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EFEK PEMBERIAN SENYAWA KOLKISIN TERHADAP PERTUMBUHAN TANAMAN TOMAT (Lycopersicum esculentum) Azmi Darotulmutmainnah
HERBAPHARMA : Journal of Herb Farmacological Vol 2 No 2 (2020): Volume 2 Nomor 2 Desember 2020
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v2i2.154

Keragaman genetik melalui induksi mutasi dapat dimanfaatkan sebagai salah satu metode dalam program pemuliaan tanaman untuk meningkatkan variasi genetik. Mutasi pada tanaman dapat dilakukan dengan senyawa anti mitosis seperti kolkisin. Tujuan penelitian ini adalah untuk mengetahui respon fenotipe tiga varietas tomat akibatpemberian kolkisin dan mengetahui konsentrasi kolkisin yang mampu meningkatkan pertumbuhan ketiga varietas tersebut. Rancangan percobaan menggunakan Rancangan Acak Lengkap (RAL) Faktorial dengan duafaktor. Faktor pertama berupa varietas tomat yang terdiri atas 3 jenis, yaitu varietas Rewako (V1), varietas Tymoti(V2), dan varietas Tropical ruby (V3). Faktor kedua berupa konsentrasi kolkisin dengan 4 taraf, yaitu 0% (K0), 0,2% (K1). 0,3% (K2), dan 0,4% (K3). Parameter penelitian yang diamati adalah presentase perkecambahan, tinggi tanaman, jumlah daun dan diameter batang. Hasil penelitian menunjukkan bahwa konsentrasi kolkisin tidak berpengaruh nyata terhadap presentase perkecambahan, tinggi tanaman dan jumlah daun. Diameter batang pada 0,3% dan 0,2% kolkisin lebih besar dibandingkan pada perlakuan 0% dan 0,4%.

Pendampingan Penanaman dan Pemanfaatan Tanaman Obat Keluarga (TOGA) Dalam Program Peningkatan Peranan Wanita menuju Keluarga Sehat Sejahtera (P2WKSS) di Desa Sakerta Timur Kabupaten Kuningan Marini Marini; Imas Maesaroh; azmi Darotulmutmainnah; Nova Oktavia
JURNAL BESEMAH : Jurnal Pengabdian dan Pemberdayaan Masyarakat Vol. 2 No. 1 (2023): JANUARI-JUNI
Publisher : Gayaku Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/jurnalbesemah.v2i1.113

In order to improve the degree of public health, one thing that can be done is planting and utilizing TOGA (family medicinal plants). TOGA development can also be used as a flagship program for residents in East Sakerta Village (Saktim) Darma District, Kuningan Regency, in addition to improving health as well as being a superior product to increase the economic value of the community through post-harvest processing. This community service aims to increase the knowledge and abilities of community members, especially members of the tourism awareness group (Pokdarwis) in Saktim Village in the utilization and processing of medicinal plants into more economical drug dosage forms. Community service activities in the Increasing the Role of Women towards a Healthy and Prosperous Family (P2WKSS) program are carried out by providing counseling about the properties of medicinal plants, and training in making TOGA gardens and the process of making traditional medicines.

PHYSICAL EVALUATION OF CURCUMA RHIZOME EXTRACT (Curcuma xanthorrhiza) FORMULATION IN ANTI ACNE LOOSE POWDER Marini Marini; Haty Latifah Priatni; Azmi Darotulmutmainnah; Dea Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.811

When Staphylococcus aureus and Staphylococcus epidermis are isolated from acne-proneskin, the essential oil and curcuminoids in curcumin (Curcuma zanthorrhiza Roxb) exhibitantibacterial activity against blemished skin. The purpose of this study was to create an antiacne loose powder using Curcuma rhizome extract and to determine which formulationsmeet the best test requirements. Extraction was carried out using the maceration methodwith 96% ethanol solvent. The powder formulation consisted of alba bolus, magnesiumcarbonate, magnesium stearate, zinc oxide, oleum rosae, and talc, developed withtemulawak rhizome extract at concentrations of F0 (0%), F1 (8%), F2 (10%), and F3 (12%).The evaluation of the powder preparation was organoleptic, humidity, powder flow rate,specific gravity, and pH.. The results indicated that the F1 formulation's humidity test resultsof less than 10%, the speed of the powder flow evaluation test results was 15.6%, the angleof repose test result was 26.6°, and the measurement of pH showed that the result of 6fulfilled the requirements. Based on a physical test of the anti-acne loose powder, theCurcuma rhizome extract in the FI formulation with an 8% concentration produced optimalresults. Keywords: anti acne, physical evaluation, loose powder, curcuma

Uji Toksisitas Akut Ekstrak Etanol Anggur Merah (Vitis vinifera Linn) Menggunakan Metode Thomson Dan Weil Pada Tikus Putih Wistar (Rattus norvegicus) Gelda Myrna Parwanty; Nur Azizah; Azmi Darotulmutmainah
CERATA Jurnal Ilmu Farmasi Vol 14 No 1 (2023)
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Buah anggur (Vitis vinifera Linn) mengandung polifenol dan antosianin yang cukup tinggi. Salah satu manfaat dari buah anggur yaitu sebagai antikolesterol dengan memodulasi metabolisme lipid dan menghambat oksidasi LDL (Low Density Lipoprotein). Penelitian ini bertujuan untuk menetapkan nilai LD50 dari Ekstrak Etanol Anggur Merah (EEAM). Metode uji toksisitas akut pada penelitian ini menggunakan metode konvensional. Sebanyak 25 ekor tikus Wistar dibagi secara acak menjadi 5 kelompok, dengan jumlah masing-masing kelompok 5 ekor. Kelompok I diberikan aquades, kelompok II diberi EEAM dosis 500 mg/200gBB/hari, kelompok III diberi EEAM dosis 1000 mg/200gBB/hari, kelompok IV diberi EEAM dosis 1500 mg/200gBB/hari, kelompok V diberi EEAM dosis 2000 mg/200gBB/hari. Gejala toksik dan perubahan berat badan diamati selama 14 hari. Nilai LD50 dihitung menggunakan metode Thomson dan Weil. Hasil penelitian menunjukkan bahwa tikus yang diberi EEAM dosis 500 mg/kgBB menunjukkan gejala toksik yaitu ruam kulit pada hidung selama 3 hari, sedangkan pada dosis 1500 dan 2000 mg/kgBB tikus menunjukkan gejala toksik seperti kelemahan, tidur berlebihan, koma, perubahan berat badan dan kematian. Dosis 2000 mg/kgBB menyebabkan kematian pada semua tikus dalam kelompok tersebut (100%). Nilai LD50 yang diperoleh adalah 9,32 mg/kgBB, ekstrak anggur merah memiliki efek toksik pada tikus Wistar.

Uji Toksisitas Akut Ekstrak Etanol Anggur Merah (Vitis vinifera Linn) Menggunakan Metode Thomson Dan Weil Pada Tikus Putih Wistar (Rattus norvegicus) Gelda Myrna Parwanty; Nur Azizah; Azmi Darotulmutmainah
CERATA Jurnal Ilmu Farmasi Vol 14 No 1 (2023): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v14i1.759

Buah anggur (Vitis vinifera Linn) mengandung polifenol dan antosianin yang cukup tinggi. Salah satu manfaat dari buah anggur yaitu sebagai antikolesterol dengan memodulasi metabolisme lipid dan menghambat oksidasi LDL (Low Density Lipoprotein). Penelitian ini bertujuan untuk menetapkan nilai LD50 dari Ekstrak Etanol Anggur Merah (EEAM). Metode uji toksisitas akut pada penelitian ini menggunakan metode konvensional. Sebanyak 25 ekor tikus Wistar dibagi secara acak menjadi 5 kelompok, dengan jumlah masing-masing kelompok 5 ekor. Kelompok I diberikan aquades, kelompok II diberi EEAM dosis 500 mg/200gBB/hari, kelompok III diberi EEAM dosis 1000 mg/200gBB/hari, kelompok IV diberi EEAM dosis 1500 mg/200gBB/hari, kelompok V diberi EEAM dosis 2000 mg/200gBB/hari. Gejala toksik dan perubahan berat badan diamati selama 14 hari. Nilai LD50 dihitung menggunakan metode Thomson dan Weil. Hasil penelitian menunjukkan bahwa tikus yang diberi EEAM dosis 500 mg/kgBB menunjukkan gejala toksik yaitu ruam kulit pada hidung selama 3 hari, sedangkan pada dosis 1500 dan 2000 mg/kgBB tikus menunjukkan gejala toksik seperti kelemahan, tidur berlebihan, koma, perubahan berat badan dan kematian. Dosis 2000 mg/kgBB menyebabkan kematian pada semua tikus dalam kelompok tersebut (100%). Nilai LD50 yang diperoleh adalah 9,32 mg/kgBB, ekstrak anggur merah memiliki efek toksik pada tikus Wistar.

PHYSICAL EVALUATION OF CURCUMA RHIZOME EXTRACT (Curcuma xanthorrhiza) FORMULATION IN ANTI ACNE LOOSE POWDER Marini Marini; Haty Latifah Priatni; Azmi Darotulmutmainnah; Dea Safitri
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.811

When Staphylococcus aureus and Staphylococcus epidermis are isolated from acne-proneskin, the essential oil and curcuminoids in curcumin (Curcuma zanthorrhiza Roxb) exhibitantibacterial activity against blemished skin. The purpose of this study was to create an antiacne loose powder using Curcuma rhizome extract and to determine which formulationsmeet the best test requirements. Extraction was carried out using the maceration methodwith 96% ethanol solvent. The powder formulation consisted of alba bolus, magnesiumcarbonate, magnesium stearate, zinc oxide, oleum rosae, and talc, developed withtemulawak rhizome extract at concentrations of F0 (0%), F1 (8%), F2 (10%), and F3 (12%).The evaluation of the powder preparation was organoleptic, humidity, powder flow rate,specific gravity, and pH.. The results indicated that the F1 formulation's humidity test resultsof less than 10%, the speed of the powder flow evaluation test results was 15.6%, the angleof repose test result was 26.6°, and the measurement of pH showed that the result of 6fulfilled the requirements. Based on a physical test of the anti-acne loose powder, theCurcuma rhizome extract in the FI formulation with an 8% concentration produced optimalresults. Keywords: anti acne, physical evaluation, loose powder, curcuma

Formulasi Sediaan Scented Candle Kombinasi Minyak Daun Mint (Mentha piperita L.) dan Minyak Cacao (Theobroma cacao L.) Sebagai Aromatherapy Untuk Relaksasi Marini, Marini; Darotulmutmainnah, Azmi; Roselita Dewi, Lita
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 1 (2024): Volume 6 Nomor 1 Juni 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i1.529

Scented Candle (lilin aromaterapi) dapat dimanfaatkan sebagai relaksasi. Lilin aromaterapi merupakan produk alternatif yang kekuatannya dapat dirasakan melalui indera penciuman (dengan pernafasan). Bahan alam yang dapat dimanfaatkan sebagai aromaterapi yaitu minyak daun mint (Mentha piperita L.) dan minyak kakao (Teobroma cacao L.). Kandungan minyak atsiri dan menthol pada minyak daun mint dapat berinteraksi dengan system syaraf pusat dan kandungan minyak kakao berupa teobromine menstimulasi kerja otak dan merileksasikan suasana. Penelitian ini bertujuan untuk mengetahui apakah kombinasi minyak daun mint dan minyak kakao dapat diformulasikan menjadi lilin aromaterapi untuk relaksasi. Metode penelitian yang digunakan jenis penelitian eksperimental dengan membuat formulasi sediaan lilin aromaterapi dengan konsentrasi perbandingan minyak daun mint dan minyak cacao yaitu, F0 (0%:0%) F1 (2%:4%), F2 (3%:3%), F3 (4%:2%) selanjutnya dilakukan evaluasi sifat fisik sediaan lilin aromaterapi meliputi uji organoleptik, uji waktu bakar, uji titik leleh, uji kesukaan dan uji efektivitas terhadap 27 responden. Hasil uji waktu bakar paling lama 6 jam 41 menit, uji titik leleh kisaran 50Â°C- 55Â°C, uji hedonik scented candle yang paling disukai oleh responden dengan presentasi tertinggi yaitu 44,44% (sangat suka sekali) ditunjukan pada F2 dengan konsentrasi (3%:3%) dan untuk uji efek terapi dapat disimpulkan scented candle kombinasi minyak daun mint dan minyak cokelat memberikan rangsangan positif bagi responden sehingga dapat menstimulasi kerja otak dan merileksasikan suasana. Minyak daunt mint dan minyak cokelat dapat diformulasikan menjadi sediaan scanted candle sebagai aromaterapi untuk relaksasi dan sudah sesuai dengan SNI : 0386-1989-A/SII.

COMPARISON OF TOTAL FLAVONOID CONTENT AND ANTIOXIDANT ACTIVITY OF PURPLE LEAF EXTRACT (Graptophyllum pictum (L.) Griff.) USING MACERATION AND SOXHLETATION EXTRACTION METHODS Darotulmutmainnah, Azmi; Marini, Marini; Herliningsih, Herlingsih; Handayani, Hana
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 10 No 1 (2025)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v10i1.1608

Purple leaves in Indonesia can be used as an anti-inflammatory medication and laxative to treat hemorrhoids, rheumatism, boils, and skin diseases. Purple leaves are also used as free-radical antidotes. This was due to the presence of secondary metabolite compounds in purple leaves. The right extraction method determines the amount of flavonoids that can be extracted and achieves a high flavonoid content. This study aimed to determine the total flavonoid content and antioxidant activity of purple leaves using different extraction methods, namely maceration and Soxhletation. This study employed an experimental method of testing total flavonoid levels using UV-Vis spectrophotometry and antioxidant activity using the DPPH method. The results showed that the maceration method yielded a total flavonoid level of 4,422 ± 0,047 ppm, which was higher than that obtained using the Soxhletation method (1,547 ± 0,027 ppm). In the antioxidant activity test, vitamin C was used as a comparator, with an IC50 of 2.263 ppm (very strong). The IC50 of purple leaf extract using the maceration method was 123,32 ppm (medium), while the soxhletation method yielded an IC50 of 104,42 ppm (medium). This shows that vitamin C has more potent antioxidant activity in counteracting free radicals than purple leaf extract, using maceration and Soxhletation methods. The results showed a significant difference in total flavonoid levels using different extraction methods, while there was no significant difference in the antioxidant activity of purple leaf extract using maceration and Soxhletation methods. Keywords: antioxidant, extraction, flavonoid, maceration, purple leaf, soxhletation

Assistance in identifying and cultivating medicinal plant to prepare herbal tourism in Cisantana Village, Kuningan District Anwarudin, Wawang; Azizah, Nur; Darotulmutmainnah, Azmi; Wardaya, Ahmad Wildhan Wisnu; Puspita, Diah Ayu; Alfarra, Fathya Rayhan
Community Empowerment Vol 10 No 1 (2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/ce.10606

Cisantana Village is endowed with abundant natural resources due to its geographical location on the slopes of Mount Ciremai, making it a potential tourist village. However, this potential has not been optimally utilized due to the lack of proper management of the village's land resources. Therefore, providing assistance in identifying and cultivating medicinal plants has emerged as a viable solution to prepare Cisantana as a Herbal Tourism destination. This community service activity aimed to disseminate information about medicinal plants identified through exploration and expeditions in Cisantana Village, and to enhance participants' skills in cultivating these valuable plants. The participants in this activity were members of the Dahlia Integrated Health Post Working Group and the Cisantana Village Government. The results of the activity revealed that there are 26 types of herbal plants in Cisantana Village. Furthermore, there was an increase in public understanding of the benefits of medicinal plants, from 65% to 80%, and an increase in understanding of how to cultivate medicinal plants, from 70% to 85%.

Increasing the Role of Posyandu cadres by Processing Temulawak Milk Candy (Sutela) in an Attempt to Raise Children's Appetite in Support of Improved Nutrition for Children in Sukamulya Village Marini, Marini; Nourma Nurjanah; Azmi Darotulmutmainnah; Sukmawati Sukmawati; Ani Siti Wiryani; Herliningsih Herliningsih; Nova Oktavia; Nur Azizah
ABDIMAS: Jurnal Pengabdian Masyarakat Vol. 8 No. 1 (2025): ABDIMAS UMTAS: Jurnal Pengabdian Kepada Masyarakat
Publisher : LPPM Universitas Muhammadiyah Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35568/abdimas.v8i1.5523

The role of cadres is very much needed in posyandu services, apart from being tasked with providing education to parents regarding the importance of providing adequate and balanced nutritional intake but also helping to monitor the nutritional. One plant that can help kids eat more is Temulawak; its curcuminoid content and essential oils can support the function of the pancreas and bile to improve food absorption in the intestines; additionally, the nutrients in pure milk are critical for the development of healthy bones and teeth, so feeding kids this combination can help them eat better. This community service aims to increase the role of posyandu cadres through training activities on processing medicinal plants into temulawak milk candy (Sutela) in an effort to increase children's appetite. The method used is in the form of counseling and training for posyandu cadres on how to process ginger and pure milk plants into silk candy in Sukamulya Village. As a tool to ensure the achievement of this service activity, an assessment is carried out using a questionnaire before the counseling begins to measure participants' initial knowledge and after the counseling to evaluate the extent to which participants' understanding and knowledge have increased after participating. The result of this community service is that posyandu cadre participants enthusiastically took part in this activity, this can be seen from the number of participants who attended, namely 90% and increased knowledge of participants relating to counseling and training materials delivered before and after the activity, namely before the activity by 30,8% and after by 95,4%. In conclusion, there is an increase in the theoretical understanding and skills of posyandu cadres regarding the processing of temulawak milk candy which is beneficial for children's health in Sukamulya Village.

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