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All Journal Current Biochemistry Justek : Jurnal Sains Dan Teknologi Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Jurnal Ilmiah Kanderang Tingang Panrita Inovasi: Jurnal Pengabdian Kepada Masyarakat
Najmah Najmah
Department Of Biochemistry, IPB University
Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Education Engineering Environmental Science Mathematics Physics Public Health Social Sciences

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Antioxidant Activity, Inhibition α-Glucosidase of Cymbopogon nardus (L.) Rendle and Identification of Active Compounds Najmah Najmah; Hasim Hasim; Didah Nur Faridah
Current Biochemistry Vol. 8 No. 1 (2021)
Publisher : IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/cb.8.1.3

Abstract

Diabetes mellitus (DM) has become a health problem in various countries, even in Indonesia, multiple of Covid-19 sufferers have DM as comorbid. Treatment of DM can be conducted by delaying glucose intake performed by the α-glucosidase enzyme in the intestine. Treatment using synthetic drugs often causes side effects. Instead to overcome these problems, herbal medicine is a choice. Cymbopogon nardus (L.) Rendle served as a potential candidate as seen from prior research but related to DM drugs, further exploration needs to be performed. This study aims to acquire a DM medicine by using Cymbopogon nardus (L.) Rendle . The leaves were macerated using 96% concentration of ethanol followed by multilevel fractionation with n-hexane, water and ethyl acetate as solvents. The test results showed that the n-hexane fraction was the best for antioxidant activity and α -glucosidase inhibition with IC50 values of 8,23 ppm and 311,87 ppm while the identification of the compound by using Liquid Chromatograph-Mass Spectrometry (LC-MS/MS) suspected compounds that have a role were ar-turmerone, beesioside N and notohamosin A. Based on the test, the n-hexane fraction was found as a source of antioxidants as well as α -glucosidase inhibitors. Keywords: Antioxidant, α -glucosidase, Cymbopogon nardus (L.) Rendle, LC-MS/MS.
Cytotoxic Activity of Volatile Compounds in Cymbopogon nardus’ Essential Oils Rizki Fitria; Djarot Sasongko Hami Seno; Bambang Pontjo Priosoeryanto; Najmah Najmah; Waras Nurcholis
Justek : Jurnal Sains dan Teknologi Vol 5, No 2 (2022): November
Publisher : Unversitas Muhammadiyah Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/justek.v5i2.10194

Abstract

Abstract:  Plants produce a variety of secondary metabolites, one of which is essential oils that contain a variety of volatile compounds and are useful for humans. Cymbopogon nardus contains volatile compounds that can inhibit the proliferation of cancer cells. This research aims to explore the antiproliferation activity of C.nardus’ essential oils with different concentrations against breast cancer Michigan Cancer Foundation-7 (MCF-7) cells. Antiproliferation test was carried out with total cells method using trypan blue and cells were calculated using a microscope. Gas Chromatography-Mass Spectrometer (GC-MS) was performed to identify the volatile compounds. The results showed that the Inhibitory Concentration 50 (IC50) value was 359.6 ppm with an inhibition percent of 44.49% at 170 ppm. Meanwhile, inhibition percent against Vero normal cell was 29.04%, compared to Doxorubicin 35.23%. The dominant volatile compound in C. nardus’ essential oil were Geraniol and Citronellol.Abstrak Tanaman menghasilkan berbagai macam metabolit sekunder, salah satunya dalam bentuk minyak atsiri yang mengandung berbagai macam senyawa volatil yang berguna bagi manusia. Cymbopogon nardus mengandung senyawa volatil yang dapat menghambat proliferasi sel kanker. Penelitian ini bertujuan untuk mengetahui aktifitas antiproliferasi minyak atsiri C. nardus dengan beberapa konsentrasi terhadap sel kanker payudara Michigan State Foundation-7 (MCF-7). Uji antiproliferasi dilakukan dengan metode total sel menggunakan trypan blue dan sel dihitung menggunakan mikroskop. Gas Chromatography-Mass Spectrometer (GC-MS) dilakukan untuk mengidentifikasi senyawa volatil. Hasil menunjukkan bahwa konsentrasi penghambatan 50 (IC50) sebesar 359.6 ppm dengan persen penghambatan sebesar 44.49% pada konsentrasi 170 ppm. Sementara itu, persen ihibisi terhadap sel normal Vero sebesar 29.04%, dibandingkan dengan Doksorubisin yang sebesar 35.23%. Senyawa volatil dominan yang terdapat pada C. nardus adalah Geraniol dan Citronellol.           
Keefektifan Grup Whatsapp Dalam Pembentukan Community Of Inquiry (CoI) Melalui Blended Learning Pada Materi Penyetaraan Reaksi Mohammad Alex Firdaus; Haris Munandar; Najmah Najmah
Jurnal Ilmiah Kanderang Tingang Vol 14 No 1 (2023): Jurnal Ilmiah Kanderang Tingang
Publisher : FKIP Universitas Palangka Raya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37304/jikt.v14i1.194

Abstract

The aim of this study was to know the effectiveness of WhatsApp group in creating Community of Inquiry (CoI) through blended learning in Balancing Chemical Equations. The object research was 30 students of 1 Giri senior High School. The research method used was descriptive qualitative. The success rate of CoI through blended learning can be seen from the relationship of the three elements of the CoI framework: social relations, appropriate teaching methods, and cognitive aspect. The social relations of this study were characterized by the variety of learning resources used by students in discussion forums in WhatsApp group, either of textbooks, videos, or sources from the internet. This was because students felt comfortable as evidenced by the quantity of interaction among students and the interaction of students with educators in discussion forums. The success of the teaching element was observed from the process of providing facilities and guidance. The facility for establishing CoI through blended learning in this study was accommodated by the WhatsApp group. While the guidance carried out by educators is done by explaining the learning flow and directing students to actively interact and provide reinforcement for answers. The success of the cognitive aspect was obtained from the passage of all stages of CoI in constructing the Balancing Chemical Equations material. In this study, it was known that the exploration and integration stages dominate more than the other steps. This indicated that students were able to focus themselves on questions posed by other students related to teaching materials by seeking information through various sources.
Penyuluhan Budaya Siaga Bencana Siswa SDN 3 Kabila Bone Ayub Pratama Aris; Ninasafitri Ninasafitri; Masruroh Masruroh; Moch Rio Pambudi; Najmah Najmah; Erga Kurniawati
Panrita Inovasi: Jurnal Pengabdian Kepada Masyarakat Vol 1 No 1 June 2022
Publisher : Universitas Negeri Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (585.033 KB) | DOI: 10.56680/pijpm.v1i1.36547

Abstract

Disasters in Indonesia can be detrimental every time they occur, Gorontalo, which is on the Pacific plate route, has the potential for disasters to occur, therefore it is necessary to be prepared for disasters, most victims of school-age children, the importance of disaster knowledge from an early age in order to reduce threats to children. among others (before, during, and after a disaster) conducted using the lecture method which is expected to provide an overview of disaster preparedness. from this counseling explains the culture of disaster preparedness where this explanation is carried out for six disasters that often occur in Indonesia. To reduce disaster risk, a culture of preparedness must be instilled from an early age on a regular basis so that disaster preparedness is a step to deal with disasters. disaster preparedness can be improved from a low level of knowledge to be better by implementing a daily disaster preparedness culture
SKRINING FITOKIMIA, TOTAL FLAVONOID DAN FENOLIK DAUN SEREH WANGI (Cymbopogon nardus (L.) Rendle) Najmah Najmah; Rizki Fitria; Erga Kurniawati
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 5 No. 1 (2023): Penelitian Kimia dan terapannya 2023
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v5i1.2642

Abstract

Sereh wangi (Cymbopogon nardus (L.) Rendle) memiliki banyak manfaat dan telah lama dibudidayakan di Indonesia. Senyawa metabolit sekunder terdapat pada semua bahan alam. Penelitian ini bertujuan untuk mengetahui skrining fitokimia, total fenolik, dan total flavonoid ekstrak dan fraksi daun sereh wangi. Daun sereh wangi dimaserasi kemudian difraksinasi dengan pelarut N-heksana, air, dan etil asetat. Uji terdiri dari skrining fitokimia, uji total fenolik dengan standar asam galat, dan total flavonoid menggunakan standar kuersetin. Hasil penelitian menunjukkan bahwa ekstrak mengandung tanin, alkaloid, triterpenoid/steroid, saponin, fenolat, dan flavonoid. Total fenolik pada ekstrak adalah 81,67 mg GAE/sampel; fraksi N-heksana adalah 466,67 mg GAE/sampel; fraksi etil asetat sebesar 369,44 mg GAE/sampel dan fraksi air sebesar 268,89 mg GAE/sampel. Total flavonoid pada ekstrak adalah 161,11 mg QE/g sampel; fraksi N-heksana adalah 239,85 mg GAE/sampel; fraksi etil asetat sebesar 129,48 mg GAE/sampel dan fraksi air sebesar 74,52 mg GAE/sampel.
KOMPONEN FITOKIMIA DAN AKTIVITAS ANTIOKSIDAN RUMPUT LAUT EUCHEUMA COTTONII DI PERAIRAN DESA PAJUKUKANG BANTAENG Saadatul Husna; Nurlaida Nurlaida; Yusriadi Yusriadi; Hermin Utami; najmah najmah
Jurnal Crystal : Publikasi Penelitian Kimia dan Terapannya Vol. 5 No. 2 (2023): Penelitian Kimia dan Terapannya
Publisher : Program Studi Kimia, Fakultas MIPA, Universitas PGRI Banyuwangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36526/jc.v5i2.2769

Abstract

Red seaweed (Eucheuma cottoni) is a plant that has high cultivation potential and is growing rapidly. Bantaeng Regency is one of the 15 seaweed processing centers in Indonesia. The use of seaweed is very diverse, both for food, feed, fertilizer, cosmetics and pharmaceuticals. This is related to the content of nutrients, minerals and bioactive compounds contained in seaweed. This research aims to determine the water content, ash content, phytochemical compound and antioxidant activity of red seaweed in the waters of Pajukukang Village Bantaeng. The research result showed that water content and ash content of red seaweed were 7.21%,17.626% respectively. Red seaweed ethanol extract contains alkaloids, flavonoids, saponins, and steroids. The result of antioxidant test showed that the red seaweed ethanol extract has weak antioxidant activity with IC50 value of 961,83 ppm.
Co-Authors Aris, Ayub Pratama Bambang Pontjo Priosoeryanto Djarot Sasongko Hami Seno Elfrida Ratnawati Erga Kurniawati Haris Munandar Hasim Hasim Hermin Utami Masruroh Masruroh Moch Rio Pambudi Mohammad Alex Firdaus Ninasafitri, Ninasafitri Nurlaida Nurlaida Rizki Fitria Saadatul Husna Waras Nurcholis