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All Journal Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Pharmaceutical Science and Technology JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmiah Farmasi Farmasyifa Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Riset Farmasi Jurnal Farmasi Klinik dan Sains Polinomial : Jurnal Pendidikan Matematika Bandung Conference Series: Pharmacy Jurnal Multidisiplin Indonesia

Hilda Aprilia, Hilda

Program Studi Farmasi, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Islam Bandung

Author-ID : 605204

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Desain Biosensor Berbasis Nanopartikel Perak untuk Deteksi Protein Hemoglobin pada Babi secara In Silico Latifa Hana Silfadani; Taufik Muhammad Fakih; Hilda Aprilia Wisnuwardhani
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. A product containing pork cannot be consumed by Muslims. A surface plasmon resonance (SPR) biosensor using a silver nanoparticle base was developed to analyze the hemoglobin content of porcine in silico using the molecular docking method. The variation of the thin layer system on the SPR by adding a layer of silver nanoparticles can increase the selectivity and sensitivity of the SPR biosensor. The surface of silver nanoparticles has a high sensitivity plasmon resonance spectra, so it can be used as a detector. The smaller the gibbs free bond energy (∆G), the stronger the bond stability between silver nanoparticles (AgNPs) with porcine and bovine hemoglobin protein receptors. Silver nanoparticles with an amount of 10 Ag had the lowest Gibbs free binding energy values for the two receptor proteins, -2.04 kcal/mol in porcine hemoglobin protein and -2.18 Kcal/mol in bovine. In order to function as sensors in SPR biosensors, silver nanoparticles must be more sensitive to porcine hemoglobin protein than bovine hemoglobin (∆G porcine<∆G bovine). The results of silver nanoparticles (AgNPs) which have the largest difference in Gibbs free bond energy (∆G) with porcine ∆G<∆G bovine are 3 silver nanoparticles with a difference of 0.07 So 3 Ag silver is more sensitive to pig hemoglobin receptors which can later be detected. applied as a sensor in biosensor applications. Abstrak. Suatu produk yang mengandung babi tidak dapat dikonsumsi umat muslim. Biosensor surface plasmon resonance (SPR) dengan menggunakan basis nanopartikel perak dikembangkan untuk menganalisis kandungan hemoglobin babi yang dilakukan secara in silico menggunakan metode molecular docking. Variasi sistem lapisan tipis pada SPR dengan menambahkan lapisan nanopartikel perak dapat meningkatkan selektivitas dan sensivitas biosensor SPR. Permukaan nanopartikel perak memiliki efek spektra plasmon resonansi dengan sensitivitas tinggi, sehingga bisa digunakan sebagai detektor. Semakin kecil energi ikatan bebas gibbs (∆G) maka stabilitas ikatan antara nanopartikel perak (AgNPs) dengan reseptor protein hemoglobin babi dan sapi akan semakin kuat. Nanopartikel perak dengan jumlah 10 Ag memiliki nilai energi ikatan bebas Gibbs paling rendah pada kedua protein reseptor yaitu sebesar -2,04 kcal/mol pada protein hemoglobin babi dan -2,18 Kcal/mol pada sapi. Agar dapat berfungsi sebagai sensor dalam biosensor SPR, Nanopartikel perak harus lebih sensitif dengan protein hemoglobin babi dibanding dengan hemoglobin sapi (∆G babi<∆G sapi). Hasil nanopartikel perak (AgNPs) yang memiliki selisih energi ikatan bebas Gibbs (∆G) paling besar dengan ∆G babi<∆G sapi yaitu pada 3 nanopartikel perak dengan selisih 0,07 Sehingga perak 3 Ag lebih sensitif terhadap reseptor hemoglobin babi yang nantinya dapat diaplikasikan sebagai sensor dalam aplikasi biosensor.

Uji Aktivitas dan Toksisitas Secara In Silico Senyawa Turunan Flavonoid pada Jeruk Bali (Citrus Maxima) sebagai Antimelanogenesis Alivia Dyanira; Taufik Muhammad Fakih; Hilda Aprilia Wisnuwardhani
Bandung Conference Series: Pharmacy Vol. 2 No. 2 (2022): Bandung Conference Series: Pharmacy
Publisher : UNISBA Press

Abstract. Melanogenesis is the production of the pigment melanin, which is produced by cells called melanocytes. The enzyme that plays an important role in the melanin synthesis pathway is tyrosinase. Flavonoid compounds can prevent the process of melanogenesis because it contains antioxidants. Identification of flavonoids showed that grapefruit (Ctrus maxima) contains flavonoid compounds acacetin and tangeretin, rutin, eriocitrin, hespiridine, and naringenin. The purpose of this study was to test the activity of flavonoid derived compounds in grapefruit (Citrus maxima) as an antimelanogenesis candidate with tyrosinase receptors in silico. In this research, identification of physicochemical properties of flavonoid derivative test compounds using ChemBioDraw 2D software was carried out. The test compounds for flavonoid derivatives were optimized using the Gauss View software version 5.0.8 and Gaussian version 09. Then proceed to the docking simulation stage for the flavonoid derivative test compounds to the tyrosinase receptor which has been separated from its natural ligand and has been validated using the MGL Tools 1.5.6 software. has been equipped with Autodock Tools version 4.2. Based on the research results, the docking result of acacetin compound has a good affinity value compared to other compounds, namely -5.96 kcal/mol. Predicted results of acacetin toxicity have a high toxicity potential, are within the exposure threshold with a low risk of exposure and cannot cause carcinogenicity or mutagenicity. Abstrak. Melanogenesis merupakan produksi dari pigmen melanin yang diproduksi oleh sel yang disebut dengan melanosit. Enzim yang berperan penting pada jalur sintesis melanin adalah tyrosinase. Senyawa flavonoid dapat mencegah terjadinya proses melanogenesis karena terkandung antioksidan didalamnya. Identifikasi flavonoid menunjukkan dalam Jeruk bali (Citrus maxima) mengandung senyawa flavonoid acacetin dan tangeretin, rutin, eriocitrin, hespiridin, dan naringenin. Tujuan dilakukannya penelitian ini untuk menguji aktivitas senyawa turunan flavonoid pada Jeruk bali (Citrus maxima) sebagai kandidat antimelanogenesis dengan reseptor tyrosinase seacara in silico. Pada penelitian ini dilakukan identifikasi sifat fisikokimia pada senyawa uji turunan flavonoid menggunakan software ChemBioDraw 2D. Senyawa uji turunan flavonoid dilakukan optimasi menggunakan software Gauss View versi 5.0.8 dan Gaussian versi 09. Kemudian dilanjutkan ke tahap simulasi docking senyawa uji turunan flavonoid terhadap reseptor tyrosinase yang telah dipisahkan dengan ligan alaminya dan telah di validasi menggunakan software MGL Tools 1.5.6 yang telah dilengkapi dengan Autodock Tools versi 4.2. Berdasarkan hasil penelitan, hasil docking dar senyawa acacetin memiliki nilai afinitas yang baik dibandingkan dengan senyawa yang lain yaitu -5,96kcal/mol. Hasil prediksi toksisitas acacetin memiliki potensi toksisitas yang tinggi, berada dalam ambang batas paparan dengan resiko paparan yang masih rendah serta tidak dapat menyebabkan karsinogenik atau mutagenisitas.

Exploration of the flavonoid content of Ziziphus spina-christi leaf extract and antioxidant activity assay through in vitro and in silico methods Fitrianti Darusman; Taufik Muhammad Fakih; Dwi Syah Fitra Ramadhan; Hilda Aprilia Wisnuwardhani; Teti Sofia Yanti
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

One plant that has the potential as an antioxidant is Ziziphus spina-christi (ZSC) because it contains phenolics and flavonoids. This study aims to determine the flavonoid content both qualitatively and quantitatively and to test the antioxidant activity of ZSC leaf extract using in vitro and in silico attenuation methods. Determination of the total flavonoid content of ZSC leaf extract using a comparison of quercetin. In vitro the antioxidant activity assay of ZSC leaf extract was carried out by measuring the reducing activity of ZSC leaf extract against the radical DPPH using ascorbic acid as comparison, while the in silico method using QSAR and pharmacophore modeling techniques. The results showed that the total flavonoid content obtained from ZSC leaf extract was 0.2515 ± 0.0013 mg QE/g D.W with an IC50 of 58.9296 ppm. This value indicates that ZSC leaf extract has potential as a strong antioxidant. Furthermore, from the in silico method using pharmacophore modeling and QSAR techniques, 8 hit compounds were obtained from the content of ZSC with IC50 QSAR ranging from 6.57 to 0.0004, which was thought to be the metabolite that had the most role in its antioxidant activity. This value indicates that ZSC leaf extract has potential as a very strong antioxidant. It also proves that QSAR and pharmacophore modeling techniques can be used as confirmatory tests for in vitro results in determining the antioxidant activity of natural materials.

Pelatihan Teknologi Ekstraksi Rimpang Jahe (Zingiber officinale) pada Masyarakat Kampung Jahe Kelurahan Karasak-Astanaanyar: Ginger (Zingiber officinale) Rhizome Extraction Technology Coaching for the people of Kampung Jahe, Karasak-Astanaanyar Sub District Aryani, Ratih; Yuliawati, Kiki Mulkiya; Lukmayani, Yani; Lestari, Fetri; Sadiyah, Esti Rachmawati; Aprilia, Hilda
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 4 (2024): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v9i4.7040

The people of Ginger Village at Karasak Urban Village support the urban greening program by planting ginger plants in the yards and roadsides. Ginger is a traditional medicinal plant commodity that has the potential to be cultivated and developed into health products because of its various pharmacological effects. The PkM team has conducted Community Service Activities for active PKK cadres in Jahe village. This activity aims to educate residents of Ginger Village through PKK cadres about the importance of knowing reasonable ginger extraction procedures so that the benefits of ginger can be optimal as a nutritious ingredient with pharmacological effects. The service method is training in processing ginger using the infusion method. The results showed an increase in participants' knowledge of up to 67%, which indicates that PKK cadres could understand how to extract ginger correctly to maintain its quality and properties.

Strategi Bertahan Hidup Petani dalam Menghadapi Ketidakpastian Harga Komoditas Pertanian di Desa Margaluyu Kabupaten Bandung Ambarwati, Deya; Aprilia, Hilda; Lintang, Najwa; Anggraeni, Nurdian; Fauzan Rahmadani, Muhamad; Ifan, Muhammad
Jurnal Multidisiplin Indonesia Vol. 3 No. 12 (2024): Jurnal Multidisiplin Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jmi.v3i12.2070

This study aims to analyze the survival strategies used by farmers in Margaluyu Village, Bandung Regency, in dealing with the uncertainty of agricultural commodity prices. The instability of agricultural product prices is one of the main challenges faced by farmers, which has an impact on their economic and social welfare. A qualitative descriptive approach was used in this study with data collection techniques through in-depth interviews, observation, and documentation. The results of the study indicate that farmers in Margaluyu Village developed several adaptive strategies, such as diversifying income sources by borrowing capital from dealers, using the Tumpang sari technique to overcome challenges arising from the uncertainty of agricultural commodity prices, and forming social networks between farmers. In addition, support from the government and local institutions also plays an important role in strengthening farmers' resilience to market price fluctuations. This study provides in-depth insight into effective survival mechanisms for farmers in dealing with economic uncertainty in the agricultural sector. These findings are expected to be the basis for policy makers in designing programs that support the sustainability of the agricultural sector.

Studi Interaksi Monomer Fungsional dengan Senyawa Ritonavir Luthfina Adhwa Safitri; Hilda Aprilia Wisnuwardhani; Taufik Muhammad Faqih
Jurnal Riset Farmasi Volume 5, No. 1, Juli 2025, Jurnal Riset Farmasi (JRF)
Publisher : UPT Publikasi Ilmiah Unisba

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jrf.v5i1.6804

Abstract. Ritonavir (RTV) is a Human Immunodeficiency Virus (HIV) drug that has a narrow therapeutic window so its use requires monitoring of drug levels in the blood. Currently, there is no optimal Ritonavir analysis method for determining Ritonavir levels in preparations and biological matrices. Therefore, it is necessary to develop an analytical method using molecularly imprinted polymer (MIP) which is expected to increase the specificity of the RTV analytical method. In this study, functional monomers were determined, which are important components in the synthesis of MIPs. The selection of functional monomers was determined computationally by the Density Functional Theory (DFT) method using Gaussian®16 and GFN2-xTB software. Visualization was performed with BIOVIA Discovery Studio software. Functional monomers wereِ determined basedِ onِ theِ values ِofِ binding energy (∆E)ِ and ِGibbsِ freeِ energyِ (∆G). The number of hydrogen bonds formed between RTV and functional monomers was also used as a basis for determination. The results showed that the functional monomers that interacted best with RTV were vinylglycine ِwithِ ∆Eِ valuesِ ofِ -71.7299 kcal/mol and -8,5781 kcal/mol. Abstrak. Ritonavir (RTV) adalah obat Human Immunodeficiency Virus (HIV) yang memiliki jendela terapi yang sempit sehingga penggunaannya memerlukan pemantauan kadar obat dalam darah. Saat ini, belum ada metode analisis Ritonavir yang optimal untuk menentukan kadar Ritonavir dalam sediaan dan matriks biologis. Oleh karena itu, perlu dikembangkan metode analisis dengan menggunakan molecularly imprinted polymer (MIP) yang diharapkan dapat meningkatkan spesifisitas metode analisis RTV. Pada penelitian ini dilakukan penentuan monomer fungsional yang merupakan komponen penting dalam sintesis MIP. Pemilihan monomer fungsional ditentukan secara komputasi dengan metode Density Functional Theory (DFT) menggunakan perangkat lunak Gaussian®16 dan GFN2-xTB. Visualisasi dilakukan dengan perangkat lunak BIOVIA Discovery Studio. Monomer fungsional ditentukan berdasarkan nilai energi ikat (∆E) dan energi bebas Gibbs (∆G). Jumlah ikatan hidrogen yang terbentuk antara RTV dan monomer fungsional juga digunakan sebagai dasar penentuan. Hasil penelitian menunjukkan bahwa monomer fungsional yang berinteraksi paling baik dengan RTV adalah vinilglisin dengan nilai ∆E sebesar -71,7299 kkal/mol dan -8,5781 kkal/mol.

Peningkatan Kemampuan Pemecahan Masalah Matematis Siswa Kelas VII di MTs Ath-Thohiriyah dengan Menggunakan Model Pembelajaran Kooperatif Tipe STAD Rahmawati, Astri; Faturohman, Ikhsan; Sahadah, Ina; Sa'baniah, Sufi Nur; Aprilia, Hilda; Awaliya, Siti Nazatul
Polinomial : Jurnal Pendidikan Matematika Vol. 4 No. 3 (2025)
Publisher : Papanda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56916/jp.v4i3.2255

This study aims to determine the effectiveness of the implementation of the Student Teams Achievement Division (STAD) Cooperative Learning Model in improving students' mathematical problem solving skills. The method used is quantitative research with a pre-experimental one group pretest-posttest design. The sampling technique used purposive sampling, namely selecting 25 students from class VII of MTs Ath-Thohiriyah, selected based on the mathematics teacher’s consideration that the class had heterogeneous abilities and was conducive to implementing the new learning model. The data analysis technique used descriptive statistics (mean,median,mode,standard deviatio, minimum and maximum values) and inferential statistics in the form of the Shapiro-Wilk normality test and paired sample t-test to see significant differences between the pretest and posttest. In addition, the N-Gain Score was also calculated to measure the magnitude of the increase and its category. The results of the study showed an increase in the mathematical problem-solving ability of seventh-grade students at MTs Ath-Thohiriyah after the implementation of the STAD type cooperative learning model.

Co-Authors Alivia Dyanira Ambariyanto Ambariyanto Ambarwati, Deya Amila Gadri Amila Gadri Anggi Arumsari Anggraeni, Nurdian Annisa Fitriyani Suryana Arinda Roosma Arlina Prima Putri Arlina Prima Putri, Arlina Prima Aulia Fikri Hidayat Awaliya, Siti Nazatul Bertha Rusdi Dewi, Mentari Luthfika Dwi Syah Fitra Ramadhan Faturohman, Ikhsan Fauzan Rahmadani, Muhamad Fetri Lestari Fetri Lestari Fitrianti Darusman Humairani Rahman Ifan, Muhammad Kiki Mulkiya Yuliawati Latifa Hana Silfadani Lintang, Najwa Luthfina Adhwa Safitri Nadia Athiyyah Rahma Nur Annisa Nur Annisa Rahmawati, Astri Ratih Aryani, Ratih Reisya Nabila Riesma Azhar Falahul Alam Robby Prayitno Rusnadi Rusnadi Sa'baniah, Sufi Nur Sadiyah, Esti Rachmawati Sahadah, Ina Taufik Muhammad Fakih Taufik Muhammad Faqih Teti Sofia Yanti Trini Octari Trini Octari, Trini Trully Nouval Larasati Yani Lukmayani

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