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All Journal Biology, Medicine, & Natural Product Chemistry CHEMPUBLISH JOURNAL Jurnal Pertanian Terpadu Jurnal Teknika Jurnal Surya Medika PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Abdi Insani COMMUNITY : Jurnal Pengabdian Kepada Masyarakat Jurnal Seni dan Pembelajaran Prabayaksa: Journal of History Education Global Journal Basic Education Jurnal Wicara Desa
Mirnawati Dewi, Mirnawati
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PEMBERDAYAAN MASYARAKAT MELALUI PROGRAM PERPUSNAS DALAM RANGKA PENGEMBANGAN LITERASI DI KELURAHAN RAKAM, KECAMATAN SELONG, KABUPATEN LOMBOK TIMUR Ramadhani, Muhamad; Haq, Muhammad; Gani, Raden; Sujakti, I; Hulfiani, Siti; Safitri, Dita; Saputra, Adriyan; Maharani, Dewi; Dewi, Mirnawati; Zalty, Rani; Ramadhani, Muhammad
Jurnal Wicara Vol 3 No 6 (2025): Jurnal Wicara Desa
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/5at88w77

Abstract

This study discusses the implementation of the literacy program initiated by the National Library of Indonesia (Perpusnas) through the Community Service Program (KKN) in Rakam Village, Selong District, East Lombok Regency, as an effort to improve reading culture among elementary school children. Rakam Village has a population of 8,688 people and 2,592 households, with the majority working as traders, laborers, farmers, fishermen, and entrepreneurs, and with an average education level ranging from elementary to senior high school. These socio-economic conditions contribute to the community’s low literacy awareness, even though the village has several educational institutions ranging from early childhood education (PAUD) to senior high schools (SMA/SMK) that can serve as strategic partners. Using a descriptive qualitative method, data were collected through observation, interviews, documentation, and direct participation with Community Reading Garden (TBM) managers, teachers, the village government, parents, and students. The findings show that literacy programs such as read-aloud activities, creative writing training, cataloging and organizing TBM collections, book-based creative projects, and book review competitions successfully improved reading interest, writing creativity, and the utilization of TBM facilities. Supporting factors included the involvement of the local government, teachers, and parents, as well as the provision of diverse and engaging literacy activities. However, program sustainability still requires long-term commitment from TBM, schools, and the village government to ensure continuous literacy development. These findings emphasize that multi-stakeholder collaboration and participatory literacy strategies can be effective solutions to address low literacy rates at the village level.
Integrative Network Pharmacology and Molecular Docking Analysis of Tinospora crispa L. for Breast Cancer Therapy Dewi, Mirnawati; Ariefin, Mokhamat; Yolan Kalalinggi, Septaria; Andini, Novelia; Jipasca, Elon
Chempublish Journal Vol. 10 No. 1 (2026): Chempublish Journal (January - June)
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

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Abstract

Breast cancer remains one of the leading mortality causes of disease related to cancer. Therefore, it is necessary to explore novel alternative therapeutic, particularly through the utilization of plant-derived natural product. Tinospora crispa L. contains diverse bioactive compounds with reported antioxidant and anticancer activities. This study integrates network pharmacology and molecular docking approaches to elucidate the molecular mechanisms of T. crispa against breast cancer. A total of 72 overlapping targets were identified between T. crispa compounds and breast cancer-related proteins, forming a highly interconnected PPI network consisting of 72 nodes and 340 edges. Clustering and enrichment analyses revealed that second cluster was significantly associated with cancer-related pathways, including AKT1, MAPK, and EGFR. The compound–protein–pathway network demonstrated two compound from T. crispa, apigenin and cycloeucalenone, possessed the highest degrees, suggesting their central regulatory roles. Molecular docking further confirmed these findings, showing that cycloeucalenone exhibited the strongest binding affinity toward EGFR and AKT1 through extensive hydrophobic interactions, whereas apigenin bound more stably to MAPK3 via multiple hydrogen bonds and hydrophobic interactions. These findings indicate that T. crispa compounds may exert anticancer effects by modulating multiple oncogenic pathways, supporting their potential development as multi-target agents in breast cancer therapy.
Co-Authors Adriyan Saputra Ali Alhamidi, Ali Andini, Novelia Fandi Tuju Fandi Tuju Gani, Raden Hamzah, Pratiwi Haq, Muhammad Hery Porda Nugroho Putro Hulfiani, Siti Jipasca, Elon Kalalinggi, Septaria Yolan Kristin, Jane La Sarido, La Lasari, Reysha Mei Lestari, Goesthy Ayu Mariana Devi Lestari, Kiki Ayu M. Fitrullah, M. Maharani, Dewi Maulida, Maulida Maulidya, Yova Mokhamat Ariefin Mustika, Maya Pangestu, Reyyo Pasaribu, Tupaida Purba, Ella Afrida Rahayu, Emy Rahmanina, Lilih Ramadhani, Muhamad Ramadhani, Muhammad Rika Kurnia Rudi Rudi Safitri, Dita Sari, Fatma Puspita Sujakti, I Susi Wendhaningsih Wibowo, Wahyu Hadi Yolan Kalalinggi, Septaria Zalty, Rani