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All Journal Jurnal Biomedika dan Kesehatan Narra J JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti
Suweino Suweino, Suweino
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PERAN PENANDA LC3 SEBAGAI FUNGSI AUTOFAGI PADA AGING Xavierees, Endrico; Yohana, Yohana; Faradilla, Meutia Atika; Yastani, Deasyka; Anastasya, Karina Shasri; Suweino, Suweino
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 10, Nomor 1, Januari 2025
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v10i1.21848

Abstract

Autofagi adalah proses kompleks yang masih perlu diteliti lebih dalam. Proses ini ditandai dengan adanya pembentukan membran oleh peran protein spesifik yang disebut LC3, yang memainkan peran penting dalam mekanisme autofagi. Autofagi adalah bagian penting dari proses metabolisme, karena melibatkan pergerakan organel dari limbah ke autofagosom. Proses ini difasilitasi oleh adanya fagofor dan isolasi membran, yang penting untuk pembentukan autofagosom. Autofagosom kemudian membentuk struktur kompleks dengan lisosom, yang kemudian diubah menjadi autolisosom dan bahan yang terdegradasi. Secara umum juga dikenal dengan makroautofagi namundapat ditemukan jenis lain seperti xenofagi, chaperon-mediated autofagi. Merupakan proses penting dalam menjaga keseimbangan organ-organ internal tubuh, Autofagi juga terlibat dalam pengaturan berbagai proses fisiologis, seperti sekresi insulin, pengaturan gula darah, dan respons imun. Aging mulai dihubungkan dengan autofagi dan masih memiliki banyak ruang yang perlu didalami. Memiliki peran penting dalam aging, kehamilan dan kasus kehamilan lain seperti hambatan pertumbuhan janin, kelahiran preterm, dan Diabetes Gestasional yang banyak ditemukan pada Wanita dengan usia lebih tinggi. Mulai banyak penelitian yang menghubungkan autofagi dengan bertambahnya usia. Hasil Penelitian sebelumnya menunjukkan hubungan erat sehingga mendorong penelitian lebih lanjut untuk menjelaskan fungsi Autofagi pada aging.
Endometriosis pada Luka Operasi Seksio Sesarea: Suatu Laporan Kasus Yastani, Deasyka; Wirawan, Jimmy Panji; Anastasya, Karina Shasri; Faradilla, Meutia Atika; Xavierees, Endrico; Yohana, Yohana; Suweino, Suweino; Rahmansyah, Mulia; Mahardieni, Karlina; Ferina, Mutiara
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.329-333

Abstract

Caesarean scar endometriosis is a rare form of extra pelvic extrapelvic or extra-pelvic endometriosis that often presents with nonspecific symptoms, leading to diagnostic challenges. We report the case of a 41-year-old woman who presented with a painful subcutaneous mass at the site of a previous caesarean section, noted eight months post-surgery. MRI imaging revealed a mass suggestive of cutaneous endometriosis, and a wide excision was performed. Histopathological analysis confirmed the diagnosis by identifying endometrial glands and stroma within the cutaneous tissue. We report the case of a 41-year-old woman with a painful subcutaneous mass at the site of a previous cesarean section. The mass was detected eight months after the cesarean section. Following magnetic resonance imaging (MRI), which demonstrated a mass characterized as cutaneous endometriosis, the patient underwent wide excision. Histopathological analysis confirmed the diagnosis by demonstrating endometrial glands and stroma within the cutaneous tissue. Caesarean scar endometriosis is often associated with Pfannenstiel incisions, with a latency period of symptom onset averaging over two years. While imaging, such as MRI, is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is uncommon but can occur. Iatrogenic seeding of endometrial cells during surgery is a likely etiological factor, highlighting the importance of proper surgical technique and wound cleaning. Cesarean scar endometriosis is often associated with a Pfannenstiel incision, with an average latency period of more than two years. Although imaging such as MRI is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is rare but can occur. Iatrogenic endometrial cell seeding during surgery is a likely etiologic factor, highlighting the importance of proper surgical technique and wound cleansing. The conclusion was although rare, cutaneous endometriosis should be considered in women presenting with cyclical pain and masses at surgical scars post-caesarean - cyclic pain and masses in their post-cesarean scars. Early recognition and surgical intervention are key to effective management and prevention of cutaneous endometrosis recurrence.
Association between MC4R rs17782313 genotype and body fat percentage as an indicator of obesity among Indonesian adults Faradilla, Meutia Atika; Yohana, Yohana; Yastani, Deasyka; Handayani, Astri; Suweino, Suweino
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 17, No 1, (2026)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol17.Iss1.art5

Abstract

Background: Obesity is influenced by both environmental and genetic factors, including variation in the melanocortin-4 receptor (MC4R) gene, which plays a role in appetite regulation and energy balance. Identifying genetic risks, particularly whether obesity linked to inherited dysregulation of appetite, is crucial for early intervention and personalized prevention strategies.Objectives: This study aimed to examine the association between MC4R genotype and body fat percentage as an indicator of obesity among Indonesian adults. Methods: A cross-sectional study was conducted among 79 Indonesian adults aged 21–56 years in Jakarta. Participants were consecutively recruited and screened based on predefined inclusion and exclusion criteria. Anthropometric data, including height and weight, were obtained using a standardized stadiometer and digital scale to calculate body mass index (BMI). Body fat percentage (BFP) was assessed using bioelectrical impedance analysis (BIA) with an Omron Karada Scan device. Genomic DNA was extracted from venous blood samples, and the MC4R rs17782313 polymorphism was genotyped using the polymerase chain reaction– fragment length polymorphism (PCR-RFLP) method. Statistical analyses were performed to assess the association between genotypes and body fat percentages. Results: Most participants were classified as overweight (36.1%) or obese (41.7%) based on BMI. The genotypic distribution of rs17782313 was TT (48.1%), CT (39.2%), and CC (12.7%). Higher body fat percentages were significantly more common among individuals carrying the C allele. The CC genotype demonstrated the strongest association with obesity, with an odds ratio (OR) of 4.00 (95% CI: 1.02–15.64, p=0.04) compared to the wild-type TT genotype. Conclusion: Variations in the MC4R rs17782313 gene are associated with increased body fat percentage and a higher risk of obesity among Indonesian adults. Individuals carrying the risk allele may have greater susceptibility to excess fat accumulation, underscoring the importance of incorporating genetic factors into obesity prevention and management strategies.
Oxidative stress as a converging mechanism of aging and neurodegeneration: From molecular pathways to therapeutic targets Faradilla, Meutia A.; Anastasya, Karina S.; Yastani, Deasyka; Yohana, Yohana; Tungka, Endrico X.; Suweino, Suweino
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3042

Abstract

Aging is the primary risk factor for major neurodegenerative disorders, yet the precise molecular links between biological aging and progressive neuronal loss remain complex. Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses, has emerged as a central converging mechanism driving both processes. This review aims to synthesize current evidence demonstrating how chronic redox imbalance drives cellular senescence and neuronal vulnerability through mitochondrial dysfunction, lipid peroxidation, and oxidative protein damage. These insights underscore how sustained oxidative insults promote the misfolding and aggregation of disease-defining proteins, including amyloid-beta in Alzheimer’s disease and α-synuclein in Parkinson’s disease, thereby amplifying neuroinflammation, synaptic dysfunction, and bioenergetic failure. Furthermore, antioxidant-based therapeutic strategies are critically reassessed, highlighting a paradigm shift from non-specific radical scavenging toward targeted modulation of endogenous defense systems, particularly NRF2 signaling and mitochondria-directed antioxidants. By integrating molecular mechanisms with translational perspectives, this review integrates molecular, cellular, and translational evidence to explain how oxidative stress links biological aging to neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.
Co-Authors Anastasya, Karina S. Anastasya, Karina Shasri Deasyka Yastani Faradilla, Meutia A. Faradilla, Meutia Atika Ferina, Mutiara Handayani, Astri Jimmy Panji Wirawan Mahardieni, Karlina Rahmansyah, Mulia Tungka, Endrico X. Xavierees, Endrico Yohana Yohana Yohana