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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Biomedical Journal of Indonesia Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan Indonesian Journal of Obstetrics & Gynecology Science Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia) Indonesian Journal for Health Sciences (IJHS) Majalah Patologi Indonesia Andalas obstetrics and gynecology journal Jurnal Pengabdian Masyarakat: Humanity and Medicine The Avicenna Medical Journal Eastasouth Journal of Impactive Community Services
Nurwany, Raissa
Fakultas Kedokteran Universitas Sriwijaya
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

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Vitamin A dan perannya dalam siklus sel Rizal Sanif; Raissa Nurwany
JURNAL KEDOKTERAN DAN KESEHATAN Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Mekanisme normal pengatur proliferasi sel melalui siklus sel, dimana sebagai pengontrolnya adalah pada chech point yaitu fase G1 dan S. Tumor supresor gen sangat berperan dalam mengatur mekanisme sel untuk istirahat atau memperbaikinya apabila terjadi abnormal, dimana bila tidak bisa diperbaiki akan terjadi proses kematian atau apoptosis. Vitamin A merupakan sebagai salah satu substrat yang ikut berperan didalam pengatur mekanisme siklus sel, utamanya  pada fase G1 dan S istirahat.Vitamin A didapatkan dari konsumsi makan yang berasal dari hewan atau provitamin A dari tumbuh-tumbuhan. Vitamin A diabsorbsi dari usus masuk ke  aliran linfe atau darah dan dengan mekanismenya akan masuk kedalam inti sel yang berikatan dengan reseptornya untuk memberikan sinyal sinyal didalam proses pengaturan siklus sel.
Program pendampingan latihan fisik dalam upaya peningkatan kesehatan ibu hamil pada masa adaptasi kebiasaan baru Zulissetiana, Eka Febri; Syifa, Syifa; Nurwany, Raissa; Susilawati, Susilawati
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 3 No 1 (2022): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V3I1.70

Abstract

Pregnant women as one of the groups vulnerable to COVID-19 infection are advised to stay at home and reduce face-to-face social contact so that they are at risk of reducing physical activity. These lifestyle changes are associated with an increased risk of depression, anxiety, maternal obesity, and various other pregnancy complications such as Gestational Diabetes Mellitus, Preeclampsia, and Low Back Pain. Providing education and assistance as well as empowering pregnant women to do physical exercise regularly is the right strategy to change the pattern of physical activity in order to improve health status during the adaptation period to new habits. This community service activity was carried out to 56 pregnant women in the city of Palembang in the form of providing regular counseling and education. The activity is also accompanied by assistance efforts so that pregnant women can do regular physical exercise for 1 month. The assessment of the success of this community service was carried out by assessing the increase in participants' knowledge before and after the activity, the achievement of the frequency target for all participants during the training session, and also a questionnaire on the benefits of regular physical exercise. The results of the assessment with the questionnaire showed an increase in the average knowledge before and after undergoing the educational program. From this community service activity, it can be concluded that counseling and mentoring activities can be carried out to increase the knowledge and habituation of pregnant women in doing physical exercise, especially during this COVID-19 pandemic.
Efek Puasa Terhadap Biomarker Hepar : Sebuah Tinjauan Pustaka Sistematis Anggraini, Wieke; Irfannuddin, Irfannuddin; santoso, budi; Sinulingga, Sadakata; Zulissetiana, Eka Febri; Nurwany, Raissa
Syifa'Medika Vol 15, No 1 (2024): Syifa' MEDIKA: Jurnal Kedokteran dan Kesehatan
Publisher : Faculty of Medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32502/sm.v15i1.8773

Abstract

Terdapat berbagai penelitian yang melihat dampak puasa sebagai intervensi diet yang untuk menurunkan berat badan, menurnkan hemoglobin terglikosilasi, menurunkan risiko aterogenik, meningkatkan sirkulasi sitokin dan proliferasi sel imun. Tinjauan ini bertujuan untuk melihat penelitian terkait puasa dalam menurunkan inflamasi. Tinjauan ini disusun sesuai dengan algoritma PRISMA yang melibatkan 31 kepustakaan yang dikumpulkan dari Pubmed maupun EuropePMC. Tinjauan ini menemukan bahwa puasa dapat mengurangi inflamasi yang ditandai dengan berbagai biomarker. Oleh karena itu puasa dapat menjadi salah satu intervensi diet yang dapat bermanfaat bagi kesehatan jika dilakukan dalam jangka waktu yang lama dan secara konsisten
THE RELATIONSHIP BETWEEN SLEEP QUALITY AND COMPUTER VISION SYNDROME IN ADOLESCENT DURING COVID-19 PANDEMIC Laeto, Arwan Bin; Nurwany, Raissa; Lubis, Dhiyan Handi Asyhari
Indonesian Journal for Health Sciences Vol 8, No 2 (2024): September
Publisher : Universitas Muhammadiyah Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24269/ijhs.v8i2.7745

Abstract

Computer Vision Syndrome (CVS) is a group of eye and vision problems caused by long-term use of visual electronics. Since the COVID-19 pandemic, the use of digital devices has increased, resulting in increased ease of exposure to CVS which is feared to disrupt sleep quality. This study aimed to determine the relationship between sleep quality and CVS among adolescents during the COVID-19 pandemic. This research is an observational analytic study with a cross-sectional design using primary data. Data were taken through a questionnaire with a sample of 96 adolescents who met the inclusion and exclusion criteria. Data analysis was carried out with the Chi-Square test. In this study, the results showed that the quality of sleep in adolescents had a prevalence of 59,4% as well as the prevalence of adolescents diagnosed with CVS by 56,3%. There is a statistically significant relationship between sleep quality and CVS with a p-value of 0,001. There is a high prevalence of poor sleep quality and CVS among adolescents. CVS is significantly related to sleep quality.  The implication of this result is that can impact academic performance and exacerbate the symptoms of CVS, such as eye strain, blurred vision and headaches
Providing Antioxidants to Reduce Symptoms of Endometriosis Related Pain: Systematic Review Nurwany, Raissa; Alfarobi, Muhammad Farhan; Alkaf, Syifa
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 2 Juli 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i2.626

Abstract

Introduction: Approximately 10 - 15% of women in their reproductive age experience endometriosis. Endometriosis is defined by chronic discomfort and pain, specifically dysmenorrhea, dyspareunia, and dyschezia. A recent study has provided insight into the involvement of oxidative stress in the progression of endometriosis. Oxidative stress refers to an imbalance between reactive oxygen species (ROS) and antioxidants, resulting in inflammation within the peritoneal cavity. This comprehensive analysis examined the efficacy of antioxidant administration and its impact on pain symptoms associated with endometriosis. Method: This study reviewed literature by searching the PubMed, ScienceDirect, and Cochran Library databases. The search query included “endometriosis” and “antioxidant.” The study was reviewed using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) standards. The scope of analysis was restricted to clinical trials conducted exclusively from 2012 to 2023. Result: A total of 10 studies were incorporated, encompassing the utilisation of vitamin C and vitamin E, N-acetylcysteine, alpha-lipoic acid, bromelain, zinc, melatonin, and combination oral contraception. After administering antioxidants, the analysis of different groups consistently revealed a greater degree of improvement in dysmenorrhoea, dyspareunia, and chronic pelvic pain. Vitamin C, vitamin E, and N-acetylcysteine act as antioxidants and effectively decrease oxidative stress and the development of endometriosis discomfort. Conclusion: using antioxidants, including vitamin C and vitamin E, or N-acetylcysteine, has a beneficial effect in decreasing pain sensations associated with endometriosis.Pemberian Antioksidan untuk Mengurangi Gejala Nyeri Endometriosis: Sistematik ReviewAbstrakPendahuluan: Diperkirakan 10 - 15%wanita usia produktif di dunia mengalami endometriosis. Endometriosis ditandai dengan rasa tidak nyaman dan nyeri yang terus-menerus, meliputi dismenore, dyspareunia, dan disychezia serta menjadi salah satu penyebab infertilitas. Studi terbaru menjelaskan adanya peran stres oksidatif pada patofisiologi endometriosis yang didefinisikan sebagai ketidakseimbangan antara Reactive Oxygen Species (ROS) dan antioksidan yang menyebabkan respons inflamasi di rongga peritoneum. Systematic review ini membahas mengenai efektivitas pemberian antioksidan dan pengaruhnya terhadap gejala nyeri endometriosis. Metode: Pencarian literatur dilakukan pada database PubMed dan ScienceDirect, dan Cochrane Library Pencarian dilakukan menggunakan istilah “endometriosis” DAN “antioksidan”. Penulisan systematic review disesuaikan dengan pedoman professed reporting for systematic review and meta-analysis (PRISMA). Semua studi yang diinklusi merupakan clinical trials pada periode tahun 2012-2023. Hasil: Terdapat 10 penelitian yang disertakan, meliputi penelitian menggunakan vitamin C dan vitamin E, N-asetilsistein, asam alfa lipoat, bromelain, zinc, melatonin dan kontrasepsi oral kombinasi. Perbandingan antar kelompok secara umum menunjukkan perbaikan nyeri dismenorea, dispareunia, dan nyeri panggul kronis yang lebih baik setelah suplementasi antioksidan. Hal ini berkaitan dengan peran vitamin C, vitamin E, N-asetilsistein sebagai antioksidan yang dapat mengurangi stress okisdatif sebagai pathogenesis terjadinya nyeri endometriosis. Kesimpulan: Pemberian antioksidan secara umum terutama vitamin C, vitamin E, dan N-asetilsistein berkaitan dengan berkurangnya gejala nyeri pada endometriosis.kata kunci: Endometriosis; antioksidan; dismenorea; dispareunia; nyeri pelvik kronis
Eleven Years’ Experience of Sociodemographic and Clinicopathologic Characteristics of Endometrial Carcinoma Patients at a Tertiary Hospital Binti H., Humairah; Dewi, Citra; Nurwany, Raissa
Majalah Patologi Indonesia Vol. 33 No. 3 (2024): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v33i3.630

Abstract

Endometrial carcinoma is a malignant proliferation of the endometrium cells. This particular type of carcinoma is a world problem since it was ranked the second most common gynecology malignancy, and is the most common malignancy found in the uterus. This research is conducted to identify the sociodemographic and clinicopathologic characteristics of endometrial carcinoma patients at RSUP Dr. Mohammad Hoesin Palembang. This is an observational study with a cross-sectional design. Of all 37 samples collected, the majority are women of ages 20-50 (81,1%), married (83,8%), housewives (40,5%), and live within the city of Palembang (73%). Histopathologically, the most common subtypes found are endometrioid adenocarcinoma (62,2%), and of grade G3. The majority of the samples are within stage 1 cancer (27%), and with no metastases (83,8%). It can be concluded that, socio-demographically, the majority of endometrial carcinoma patients are aged 20-59 years, are married, work as housewives, and live in the city of Palembang, while the histopathological characteristics that are commonly found are the endometrioid adenocarcinoma subtype, grade G3 carcinoma, stage 1 carcinoma, and carcinoma without metastases.
Prevalence and Distribution of Risk Factors for Preterm Labor in RSUP DR. Mohammad Hoesin Palembang Period January 1 2020 – December 31 2023 Beumaputra, Adyatma Utama; Martadiansyah, Abarham; Nurwany, Raissa; Mirani, Putri; Putra, Hadrians Kesuma
Indonesian Journal of Obstetrics & Gynecology Science Volume 8 Nomor 1 Maret 2025
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v8i1.825

Abstract

Objective: This study aims to determine the prevalence and distribution of risk factors for preterm labor.Methods: This is a descriptive observational study with a cross-sectional design. The data used in this study were secondary data obtained with the total sampling method from the medical records of Dr. Mohammad Hoesin Palembang Hospital from January 1, 2020 to December 31, 2023.Results: This study found 1,654 cases of preterm labor from January 1, 2020 to December 31, 2023. The analysis of risk factors among mothers indicated that those within the high-risk age categories (<20 years and >35 years) constituted 31.7%. Multiparous and grand multiparous women represented 41.7%, while multiple pregnancies accounted for 6.6%. A history of premature rupture of membranes was noted in 25.4% of cases, polyhydramnios was observed in 1.3%, and a history of cesarean delivery was found in 25.4%. Furthermore, 33% suffered from hypertension, and 2.5% had diabetes. Anemia was prevalent in 47.9% of the mothers, and infection was reported in 42.8%. A history of preterm delivery was noted in 13.7%, risky gestational distance was found in 10.6%, and 25% had a history of antepartum hemorrhage. Finally, obesity was observed in 14.5% of the mothers.Conclusion: The number of deliveries continued to decrease, but the prevalence of preterm labor increased from 2020 to 2023. Anemia is the most common risk factor found in mothers with preterm labor.Prevalensi dan Distribusi Faktor Risiko Persalinan Prematur di RSUP Dr. Mohammad Hoesin Palembang dalam Tiga TahunAbstrakTujuan: Penelitian ini bertujuan untuk mengetahui prevalensi serta distribusi faktor risiko persalinan prematur.Metode: Penelitian ini merupakan penelitian deskriptif observasional dengan desain cross-sectional. Data yang digunakan dalam penelitian ini merupakan data sekunder dengan metode total sampling dari data rekam medik RSUP Dr. Mohammad Hoesin Palembang periode 1 Januari 2020 – 31 Desember 2023.Hasil: Terdapat 1654 kasus persalinan prematur dengan periode 1 Januari 2020 – 31 Desember 2023. Distribusi faktor risiko didapatkan ibu dengan usia berisiko (<20 tahun dan >35) tahun (31,7%), paritas multipara dan grandemultipara (41,7%), kehamilan multipel (6,6%), riwayat ketuban pecah dini (25,4%), polihidramnion (1,3%), riwayat persalinan sesar (25,4%), hipertensi (33%), diabetes (2,5%), anemia (47,9%), infeksi (42,8%), riwayat persalinan prematur (13,7%), jarak kehamilan berisiko (10,6%), riwayat perdarahan antepartum (25%), obesitas (14,5%). Kesimpulan: Jumlah persalinan terus mengalami penurunan, namun prevalensi kejadian persalinan prematur terus mengalami peningkatan dari tahun 2020-2023. Anemia menjadi faktor risiko paling banyak yang ditemukan pada ibu dengan persalinan prematur.Kata kunci: Prevalensi, Persalinan Prematur, Faktor Risiko
Eliminating HPV DNA Positive Result with Large Loop Excision of the Transformation Zone (LLETZ)/Loop Electrosurgical Excision Procedure (LEEP) in Precancerous Cervical Lesions Sanif, Rizal; Agustiansyah, Patiyus; Nurwany, Raissa; Sastradinata, Irawan; Theodorus; Agustian, Wisman
Indonesian Journal of Obstetrics and Gynecology Volume 12 No. 2 April 2024
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v12i2.1897

Abstract

Abstract Objective: To determine the use of LLETZ/LEEP to eliminate HPV DNA positive result in patients with cervical precancerous lesions at General Hospital dr. Mohammad. Hoesin, Palembang. Methods: A case series with cervical precancerous lesions was undertaken at the Oncology Polyclinic of dr.Mohammad Hoesin Hospital Palembang from January to October 2022. There were 24 samples with positive HPV DNA before LLETZ/LEEP. Samples then checked for HPV DNA after LLETZ/LEEP. The effectiveness of LLETZ/LEEP therapy was analyzed using the Mc Nemar test. Comparison of HPV DNA outcomes (positive or negative) based on procedure, HPV DNA type and histopathological type was analyzed using Fisher Exact and Pearson Chi Square tests. All data were analyzed using SPPS version 22.0. Results: In this study, it was found that the average age of patients with cervical precancerous lesions was 40.25 ± 7.67 years (28 - 57 years). Based on the diagnosis, 8 samples were found with High-grade Squamous Intraepithelial Lesion (HGSIL) and 16 samples with Low-grade Squamous Intraepithelial Lesion (LGSIL). All samples in this study were housewives and the majority were multiparas (75.0%). History of abortion in the patients in this study was only found in 5 samples (20.8%). The results showed that there were significant differences in the HPV DNA before and after LLETZ/LEEP therapy (p = 0.000). In addition, the results showed that there was no difference in the outcome of HPV DNA based on the procedure (p = 1.000) and the type of HPV DNA (p = 0.643). After LLETZ/LEEP therapy was carried out, it was found that only 1 subject has positive HPV DNA result and the HPV DNA virus found was type 52 and (high risk) and 42 (low risk). Conclusion: It can be concluded that LLETZ/LEEP therapy is effective in eliminating HPV DNA positive results in cervical precancerous lesions Keywords: cervical cancer, HPV DNA, LLETZ/LEEP, precancerous lesions, RCT
Pelatihan tenaga kesehatan dalam penegakan diagnosis penyakit menular seksual dengan pemeriksaan mikroskopis sederhana di fasilitas kesehatan primer Rivani, Erizka; Nurwany, Raissa; Oktharina, Eka Handayani
Jurnal Pengabdian Masyarakat: Humanity and Medicine Vol 6 No 1 (2025): Jurnal Pengabdian Masyarakat: Humanity and Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/Hummed.V6I1.162

Abstract

Sexually transmitted diseases (STDs) encompass a range of infectious diseases that can be attributed to parasites, bacteria, viruses, or fungi. Inaccurate diagnosis can lead to ineffective treatment and increase transmission rates. Furthermore, in an era of widespread antimicrobial resistance, it is imprudent to administer empirical antimicrobial treatment without revelation of potential etiology information which could leads to suboptimal clinical outcomes. Patients suffering from STDs frequently seek initial assistance at primary healthcare facilities, such as community health centres. Enhancing the understanding of health professionals regarding the current state of STDs, including proper diagnostic techniques, will contribute to the improvement of health services. A simple test that can be performed is a microscopic examination of specimens containing genital secretions. The accuracy of microbiological examination heavily relies on the quality of the specimen. Providing training to general practitioners, nurses, midwives, and laboratory personel on specimen collecting techniques and microscopic examination techniques is needed to enhance the precision of diagnosis. The training involved both presentations and hands-on experience in collecting specimens for microscopic examination, as well as techniques for simple microscopic examinations to confirm the etiological diagnosis of STDs. An increase in the trainees' understanding was evident after the training, as reflected in the rise in the average post-test score compared to the pre-test score. Health workers have also been able to independently practice specimen collection techniques and conduct microscopic examinations after attending the training. This training has improved health workers' proficiency in managing STDs and contributed to a higher diagnosis coverage rate.
Factors Affecting Symptoms of Depression and Anxiety among Pregnant Women during COVID-19 Pandemic Syauki, Aqilah Syahrina; Hartati, Hartati; Nurwany, Raissa; Aini, Syarifah
The Avicenna Medical Journal Vol 5, No 2 (2024): The Avicenna Medical Journal
Publisher : Faculty of Medicine, UIN Syarif Hidayatullah Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/avicenna.v5i2.42114

Abstract

ABSTRACTBackground:  Mental health issues, including anxiety and sadness, are exacerbated by changes in social life. Mood and anxiety disorders, such as depression, may strike pregnant women more often than other women. In light of the current COVID-19 epidemic, this research seeks to determine what variables impact the occurrence of depressive and anxious symptoms in pregnant women.Methods:  This study made use of analytical observational research methods. In the year 2021, primary data was collected from November 1st to the 28th. To collect data, we went to seven different obstetrics clinics and handed out paper questionnaires and online surveys. This study makes use of three distinct measures: the Beck Depression Inventory (BDI), the Fear of COVID-19 Scale (FCV-19S), and the Beck Anxiety Inventory (BAI).Results:  Results showed that out of 308 pregnant women in Palembang, 13.0% had mild depression, 5.2% moderate, and 1.6% severe symptoms. Also, 41.9% of people took part in the study; among them, 31.5% experienced mild to moderate anxiety, 9.1% reported moderate to severe anxiety, and 1.3% reported severe anxiety. In the bivariate analysis, a strong correlation was found between the age of pregnant women and depressive symptoms, a significant association was found between packaging symptoms and abortion history, and a significant association was found between anxiety symptoms and fear related to COVID-19. We found statistically significant connections with all of these variables.Conclusions:  The study's results demonstrated a link between maternal age and depressive symptoms, as well as a history of abortion and anxious symptoms. The research participants also reported higher rates of anxiety and despair when they were afraid of contracting the COVID-19 virus. This highlights the critical need of mental health treatment in this context.
Co-Authors Agustian, Wisman Alfarobi, Muhammad Farhan Amir Fauzi Anggraini, Wieke Ardelia Bianda Arwan Bin Laeto Beumaputra, Adyatma Utama Binti H., Humairah Citra Dewi Dwi Budi Santoso Eka Febri Zulissetiana Emira Ramadhany, Nuzla HARTATI Hartati Hartati Hasbi, Alfian Irfannuddin Irfannuddin Juenli, Angelica Krisna, Ratih Lubis, Dhiyan Handi Asyhari Martadiansyah, Abarham Nadhira Tsurayya Ramadhani Oktharina, Eka Handayani Olivia, Viona pariyana, Pariyana PATIYUS AGUSTIANSYAH, PATIYUS Putra, Hadrians Kesuma Putri Mirani Putri, Nabila Azzahra Putri, Sarahdeaz Siti Fazzaura Ramadhina, Shafira Fitri Rivani, Erizka Rizal Sanif Sadakata Sinulingga Sastradinata, Irawan Susilawati, Susilawati Syarifah Aini Syauki, Aqilah Syahrina Syifa Alkaf Syifa, Syifa Theodorus Yuwono, Brian Jordan