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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Kedokteran Sriwijaya JPSriwijaya Biomedical Journal of Indonesia Jurnal Farmasi Sains dan Komunitas Universa Medicina Jurnal Fitofarmaka Indonesia Jurnal Kedokteran dan Kesehatan Midwifery Journal: Jurnal Kebidanan UM. Mataram Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Jurnal Ilmu Kefarmasian Indonesia Majalah Kedokteran Andalas YARSI Medical Journal Jurnal Teknik Kimia Cermin Dunia Kedokteran Conferences of Medical Sciences Dies Natalis JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Kreativitas Pada Pengabdian Masyarakat (Krepa) Fajar: Media Komunikasi dan Informasi Pengabdian Kepada Masyarakat
Safyudin
Bagian Biokimia Dan Kimia Medik, Fakultas Kedokteran, Universitas Sriwijaya
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Effect of solvent polarity on secondary metabolite content and α-glucosidase enzyme IC50 of Dendrophthoe pentandra (L). Miq leaves extract Subandrate, Subandrate; Sinulingga, Sadakata; Adma, Annes Claudia; Monanda, M. Dias Athallah; Fatmawati, Fatmawati; Safyudin, Safyudin; Oswari, Liniyanti D
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1363

Abstract

Cherry mistletoe (Dendrophthoe pentandra (L). Miq) have an inhibitory effect on the α-glucosidase enzyme, but research related to solvent optimization to find active compound is unclear. Secondary metabolites that can be identified depend on the level of solvent polarity. This study aims to determine the effect of solvent polarity on the secondary metabolite content and the α-glucosidase enzyme by using the polar and nonpolar fractions of the ethyl acetate extract of cherry mistletoe leaves. Cherry mistletoe leaves were extracted using ethyl acetate and were followed by a liquid-liquid fractionation. The polar fraction used ethanol and ethyl acetate as solvents, whereas the nonpolar fraction used n-hexane and ethyl acetate as solvents. Secondary metabolites present in polar fractions were alkaloids, flavonoids, steroids, tannins, and terpenoids, whereas those present in nonpolar fractions were flavonoids and steroids. The IC50 value of the polar fraction (54.8 ppm) was lower than that of the nonpolar fraction (192.0 ppm). The polar fraction of the ethyl acetate extract of cherry mistletoe leaves could inhibit the α-glucosidase enzyme and, therefore, is classified as active. On the other hand, the nonpolar fraction of the ethyl acetate extract of cherry mistletoe leaves could not inhibit the α-glucosidase enzyme and, therefore, is classified as inactive in general.
PENERAPAN CASE BASED METHOD DALAM EDUKASI PRAPUBERTAS SISWA USIA SEKOLAH DASAR Subandrate, Subandrate; Amalia, Ella; Rahayu, Sri; Safyudin, Safyudin
Kreativitas Pada Pengabdian Masyarakat (Krepa) Vol. 5 No. 1 (2025): Kreativitas Pada Pengabdian Masyarakat (Krepa)
Publisher : CV SWA Anugerah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.8765/krepa.v5i1.12492

Abstract

Siswa sekolah dasar (SD) laki-laki prapubertas berada pada fase perkembangan yang penting, di mana mereka mulai mengalami perubahan fisik, emosional, dan psikologis yang signifikan. Untuk membantu siswa SD laki-laki prapubertas memahami dan mengelola perubahan yang terjadi dalam tubuh mereka, pendekatan yang dapat digunakan adalah dengan memberikan pengajaran tentang pendidikan seks dan hormon seks. Penerapan case-based method dapat membantu siswa memahami perubahan fisik dan emosional yang terjadi pada masa prapubertas secara konkret. Kegiatan pengabdian ini diikuti oleh 43 siswa laki-laki dari kelas empat, kelas lima, dan kelas enam. Sebagian besar siswa berumur 11 tahun. Pembicara mengambil tema “Saleh di Masa Pubertas” dengan tiga subtopik yakni tahapan proses penciptaan manusia, proses pertumbuhan dan perkembangan manusia, dan masa dan tanda pubertas pada laki-laki. Pada pengabdian ini, didapatkan ada dua anak (4,7%) yang sudah mengalami pubertas. Sebagian besar siswa dapat memahami topik dengan baik (55,8%). Kegiatan pengabdian kepada masyarakat dilaksanakan dengan baik. Siswa senang dengan metode berbasis kasus yang digunakan pada kegiatan ini. Mereka berharap topik-topik edukasi dapat diberikan dengan metode tersebut. Peran utama dari penerapan metode ini adalah untuk mendorong siswa berpikir kritis, memecahkan masalah, dan memahami konsep-konsep yang kompleks melalui penerapan pengetahuan dalam situasi nyata.
Dosage and Ferritin Reduction in Paediatric Thalassemia Major: A Cross-Sectional Study Athiah, Medina; Zikra, Muhamad; Safyudin; Lestari, Hertanti Indah; Fatmawati
Sriwijaya Journal of Medicine Vol. 8 No. 1 (2025): Vol 8, No 1, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i1.332

Abstract

Thalassemia is a genetic disorder that requires regular blood transfusions, often resulting in iron overload. Iron chelation therapy with deferiprone is commonly used to manage the iron overload, yet the relationship between deferiprone dosage and ferritin level reduction remains unclear. This study aimed to find out how the dose of deferiprone affects the reduction of serum ferritin levels in children with thalassemia major. A cross-sectional analytical study was conducted involving 69 paediatric patients with thalassemia major receiving deferiprone therapy at Dr. Mohammad Hoesin Central General Hospital, Palembang. Data on patient demographics, transfusion frequency, deferiprone dose, and serial ferritin levels (3–6 months apart) were collected. The optimal dose cut-off was determined using ROC analysis, and statistical association was tested using the Chi-Square test. Most patients (56.5%) received deferiprone doses ≤77.95 mg/kgBW. Only 36.2% achieved a ferritin reduction of ≥20%, while 50.7% experienced increased ferritin levels. No statistically significant association was found between deferiprone dose and ferritin reduction (p = 0.051), although a trend toward lower success in the high-dose group was observed (PR 0.355, 95% CI: 0.124–1.019). The average dose of deferiprone administered in this study was below the minimum dose recommended by the FDA, which may explain the lack of significant association with serum ferritin reduction. Further research with controlled dosing and exclusion of confounding variables is recommended to evaluate deferiprone effectiveness more accurately
Total Phenol, Flavonoid Content, and Antioxidant Activity of the Ethanol Fraction of Arcangelisia Flava Stem Fatmawati, Fatmawati; Oktharina, Eka Handayani; Mulawarman, Hisham; Sinulingga, Sadakata; Safyudin, Safyudin
Biomedical Journal of Indonesia Vol. 11 No. 2 (2025): Vol 11, No 2, 2025
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v11i2.225

Abstract

Introduction. Oxidative stress caused by an imbalance between reactive oxygen species (ROS) production and antioxidant defenses leads to various diseases. Arcangelisia flava, a medicinal plant, contains antioxidant-active phenols and flavonoids. This study evaluates the total phenol and flavonoid content and the antioxidant activity of the ethanol fraction of A. flava stem. Methods. An experimental study was conducted using 750 grams of A. flava stem. The sample underwent fractionation and was analyzed using Folin-Ciocalteu and AlCl3 methods to determine total phenol and flavonoid content. Antioxidant activity was assessed using the DPPH method. Data were analyzed using regression equations and IC50 values. Results. The ethanol fraction contained 57.81 ± 3.28 mg GAE/g of total phenol and 114.6 ± 1.02 mg QE/g of total flavonoid. The IC50 value for the ethanol fraction was 72.88 ppm, indicating strong antioxidant activity, albeit less potent than ascorbic acid (IC50 7.37 ppm). Conclusion. The ethanol fraction of A. flava stem is a potential natural antioxidant source.
EFEK DURASI PENYIMPANAN DI LEMARI PENDINGIN TERHADAP KADAR PROTEIN ASI PERAH Arrafi, Muhammad Hafizh; Subandrate, Subandrate; Safyudin, Safyudin
Midwifery Journal: Jurnal Kebidanan UM. Mataram Vol 10, No 2 (2025): Juli
Publisher : Universitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/mj.v10i2.6475

Abstract

Abstract: Exclusive breastfeeding is the best nutrition for babies to grow and develop. Currently, urban communities tend to stop breastfeeding at earlier age because of working mother. To overcome this, mothers can give expressed breast milk to babies by paying attention to the duration and temperature of storage, because it can affect the nutrients contained in breast milk. This study aims to determine the effect of the duration of storage of breast milk in the refrigerator on the protein contained in the breast milk. This research is a pure experimental research study with one group pre-test and post-test research design. The research was conducted at the Basic Medical Chemistry Laboratory, Faculty of Medicine, Universitas Sriwijaya. The number of expressed breastmilk samples in this study was 30 samples. Samples were divided into 5 groups, with variations in the duration of storage in the refrigerator (4-8°C) for 0 hour (control), 24 hours, 72 hours, 120 hours, and 192 hours. Protein level was measured by using Lowry method. Data were analyzed by repeated anova and paired t-test. The average protein content of ASIP at 0, 24, 72, 120, and 192 hours, respectively, was 2.93, 2.64, 2.61, 2.35, and 2.14 mg/dL (p=0,000 for repeated anova). The p values of the paired t-test storage durations of 24, 72, 120, and 192 hours, respectively, were 0.231, 0.137, 0.047 and 0.001. The duration of storage in the refrigerator that affects the protein levels of expressed breatmilk is 120 and 192 hours. Expressed breast milk protein levels significantly decrease after being stored in the refrigerator for 120 hours.Abstrak: ASI eksklusif adalah nutrisi terbaik bagi bayi untuk tumbuh dan berkembang. Saat ini masyarakat perkotaan cenderung menghentikan pemberian ASI pada usia yang lebih dini karena ibu bekerja. Untuk mengatasinya, ibu dapat memberikan ASI Perah (ASIP) pada bayi dengan memperhatikan durasi dan suhu penyimpanannya karena dapat mempengaruhi nutrisi yang dikandung ASI. Penelitian ini bertujuan untuk mengetahui efek durasi penyimpanan di lemari pendingin terhadap kadar protein ASI perah. Studi ini merupakan penelitian eksperimental murni (true ekseperimental) dengan desain penelitian one group pretest and posttest. Pemeriksaan kadar protein dilakukan di Laboratorium Kimia Dasar Kedokteran Fakultas Kedokteran Universitas Sriwijaya, dengan total sampel 30 sampel ASIP. Sampel dibagi menjadi 5 kelompok, dengan variasi durasi penyimpanan dalam lemari pendingin (4-8°C) selama 0 jam (kontrol), 24 jam, 72 jam, 120 jam, 192 jam. Uji kadar protein dengan metode Lowry. Data dianalisis dengan repeated annova dan paired t-test. Rata-rata kadar protein ASIP secara berturut-turut pada 0, 24, 72, 120, dan 192 jam adalah 2,93, 2,64, 2,61, 2,35, dan 2,14 mg/dL dengan hasil uji repeated anova p=0,000. Nilai p dari paired t-test masing-masing durasi penyimpanan 24, 72, 120, dan 192 jam adalah 0,231, 0,137, 0,047 dan 0,001. Lama penyimpanan dalam lemari es yang mempengaruhi kadar protein ASI perah adalah 120 dan 192 jam. Kadar protein ASI perah mengalami penurunan signifikan setelah disimpan dalam lemari pendingin selama 120 jam.
Pendampingan Keterampilan Mengenali dan Mencegah Thalassemia Pada Masyarakat Safyudin, Safyudin; Sinulingga, sadakata; fatmawati, fatmawati; Subandrate, Subandrate; Haryadi, Kusumo; Yana, Rini; Romadhon, M Fitra; Monanda, M Dias Athallah
Fajar: Media Komunikasi Dan Informasi Pengabdian Kepada Masyarakat Vol. 20 No. 1 (2020)
Publisher : Center of Community Service (PPM), Institute for Research and Community Services (LP2M) UI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jf.v20i1.20325

Abstract

Abstract:Thalassemia is a genetic disease that is inherited through marriage. At present, the incidence of thalassemia can only be reduced by reducing the birth of thalassemia children. Giving a correct understanding to the community is the right way to prevent the increase in new thalassemia sufferers. This community service activity is carried out in Lubuklinggau City, South Sumatra by involving lecturers who focus on the prevention of thalassemia. Activities carried out in the form of counseling and demonstration about thalassemia to 56 participants. In this activity, the demonstration was carried out using tools such as brochures / leaflets. An evaluation of the success of the activity is carried out using random questions to the participants before and after the activity. After counseling, most participants understood the simple way to recognize and prevent thalassemia. From these community service activities, it can be concluded that counseling and demonstration, can be used to improve people's knowledge and simple skills in recognizing and preventing thalassemia. Keywords:  Counseling, prevent, recognize, thalassemia Abstrak: Thalassemia merupakan penyakit genetik yang diturunkan melalui perkawinan. Saat ini, angka kejadian penyakit thalassemia hanya dapat turunkan dengan cara mengurangi kelahiran anak thalassemia. Pemberian pemahaman yang benar kepada masyarakat merupakan cara yang tepat guna mencegah peningkatan penderita thalassemia baru. Kegiatan pengabdian masyarakat ini dilakukan di Kota Lubuklinggau, Sumatera Selatan dengan melibatkan dosen yang fokus pada usaha pencegahan thalassemia. Kegiatan yang dilakukan berupa penyuluhan dan demonstrasi tentang thalassemia terhadap 56 orang peserta. Dalam kegiatan ini, demontrasi dilakukan dengan menggunakan alat bantu berupa brosur/leaflet. Evaluasi terhadap keberhasilan kegiatan dilakukan dengan menggunakan pertanyaan acak kepada peserta sebelum dan sesudah kegiatan. Setelah penyuluhan, sebagian besar peserta memahami cara sederhana mengenali dan mencegah thalassemia. Dari kegiatan pengabdian masyarakat ini, dapat simpulkan bahwa penyuluhan dan demonstrasi, dapat digunakan untuk meningkatkan pengetahuan dan keterampilan sederhana masyarakat dalam mengenali dan mencegah thalassemia. MIOS. Kata Kunci: Mencegah, mengenali, penyuluhan, thalassemia  
Inhibitory Effect of Ethanol Extract of Cherry Mistletoe Leaves (Dendrophthoe pentandra (L.) Miq) on Xanthine Oxidase Enzyme Sabathania, Hana Daini; Subandrate, Subandrate; Sinulingga, Sadakata; Safyudin, Safyudin; Oswari, Liniyanti D; Fatmawati, Fatmawati
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 22, No 2 (2025)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.008252

Abstract

One plant that can be used as an alternative treatment for hyperuricemia is the cherry plant. The usefulness of these plants is due to the secondary metabolite compounds that can inhibit the enzyme xanthine oxidase. Cherry mistletoe is thought to have the same flavonoids, saponins, alkaloids, terpenoids, and tannins as the cherry plant, which can act as inhibitors. The aim of the study was to determine the inhibitory effect of an ethanol extract of cherry mistletoe leaves on the xanthine oxidase enzyme. This study was conducted as  an in vitro experimental study. Cherry mistletoe leaves were extracted with 96% ethanol. The extract was done with phytochemical screening, followed by an inhibition test on the xanthine oxidase enzyme using a spectrophotometer at a wavelength of 400 nm. Allopurinol was a positive control. The ethanol extract of cherry mistletoe leaves contains flavonoids, saponins, alkaloids, terpenoids, and tannins. The IC50 value of the ethanol extract of cherry mistletoe leaves was 23.44 mg/L. The ethanol extract of cherry mistletoe leaves has an inhibitory effect on the xanthine oxidase enzyme with moderate activity. Accordingly, the cherry mistletoe leaf extract can be considered as an alternative inhibitor of the xanthine oxidase enzyme in the control of hyperuricemia.
Co-Authors Adma, Annes Claudia Annes C. Adma Arifin, Mutmainah Arrafi, Muhammad Hafizh Athiah, Medina Auliya Bella Oktarina Az Zahra, Fatihah Dian Natalia Dwi Indira Setyorini Dwi Indira Setyorini Dwirini Retno Gunarti Ella Amalia, Ella Ellla Amalia Fatihah Az Zahra Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati Fatmawati, Fatmawati Hasri Salwan Hermansyah Hertanti Indah Lestari, Hertanti Indah Irfannuddin Irfannuddin Kms Yusuf Effendi Kusumo Hariyadi Kusumo Haryadi L.O Oswari Legiran Legiran Lia Damayanti M Athiah M. Dias A. Monanda M. Hafizh Arrafi M. Hafizh Arrafi M. Nadhif Prasetyo M. Nadhif Prasetyo Marlisa, Ade Medina Athiah Medina Athiah Medina Athiah Mohammad Fiqih Monanda, M Dias Athallah Monanda, M. Dias Athallah Muhammad Irsan Saleh Mulawarman, Hisham Naomi W Tioline Okta Emilia Oktalisa, Wenni Oktharina, Eka Handayani Oswari, Liniyanti D Pierre Ramandha K Riani Erna Rini Yana Rini Yana Romadhon, M Fitra S Sinulingga Sabathania, Hana Daini Sadakata Sinulingga Sembiring, Rinawati Setyorini, Dwi Indira SRI RAHAYU Subandrate Susilawati Susilawati Susilawati, Susilawati Syadra Bardiman Rasyad Syifa Alkaf Yana, Rini Yusuf Effendi Zikra, Muhamad