PEG (a mixture of PEG 400 and PEG 4000) for control group, ointment 2 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active subtance consentration of 0.5%) for group 1, ointment 3 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active substance concentration of 1%) for group 2, and Ointment 4 containing Moringa oleifera leaf extract and DFDBBX and PEG (at active substance consentration of 2%) for group 3. paraffin block preparations were made for histopathology examination using hematoxylin eosin staining. Result: The results showed that there were significant differences of the number of osteoblasts and osteoclasts in each treatment group (p <0.05). Conclusion: It can be concluded that the combination of Moringa oleifera leaf extract and DFDBBX at 2% cocentration can increase the number of osteoblasts and decrease osteoclasts in the healing of tooth extraction sockets of cavia cobaya.

The Effect of a combination of 12% spirulina and 20% chitosan on macrophage, PMN, and lymphocyte cell expressions in post extraction wound Nike Hendrijantini; Rostiny Rostiny; Mefina Kuntjoro; Kevin Young; Bunga Shafira; Yunita Pratiwi
Dental Journal (Majalah Kedokteran Gigi) Vol. 50 No. 2 (2017): June 2017
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Tooth extraction is the ultimate treatment option for defective teeth followed by the need for dentures. Inflammation is one phase of the healing process that should be minimized in order to preserve alveolar bone for denture support. Macrophage, PMN and lymphocyte cells are indicators of acute inflammation. Spirulina and chitosan are natural compounds with the potential to be anti-inflammatory agents. Purpose: This research aimed to determine macrophage, PMN and lymphocyte cells of animal models treated with a combination of 12% spirulina and 20% chitosan on the 1st, 2nd and 3rd post-extraction day. Methods: Animal models were randomly divided into control (K) and treatment (P) groups. Each group was further divided into three subgroups (KI, KII, KIII and PI, PII, PIII). The post-extraction sockets of the control group animals were then filled with CMC Na 3%. Meanwhile, the post-extraction sockets of the treatment group members were filled with a combination of 12% spirulina and 20% chitosan. Subsequently, the number of PMN, macrophage and lymphocyte cells was analyzed by means of HE analysis on the 1st., 2nd. and 3rd. days. Statistical analysis was then performed using a T-test. Results: There was a decrease in PMN cells and an increase in macrophage and lymphocyte cells on Days 1, 2, and 3. Conclusion: It can be concluded that a combination of 12% spirulina and 20% chitosan can not only decrease PMN cells, but can also increase macrophage and lymphocyte cells on Days 1, 2 and 3 after tooth extraction.

Comparative in vitro study of the cytotoxicity of gelatine and alginate to human umbilical cord mesenchymal stem cells Nike Hendrijantini
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 1 (2019): March 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Mesenchymal stem cells (MSCs) and scaffold combination constitute a promising approach currently adopted for tissue engineering. Umbilical cord-derived mesenchymal stem cells (hUC-MSCs) are easily obtained and non-invasive. Gelatine and alginate constitute a biocompatible natural polymer scaffold. At present, a cytotoxicity comparison of gelatine and alginate to hUC-MSCs is not widely conducted Purpose: This study aimed to compare the cytotoxicity of gelatine and alginate in hUC-MSCs in vitro. Methods: Isolation and culture were performed on hUC-MSCs derived from healthy full-term neonates. Flow Cytometry CD90, CD105 and CD73 phenotype characterization was performed in passage 4. 3-(4,5-dimethythiazol- 2-yl)-2,5-diphenyl tetrazolium bromide (MTT) colorimetric assay was performed to measure the cytotoxicity. The three sample groups were: (T1) hUC-MSCs with α-MEM (alpha-minimum essential medium) solution as control; (T2) hUC-MSCs with gelatine; (T3) hUC-MSCs with alginate Results: Flow cytometry of hUC-MSCs displayed positive CD90, CD105 and CD73 surface markers. Gelatine and alginate had no effect on the viability of hUC-MSCs and no statistically significant difference (p>0.05) of cytotoxicity between gelatine and alginate to hUC-MSCs. Conclusion: Gelatine and alginate proved to be non-toxic to hUC-MSCs in vitro.

An Overview of Type 2 Diabetes Mellitus (T2DM): Dental Implant Survival Rates Mefina Kuntjoro; Nike Hendrijantini; Agus Dahlan; Husniya Juwita Farha; Mayang Aziza Hanif Ardianto
Indonesian Journal of Prosthodontic Vol 3 No 2 (2022): December 2022
Publisher : Indonesia Prosthodontic Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46934/ijp.v3i2.124

Background: Dental implants are an alternative treatment to replace missing teeth, as it is one of the oral health problems in the elderly. The success of dental implants is affected by a process known as osseointegration. Systemic conditions such as T2DM can interfere with the osseointegration process which can lead to implant failure. As the patient's blood glucose level increases, it will increase the accumulation of AGEs. These AGEs will interfere with the stages of bone-implant contact and also bone growth around the implant Objectives: To review dental implant survival rates in T2DM patients based on HbA1c, ISQ and CBCT examinations. Conclusion: Dental implants in T2DM patients after being evaluated for 2 years showed a good result. This result is obtained with the condition that HbA1c control is below 8%. Another solution to support the success of dental implants placement in T2DM patients is the use of delayed insertion technique and modification of the implant surface with HA or SLA is also recommended. Evaluation of implant success can also be done with pre-operative planning, such as evaluation of the bone condition with ISQ and CBCT examinations.

The importance of good health and well-being in Sekarkare Village, Probolinggo, East Java Village, Probolinggo, East Java Kuntjoro, Mefina; Hendrijantini, Nike; Safari Azhar, Imam; Ayu Nararya, Sheila; Danang Subeqi, mochamad
Indonesian Journal of Dental Medicine Vol. 7 No. 1 (2024): Indonesian Journal of Dental Medicine
Publisher : Faculty of Dental Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijdm.v7i1.2024.17-19

Background: Oral health is essential to total health and a satisfactory quality of life. One of the most contributingfactors is how a human being has an understanding of how to maintain oral health to improve the quality and well-being of life. Purpose: to provide and describe the community knowledge about the importance of replacing missing teeth using dentures and maintaining oral health to improve the quality of life. Methods: The event was carried out with an interactive educational concept by giving pre- and post-tests at the beginning and end of the event. There were at least 80 education participants, consisting of the people of Sekarkare village of various ages, from late adolescents to the elderly, along with village officials and guests from the Sekarkare Health Center. The activity was carried out at the village hallof Sekarkare Village, Dringu District, Probolinggo Regency, East Java. Results: The majority of people understand and are enthusiastic about participating in a series of counseling events. There is an increase in scores in the pre-test (59,06%) and post-test (65,58%) results. Conclusion: The existence of counseling events with interactive educational concepts can increase public enthusiasm for participating in events, making it easier for people to gain new knowledge.

Bone formation and mineralization around the implant in osteoporotic animal models enhanced by mesenchymal stem cells Hendrijantini, Nike; Kuntjoro, Mefina; Agustono, Bambang; Ari, Muhammad Dimas Aditya; Kurdi, Abil; Mundiratri, Karina; Prasetyo, Eric Priyo; Hong, Guang
Dental Journal (Majalah Kedokteran Gigi) Vol. 57 No. 2 (2024): June
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v57.i2.p91-96

Background: Poor bone quality, sometimes caused by osteoporosis, can lead to dental implant failure. Human umbilical cord mesenchymal stem cells (hUCMSCs) can differentiate into osteoblasts and offer an alternative therapy for poor bone conditions. Purpose: This study aims to evaluate the effect of hUCMSCs induction on the extent of osseointegration by the new bone formation area of dental implants in osteoporotic animal models. Methods: The samples were divided into two groups, i.e., control and induced hUCMSCs groups at different times. An ovariectomy was performed to assess the osteoporosis condition. The control group was injected using gelatin, and the treatment group was administered hUCMSCs. Terminations were conducted at 2 and 4 weeks, respectively. The collected samples were then subjected to histological examination to analyze new bone formation and its proportion. In addition, alkaline phosphatase staining was also performed to evaluate the mineralization area. The data was analyzed using the one-way analysis of variance (ANOVA). Results: Both for new bone formation area as well as the proportion of new bone, it was observed that the best results were in the group with induction of hUCMSCs at 2 weeks. Alkaline phosphatase staining also confirmed that the highest mineralization was observed in the same group. Conclusion: hUCMSCs induced new bone formation in the implant placement in osteoporotic animal models.

The number of osteoblasts and osteoclasts in bone remodeling of bone defects caused by peri-implantitis using Anadara granosa bone graft: an experimental study Ariestania, Vivin; Hendrijantini, Nike; Prahasanti, Chiquita; Kurniawan, Hansen; Ashrin, Meinar Nur; Nanik, Chaterina Diyah; Apsari, Anindita; Megantara, Rizko Wira Artha; Sari, Rima Parwati; Hermanto, eddy; Fauzia, Bunga; Matsuyama, Miwa
Padjadjaran Journal of Dentistry Vol 37, No 3 (2025): November 2025
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjd.vol37no3.64295

Introduction: Peri-implantitis treatment aims to replace the damaged bone with new and healthy tissue during bone remodeling process. Bone grafts are materials used to stimulate the formation of new bone. Bone graft material derived from Anadara granosa (AG) can be synthesized into hydroxyapatite–tricalcium phosphate (HA-TCP) at a 70:30 ratio, which supports bone regeneration, as indicated by an increase in osteoblast numbers and decrease in osteoclast numbers. This study aims to analyze the effectiveness of Anadara granosa bone graft in the number of osteoblasts and osteoclasts during bone remodeling process. Methods: This study employed an experimental design with a post-test only control group. A total of 84 mice were divided into 12 groups (7 mice per group): negative control (K−), positive control (K+), and treatment group (P), each observed on days 14 and 28. Histological analysis was performed to count osteoblasts and osteoclasts. Data were analyzed using one-way ANOVA. Results: The number of osteoclasts was significantly reduced in the treatment groups (P14: 7.00 ± 1.528; P28: 6.57 ± 1.512) compared to the positive controls (K+14: 13.86 ± 2.410; K+28: 14.29 ± 1.496). On the contrary, the number of osteoblasts increased in the treatment groups (P14: 7.14 ± 1.676; P28: 8.57 ± 1.272) compared to the positive controls (K+14: 2.57 ± 1.512; K+28: 3.86 ± 1.574). Statistical analysis indicated that osteoblasts showed significant differences after AG treatment (p<0.05), and the ANOVA test showed significant differences in osteoclast number after AG treatment (p<0.05). Conclusion: The number of osteoblasts increases while the number of osteoclast reduces in bone remodelling of bone defect caused by peri-implantitis using AG bone graft.

Co-Authors - UBSI Karawang, Djulaeha A, Maretaningtias Dwi Agus Dahlan Agus Pudijanto Apsari, Anindita Ariestania, Vivin Ayu Nararya, Sheila Azhar, Imam Safari Bambang Agustono Bunga Shafira Chiquita Prahasanti Danang Subeqi, mochamad Eddy Hermanto Eric Priyo Prasetyo Fauzia, Bunga Guang Hong, Guang Husniya Juwita Farha K.K., Michael Josef Karina Mundiratri Kevin Young Kurdi, Abil Kurniawan, Hansen Matsuyama, Miwa Mayang Aziza Hanif Ardianto Mefina Kuntjoro Megantara, Rizko Wira Artha Meinar Nur Ashrin Muhammad Dimas Aditya Ari Nanik, Chaterina Diyah Rima Parwati Sari, Rima Parwati Rostiny Rostiny, Rostiny Sherman Salim, Sherman W, Wiwik Herawati Yunita Pratiwi

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