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Identification of Lactic Acid Bacteria Isolate From Fermentation Food Bekasam Ardesy Melizah; Syarif Husin; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 2 No. 1 (2018): Bioscientia Medicina: Journal of Biomedicine and Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v2i1.34

Bekasam is a local food from South Sumatera Indonesia, which is obtained through fermentation of fish. Previous study has shown that fermented food contained Lactic Acid Bacteria (LAB) bacteria, such as Lactobacillus plantarum, Lactobacillus sp, Pediococus sp and Weissella sp. The study was conducted to identify isolate LAB from bekasam. Bekasam contained fish, rice, and salt with a certain ratio. Further isolation of isolated LAB isolate, then performed PCR for bacterial analysis. Isolate 1 showed alleged bacteria Staphylococcus sp, non pathogen, while isolate 2 leads to Lactobacillus sp. The PCR results show the suitability of the bands formed between the Lactobacillus standard and the isolates. Keywords: bacteria, lactobacillus, acid

The Association between Aromatase Gene Polymorphism Cyp19 Val 80 and Endometriosis Risk Syifa Alkaf; Ziske Maritska; Venny Patricia
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 5 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i5.230

Background: Endometriosis implant has been known to express aromatase enzyme, Cytochrome p450 that catalyzes androgen into estrogen. It causes local estrogen production, leading to increased estrogen level, and subsequently triggers endometriosis lesion. CYP19 gene resided at chromosome 15q21.1 is the biggest component of aromatase coding cytochrome p450 enzyme. Objective: To identify relationship between aromatase gene polymorphism CYP19 Val 80 and the risk of endometriosis. Methods: This is an observational case-control study using frozen DNA sample from women with endometriosis and/ or adenomyosis who had undergone laparotomy/ laparoscopy at Obstetrics and Gynecology Department Dr. Mohammad Hoesin General Hospital Palembang January-November 2013. Samples were amplified and cut by PCR-FRLP using Rsa1 restriction enzyme. Results were divided into A/A genotype (homozygote mutant), G/A (heterozygote mutant), and G/G (homozygote wild type). Data were analyzed by SPSS 21.0 version. Results: PCR-RFLP results for A/A genotype were 20 (21.3%) in endometriosis group and 8 (8.5%) in control group. G/A genotype were 18 (19.1%) in endometriosis group and 22 (23.4%) in control group. G/G genotype were 9 (9.6%) and 17 (18.1%) in endometriosis group and control group, respectively. There was significant increase risk of endometriosis in women carrying genotype A/A to those with genotype G/G with OR 4.722 (p<0.05). Conclusion: Polymorphism on aromatase gene CYP19 Val 80 A/A increases risk of endometriosis.

EDUKASI PENANGGULANGAN DAMPAK PEMBELAJARAN DARING TERHADAP KESEHATAN REMAJA SELAMA PANDEMI COVID-19 Arwan Bin Laeto; Budi Santoso; Siti Sarahdeaz Fazzaura Putri; Syifa Alkaf
Lontara Abdimas : Jurnal Pengabdian Kepada Masyarakat Vol 3 No 2 (2022): Desember
Publisher : Lembaga Penelitian Dan Pengabdian Masyarakat Politeknik Kesehatan Muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53861/lomas.v3i2.301

Health is an important thing that needs to be maintained at all times. The COVID-19 pandemic that has hit the world, including Indonesia, has had a significant impact on the health and social life of teenagers. The social impact experienced by adolescents is in the aspect of education which requires adolescents to take part in online learning. The online learning that teenagers go through has an influence on the health of their bodies. Health complaints experienced by adolescents during online learning include backache, disturbed sleep, eye fatigue and weight gain. Seeing this situation, this community service activity was carried out. This activity involves youth participants and is carried out using educational and demonstration methods. The education provided discussed the impact of online learning during the covid-19 pandemic, the concept of body fitness and forms of exercise in an effort to overcome the impact of online learning. The results obtained indicate that through education, there is an increase in participants' understanding of the various impacts received by adolescents during online learning. In addition, adolescent knowledge related to the concept of fitness and efforts to maintain fitness through exercise has also increased. The sports demonstration provided succeeded in opening the participants' insight that sports can still be done during the covid-19 pandemic, through technology media, both independently and in groups. So it can be concluded that sport is the best effort in overcoming the impact of online learning on adolescent health during the covid-19 pandemic.

Edukasi peran vitamin C dalam pencegahan COVID-19 melalui media sosial Vanda, Geo; Sijabat, Nofitri Dewitasari; Tioline, Naomi Winny; Batubara, Rizka Samira; Letissia, Adela Nadya; Kurniati, Ardesy Melizah; Husin, Syarif; Alkaf, Syifa; Ningsih, Windi Indah Fajar; Anastasia, Monika
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 2 No 2 (2021): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V2I2.69

menyusul

Providing Antioxidants to Reduce Symptoms of Endometriosis Related Pain: Systematic Review Nurwany, Raissa; Alfarobi, Muhammad Farhan; Alkaf, Syifa
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.626

Introduction: Approximately 10 - 15% of women in their reproductive age experience endometriosis. Endometriosis is defined by chronic discomfort and pain, specifically dysmenorrhea, dyspareunia, and dyschezia. A recent study has provided insight into the involvement of oxidative stress in the progression of endometriosis. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidants, resulting in inflammation within the peritoneal cavity. This comprehensive analysis examined the efficacy of antioxidant administration and its impact on pain symptoms associated with endometriosis. Method: This study reviewed literature by searching the PubMed, ScienceDirect, and Cochran Library databases. The search query included “endometriosis” and “antioxidant.” The study was reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The scope of analysis was restricted to clinical trials conducted exclusively from 2012 to 2023. Result: A total of 10 studies were incorporated, encompassing the utilisation of vitamin C and vitamin E, N-acetylcysteine, alpha-lipoic acid, bromelain, zinc, melatonin, and combination oral contraception. After administering antioxidants, the analysis of different groups consistently revealed a greater degree of improvement in dysmenorrhoea, dyspareunia, and chronic pelvic pain. Vitamin C, vitamin E, and N-acetylcysteine act as antioxidants and effectively decrease oxidative stress and the development of endometriosis discomfort. Conclusion: using antioxidants, including vitamin C and vitamin E, or N-acetylcysteine, has a beneficial effect in decreasing pain sensations associated with endometriosis.Pemberian Antioksidan untuk Mengurangi Gejala Nyeri Endometriosis: Sistematik ReviewAbstrakPendahuluan: Diperkirakan 10 - 15%wanita usia produktif di dunia mengalami endometriosis. Endometriosis ditandai dengan rasa tidak nyaman dan nyeri yang terus-menerus, meliputi dismenore, dyspareunia, dan disychezia serta menjadi salah satu penyebab infertilitas. Studi terbaru menjelaskan adanya peran stres oksidatif pada patofisiologi endometriosis yang didefinisikan sebagai ketidakseimbangan antara Reactive Oxygen Species (ROS) dan antioksidan yang menyebabkan respons inflamasi di rongga peritoneum. Systematic review ini membahas mengenai efektivitas pemberian antioksidan dan pengaruhnya terhadap gejala nyeri endometriosis. Metode: Pencarian literatur dilakukan pada database PubMed dan ScienceDirect, dan Cochrane Library Pencarian dilakukan menggunakan istilah “endometriosis” DAN “antioksidan”. Penulisan systematic review disesuaikan dengan pedoman professed reporting for systematic review and meta-analysis (PRISMA). Semua studi yang diinklusi merupakan clinical trials pada periode tahun 2012-2023. Hasil: Terdapat 10 penelitian yang disertakan, meliputi penelitian menggunakan vitamin C dan vitamin E, N-asetilsistein, asam alfa lipoat, bromelain, zinc, melatonin dan kontrasepsi oral kombinasi. Perbandingan antar kelompok secara umum menunjukkan perbaikan nyeri dismenorea, dispareunia, dan nyeri panggul kronis yang lebih baik setelah suplementasi antioksidan. Hal ini berkaitan dengan peran vitamin C, vitamin E, N-asetilsistein sebagai antioksidan yang dapat mengurangi stress okisdatif sebagai pathogenesis terjadinya nyeri endometriosis. Kesimpulan: Pemberian antioksidan secara umum terutama vitamin C, vitamin E, dan N-asetilsistein berkaitan dengan berkurangnya gejala nyeri pada endometriosis.kata kunci: Endometriosis; antioksidan; dismenorea; dispareunia; nyeri pelvik kronis

Pengayaan pembelajaran dalam upaya peningkatan pengetahuan mengenai ambigus genitalia pada mahasiswi Sekolah Tinggi Ilmu Kesehatan Abdurrahman Palembang Maritska, Ziske; Alkaf, Syifa; Inggarsih, Rara; Hafy, Zen; Purnamasari, Septi; Nindela, Rini
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.163

Learning Enrichment to increase knowledge about ambiguous genitalia in students at STIKES Abdurrahman Palembang. Disorders of Sex Development (DSD) is a rare disease in which atypical gonads, chromosomes, and sex anatomy are found. Although it has a significant impact on both the physical and mental health of individuals with DSD, DSD cases are often undetected and underdiagnosed. Efforts to enrich material and learning to training on DSD for prospective midwife health workers are one of the real actions that can be taken to increase knowledge and awareness of DSD which is then expected to increase early identification efforts to improve the quality of life and patient outcomes. This community service activity was carried out for one semester through a series of activities in the form of guest lectures for enrichment of learning which were carried out in stages three times online for 55 students of STIKES Abdurrahman Palembang. Measurement of the level of knowledge of STIKES Abdurrahman students was carried out twice, namely before the series of activities began (pre-test) and after the activities were completed (post-test). From the results of the pre- and post-test, an increase in knowledge was obtained, which was originally only 36.4% with a sufficient level of knowledge at the time of the pre-test, to 69.1% with a sufficient level of knowledge at the time of the post-test. It is hoped that with the enrichment of learning, prospective midwives can know and understand DSD so that in the future they can improve early screening for ambiguous genitalia cases which can lead to improving the quality of life of sufferers.

Program Pendampingan Stimulasi dan Pijat Pada Bayi dan Balita Dalam Upaya Mengoptimalkan Pertumbuhan dan Perkembangan Eka Febri Zulissetiana; Susilawati, Susilawati; Nurwany , Raissa; Hasbi, Alfian; Kurniato, Andra; Alkaf, Syifa
JPNM Jurnal Pustaka Nusantara Multidisiplin Vol. 3 No. 2 (2025): July : Jurnal Pustaka Nusantara Multidisiplin
Publisher : SM Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59945/jpnm.v3i2.428

Usia 0 – 24 bulan adalah periode penting dalam pertumbuhan dan perkembangan karena pada masa ini anak akan bertumbuh kembang secara optimal untuk perkembangan kognitif dan fisik. Stimulasi adalah kegiatan merangsang kemampuan dasar anak umur 0-6 tahun agar anak tumbuh dan berkembang secara optimal. Pijat biasa disebut dengan stimulus touch atau sentuhan. Pijat bayi dan balita dapat diartikan sebagai sentuhan komunikasi yang nyaman antara ibu dan bayi/ balita.. Jika tindakan ini dilakukan secara teratur, maka sentuhan ini dapat merupakan bentuk stimulasi dan intervensi yang dapat memberikan banyak manfaat untuk anak. Pemberian edukasi dan pendampingan serta pemberdayaan pendamping bayi dan balita serta kader posyandu untuk melakukan stimulasi dan pijat secara rutin merupakan strategi yang tepat untuk mendampingi pola asuh dalam rangka meningkatkan dan mengoptimalkan pertumbuhan dan perkembangan pada bayi dan balita. Kegiatan pengabdian masyarakat ini dilakukan kepada 68 orang pendamping bayi dan balita serta 20 orang kader posyandu di wilayah Puskesmas 7 Ulu Kota palembang berupa pemberian penyuluhan dan edukasi. Kegiatan juga disertai upaya pendampingan kepada para kader posyandu agar untuk selanjutnya dapat memberikan edukasi secara rutin. Penilaian keberhasilan pengabdian masyarakat ini dilakukan dengan menilai peningkatan pengetahuan peserta sebelum dan sesudah kegiatan dan tercapainya target frekuensi untuk semua peserta selama sesi kegiatan. Dari kegiatan pengabdian masyarakat ini, dapat disimpulkan bahwa Kegiatan penyuluhan dan pendampingan dapat dilakukan untuk meningkatkan pengetahuan dan pembiasaan para pendamping bayi dan balita dalam melakukan stimulasi dan pijat bayi dan balita.

Characteristics of Endometriosis Patients in Dr. Mohammad Hoesin General Hospital on 2018 to 2020 Leriva, Ratu Tenny; Iskandar Zulqarnain; Hadrians Kesuma Putra; Awan Nurtjahyo; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.478

Background. Endometriosis is defined as the presence of endometrial-like tissue outside the uterus. The prevalence of endometriosis is not known with certainty because it is necessary to perform a laparoscopy to confirm the diagnosis of endometriosis and is usually found during examination for other indications. This study aims to explore the characteristics of endometriosis patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This research is descriptive observational research. The research data were obtained from the medical records of endometriosis patients treated at Dr. Mohammad Hoesin General Hospital Palembang from 2018 to 2020. Results. Of the 105 sample data studied, the most distribution of endometriosis patients was in the reproductive age group (15-49 years) (99%), menarche 12-14 years (67.6%), the location of endometriosis in the ovaries (58.1%), status indoor workers (99%), marital status (85.7%), fertile (43.8%), and infertile patients (41.9%), the chief complaint of dysmenorrhea (66.7%), stage IV disease (63, 8%), nullipara (60%), surgical management (79%). Conclusion. Most of the characteristics of endometriosis patients were in the reproductive age group (15 – 49 years), menarche 12-14 years, endometriosis location in the ovary, indoor worker status, marital status, infertility, the main complaint of dysmenorrhea, stage IV disease, nullipara, surgical treatment.

Characteristics of Endometriosis Patients in Dr. Mohammad Hoesin General Hospital on 2018 to 2020 Leriva, Ratu Tenny; Iskandar Zulqarnain; Hadrians Kesuma Putra; Awan Nurtjahyo; Syifa Alkaf
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 4 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i4.478

Background. Endometriosis is defined as the presence of endometrial-like tissue outside the uterus. The prevalence of endometriosis is not known with certainty because it is necessary to perform a laparoscopy to confirm the diagnosis of endometriosis and is usually found during examination for other indications. This study aims to explore the characteristics of endometriosis patients at Dr. Mohammad Hoesin General Hospital Palembang. Methods. This research is descriptive observational research. The research data were obtained from the medical records of endometriosis patients treated at Dr. Mohammad Hoesin General Hospital Palembang from 2018 to 2020. Results. Of the 105 sample data studied, the most distribution of endometriosis patients was in the reproductive age group (15-49 years) (99%), menarche 12-14 years (67.6%), the location of endometriosis in the ovaries (58.1%), status indoor workers (99%), marital status (85.7%), fertile (43.8%), and infertile patients (41.9%), the chief complaint of dysmenorrhea (66.7%), stage IV disease (63, 8%), nullipara (60%), surgical management (79%). Conclusion. Most of the characteristics of endometriosis patients were in the reproductive age group (15 – 49 years), menarche 12-14 years, endometriosis location in the ovary, indoor worker status, marital status, infertility, the main complaint of dysmenorrhea, stage IV disease, nullipara, surgical treatment.

Long-Term Risks of Early Initiation of Breastfeeding to Mothers and Infants in Asia: a Systematic Review Raisa Nurwany; Syifa Alkaf; Jeyaseelan, Ajay Varmaa
Andalas Obstetrics And Gynecology Journal Vol. 8 No. 1 (2024)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.8.1.502-510.2024

Objective: This systematic review aims to determine the long-term risks of early initiation of breastfeeding in mothers and babies in Asia. Method: The method used in writing this literature review is systematization using keywords, namely "Early Initiation of Breastfeeding", "Breastfeeding", "ASI", "Asia", "Risk", "Baby and Mother", "Long Term Risk" , and "Benefits".A literature search was conducted using Google Scholar, Pubmed and NCBI databases. Results: From the results of a literature search based on keywords, 25 journals were obtained, of which seven journals met the criteria for long-term risk of IMD for mothers and babies in Asia. One study in this study used a systematic review, five studies used a retrospective cohort study, and one study used a cross-sectional study. The study found many positive risks and benefits of early initiation of breastfeeding for mothers and babies in the long term in Asia. Conclusion: Positive risks for babies include increasing immunity, reducing the risk of death, and preventing obesity. Meanwhile, long-term risks for mothers include accelerating uterine involution, preventing breast cancer, and reducing the risk of diabetes and prediabetes in mothers who have experienced gestational diabetes.

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