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Journal : JOURNAL LA MEDIHEALTICO

The Effect of Nigella Sativa L. Extract on Blood Glucose Levels in Alloxan-Induced Hyperglycemic Mus musculus Khoirunnisa, Nur; Makmun, Armanto; Surdam, Zulfiyah; Nur, Muhammad Jabal; Ardiansar, Abdul Mubdi; Zulfahmidah, Zulfahmidah
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2055

Abstract

Hyperglycemia is one of the conditions of increasing blood glucose levels. There are various treatment options in patients with hyperglycemia, one of which is non-drug therapy with traditional medicine. A traditional medicinal plant with various benefits, namely black cumin which is known to have a variety of ingredients that can lower blood glucose levels. Knowing the effect of black cumin extract on blood glucose levels in mice with alloxane-induced hyperglycemia. The research design used was a pre and post test with control group design with a total sample of 27 mice divided into 3 groups where each group consisted of 9 heads. Group 1 is the control group while group 2 and group 3 will be treated respectively. The analysis was carried out with a paired sample t-test to see the differences between each group before and after treatment. The results of the study on the average blood glucose levels before treatment and after the administration of black cumin treatment there were changes in each group obtained a significance value of 0.000 at both doses of black cumin extract. Based on the results obtained, it is known that black cumin extract can reduce blood glucose levels where the greater the dose is directly proportional to the decrease in blood glucose levels.
Literature Review: Development of Antiretroviral Therapy in Hiv/Aids Treatment Amir, Nur Ainun; Hamzah, Pratiwi Nasir; Nur, Muhammad Jabal
Journal La Medihealtico Vol. 6 No. 4 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i4.2304

Abstract

Human Immunodeficiency Virus (HIV) is a virus that attacks the human immune system. The United Nations Joint Program for HIV/AIDS (UNAIDS) in 2019, stated that the largest HIV-infected population in the world is on the African continent (25.7 million), then in Southeast Asia (3.8 million), and in the Americas (3.5 million). HIV/AIDS symptoms consist of 4 stages, namely stage 1, this phase is referred to as asymptomatic HIV infection where the initial HIV symptoms are still not felt. The goal of antiretroviral therapy (ARV) is to increase the number of CD4+ in T cells, reduce viral load, so that it is expected to reduce mortality. Recommendations for ARV administration are always evolving. Currently, ARVs are given to patients with PLWHA at any clinical stage and CD4+ count. This study aims to determine the development of Antiretroviral therapy (ARV) in the treatment of HIV/AIDS. The method used was literature review with narrative review design to identify and summarise previously published articles on the development of Antiretroviral (ARV) therapy in the treatment of HIV/AIDS. From the 10 articles summarised, it was found that there was an influence of the development of Antiretroviral (ARV) therapy in the treatment of HIV/AIDS over time.