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All Journal Acta Biochimica Indonesiana Jurnal Biomedika dan Kesehatan Science Midwifery Narra J Jurnal Penelitian dan Karya Ilmiah Lembaga Penelitian Universitas Trisakti AMMA : Jurnal Pengabdian Masyarakat
Deasyka Yastani
Department Of Biochemistry, Faculty Of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
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The role of Nrf2 transcription factors in various physiological and pathological states Deasyka Yastani; Sri Widia A Jusman
Acta Biochimica Indonesiana Vol. 6 No. 2 (2023): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.103

Abstract

Since its first report in 1994, understanding of the nuclear factor erythroid 2-related factor 2 (Nrf2) has continued to grow. Initially recognized for its role in cellular response to oxidative stress, Nrf2 is now known to be involved in a variety of regulatory process, including metabolic regulation, autophagy, protein homeostasis (proteostasis), and mitochondrial biogenesis. The expression of Nrf2 target genes is highly dependent on stimulus activation and interactions with transcription factors, activators, and repressors. Nrf2 activation serves as a defense mechanism under physiological conditions, but in the context of cancer, it can trigger the development of cancer cells due to its complex roles. Nrf2 is strongly associated with the onset and development of many diseases, including those caused by metabolic disorders and inflammation. Understanding Nrf2's diverse functions offers valuable insights into disease pathogenesis and potential therapeutic approaches. This review explores the pleiotropic role of Nrf2 regulation.
PERAN PENANDA LC3 SEBAGAI FUNGSI AUTOFAGI PADA AGING Xavierees, Endrico; Yohana, Yohana; Faradilla, Meutia Atika; Yastani, Deasyka; Anastasya, Karina Shasri; Suweino, Suweino
JURNAL PENELITIAN DAN KARYA ILMIAH LEMBAGA PENELITIAN UNIVERSITAS TRISAKTI Volume 10, Nomor 1, Januari 2025
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25105/pdk.v10i1.21848

Abstract

Autofagi adalah proses kompleks yang masih perlu diteliti lebih dalam. Proses ini ditandai dengan adanya pembentukan membran oleh peran protein spesifik yang disebut LC3, yang memainkan peran penting dalam mekanisme autofagi. Autofagi adalah bagian penting dari proses metabolisme, karena melibatkan pergerakan organel dari limbah ke autofagosom. Proses ini difasilitasi oleh adanya fagofor dan isolasi membran, yang penting untuk pembentukan autofagosom. Autofagosom kemudian membentuk struktur kompleks dengan lisosom, yang kemudian diubah menjadi autolisosom dan bahan yang terdegradasi. Secara umum juga dikenal dengan makroautofagi namundapat ditemukan jenis lain seperti xenofagi, chaperon-mediated autofagi. Merupakan proses penting dalam menjaga keseimbangan organ-organ internal tubuh, Autofagi juga terlibat dalam pengaturan berbagai proses fisiologis, seperti sekresi insulin, pengaturan gula darah, dan respons imun. Aging mulai dihubungkan dengan autofagi dan masih memiliki banyak ruang yang perlu didalami. Memiliki peran penting dalam aging, kehamilan dan kasus kehamilan lain seperti hambatan pertumbuhan janin, kelahiran preterm, dan Diabetes Gestasional yang banyak ditemukan pada Wanita dengan usia lebih tinggi. Mulai banyak penelitian yang menghubungkan autofagi dengan bertambahnya usia. Hasil Penelitian sebelumnya menunjukkan hubungan erat sehingga mendorong penelitian lebih lanjut untuk menjelaskan fungsi Autofagi pada aging.
Peran Sitoglobin pada Kanker Yastani, Deasyka; H, Novi Silvia; Jusman, Sri Widia A
Jurnal Biomedika dan Kesehatan Vol 6 No 2 (2023)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2023.v6.250-260

Abstract

Cytoglobin (Cygb) is a new member of the globin protein family, following the discovery of other globin proteins such as hemoglobin (Hb), myoglobin (Mb), and neuroglobin (Ngb). In 2001, Kawada et al. identified Cygb in hepatic stellate cells (HSCs) that play an important role in the repair of damaged liver cell tissue, hence the name stellate cell activation-associated protein (STAP). Cygb has a more universal role than Hb, Mb, and Ngb, and is expressed throughout mammalian tissues. Cygb is a globin with 6 coordination bonds (hexacoordinate globin). Cygb has been shown to play an important role in the normal cell respiratory chain, including oxygen storage, destruction of reactive oxygen species (ROS), terminal oxidase activity, regulation of fibrogenesis, and regulation of apoptosis. The role of Cygb in the respiratory process has been studied because it is associated with the globin family, and because of the upregulation of Cygb during hypoxia, but its specific role has not been elaborated. Recent research reports that Cygb has several implications for cancer. In most cancer cells, Cygb expression is upregulated by hypermethylation, suggesting epigenetic control. In cancer cells, downregulation of Cygb occurs which indicates a possible role as a tumor suppressor gene. In some malignancies, on the contrary, Cygb upregulation may be associated with resistance to hypoxia which indicates Cygb has two sides or Janus faces related to its role in cancer cells.
Endometriosis pada Luka Operasi Seksio Sesarea: Suatu Laporan Kasus Yastani, Deasyka; Wirawan, Jimmy Panji; Anastasya, Karina Shasri; Faradilla, Meutia Atika; Xavierees, Endrico; Yohana, Yohana; Suweino, Suweino; Rahmansyah, Mulia; Mahardieni, Karlina; Ferina, Mutiara
Jurnal Biomedika dan Kesehatan Vol 8 No 3 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.329-333

Abstract

Caesarean scar endometriosis is a rare form of extra pelvic extrapelvic or extra-pelvic endometriosis that often presents with nonspecific symptoms, leading to diagnostic challenges. We report the case of a 41-year-old woman who presented with a painful subcutaneous mass at the site of a previous caesarean section, noted eight months post-surgery. MRI imaging revealed a mass suggestive of cutaneous endometriosis, and a wide excision was performed. Histopathological analysis confirmed the diagnosis by identifying endometrial glands and stroma within the cutaneous tissue. We report the case of a 41-year-old woman with a painful subcutaneous mass at the site of a previous cesarean section. The mass was detected eight months after the cesarean section. Following magnetic resonance imaging (MRI), which demonstrated a mass characterized as cutaneous endometriosis, the patient underwent wide excision. Histopathological analysis confirmed the diagnosis by demonstrating endometrial glands and stroma within the cutaneous tissue. Caesarean scar endometriosis is often associated with Pfannenstiel incisions, with a latency period of symptom onset averaging over two years. While imaging, such as MRI, is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is uncommon but can occur. Iatrogenic seeding of endometrial cells during surgery is a likely etiological factor, highlighting the importance of proper surgical technique and wound cleaning. Cesarean scar endometriosis is often associated with a Pfannenstiel incision, with an average latency period of more than two years. Although imaging such as MRI is useful for preoperative assessment, surgical excision remains the definitive treatment. Recurrence is rare but can occur. Iatrogenic endometrial cell seeding during surgery is a likely etiologic factor, highlighting the importance of proper surgical technique and wound cleansing. The conclusion was although rare, cutaneous endometriosis should be considered in women presenting with cyclical pain and masses at surgical scars post-caesarean - cyclic pain and masses in their post-cesarean scars. Early recognition and surgical intervention are key to effective management and prevention of cutaneous endometrosis recurrence.
Penyuluhan Apakah Kanker Serviks Itu Pada Ibu Dan Remaja Putri Di Desa Nagrak - Ciangsana, Bogor. Cicih Mayasari, Atut; Marliany Surjadi, Lily; Maharani, Laksmi; Yastani, Deasyka
AMMA : Jurnal Pengabdian Masyarakat Vol. 5 No. 1 : Februari (2026): AMMA : Jurnal Pengabdian Masyarakat
Publisher : CV. Multi Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Cervical cancer is the second leading cause of death in women. Yet, cervical cancer is preventable because it is caused by the Human Papilloma Virus (HPV), which, if infected, can take decades to develop into cancer. Cervical cancer prevention efforts have not yet reached their target. Coverage remains low. Knowledge about cervical cancer itself is still lacking, as is prevention. The perceived discomfort of early detection tests makes women reluctant to undergo them. Therefore, education about cervical cancer is needed to increase knowledge and thus increase the coverage of early detection tests. The ultimate goal is to reduce the incidence and mortality caused by cervical cancer. To this end, education about cervical cancer is being conducted for women, namely mothers and young girls, especially in the villages of Nagrak and Ciangsana, Bogor.
Serum 25-hydroxyvitamin D is associated with body fat percentage and skeletal muscle mass in adults: A cross-sectional study Faradilla, Meutia Atika; Yastani, Deasyka; Yohana, Yohana; Anastasya, Karina Shasri; Salma, Nabila Maudy
Science Midwifery Vol 13 No 6 (2026): February: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i6.2253

Abstract

Background: Vitamin D is widely recognized for its role in bone and musculoskeletal health, yet accumulating evidence suggests it may also influence body composition through regulatory effects on adipose and skeletal muscle tissues. This study aimed to evaluate the association between serum vitamin D status and body composition parameters in adults. Methods: A cross-sectional study was conducted in 77 adults. Serum 25-hydroxyvitamin D [25(OH)D] concentrations were measured using an enzyme-linked immunosorbent assay (ELISA), while body composition (percent body fat and skeletal muscle mass) was assessed using bioelectrical impedance analysis (BIA). Participants were categorized based on vitamin D status, and group comparisons as well as Pearson correlation analyses were performed. Results: The mean age of participants was 35.8 ± 9.6 years, and 40.2% were men. The prevalence of vitamin D deficiency (<20 ng/mL) was 36%, while 68% of participants had suboptimal vitamin D levels (deficiency or insufficiency). Individuals with vitamin D deficiency showed significantly higher body fat percentage and lower skeletal muscle mass compared with the non-deficient group (p < 0.05). Serum 25(OH)D was moderately inversely correlated with body fat percentage (r = −0.41, p = 0.018) and positively correlated with skeletal muscle mass (r = 0.29, p = 0.012). Conclusion: Lower vitamin D status was associated with increased adiposity and reduced skeletal muscle mass in adults. These findings highlight the potential importance of maintaining adequate vitamin D levels as part of strategies supporting healthier body composition. Longitudinal and interventional studies are needed to clarify causality and clinical implications.
Oxidative stress as a converging mechanism of aging and neurodegeneration: From molecular pathways to therapeutic targets Faradilla, Meutia A.; Anastasya, Karina S.; Yastani, Deasyka; Yohana, Yohana; Tungka, Endrico X.; Suweino, Suweino
Narra J Vol. 6 No. 1 (2026): April 2026
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v6i1.3042

Abstract

Aging is the primary risk factor for major neurodegenerative disorders, yet the precise molecular links between biological aging and progressive neuronal loss remain complex. Oxidative stress, defined as an imbalance between the production of reactive oxygen species (ROS) and antioxidant defenses, has emerged as a central converging mechanism driving both processes. This review aims to synthesize current evidence demonstrating how chronic redox imbalance drives cellular senescence and neuronal vulnerability through mitochondrial dysfunction, lipid peroxidation, and oxidative protein damage. These insights underscore how sustained oxidative insults promote the misfolding and aggregation of disease-defining proteins, including amyloid-beta in Alzheimer’s disease and α-synuclein in Parkinson’s disease, thereby amplifying neuroinflammation, synaptic dysfunction, and bioenergetic failure. Furthermore, antioxidant-based therapeutic strategies are critically reassessed, highlighting a paradigm shift from non-specific radical scavenging toward targeted modulation of endogenous defense systems, particularly NRF2 signaling and mitochondria-directed antioxidants. By integrating molecular mechanisms with translational perspectives, this review integrates molecular, cellular, and translational evidence to explain how oxidative stress links biological aging to neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases.
Co-Authors Anastasya, Karina S. Anastasya, Karina Shasri Cicih Mayasari, Atut Faradilla, Meutia A. Faradilla, Meutia Atika Ferina, Mutiara H, Novi Silvia Jimmy Panji Wirawan Jusman, Sri Widia Azraki Laksmi Maharani Mahardieni, Karlina Marliany Surjadi, Lily Rahmansyah, Mulia Salma, Nabila Maudy Sri Widia A Jusman Suweino Suweino, Suweino Tungka, Endrico X. Xavierees, Endrico Yohana Yohana Yohana