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All Journal Proceedings of the International Conference on Nursing and Health Sciences JIFI (Jurnal Ilmiah Farmasi Imelda) International Journal of Medicine and Health International Journal of Health, Engineering and Technology Journal of Innovative and Creativity
Kharisma Jayak Pratama
Universitas Duta Bangsa Surakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Characteristic and Antibacterial Activity Test of Red Betel Leaf Essential Oil Against Propionibacterium Acne Bacteria Bangkit Riska Permata; Kharisma Jayak Pratama; Mei Ika Nurul Khotimah; Sabrina Karim
Proceedings of the International Conference on Nursing and Health Sciences Vol 4 No 1 (2023): January-June 2023
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/picnhs.v4i1.1688

Abstract

Many Indonesian plants have the potential to have anti-acne activity, one of which is the red betel plant. Red betel leaf (Piper crocatum) contains flavonoids, alkaloids, tannins, and essential oils which are thought to be used as antimicrobials. The purpose of this study was to test the quality characteristics and test the antibacterial activity of red betel leaf essential oil against Propionibacterium acne bacteria. This research was an experimental study by identifying the physical quality and testing the antibacterial activity of the essential oil. human senses with the results of the smell or aroma obtained, namely the strong or stinging characteristic odor of red betel. The color of the essential oil obtained was yellow with a little brownish, bitter taste, the pH obtained from the essential oil was 4.65, the specific gravity of red betel leaf essential oil was 0.739, the ethanol soluble test obtained from the essential oil completely dissolved and white clear in a quantity of alcoholic solution. Antibacterial activity test results with red betel leaf essential oil concentrations of 5%, 10%, and 20%, could inhibit antibacterial of 7.16 mm, 10.3 mm, and 11.6 mm.
Formulasi dan Uji Aktivitas Antioksidan Sediaan Face Toner Ekstrak Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) Menggunakan Metode DPPH Rahmadini Rahmadini; Alfina Nurrahman; Kharisma Jayak Pratama
Journal of Innovative and Creativity Vol. 6 No. 1 (2026)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v6i1.8211

Abstract

ABSTRACT Free radicals are unstable molecules that can damage cell membranes, DNA, and proteins, thereby triggering premature aging. Preventive efforts can be carried out through skin care using cosmetic products containing natural antioxidants, which are considered safer and capable of providing long-term protection. One cosmetic product that functions as a moisturizer is face toner. Fragrant pandan leaves (Pandanus amaryllifolius Roxb.) are known to contain antioxidant compounds, making them potential active ingredients in face toner formulations. This study aimed to formulate a face toner containing fragrant pandan leaf extract in three concentration variations, namely 1%, 2%, and 3%. Antioxidant activity was evaluated using the DPPH method to determine IC₅₀ values. Physical quality evaluations were also conducted, including organoleptic tests, homogeneity, pH, and viscosity. The results showed that formula 0 had an IC₅₀ value of 261.11 ppm (very weak), formula 1 had an IC₅₀ value of 51.95 ppm (strong), formula 2 had an IC₅₀ value of 40.32 ppm (very strong), and formula 3 had an IC₅₀ value of 32.91 ppm (very strong). In addition, all formulations (0%, 1%, 2%, and 3%) met the physical quality requirements for cosmetic preparations. Keywords: Antioxidant, Fragrant Pandan Leaves, Extract, Face toner
Relationship of Medication Adherence to Clinical Outcome in Patients Type 2 Diabetes with Modified Morisky Adherence Scale 8 (MMAS 8) Niken Luthfiyanti; Ardi Setyawan; Kharisma Jayak Pratama
International Journal of Medicine and Health Vol. 3 No. 4 (2024): Desember : International Journal of Medicine and Health (IJMH)
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/ijmh.v3i4.4547

Abstract

Diabetes melitus is a chronic condition desease that requires continued use of medication. High adherence to treatment will produce good clinical results and play a role in improving the quality of life of diabetes melitus sufferers. The following research aims to assess the relationship between adherence to medication use and clinical outcomes for patients with type 2 diabetes mellitus at RSUD DR. Moewardi Surakarta which was conducted in the period April – June 2024. This research used a cross sectional method with a total of 98 patients as respondents who met the inclusion and exclusion criteria. Adherence data was assessed using the Modified Morisky Adherence Scale 8 (MMAS 8) questionnaire, and clinical outcomes were assessed from fasting or fasting blood glucose values ​​and %HbA1C from medical record data. Analysis of the relationship between adherence and clinical outcomes using chi-square. The results of the level of treatment compliance can be divided into 3 categories, namely: high treatment compliance has a percentage of 24.5%, moderate treatment compliance has a percentage of 46.9%, and low treatment compliance has a percentage of 28.6%. Clinical outcomes were achieved by 38.8% and not achieved by 62.2%. There is a relationship between adherence medication and therapeutic outcomes in type 2 diabetes melitus patients with a Pearson chi square value of 0.011. Based on these data, pharmacist professionals need to place greater emphasis on adherence with medication use in type 2 diabetes mellitus patients to obtain good clinical outcomes.
HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA Neha Azziza Cherrysha Alifia; Kharisma Jayak Pratama; Anna Fitriawati
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2035

Abstract

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.
Cost-Effectiveness Analysis Of Pulmicort-Combivent And Pulmicort Single Use In Inpatients With Chronic Obstructive Pulmonary Disease At Dr. Moewardi Regional Hospital Yustina Esha Maunia Chantika; Kharisma Jayak Pratama; Vivin Marwiyati Rohmana
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.633

Abstract

Chronic Obstructive Pulmonary Disease (COPD) causes a high economic burden due to repeated hospitalizations, but the cost-effectiveness of Pulmicort-Combivent versus Pulmicort alone has not been evaluated at Dr. Moewardi Regional General Hospital. This study aims to determine ACER, ICER, and cost-effectiveness of therapy using CEA. This study was a retrospective, descriptive, cross-sectional observational study with a total sampling of 62 hospitalized COPD patients from January 2024 to November 2025. Medical record data instruments were analyzed using ACER, ICER, and the Mann-Whitney test. The results showed that the ACER of Pulmicort-Combivent Rp225,775 (40% effectiveness) was lower than that of Pulmicort alone Rp765,036 (14.03%), ICER Rp-65,554, with no significant difference (p>0.05). Both therapies were equivalent in terms of cost-effectiveness.
Evaluation Of The Rationality Of Antibiotic Use In Hospitalized Adult Patients With UTI Diagnosis On Clinical Outcome At Dr. Moewardi Regional Hospital Malinda Apriliani; Kharisma Jayak Pratama; Niken Luthfiyanti
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.651

Abstract

Urinary Tract Infection (UTI) is a common infection with high antibiotic resistance due to irrational use.  To assess the rationality of antibiotics in adult inpatients with UTI at Dr. Moewardi Regional General Hospital using the Gyssens method, ATC/DDD patterns, and their relationship with clinical outcomes. A retrospective descriptive observational study of medical records of 50 acute pyelonephritis patients (population 270, Slovin sample e=10%, consecutive sampling), collected in December 2025. LPD medical records; analysis: Gyssens (qualitative Permenkes 28/2021), ATC/DDD (quantitative), Fisher's Exact (p<0.05). 64% female, 52% >60 years; ciprofloxacin 90%; rationality 46% (Gyssens category 0), 54% irrational (mainly short duration 44%); ATC/DDD: ciprofloxacin 47.2%, ceftriaxone 52.8%; outcome improved 94%; p=0.090 (not significant). Rationale was low, especially for duration, with no significant association with outcome; stewardship is recommended to prevent resistance.
Co-Authors Alfina Nurrahman Anna Fitriawati Ardi Setyawan Bangkit Riska Permata Malinda Apriliani Mei Ika Nurul Khotimah Neha Azziza Cherrysha Alifia Niken Luthfiyanti Rahmadini Rahmadini Rohmana, Vivin Marwiyati Sabrina Karim Yustina Esha Maunia Chantika