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IMUNOHISTOKIMIA PADA KONDILOMATA AKUMINATA Widyaswari, Meidyta Sinantryana; Lumintang, Hans; Soemarno, Troef
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): February
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Condylomata Acuminata (CA) is a sexually transmitted disease caused by the Human Papilloma Virus (HPV) type-specific and may be simultaneously co-infected with other HPV types associated with malignancy. Purpose: To differentiate between CA and histopathological of malignancy by immunohistochemistry. LiteratureReview: CA refers to benign epidermal proliferation caused by the HPV types 6 and 11, but co-infection with high- risk HPV types are common. The clinical presentation of CA can’t differentiate between benign or preneoplastik diplasia lesions. Koilocytes considered pathognomonic for HPV lesions, these findings sometimes don’t appear on CA, and histopathology was not accurate, that immunohistochemistry with MIB-1 (Ki-67) and p16 can beused. Conclusion: Immunohistochemistry examination can help differentiate the diagnosis between malignancy or non- malignancy in the case of CA.

The Effect of Brown Algae (Sargassum sp) Extract on Wound Healing: pH gel ; diameter Tri Wahyuni Bintarti; Meidyta Sinantryana Widyaswari
Jurnal Ilmu Kesehatan dan Kesehatan Vol 6 No 1 (2022): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v6i1.2518

Backgroud: The wound care method that is currently developing uses the principle of moisture balance which is also known as the modern dressing method. Seaweed is a potential commodity in Indonesia, which has been widely used as a medicinal ingredient. However, the use of seaweed in the form of hydrogel ointment in the treatment of burns has not been widely studied. Therefore, this study was conducted to determine the effect of giving seaweed extract (Sargassum sp.) in the form of hydrogel ointment to burns. Methods: The design in this study was an experimental study with a randomized post-test only control group design, using musmusculus mice. This study was divided into 4 groups, group 1 was a negative control without treatment, group 2 was a group with burns and was given bioplacenton, group 3 was a burn group treated with 5% Sargassum sp extract hydrogel ointment and group 4 was a burn group given 5% ointment. Sargassum sp extract hydrogel ointment 10%. The treatment was carried out for 14 days and evaluated the diameter of the burn and the percentage of burn healing. Results: The results of this study showed that the difference in burn diameter at 0 days and after 14 days in the negative control group experienced a difference of 1.2 cm with a healing percentage of 44.85%. In treatment group 1, there was a difference in diameter of 1.2 cm, with a healing percentage of 49.41%, the 2-day treatment group obtained a difference in diameter of 1.2 cm, with a healing percentage of 50.31%, and in the positive control group a wound diameter of 1.0 cm, while the percentage of cure is 55.75%. The results of statistical tests on the percentage of wound healing between groups were not significantly different. Conclusion: In this study the seaweed extract (Sargassum sp.) formed in the hydrogel ointment did ot affect the healing of burns, this may be due to the long duration of administration.

Eskalasi Daya Saing Usaha Kelompok Wanita Tani Jawa Timur di Era Revolusi Industri 4.0 dengan Model Standardisasi Produk Rinurwati Rinurwati; Muslichah Erma Widiana; Mahmudah Enny Widyaningrum; Meidyta Sinantryana Widyaswari
IJECS: Indonesian Journal of Empowerment and Community Services Vol 2, No 2 (2021)
Publisher : Universitas Veteran Bangun Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32585/ijecs.v2i2.1748

Daya saing merupakan hal yang sangat penting untuk dimiliki produk di setiap daerah bahkan di setiap negara. Tingginya daya saing suatu negara akan berimplikasi pada peningkatan pertumbuhan ekonomi. Juga digunakan sebagai alat untuk mendapatkan akses pasar yang lebih luas serta mendorong pertumbuhan dalam meningkatkan kemakmuran disetiap daerah. Dalam hal peningkatan daya saing, produk Kelompok Wanita Tani (KWT) harus memiliki standar mutu yang sesuai dengan keinginan pelanggan. Untuk itu KWT harus memiliki sistem manajemen mutu untuk memastikan kualitas produk yang dihasilkan sesuai dengan keinginan pelanggan agar mampu bersaing ditengah era revolusi industry 4.0. Pengabdian masyarakat memiliki tujuan kemampuan KWT untuk dapat bersaing dari pesaingnya dalam merebut perhatian loyalitas konsumen, memperoleh laba yang berkelanjutan dan mempertahankan pasar. Untuk mencapai tujuan tersebut digunakan pendekatan kualitatif dengan melibatkan berbagai disiplin ilmu yaitu statistika dan ekonomi manajemen. Secara makro memberikan manfaat bagi kelompok wanita yang memiliki usaha memanfaatkan potensi daerahnya dan produk unggulan daerah semakin tercipta dengan kualitas tinggi. Pengabdian masyarakat ini dilakukan secara bertahap yaitu 1). melakukan pendekatan kualitatif yang difokuskan pada upaya mengidentifikasi faktor standarisasi produk KWT di Jatim. 2). melakukan pengujian model faktor standarisasi produk KWT di Jatim. 3). penerapan model pada kelompok usaha wanita lain serta dinas yang terkait.

Serum Level of Vitamin D (25[OH]D) in Patient with Atopic Dermatitis Meidyta Sinantryana Widyaswari; Iskandar Zulkarnain; Diah Mira Indramaya
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 2 (2016): AGUSTUS
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Atopic Dermatitis (AD) is a chronic inflammatory relapsing skin disorder along with itchy sensation. Etiopathogenesis DA remains unclear, however in common are caused by impaired epidermal barrier function of the skin and immune system that tend to ensue infection. Vitamin D is an immunomodulator and plays an important role in the pathogenesis of DA through improving the integrity of skin barrier permeability, expression of antimicrobial peptide (AMP), which inhibit infection, and reduce inflammation. Deficiency of vitamin D may increase the development risk of DA lesion. Purpose: To evaluate the serum levels of vitamin D (25[OH]D) in patients with DA. Methods: A descriptive observational cross-sectional study, in 34 DA patients at Dermatology and Venereology Outpatient Clinic of Dr. Soetomo Hospital Surabaya. Subjects were enrolled through consecutive sampling, serum vitamin D levels were measured using enzyme-linked immunosorbent assay (ELISA) method. Results: Serum levels of vitamin D (25[OH]D) in DA patients was 22.72±14.55 ng/mL. Serum levels of vitamin D based on the severity DA: mild (30.86±22.66 ng/mL); moderate (20.42±10.13 ng/mL); and severe (18.84±8.22 ng/mL). Conclusion: Deficiency of vitamin D can occur in DA patient with low level of serum vitamin D (25[OH]D), but the relationship with the severity of DA remains to be done further research. Key words: atopic dermatitis, vitamin D (25[OH]D).

Psoriasis Relationship with Hypertension in Psoriasis Patients at RSI Jemursari Surabaya Retna Gumilang; Meidyta Sinantryana Widyaswari; Zakiyyatur Rizkiyyah Husin
Jurnal Kesehatan Islam : Islamic Health Journal Vol 10, No 2 (2021): Jurnal Kesehatan Islam : Islamic Health Journal
Publisher : Publikasi oleh Fakultas Kedokteran Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jki.v10i2.13827

Abstract. Background: Psoriasis is a chronic inflammatory disease of the skin that characterized by firmly bound erythema plaques covered in thick squama and caused by multiple abnormalities of genetic, biochemical, immunologic, vascular with further severed by various other factors such as psychology, drugs, smoking, and alcohol consumption. Several studies revealed that psoriasis can increase the risk of cardiovascular diseases such as hypertension, however, the underlying pathophysiological mechanism has not been confirmed yet. This mechanism is probably attributed to increased levels of angiotensin-converting enzyme produce angiotensin II that regulates vascular tonus, endothelin-1 (ET-1) has been considered an important role in that vasoconstrictor proteins are potent, and increased plasma renin activity has been reported in patients with psoriasis. Purpose: In order to figure out the relationship between psoriasis and hypertension in psoriasis patients at the Outpatient Unit -RSI Jemursari Surabaya. Methods: This study was observational analytics with cross sectional study design in 28 psoriasis patients at Outpatient Unit-RSI Jemursari Surabaya during 2017-2019, using total sampling technique. Secondary data from medical records was collected and further analyzed with spearman correlation tests. Result: The obtained significance value is 0.000 (p < 0.05), which represent a significant relationship between hypertension and psoriasis. the correlation coefficient is 0.757, which indicates the strength of a strong relationship between two variables. Conclusion: There is a significant association between Psoriasis and Hypertension.

Community Service Programs for Serundeng and Marine Fish Chili Crafts Community with Local Expertise to Encourage Entrepreneurial Innovation and Competitiveness in Kenjeran, Surabaya Suhud Wahyudi; Muslichah Erma Widiana; Basuki Widodo; Soehardjoepri Soehardjoepri; Kamiran Kamiran; nur Asiyah; Meidyta Sinantryana Widyaswari
THE SPIRIT OF SOCIETY JOURNAL : International Journal of Society Development and Engagement Vol 5 No 1 (2021): September 2021
Publisher : LPPM of NAROTAMA UNIVERSITY

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29138/scj.v5i1.1404

Community service programs based on science and technology as a medium for mentoring prospective entrepreneurs in Rangkah district. Tambak Sari Kenjeran Surabaya, East Java. As partners are craftsmen of Various srundeng and sambal and young people who have connections as entrepreneurs from various groups in the target areas of the activity. The problem faced is that all this time the roasting process of srundeng and sambal sprinkles uses the conventional method, namely by using a frying pan that contains oil so it is unhealthy because it causes cholesterol and easily changes aroma. In carrying out the business activities of making srundeng and sambal sprinkled with sea fish, partners have not applied science and technology as well as potential entrepreneur partners. Many young people from various backgrounds in Rangkah Kenjeran Surabaya which has links as entrepreneurs but no one has yet facilitated assistance. As a solution for this community service program is to use a roaster with a capacity of 15kg / hour with dimensions specifications: 133x63x110cm, fuel: LPQ, 450watt electricity, 220v, to increase production capacity. Second, given training in mentoring concept knowledge and understanding of socio-spiritual and technological insight into marketing activities. Furthermore, providing training on creativity and innovation in the manufacture of products from marine fish from the Kenjeran coastal area to activity partners. The methods of implementation are (1) design, build, maintenance and use of roaster machines (2) training, practice, and assistance to increase conceptual competence and understanding of social and spiritual marketing for partners. (3) Training, practice, and mentoring transmit the mindset and behavior of an entrepreneur to students so that they behave and be entrepreneurial for partners. The results of this activity show a positive impact in improving the quality of partner products and increasing understanding, especially in entrepreneurship in improving their business going forward.

Pembentukan Karakter "BERDIRI" Bersih Diri Sendiri sebagai pencegahan Scabies di PP. Al Fitrah As Salafiyah Meidyta Sinantryana Widyaswari; Khamida; Muhammad Taufiq Hidayat; Noer Farakhin
PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT Vol. 3 No. 1 (2023): Prosiding Seminar Nasional Pengabdian Kepada Masyarakat : MEMAKSIMALKAN POTENSI
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/snpm.v3i1.1258

Latar Belakang, Scabies adalah penyakit kulit menular yang kerap kali terjadi di lingkungan Ponpes. Maka dari itu kegiatan ini bertujuan untuk meningkatkan kebiasaan personal hygiene dan bersih diri mandiri sebagai salah satu bentuk pengendalian scabies di PP Al Fitrah As Salafiyah Surabaya. Metode, pengabdian masyarakat yang dilaksanakan pada bulan Juni 2023 ini dihadiri oleh 40 peserta dari PP Al Fitrah As Salafiyah Surabaya. Kegiatan yang dilakukan berupa Pemberian edukasi, Pembentukan karakter santri dan pengurus dengan games kesehatan dan pembagian pretest dan postest. Penelitian ini dilakukan secara observasional deskriptif untuk melihat respon peserta dengan dilihat dari antusiasme dan peningkatan pengetahuan peserta dengan menggunakan analisis uji Wilcoxon. Hasil dan Pembahasan, hasil menunjukkan p-value bernilai 0,033. Karena nilal 0,033 < 0,05, maka dapat disimpulkan bahwa "Ha diterima". Artinya ada perbedaan antara pengetahuan santri sebelum dilakukan penyuluhan (Pretest) dan setelah dilakukan penyuluhan (Posttest). Kesimpulan, Terdapat pengaruh pemberian penyuluhan yang telah dilakukan pada kegiatan pengabdian kepada masyarakat di PP Fitrah As Salafiyah Surabaya terkait Pencegahan Pembentukan Karakter “BERDIRI” Bersih Diri Sendiri sebagai pencegahan Scabies 2023.

Eskalasi Daya Saing Usaha Kelompok Wanita Tani Jawa Timur di Era Revolusi Industri 4.0 dengan Model Standardisasi Produk Rinurwati, Rinurwati; Widiana, Muslichah Erma; Widyaningrum, Mahmudah Enny; Widyaswari, Meidyta Sinantryana
IJECS: Indonesian Journal of Empowerment and Community Services Vol 2 No 2 (2021)
Publisher : Universitas Veteran Bangun Nusantara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32585/ijecs.v2i2.1748

Daya saing merupakan hal yang sangat penting untuk dimiliki produk di setiap daerah bahkan di setiap negara. Tingginya daya saing suatu negara akan berimplikasi pada peningkatan pertumbuhan ekonomi. Juga digunakan sebagai alat untuk mendapatkan akses pasar yang lebih luas serta mendorong pertumbuhan dalam meningkatkan kemakmuran disetiap daerah. Dalam hal peningkatan daya saing, produk Kelompok Wanita Tani (KWT) harus memiliki standar mutu yang sesuai dengan keinginan pelanggan. Untuk itu KWT harus memiliki sistem manajemen mutu untuk memastikan kualitas produk yang dihasilkan sesuai dengan keinginan pelanggan agar mampu bersaing ditengah era revolusi industry 4.0. Pengabdian masyarakat memiliki tujuan kemampuan KWT untuk dapat bersaing dari pesaingnya dalam merebut perhatian loyalitas konsumen, memperoleh laba yang berkelanjutan dan mempertahankan pasar. Untuk mencapai tujuan tersebut digunakan pendekatan kualitatif dengan melibatkan berbagai disiplin ilmu yaitu statistika dan ekonomi manajemen. Secara makro memberikan manfaat bagi kelompok wanita yang memiliki usaha memanfaatkan potensi daerahnya dan produk unggulan daerah semakin tercipta dengan kualitas tinggi. Pengabdian masyarakat ini dilakukan secara bertahap yaitu 1). melakukan pendekatan kualitatif yang difokuskan pada upaya mengidentifikasi faktor standarisasi produk KWT di Jatim. 2). melakukan pengujian model faktor standarisasi produk KWT di Jatim. 3). penerapan model pada kelompok usaha wanita lain serta dinas yang terkait.

IMUNOHISTOKIMIA PADA KONDILOMATA AKUMINATA Widyaswari, Meidyta Sinantryana; Lumintang, Hans; Soemarno, Troef
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i1.926

Background: Condylomata Acuminata (CA) is a sexually transmitted disease caused by the Human Papilloma Virus (HPV) type-specific and may be simultaneously co-infected with other HPV types associated with malignancy. Purpose: To differentiate between CA and histopathological of malignancy by immunohistochemistry. LiteratureReview: CA refers to benign epidermal proliferation caused by the HPV types 6 and 11, but co-infection with high- risk HPV types are common. The clinical presentation of CA can’t differentiate between benign or preneoplastik diplasia lesions. Koilocytes considered pathognomonic for HPV lesions, these findings sometimes don’t appear on CA, and histopathology was not accurate, that immunohistochemistry with MIB-1 (Ki-67) and p16 can beused. Conclusion: Immunohistochemistry examination can help differentiate the diagnosis between malignancy or non- malignancy in the case of CA.

Anti-eczema Mechanism of Action of Nigella sativa for Atopic Dermatitis: Computer-aided Prediction and Pathway Analysis Based on Protein-chemical Interaction Networks Widyaswari, Meidyta Sinantryana; Noventi, Iis; Supriyana, Herdiantri
Biomolecular and Health Science Journal Vol. 2 No. 2 (2019): Biomolecular and Health Science Journal
Publisher : Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia

Introduction: Black cumin (Nigella sativa) is widely used to treat various diseases. It is also believed to relief skin conditions accompanied by itching symptom, such as atopic dermatitis (AD) or eczema. However, the anti-eczema mechanism of action is still unclear. The aims of this syudy was to identify anti-eczema mechanism of action of N. sativa for AD using computer aided prediction and pathway analysis based on protein-chemical networks. Methods: We utilized dataset consisting chemical compounds of N. sativa from KNApSAcK. It is a comprehensive species-metabolite relationship database. Using canonical SMILES strings that encode molecular structures of each compound, we predicted the probabilities of activity (Pa) for anti-eczema effect based on PASS algorithms. The compounds with Pa >0.7 were included for pathway analysis based on protein-chemical interaction networks in STITCH database. We selected interactomes built by experimental data, gene co-expression, closest gene position, fusion, co-occurence, computational prediction, and other secondary data. Results: Thirty-five active compounds of N. sativa have been utilized and 19 of them have potential anti-eczema effects. Oleic acid and lauric acid were predicted with Pa-value of 0.947 and 0.920 for anti-eczema effect, respectively. However, only lauric acid was confirmed having a plausible mechanism of action via LY96-TLR4- PIK3R1 pathway for lipopolysaccharide receptor activity (false discovery rate [FDR] = 0.0243) and low-density lipoprotein particle receptor binding (FDR = 0.0118). Conclusion: Lauric acid in N. sativa has potential antieczema effect to prevent relaps in AD patients by controlling opportunistic bacterial infection that aggravates itching symptom in this condition.

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