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Pardilawati, Citra Yuliyanda
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Analisis Peresepan Obat yang Berpotensi Tidak Tepat Berdasarkan Kriteria STOPP Pada Pasien Geriatri Salsabilla, Riefa Ayu; Pardilawati, Citra Yuliyanda; Iqbal, Muhammad; Oktarlina, Rasmi Zakiah
Medula Vol 14 No 2 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i2.952

Abstract

Potentially inappropriate prescribing (PIP) is a drug prescription without a proper clinical indication. The tools used to identify PIP in the geriatric patient is the STOPP criteria. The STOPP criteria evidently to improve treatment suitability, reduce medical costs, and reduce the occurrence of adverse drug reaction. The aim of this study is to evaluate the potentially inappropriate prescribing in geriatric patients using the STOPP criteria. This study is observational study used a cross-sectional approach. Geriatrics is an age group that is vulnerable to the side effects of drug use. Drug administration in geriatric patients is complex and requires a lot of consideration due changes in body composition and function, comorbidities, sensory and cognitive disorders, and polypharmacy, so that assistance with Potentially Inappropriate Medications (PIMs) and PPOs (Potentially Prescription Omissions) is important to improve the quality of treatment.
REVIEW ARTIKEL : UJI EFEK ANTI AGING DARI BERBAGAI EKSTRAK TUMBUHAN SECARA IN VIVO DAN IN VITRO Febriyanti, Triana; Sukohar, Asep; Pardilawati, Citra Yuliyanda; Adjeng, Andi Nafisah Tendri
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1041

Abstract

The outermost and largest organ in our body is the skin. Skin can experience aging when exposed to sunlight. Sunlight contains ultraviolet. Exposure to ultraviolet (UV) radiation causes damage to the skin and can lead to photoaging. Photoaging can be prevented with antioxidant compounds. Many plant extracts or synthetic compounds act as anti-aging agents. These plant extracts become active ingredients that can be formulated into pharmaceutical preparations. Plant extracts that have anti-aging potential include red cabbage, kepok banana peel, red pomegranate, moringa leaves, butterfly pea flower, black cumin seeds and libo fruit. To prove this, a test was carried out. The testing carried out can be in the form of in vivo and in vitro testing methods. This research was carried out using the article review method and obtained several journals from online literature, local journals and international journals, namely electronic searches with the keywords anti-aging, in vitro, in vivo on the website, namely Google Scholar. The number of journals used in this review was 11 journals spanning the last eight years. The results of the article review study showed that several methods used were UV-VIS spectrophotometer, DPPH method, anti-elastase, as well as tests on rats, mice and guinea pigs. From the results of the review of articles on plant extracts, most of them use in vivo tests on experimental animals.
Efektivitas Terapi Non-Farmakologi Pada Pasien Hipertensi Nadiya Widda Mawaddah; Damayanti, Ervina; Pardilawati, Citra Yuliyanda
Medula Vol 14 No 3 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i3.1056

Abstract

Hypertensive disease is the leading cause of early death worldwide. Hypertension is a common chronic medical condition characterized by sustained increases in arterial pressure. The high risk of side effects in the use of antihypertensive medicine for a long period of time causes non-pharmacological therapy of hypertension to be an alternative choice. This study aims to determine the effectiveness of non-pharmacological therapy in hypertensive patients in reducing and controlling normal blood pressure. The study used a literature review method with data sources of international scientific journals and articles using the PubMed database. The information search strategy used a combination of keywords such as "non-pharmacological therapy for hypertension" and "the effectiveness of non-pharmacological therapy in hypertension". Through the database search, 190 scientific articles and journals were obtained. A total of 12 scientific journals and articles were selected as reference sources for research that met the criteria. The results obtained from 12 journals and scientific articles showed that non-pharmacological therapy for hypertension was effective in reducing systolic and diastolic blood pressure. Non-pharmacological therapies recommended according to the reference sources are lifestyle modification, increasing physical activity such as aerobic exercise, intake of low sodium salt, acupuncture therapy, listening to music, relaxation therapy and increasing compliance with therapeutic interventions.
Kajian Polifarmasi Terhadap Keamanan Obat Pada Pasien Geriatri Jessy Dewi Awali; Pardilawati, Citra Yuliyanda; Soleha, Tri Umiana; Oktarlina, Rasmi Zakiah
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1059

Abstract

Geriatric patients an elderly patients suffering from a variety diseases (multimorbidity) caused by a decrease in body organ function. Multimorbidity in geriatric patients tends to lead to increased prescriptions and risks of polypharmacy. Polypharmacy can be defined as the use of five or more types of medications by a patient simultaneously. Polypharmacy is a major concern because of negative health impacts on patients, such as increased incidence of adverse drug reactions, harmful drug interactions, decreased medication adherence, and potentially inappropriate prescribing. Collaboration among doctors, pharmacists, other healthcare professionals, and families plays an important role in ensuring the effectiveness of treatment for geriatric patients, thus making the medications used safe and appropriate and reducing the negative impact of polypharmacy.
Kejadian Reaksi Obat yang Tidak Diinginkan Asidosis Tubulus Ginjal Pada Penggunaan Ibuprofen Sebagai Obat Over the Counter Alifah, Ghina Nur; Pardilawati, Citra Yuliyanda; Kurniawati, Evi; Sukohar, Asep
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1061

Abstract

Ibuprofen is an analgesic drug that can be obtained easily by patients because it is an over the counter (OTC) drug.  Ibuprofen when used can risk the lives of patients who consume it incorrectly.  Ibuprofen is a drug that causes damage to the kidneys or is nephrotoxic.  In large doses ibuprofen has been reported to cause hypokalemia, rhabdomyolysis and renal tubular acidosis Article searches with data sources from either journals or books with keywords used to facilitate searches. Journal articles used through case reports collect case reports of renal tubular acidosis due to the use of ibuprofen. In some of the case reports found, the use of ibuprofen had exceeded the dose set for OTC treatment. Patients with an average age of 41 years and reports ranged in age from 33 years to 63 years. Female patients has dominated the reported cases. The use of ibuprofen that caused the adverse drug reaction event belongs to type C, which is Chronic for continuous and long-term use of the drug. Non-pharmacological therapy that can be done is diet by limiting acid-producing foods and increasing alkaline-producing foods. Handling carried out on patients can be in the form of fluid resuscitation, electrolyte replacement through alkaline therapy, and supportive therapy according to the patient's clinical condition. Alkaline therapy using NaHCO3 and KHCO3 can be a fluid replacement and correct acidosis and hypokalemia.
Application of Non-Pharmacological Therapy in Patients with Depression Lathifah, Dina Silmi; Damayanti, Ervina; Oktarlina, Rasmi Zakiah; Pardilawati, Citra Yuliyanda
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.1079

Abstract

Gejala-gejala gangguan depresi adalah kesedihan, kehilangan minat atau kesenangan, perasaan bersalah atau harga diri yang rendah, gangguan tidur atau nafsu makan, perasaan lelah, dan konsentrasi yang buruk, yang dapat berujung pada bunuh diri. Sebagian besar pasien depresi tidak merespons dengan baik terhadap antidepresan yang saat ini tersedia. Hampir 30% pasien depresi tidak mengalami remisi. Terapi non-farmakologi menjadi alternatif pilihan. Metode yang digunakan adalah literature review dan mengambil data yang bersumber dari Pubmed. Kata kunci yang digunakan, yaitu “Nonpharmalogical treatment of depression” dan didapatkan 191 artikel dan jurnal ilmiah. Sebanyak 7 artikel dan jurnal ilmiah terpilih menjadi sumber acuan. Hasilnya adalah terapi non-farmakologi yang dapat dilakukan, seperti akupuntur, latihan fisik (aerobik, yoga, dan meditasi), pengurangan tidur dan terapi cahaya, terapi kejang magnet, stimulasi intermiten theta-burst, dan stimulasi dalam magnetic transcranial, serta terapi ekspresi.
Co-Authors Alifah, Ghina Nur Aminuyati Andrifianie, Femmy Asep Sukohar Asriani, Meni Az Zahra, Ghina Nazhifah Daffa, Meysha Nur Damayanti, Ervina Febriyanti, Triana Febyolla, Citra Lucky Firdayanti, Ratri Mawas Ihsanti Dwi Rahayu Jessy Dewi Awali Junando, Mirza Lathifah, Dina Silmi Mallarangeng, Andi Nafisah Tendri Adjeng Muhammad Iqbal Nadiya Widda Mawaddah Nurhayati Nurhayati Oktoba, Zulpakor Ramdini, Dwi Aulia Rasmi Zakiah Oktarlina Salsabilla, Riefa Ayu Sembiring, Elma Viorentina Siti Julaiha Thahir, Salsabila Anggraini Tri Umiana Soleha Wardhani, Oktiva Risma Winnugroho Wiratman, Manfaluthy Hakim, Tiara Aninditha, Aru W. Sudoyo, Joedo Prihartono