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FORMULASI PASTA GIGI EKSTRAK ETANOL DAUN MENGKUDU (Morinda citrifolia L.) DAN UJI STABILITAS DENGAN METODE Freeze and Thaw Yahdian Rasyadi; Diza Sartika; Athiyah Erza Sasmi; Selvi Merwanta; Dini Hanifa
Jurnal Akademi Farmasi Prayoga Vol 6 No 1 (2021): Jurnal Akademi Farmasi Prayoga
Publisher : Akademi Farmasi Prayoga Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (603.782 KB)

Daun Mengkudu (Morinda citrifolia L.) merupakan salah satu tumbuhan obat tradisional secara ilmiah dipercaya memiliki aktivitas antibakteri. Tujuan dari penelitian ini adalah untuk memformulasi pasta gigi dari ekstrak etanol daun mengkudu dengan variasi konsentrasi 4% (F1), 8% (F2) dan 12% (F3) serta menguji stabilitas fisiknya. Evaluasi dari sediaan pasta gigi yang dibuat meliputi uji organoleptis, uji homogenitas, uji pH, uji daya busa, uji viskositas, dan uji stabilitas. Hasil uji organoleptis dan homogenitas menunjukkan ketiga formula (F1, F2, F3) berbentuk pasta, warna coklat muda, bau mint khas mengkudu dan homogen untuk semua formula. Hasil pengujian pH sediaan pasta gigi F1(7,6), F2(7,3), F3(7,2); tinggi busa F1(1,7 cm), F2(1,5 cm), F3(1,4 cm); viskositas F1(2436 cP), F2(2446 cP), F3(2146 cP). Hasil uji stabilitas menunjukkan untuk F1, F2, F3 tidak memisah dan stabil selama penyimpanan 6 minggu. Dapat disimpulkan bahwa ekstrak etanol daun mengkudu 4% (F1), ekstrak etanol daun mengkudu 8% (F2), ekstrak etanol 12% (F3) dapat diformulasikan dalam bentuk sediaan pasta gigi gel dan stabil selama masa penyimpanan.

FORMULASI DAN EVALUASI MASKER PEEL-OFF DARI MINYAK BUAH ALPUKAT (PERSEA AMERICANA) Dini Hanifa; Wida Ningsih; Amri Bakhtiar
JURNAL KATALISATOR Vol. 8 No. 1 (2023): Jurnal Katalisator Volume 8 No. 1, April 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Penggunaan masker peel-off untuk mengatasi berbagai masalah pada kulit wajah saat ini sedang banyak diminati. Penggunaan ekstrak tumbuhan sebagai bahan aktif dalam pembuatan masker peel-off telah banyak dilaporkan. Namun, belum banyak penelitian tentang penggunaan minyak tumbuhan pada masker peel-off. Tujuan dari penelitian ini adalah memformulasi masker peel-off dari minyak alpukat sehingga dapat digunakan sebagai antioksidan dan pelembab alami pada sediaan kosmetika. Minyak alpukat merupakan sumber alami yang kaya akan asam lemak tak jenuh seperti asam oleat, linoleat, dan palmitat yang merupakan bahan yang sangat baik untuk melembabkan kulit dan meningkatkan permeabilitas kulit. Metode dalam penelitian ini meliputi ekstraksi minyak alpukat, formulasi dan evaluasi masker peel-off dari minyak alpukat. Ekstraksi minyak alpukat dilakukan dengan cara memanaskan daging buah alpukat. Sediaan masker peel-off yang mengandung minyak alpukat dibuat dengan konsentrasi 0% sebagai blanko, 5%, 7,5%, 10%, dan 12,5%. Evaluasi masker peel-off dari minyak alpukat meliputi uji organoleptik, uji homogenitas, pengukuran pH, daya sebar, waktu pengeringan, dan elastisitas. Berdasarkan hasil penelitian ini dapat disimpulkan bahwa semua formula masker gel peel-off minyak buah alpukat (Persea americana) telah memenuhi persyaratan parameter homogenitas dan pH. Masker gel peel-off F3 merupakan formula yang terbaik dengan daya sebar yang memenuhi persyaratan antara 5,03-5,60 cm, waktu mengering paling cepat yaitu 15,1 menit, dan elastisitas dengan persen daya regang tertinggi yaitu 133%.

PENENTUAN KANDUNGAN ANTIOKSIDAN DAN FENOLIK TOTAL DARI EKSTRAK TUMBUHAN SEBAGAI BIOREDUKTOR DALAM PEMBENTUKAN NANOPARTIKEL PERAK Dini Hanifa; Refilda Refilda; Akmal Djamaan
Jurnal Penelitian Farmasi & Herbal Vol 5 No 2 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v5i2.1226

The formation of metal nanoparticles (silver, gold, platinum) by biological methods (green synthesis) has advantages over chemical and physical methods because it is easier, faster, simpler, and environmentally friendly. One of the substances used in this method is plant extracts. The presence of secondary metabolites that act as antioxidants such as phenolics and flavonoids play roles in the formation of silver nanoparticles. In this study, phytochemical screening was carried out from several herbal plants as bioreductors in the formation of silver nanoparticles, such as Phyllanthus buxifolius, Pachira aquatica, Peperomia pellucida, Ageratum conyzoides, and Piper crocatum leaf extracts. The total antioxidant content was determined using the modified phenanthroline method, and the total phenolic content determined using the Folin-Ciocalteu method. The formation of silver nanoparticles was carried out by mixing silver nitrate solution with each plant extract. Colloidal silver nanoparticles formed were then measured for their absorption spectra. The results of the antioxidant content of the five consecutive samples were 26,90 ± 0,19; 26,09 ± 0,14; 18,25 ± 0,02; 42,76 ± 0,14; dan 30,94 ± 0,14 mg AA/g, while the total phenolic contents were 48,44 ± 0,45; 21,08 ± 0,92; 17,42 ± 0,27; 57,71 ± 0,47; dan 49,83 ± 0,60 mg GA/g. Silver nanoparticles mediated by Ageratum conyzoides leaf extracts provided the highest absorbance value compared to other plants. The antioxidants and phenolic contained in the extract acts as reducing agent from silver ions into silver nanoparticles.

Edukasi Titik Kritis Kehalalan Produk Pangan, Kosmetik, dan Obat-Obatan Menggunakan Flowchart pada Siswa Sekolah Menengah Analis Kimia (SMAKPA) Padang Dini Hanifa; Rustini Rustini; Purnawan Pontana Putra
Warta Pengabdian Andalas Vol 30 No 4 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.4.798-806.2023

Halal products are crucial for consumers. In Islam, halal and wholesome food consumption is vital for maintaining physical and spiritual well-being. The Indonesian government mandates halal product certification by Law No. 33 of 2014 on Halal Product Assurance. The critical points in determining the halal status of a product refer to processes or ingredients in its production that may potentially involve, contain, or mix with haram substances. Nevertheless, many students lack a clear understanding of halal and haram principles. This knowledge is essential to help students avoid using forbidden ingredients in Islamic teachings. Padang Chemical Analyst High School (SMAKPA) students are the targets of this service because vocational school students must have work-ready skills. Before the education session, a pre-test was conducted to assess the student's understanding of the material presentation. Education was delivered using a flowchart to enhance engagement and comprehension. The content encompasses the concepts of halal and haram in Islam, the responsible parties for halal certification, halal logos, and the analysis of critical points in the halal status of food, cosmetics, and medications. Following the material presentation, a post-test was administered, followed by a question and answer session to evaluate the students' understanding. Pre-tests and post-tests were employed to assess student comprehension, with pre-test scores averaging 99 and post-test scores at 99.5. Through this educational initiative, students gain a comprehensive understanding of the Critical Points of Halal Status in Food, Cosmetics, and Medications using a flowchart

PENENTUAN ASAM GALAT DAN KUERSETIN DALAM BEBERAPA TANAMAN OBAT MENGGUNAKAN METODE KCKT Refilda; Nindi Rahmi Amelia; Dini Hanifa; Yefrida
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2231

Senyawa flavonoid yang memiliki sifat antioksidan dan dapat menghambat radikal bebas diantaranya adalah asam galat dan kuersetin. Kandungan asam galat dan kuersetin dalam tanaman herbal yang sering dikonsumsi masyarakat belum banyak dilaporkan. Pada penelitian ini dilakukan penentuan asam galat dan kuersetin yang terdapat dalam ekstrak air daun belimbing wuluh (Averrhoa bilimbi L.), daun jambu bol (Syzygium malaccense), daun jeruk purut (Citrus hystrix), daun pepaya (Carica papaya L.), daun alpukat (Persea americana Miller.), daun salam (Syzygium polyanthum), daun sirih merah (Piper crocatum), daun sirsak (Annona muricata) menggunakan metode Kromatografi Cair Kinerja Tinggi (KCKT). Ekstraksi sampel dalam pelarut air dengan bantuan gelombang ultrasonik. Kondisi pemisahan asam galat dan kuersetin dilakukan dengan fasa gerak campuran asetonitril:asam fosfat 0,02% (10:90), fasa diam berupa kolom C18, kecepatan alir 0,7 mL/menit, detektor DAD, dan panjang gelombang 260 nm. Asam galat dan kuersetin terpisah pada waktu retensi 2,114 dan 2,883 menit. Berdasarkan kondisi ini diperoleh kandungan asam galat tertinggi 0,0402 mg/gFW pada ekstrak daun jambu bol, dan terendah 0,0027mg/gFW pada ekstrak daun sirih merah. Kuersetin hanya terdapat pada ekstrak air daun belimbing wuluh sebesar 0,185 mg/gFW. Informasi ini dapat menjadi landasan untuk pengembangan produk-produk herbal atau suplemen kesehatan yang mengandung senyawa-senyawa ini

Edukasi Titik Kritis Kehalalan Produk Pangan, Kosmetik, dan Obat-Obatan Menggunakan Flowchart pada Siswa Sekolah Menengah Analis Kimia (SMAKPA) Padang Dini Hanifa; Rustini Rustini; Purnawan Pontana Putra
Warta Pengabdian Andalas Vol 30 No 4 (2023)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.30.4.798-806.2023

Halal products are crucial for consumers. In Islam, halal and wholesome food consumption is vital for maintaining physical and spiritual well-being. The Indonesian government mandates halal product certification by Law No. 33 of 2014 on Halal Product Assurance. The critical points in determining the halal status of a product refer to processes or ingredients in its production that may potentially involve, contain, or mix with haram substances. Nevertheless, many students lack a clear understanding of halal and haram principles. This knowledge is essential to help students avoid using forbidden ingredients in Islamic teachings. Padang Chemical Analyst High School (SMAKPA) students are the targets of this service because vocational school students must have work-ready skills. Before the education session, a pre-test was conducted to assess the student's understanding of the material presentation. Education was delivered using a flowchart to enhance engagement and comprehension. The content encompasses the concepts of halal and haram in Islam, the responsible parties for halal certification, halal logos, and the analysis of critical points in the halal status of food, cosmetics, and medications. Following the material presentation, a post-test was administered, followed by a question and answer session to evaluate the students' understanding. Pre-tests and post-tests were employed to assess student comprehension, with pre-test scores averaging 99 and post-test scores at 99.5. Through this educational initiative, students gain a comprehensive understanding of the Critical Points of Halal Status in Food, Cosmetics, and Medications using a flowchart

Amine-Functionalized Mesoporous Silica SBA-15 for Enhanced Solubility and Release Rate of Gliclazide Sayyidina, Fasqina; Gumala, Azhoma; Zaini, Erizal; Hanifa, Dini; Hasanah, Uswatul
Science and Technology Indonesia Vol. 10 No. 3 (2025): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.3.963-971

Gliclazide (GLI), a sulfonylurea-class antidiabetic drug, exhibits poor aqueous solubility, limiting its bioavailability. This study aimed to enhance gliclazide’s solubility and dissolution rate by adsorbing it into mesoporous silica SBA-15 and amine-functionalized SBA-15 (SBA-15-A). SBA-15 was synthesized using Pluronic® P123 as a template and tetraethyl orthosilicate (TEOS) as the silica precursor, while 3-aminopropyltriethoxysilane (APTES) was used to introduce amine functional groups. Gliclazide was loaded into SBA-15 and SBA-15-A at a 1:3 mass ratio. The materials (GLI, SBA-15, SBA-15-A, GLI-SBA, and GLI-SBA-A) were characterized using nitrogen adsorption-desorption isotherms, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), and powder X-ray diffraction (PXRD). Characterization revealed that the pore diameters of SBA-15 and SBA-15-A were 6.079 nm and 5.483 nm, respectively. FT-IR confirmed the interaction between gliclazide and the mesoporous carriers. SEM and TEM analysis showed crystalline gliclazide and rod-shaped morphologies for the mesopores samples. DSC and PXRD results indicated that most of the gliclazide had been converted to an amorphous form. Solubility testing over 24 hours showed that GLI-SBA and GLI-SBA-A improved gliclazide solubility by 1.375- and 2.334-fold, respectively, compared to pure gliclazide. Dissolution testing in distilled water revealed a 6.033-fold and 3.887-fold increase in the release rate at 5 minutes for GLI-SBA and GLI-SBA-A, respectively. Both solubility and release rate improvements were statistically significant (p <0.05). These findings suggest that amine functionalization of SBA-15 effectively enhances the solubility and dissolution rate of gliclazide.

Pemeriksaan Kesehatan dan Edukasi Penggunaan Obat untuk Meningkatkan Kesadaran Kesehatan Masyarakat di Padang Panjang Dita Permatasari; Dini Hanifa; Dian Ayu Juwita; Syofyan; Sundari Anisa Angelica; Rasika Indri Pratiwi; Wiwing Nadia Putri
BULETIN ILMIAH NAGARI MEMBANGUN Vol. 8 No. 4 (2025)
Publisher : LPPM (Institute for Research and Community Services) Universitas Andalas Padang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/bina.v8i4.834

Low public awareness of routine health monitoring and knowledge of proper medication use remains a significant problem, leading to increased adverse drug reactions and a decline in health status. Furthermore, a lack of health literacy and high self-medication practices also increase the risk of inappropriate medication use. To address this need, this activity combines health screening and medication education as an integrative approach to improving public health awareness and drug literacy. This study used a quasi-experimental one-group pre-posttest design and was conducted on 24 October 2025, at SDN 07 Ganting, East Padang Panjang, involving 34 participants. Activities included blood pressure, glucose, cholesterol, and uric acid screenings; medical consultations; and medication education and counseling. The majority of participants were women (80%), with a dominant age range of 41–59 years (50%). Mean blood pressure was 129.1 ± 25.0/86.26 ± 13.60 mmHg, glucose 132.41 ± 74.5 mg/dL, cholesterol 214.7 ± 33.8 mg/dL, and uric acid 5.6 ± 1.8 mg/dL, indicating the presence of risk factors requiring monitoring. Knowledge levels were in the good category at both pre-test (90%) and post-test (93.3%), with no significant difference (p = 0.541). This activity contributed to strengthening drug literacy through direct education linked to screening findings, enabling participants to understand their personal health risks. This integrated screening-education approach shows potential as a more effective community intervention model in increasing public knowledge and awareness of health and the safe use of drugs.

Formation of Silver Nanoparticles Using Phyllantus buxifolius Leaf Extract and Its Antioxidant Activity Dini Hanifa; Purnawan Pontana Putra; Akmal Djamaan; Marta Aulia Zahra; Maharani Auliasanrah Siregar
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 8 No. 1 (2026)
Publisher : Pharmacy Department, Faculty of Health Sciences, UIN Syarif Hidayatullah Jakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v8i1.50647

Green synthesis is an approach for producing silver nanoparticles (AgNPs) that more popular because the use of bioreductor, making it safer and more eco-friendly. The use of Phyllanthus buxifolius as a source of reducing and stabilizing agents in the formation of AgNPs and its contribution to antioxidant activity is still limited. Therefore, this study aims to synthesize AgNPs using P. buxifolius leaf extract and evaluate its antioxidant activity. The leaves of P. buxifolius were extracted using ethanol in a 1:10 ratio through maceration, then followed by solvent evaporation using a rotary evaporator. AgNO3 was mixed with a 10% P. buxifolius leaf extract solution. The UV-Vis spectrum was analyzed at wavelengths ranging from 400 to 800 nm. Particle size, morphology, functional groups, and crystal structure of AgNPs were characterized. Antioxidant activity was assessed using the DPPH method to determine the IC50, with ascorbic acid as the reference standard. To confirmed the formation of silver nanoparticles, a color change from colorless to brown were observed. These nanoparticles exhibited a Surface Plasmon Resonance (SPR) peak at 420 nm, were non-spherical with the particle size around 50 nm, and showed a crystalline structure. Additionally, the silver nanoparticles synthesized with P. buxifolius extract demonstrated comparable antioxidant activity to standard ascorbic acid, indicating their potential to be developed as antioxidant agents for health and therapeutic uses.

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