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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Farmasi Sains dan Komunitas Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Midwifery Journal: Jurnal Kebidanan UM. Mataram Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas YARSI Medical Journal Jurnal Teknik Kimia Cermin Dunia Kedokteran Conferences of Medical Sciences Dies Natalis JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Kreativitas Pada Pengabdian Masyarakat (Krepa) Fajar: Media Komunikasi dan Informasi Pengabdian Kepada Masyarakat
Safyudin
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Asam Folat: Peran dalam Metabolisme dan Metode Pemeriksaan Subandrate Subandrate; Medina Athiah; Safyudin Safyudin; Ella Amalia; Irsan Saleh; Hermansyah Hermansyah; Dwirini Retno Gunarti
Majalah Kedokteran Andalas Vol 45, No 1 (2022): Online Januari 2022
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v45.i1.p51-62.2022

Abstract

Tujuan: Untuk mengetahui peran asam folat dalam metabolisme dan metode pemeriksaan asam folat serum. Metode: Artikel ini dibuat dengan mengumpulkan sumber rujukan dari Sinta, Google Scholar, Pubmed, dan ScienceDirect.  Artikel-artikel yang berisi mengenai asam folat (folic acid) atau folat (folate) dan metode pemeriksaan  asam folat (folate detection method, folate analysis method) tahun 2005-2020 dikumpulkan kemudian dibahas dan ditarik kesimpulan secara umum. Hasil: Bentuk aktif asam folat, tetrahidrofolat, berperan dalam metabolisme purin, pirimidin (timin), dan metionin dengan cara mendonorkan unit satu karbon (metil, metilen, metenil, formimino atau formil). Kadar asam folat serum normal adalah 6-20 ng/ml. Beberapa metode digunakan untuk memeriksa kadar asam folat serum yakni mikrobiologi, HPLC dan protein binding assay. Metode mikrobiologi merupakan baku emas, tetapi membutuhkan waktu yang lama, mudah terkontaminasi dan perlu tenaga mikrobiologi khusus.  Metode HPLC memberikan hasil yang lebih cepat, tetapi mahal dan kurang sensitif. Metode protein binding assay merupakan metode baru yang menggunakan protein ikat folat. Metode ini memiliki sensitivitas dan spesifisitas yang baik. Kekurangan pada metode ini adalah penyimpanan reagen dan kalibrasi. Kesimpulan: Asam folat dibutuhkan dalam metabolisme nukleotida dan asam amino. Metode pemeriksaan asam folat diharapkan dapat dikembangkan untuk pemeriksaan asam folat yang lebih sederhana, murah dan cepat.
Uji Fitokimia dan Potensi Antidiabetes Fraksi Etanol Air Benalu Kersen (Dendrophtoe petandra (L) Miq) Sadakata Sinulingga; Subandrate Subandrate; Safyudin Safyudin
Jurnal Kedokteran dan Kesehatan Vol 16, No 1 (2020): JURNAL KEDOKTERAN DAN KESEHATAN
Publisher : Faculty of Public Health, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (387.716 KB) | DOI: 10.24853/jkk.16.1.76-83

Abstract

Pengobatan diabetes melitus dengan acarbose belum sepenuhnya optimal. Perlu pengembangan obat baru dari tanaman obat. Salah satu tanaman obat yang dipercaya masyarakat memiliki potensi antidiabetes adalah daun benalu kersen (Dendrophtoe petandra (L) Miq). Penelitian ini adalah penelitian eksperimental laboratorium yang bertujuan mengetahui kandungan fitokimia dan potensi antidiabetes fraksi etanol air daun benalu kersen. Kandungan daun benalu kersen diuji secara fitokimia dan potensi antidiabetes daun benalu kersen diuji dengan cara inhibisi enzim alfa glukosidase. Hasil uji fitokimia menunjukkan bahwa fraksi etanol air daun benalu kersen mengandung flavonoid, tannin, saponin, terpenoid/steroid, dan alkaloid. Uji inhibisi oleh fraksi etanol air memperlihatkan bahwa daun benalu kersen menghambat enzim alfa glukosidase dengan kekuatan kuat (IC50= 75,73 µg/ml). Terpenoid dan saponin dalam daun benalu kersen diduga memiliki aktivitas inhibisi enzim alfa glukosidase. Hambatan terhadap kerja enzim alfa glukosidase menyebabkan penurunan hidrolisis amilum di usus halus sehingga hanya sedikit glukosa yang dapat diserap. Dengan demikian fraksi etanol air daun benalu kersen memiliki potensi sebagai obat antiadiabetes.
Korelasi Kadar Asam Urat dengan Derajat Keganasan Kanker Kolorektal Subandrate -; Ella Amalia; Dwi Indira Setyorini; Safyudin -
Cermin Dunia Kedokteran Vol 45, No 7 (2018): Onkologi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v45i7.637

Abstract

Pendahuluan: Hiperurisemia pada pasien kanker meningkatkan angka kematian terutama pada stadium lanjut. Metode: Studi observasional analitik korelatif dengan rancangan cross sectional, untuk mengetahui korelasi kadar asam urat dan derajat keganasan kanker kolorektal. Subjek penelitian 35 orang penderita kanker kolorektal yang dirawat di RSUP Mohammad Hoesin (RSMH), terdiri atas 15 laki-laki dan 20 perempuan. Stadium kanker kolorektal berdasarkan pemeriksaan histopatologi di Laboratorium Patologi Anatomi RSMH/FK Unsri Palembang. Pemeriksaan kadar asam urat serum di Laboratorium Biokimia FK Unsri. Hasil: Stadium klinis penderita terdiri dari stadium II (17,1%), stadium III (48,6%) dan stadium IV (34,3%). Rata-rata kadar asam urat penderita adalah 11,8±3,5 mg/dL, 88,6% mengalami hiperurisemia. Kadar asam urat pada pasien kanker kolorektal stadium awal adalah 10,6 mg/dL, pada pasien kanker kolorektal stadium akhir adalah 12,3 mg/dL. Korelasi antara kadar asam urat dan stadium kanker kolorektal sangat lemah (r=0,072) dan tidak bermakna (p=0,647). Simpulan: Hiperurisemia terjadi pada hampir semua penderita kanker kolorektal. Kadar asam urat tidak berkorelasi dengan stadium kanker kolorektal.Introduction: Hyperuricemia in cancer patients increases mortality, especially in advanced phase. Methods: An observational analytic correlative study with cross sectional design on correlation between uric acid level and cancer stage in colorectal cancer patients. Subjects were 15 male and 20 female colorectal cancer patients treated at RSUP Mohammad Hoesin (RSMH). Stage of colorectal cancer based on histopathology examination in Anatomy Pathology Laboratory of RSMH/Medical Faculty of Sriwijaya University, Palembang. Serum uric acid level was measured in Biochemistry Laboratory of Medical Faculty of Sriwijaya University. Results: The cancer stage of the patients were stage II (17.1%), stage III (48.6%) and stage IV(34.3%). The mean uric acid levels were 11.8±3.5 mg/dL. Approximately 88.6% of colorectal cancer patients have hyperuricemia. The mean level of uric acid in patients with early stage colorectal cancer was 10.6 mg/dL, in patients with end-stage colorectal cancer was 12.3 mg/dL. The correlation between uric acid levels and colorectal cancer stage was very weak (r=0.072) and was not significant (p=0.647). Conclusion: Hyperuricemia occurs in almost all colorectal cancer patients. Uric acid level did not correlate with colorectal cancer stage. 
Kadar MDA (Malondialdehid) Karyawan SPBU di Kota Palembang. Subandrate -; Safyudin -
Cermin Dunia Kedokteran Vol 43, No 5 (2016): Infeksi
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v43i5.53

Abstract

Lingkungan SPBU adalah salah satu lingkungan tinggi oksidan seperti toluen, benzena, xylen, atau hidrokarbon aromatik polisiklik (PAH). Senyawa ini dimetabolisme oleh hati dan menghasilkan radikal bebas yang merusak sel. Oksidasi radikal bebas terhadap lipid menghasilkan senyawa MDA (malondialdehid). Penelitian potong lintang bersifat analitik observasional ini bertujuan untuk membandingkan kadar MDA antara karyawan SPBU dan non-karyawan SPBU di Kota Palembang. Dua SPBU dipilih secara acak.  Jumlah subjek penelitian pada penelitian ini adalah 14 orang karyawan SPBU dan 7 kontrol. Sampel berupa darah yang diambil setelah selesai shift kerja. Rata-rata kadar MDA pada karyawan SPBU adalah 0,731 nmol/mL dan kontrol adalah 0,326 nmol/mL. Terdapat pengaruh bekerja di SPBU terhadap kadar MDA (p=0,004). Peroksidasi lipid darah cenderung lebih banyak terdapat pada karyawan SPBU dibandingkan kontrol.
Macronutrient and Micronutrient Content in Breast Milk Subandrate Subandrate; Ella Amalia; Medina Athiah; Safyudin Safyudin; M. Nadhif Prasetyo; M. Hafizh Arrafi
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.865 KB)

Abstract

Breast milk is the best source of nutrition for newborns. Breast milk content is composed of water, protein, carbohydrates, fats, vitamins, minerals, antibodies, and enzymes. Breast milk also contains white blood cells and substances that make up the baby`s immune system such as immunoglobulins and lysozyme. The composition of breast milk can change depending on the needs and ages of the baby. Exclusive breastfeeding is recommended by many doctors and other healthcare professionals. One of the factors that influence exclusive breastfeeding is the mother`s knowledge about the content of breast milk. Most breastfeeding mothers do not know the nutritional content of breast milk, both macronutrients, and micronutrients. Breast milk is also rich in immune cells, antibodies, and other bioactive ingredients that help protect the baby from infection until the baby has an effective antibody response in the first few months of life. Breast milk is an ideal nutrient for babies. The mixture of vitamins, proteins, and fats in breast milk can provide the nutrients and calories the baby needs to grow. Babies who have been breastfed for 6 months are more likely to reach their ideal weight.Therefore, the government recommends exclusive breastfeeding for infants up to the age of 6 months.
PRODUCTION OF YELLOW WOOD ROOT TEA AS A BLOOD SUGAR STABILIZER Fatmawati Fatmawati; M Athiah; S Sinulingga; L.O Oswari; Safyudin Safyudin
Conferences of Medical Sciences Dies Natalis Vol. 3 No. 1 (2021): Conference of Medical Sciences Dies Natalis Faculty of Medicine Universitas Sri
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (398.338 KB)

Abstract

Diabetes mellitus is a disease or metabolic disorder that is increasing year by year, characterized by high blood sugar levels as a result of insulin function insufficiency. Diabetes mellitus, which is often referred to as diabetes, is a disease or metabolic disorder that is increasing year by year, characterized by high blood sugar levels as a result of insulin function insufficiency. Treatment is by using drugs. Currently, a treatment using herbal medicine is being developed, one of which is Kayu kuning, where in previous studies it was found that the roots of Kayu kuning can reduce blood glucose levels. This has triggered the Biochemistry and Medical Chemistry section of the Faculty of Medicine to introduce to the public the preparations of this herbal medicine with ready-to-use packaging and the right dosage. The process of making tea is carried out at the Chemical Basic Medicine Laboratory, Faculty of Medicine, Sriwijaya University. About 5.6 kg of yellow wood root, washed and cut into small pieces then dried and ground to obtain a coarse powder (simplicia) of about 2.5 kg. Yellow wood root simplicia is put into tea bags weighing 10 g per bag. One tea bag can be brewed with 200 mL of hot water and drunk once a day. In this service, 250 tea bags were produced which were packaged in 50 packages (5 tea bags/package). The production of this yellow wood root tea has been carried out in the Komplek Azhar Lama, Kenten Laut, Palembang. Keywords: Herbal medicine, yellow root (Arcangelisia flava)
Relationship polymorphism exon 17 of insulin receptor (INSR) gene with polycystic ovarian syndrome among Malay ethnic in South Sumatera Okta Emilia; Legiran; Safyudin; Syifa Alkaf
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 13, No 1, (2022)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol13.Iss1.art3

Abstract

Background: A sedentary lifestyle is a risk of obesity. One of the negative effects of obesity is insulin resistance. Insulin resistance is found in 50% - 90% of women with Polycystic Ovary Syndrome (PCOS).Objective: This study aimed to analyse the relationship polymorphism exon 17 of insulin receptor (INSR) gene in Malay ethnicity in South Sumatera.Methods: This is an observational analytic study with a case-control design conducted at the Molecular Biology Laboratory, Faculty of Medicine, Sriwijaya University. This study sample used blood taken from 80 people consisting of 40 cases and 40 controls. Genotyping and allotypic were performed using PCR-RFLP. Analysis was performed using SPSS 16.Results: The statistical analysis using the Chi-Square test on IMT resulting p-value = 0.003 (OR = 4.660 95% CI = 1.764 - 12.311). (Wild type) CC, (Mutant heterozygous) CT, (Homozygous Mutant) TT. The statistical analysis using the Pearson Chi-Square Genotype PCOS resulting p-value = 0.970 and fisher exact test on SOPK allotype resulting p-value = 0.500 (OR = 0.949 95% CI = 0.503 - 1,790).Conclusion: In conclusion, there was a significant relationship between BMI and PCOS among Malay ethnic in South Sumatera. There was no significant relationship between genotypic polymorphism and allotype exon 17 of INSR with PCOS in Malay ethnic groups in South Sumatera.
PRODUKSI TEH DAUN SUNGKAI SEBAGAI MINUMAN IMUNOSTIMULATOR Subandrate Subandrate; Sadakata Sinulingga; Fatmawati Fatmawati; Irfannuddin Irfannuddin; Susilawati Susilawati; Rini Yana; Medina Athiah; Safyudin Safyudin
LOGISTA - Jurnal Ilmiah Pengabdian kepada Masyarakat Vol 6 No 1 (2022)
Publisher : Department of Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Andalas Kampus Limau Manis - Padang, Sumatera Barat Indonesia-25163

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/logista.6.1.10-14.2022

Abstract

Pada pertengahan tahun 2021 kasus Covid19 di Indonesia melonjak lagi termasuk di Kota Palembang. Lonjakan kasus tersebut tidak hanya memberikan dampak bagi masyarakat luas tetapi juga bagi lingkungan kampus Universitas Sriwijaya. Oleh karena itu, perlu dilakukan upaya meningkatkan imunitas tubuh menggunakan herbal tradisional Indonesia. Salah satu tanaman yang memiliki manfaat sebagai imunostimulator adalah tanaman sungkai. Kegiatan pengabdian kepada masyarakat ini berupa pembuatan teh dari daun sungkai. Proses pembuatan teh dilakukan di Laboratorium Kimia Dasar Kedokteran Fakultas Kedokteran Universitas Sriwijaya. Sekitar 27 kg daun sungkai segar dicuci dan dipotong kecil lalu dikeringkan. Daun sungkai kering digiling menjadi serbuk kasar (simplisia). Jumlah simplisia daun sungkai yang didapatkan sekitar 5,1 kg. Takaran sekali minum daun sungkai adalah sekitar 25 g untuk daun segar dan 3 g untuk simplisia. Simplisia daun sungkai dimasukkan ke dalam kantong teh dengan berat bersih 3 g per kantong. Satu kantong teh dapat diseduh dengan 240 mL air panas dan diminum 1-2 kali sehari selama 5 hari. Pada pengabdian ini dihasilkan 1700 kantong teh yang dikemas dalam 340 kemasan (5 kantong teh/kemasan). Produksi teh daun sungkai telah dilakukan dengan baik lalu dibagikan ke civitas akedemika melalui Dekan Fakultas Kedokteran dan Rektor Universitas Sriwijaya. Kata kunci: Covid19, Daun sungkai, Imunostimulator, Simplisia, Teh ABSTRACT In mid-2021, Covid-19 cases in Indonesia began to increase, including in Palembang. This condition not only has an impact on society but also for Sriwijaya University. To reduce the impact of Covid19, it is possible to increase the body's immunity with traditional Indonesian herbs, Sungkai. Sungkai has benefit as an immunostimulator. This community service is in the form of tea production from sungkai leaves. The process of making tea is carried out at Laboratorium Kimia Dasar Kedokteran, Faculty of Medicine, Universita Sriwijaya. About 27 kg of fresh sungkai leaves are washed, cut, and then dried to obtain about 5.1 kg of simplicia. The daily dose of sungkai leaves is about 25 g for fresh leaves and 3 g for simplicia. About 3 g simplicia was put into tea bags. One tea bag can be brewed with 240 mL of hot water and drunk 1-2 times a day for 5 days. A total of 1700 tea bags were produced and packaged in 340 packages (5 tea bags/package). Sungkai leaf tea production has been carried out well and then distributed to the academic community through the Dean of the Faculty of Medicine and the Chancellor of Universitas Sriwijaya. Keywords: Covid19, Sungkai leaf, Immunostimulator, Simplicia, Tea
EDUKASI PENYIMPANAN DAN PENYAJIAN ASI PERAH SEBAGAI UPAYA MENJAGA KANDUNGAN NUTRISI ASI Subandrate Subandrate; Ella Amalia; Dwi Indira Setyorini; Safyudin Safyudin
Kreativitas Pada Pengabdian Masyarakat (Krepa) Vol. 2 No. 3 (2024): Kreativitas Pada Pengabdian Masyarakat (Krepa)
Publisher : CV SWA Anugerah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.8765/krepa.v2i3.1947

Abstract

Exclusive breastfeeding is still not fully carried out by Indonesian mothers. The problem with breastfeeding is the lack of knowledge among mothers and working mothers. To promote exclusive breastfeeding again, educational programs can be carried out. Educational activities are carried out offline at the Prabumulih Mayor's Office Hall. Participants in this community service activity were PKK women from Prabumulih City, with a total of 54 people and ages ranging from 27 years to 71 years. The expert in this activity were dr. Ella Amalia, M.Kes, secretary of the South Sumatra Branch of the Association of Indonesian Breastfeeding Mothers (AIMI), and the national ASI counselor. She informed that breast milk contains sufficient nutrients for the growth and development of infants. Working mothers can continue to provide expressed breast milk (ASIP) to their babies. Giving ASIP to infants requires attention to how it is stored and served. Defrosting ASIP by gradually increasing the temperature, for example, from the freezer to the fridge and then to room temperature, is considered better than direct defrosting with hot water or a heater. Community service activities have been carried out well. This service can provide education to breastfeeding mothers regarding the proper storage and presentation of ASIP.
PENAPISAN TALASEMIA DENGAN PEMERIKSAAN KADAR HEMOGLOBIN Subandrate Subandrate; Sadakata Sinulingga; Medina Athiah; Safyudin Safyudin; Fatmawati Fatmawati; Rini Yana
Kreativitas Pada Pengabdian Masyarakat (Krepa) Vol. 2 No. 3 (2024): Kreativitas Pada Pengabdian Masyarakat (Krepa)
Publisher : CV SWA Anugerah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.8765/krepa.v2i3.1948

Abstract

Thalassemia is a genetic disease that affects the hemoglobin component in red blood cells. Health education is expected to provide changes in people's knowledge and attitudes in recognizing and preventing thalassemia. In addition, thalassemia self-screening is a simple way to be able to recognize and prevent thalassemia independently and sustainably. This community service activity was carried out with the method of counseling and demonstration of thalassemia screening by checking hemoglobin levels. The activity was carried out in Sako Village, Palembang City on Sunday, October 23, 2022. The participants of the activity were the community and administrators of KJS Al Aqobah 2 Pusri, Sako, Palembang. Most of the participants were 61 years old for the counseling group, and 13 years old for the thalassemia screening group. The community was very enthusiastic about participating in this activity. Some of the important questions asked by participants were 1) Can thalassemia be transmitted? 2) Is thalassemia only inherited from the mother? 3) Can thalassemia be cured? Discussions about thalassemia are carried out in general in a series of events and individually between screening activities. The results of screening with hemoglobin examination showed that there were no participants who were indicated to have thalassemia. The hemoglobin levels of all participants were normal (above 12 g/dL). Tracing symptoms and family history showed that the participant's family had not been indicated as having thalassemia. The service activities have been carried out well and provide benefits for the participants. The community expects similar activities to be carried out simultaneously.
Co-Authors Adma, Annes Claudia Annes C. Adma Arifin, Mutmainah Arrafi, Muhammad Hafizh Athiah, Medina Auliya Bella Oktarina Az Zahra, Fatihah Dian Natalia Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Ella Amalia, Ella Ellla Amalia Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Hasri Salwan Hermansyah Hertanti Indah Lestari, Hertanti Indah Irfannuddin Irfannuddin Kms Yusuf Effendi Kusumo Hariyadi Kusumo Haryadi L.O Oswari Legiran Legiran Lia Damayanti M Athiah M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Marlisa, Ade Medina Athiah Medina Athiah Medina Athiah Mohammad Fiqih Monanda, M Dias Athallah Monanda, M. Dias Athallah Muhammad Irsan Saleh Mulawarman, Hisham Naomi W Tioline Okta Emilia Oktalisa, Wenni Oktharina, Eka Handayani Oswari, Liniyanti D Pierre Ramandha K Riani Erna Rini Yana Rini Yana Romadhon, M Fitra S Sinulingga Sabathania, Hana Daini Sadakata Sinulingga Sembiring, Rinawati Setyorini, Dwi Indira SRI RAHAYU Subandrate Susilawati Susilawati Susilawati, Susilawati Syadra Bardiman Rasyad Syifa Alkaf Yana, Rini Yusuf Effendi Zikra, Muhamad