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Perbandingan Hasil Pemeriksaan Kimia Darah pada Beberapa Tabung Vakum pada Pasien Tuberkulosis Paru Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Simanjuntak, James P
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.19922

Abstract

Clinical laboratories are required to produce accurate laboratory examination results so that patient diagnoses are correct. Laboratory examination results are greatly influenced by pre-analytical stages such as the performance of the blood collection tube. Blood collection tubes used in laboratories vary in terms of brand, type and additives in them. Additives in blood collection tubes can affect the accuracy of laboratory test results. To prevent this situation, every laboratory must carry out validation before using blood collection tubes. Almost all clinical laboratories have not carried out collection tube validation activities blood before use. The study aimed to analyze differences in creatinine, GGT, HDL and LDH levels in serum collected in several blood collection tubes used in the laboratory. The research design is analytical descriptive. The sample consisted of 40 healthy adult respondents aged between 18 and 55 years (based on CLSI GP34-A). The parameters studied were creatinine, GGT, HDL and LDH levels from serum collected from blood collection tubes of different types and brands. The research was conducted in the clinical chemistry laboratory, medical laboratory technology department, Health Polytechnic, Ministry of Health, Jambi. in vitro diagnostic technology, namely validation of blood collection tubes. The resulting data from the research was tested using statistical tests.
Edukasi Vitamin D pada pasien asma dalam upaya pencegahan kekambuhan asma di wilayah Puskesmas Olak Kemang Kota Jambi Sitanggang, Fardiah Tilawati; Sakdiah, Siti; Simanjuntak, James P
BINAKES: Jurnal Pengabdian Kesehatan Masyarakat Vol 4 No 01 (2023): Jurnal Binakes
Publisher : Poltekkes Kemenkes Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35910/binakes.v4i01.656

Abstract

Asthma is a chronic inflammation of the airways characterized by recurrent wheezing, coughing and tightness in the chest, especially at night due to airway obstruction. Asthma increases with air quality and changes in lifestyle. The severity of asthma is influenced by vitamin D, which plays a role in increasing the immune response (immunomodulator) and reducing inflammation in the lungs. Research by Simanjuntak et al in 2022 shows that vitamin D deficiency is strongly correlated with asthma and the severity of asthma. The prevalence of asthma in Jambi City is 1.7% with a recurrence of 62% and is the highest cause of death in Jambi City. Olak Kemang Health Center, Jambi City is one of the health centers that has a high number of asthma patients, namely 95 people with a low level of knowledge regarding vitamin D and asthma. After providing education regarding vitamin D and asthma, there was a significant change, namely an increase in knowledge which was visible from the pre and post tests. The involvement of government officials such as community health center officers and cadres plays a significant role in motivating asthma patients to take part in educational activities.
Survey of Inflammatory Biomarkers in Blood and Sputum in Pulmonary Tuberculosis Patients Simanjuntak, James Perdinan; Sakdiah, Siti; Sitanggang, Fardiah Tilawati; Maharani, Eva Ayu
Jurnal Health Sains Vol. 4 No. 10 (2023): Journal Health Sains
Publisher : Syntax Corporation Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/jhs.v4i10.1092

Abstract

Tuberculosis (TB) is still a global health problem that exists today. Various efforts to reduce the number of TB patients have been carried out ranging from detection efforts to treatment and prevention efforts. Many studies have been conducted previously to look at the detection potential of laboratory diagnoses in finding new cases of tuberculosis. Likewise, efforts to detect prognosis in the laboratory to monitor the development of the condition of TB patients. The development of inflammatory conditions in TB patients is important to accelerate the healing process of these patients. Inflammatory marker tests have been widely performed on several types of laboratory test parameters. CRP and LDH are types of testing that have potential as markers of inflammatory development in TB patients. However, proven tests generally use blood specimens, which are commonly used in laboratory analysis for these parameters. Meanwhile, the current research theme has also been directed at the use of other types of specimens that can show inflammatory conditions experienced by a person. Saliva is known to have potential as another alternative specimen that can be used for such purposes. Saliva is easily obtained and does not require invasive techniques such as needle invocation, so it is considered to have more advantages if it can be proven as a laboratory test specimen that can provide information that is as good and accurate as blood or serum. This study aimed to assess the potential of saliva as an alternative specimen for laboratory analysis with the aim of markers in the assessment of prognosis of TB patients. CRP examination and LDH enzyme activity were chosen in this study of serum and saliva specimens of TB subjects and controls. From this study, it is expected to be shown that saliva can be used as an alternative specimen in laboratory analysis for inflammatory marker tests on both parameters. The results obtained showed that the measurement of LDH activity and and CRP levels in saliva observed in this study proved to have good potential in predicting the presence of inflammation and cell damage experienced by TB subjects. LDH test results have a strong relationship between serum and saliva as laboratory test materials, even salivary LDH levels are higher than serum. While CRP, although saliva showed low levels, the correlation test carried out still showed a strong relationship between the results of the two types of specimens.