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All Journal MEDIA KONSERVASI JURNAL PENDIDIKAN TAMBUSAI Jurnal Ilmiah Profesi Pendidikan Jurnal Penyakit Dalam Indonesia Frontier Agribisnis (Frontbiz)
Mira Yulianti, Mira
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Agriculture, Biological Sciences & Forestry Earth & Planetary Sciences Economics, Econometrics & Finance Education Medicine & Pharmacology Social Sciences

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Hubungan Frailty dengan Kesintasan Satu Tahun pada Pasien Lanjut Usia dengan Tumor Padat Ganas Stadium Lanjut Satrio, Trian; Rizka, Aulia; Prasetyawaty, Findy; Widhani, Alvina; Dwimartutie, Noto; Anggoro, RM Suryo; Yulianti, Mira; Antono, Dono
Jurnal Penyakit Dalam Indonesia
Publisher : UI Scholars Hub

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Abstract

Introduction. Frailty is characterized by a multisystem physiological decline that increases the risk of morbidity and mortality, especially in patients with advanced-stage solid malignancies. The association between frailty and one-year survival in older adults with solid malignancies in Indonesia has not yet been established. This study aimed to assess the association between frailty status and one-year survival in elderly patients with advanced-stage solid tumors. Methods. This was a retrospective cohort study conducted at Dr. Cipto Mangunkusumo National General Hospital, Jakarta utilizing patient data from a previous study conducted between November 2020 and 2021. Subjects were cancer patients aged >60 years with advanced-stage solid tumors. Frailty was assessed using the FRAIL scale, and one-year survival was determined through medical records and direct follow-up confirmation. Data analysis included bivariate tests, Kaplan-Meier survival analysis, log-rank test, and multivariate Cox regression. Results. A total of 106 elderly patients with advanced solid tumors were analyzed, with a frailty prevalence of 41.5%. A total of 44.3% of patients died within one year. Multivariate analysis showed that frailty was a significant independent predictor of survival. Frail patients had a 2.131 times higher risk of death. Other factors such as nutritional status, polypharmacy, and comorbidities were not significant. Conclusion. Frailty was identified as a significant independent predictor of reduced one-year survival in elderly patients with advanced-stage cancer.
Co-Authors Adityo Susilo, Adityo Ahmad Yousuf Kurniawan Alvina Widhani, Alvina Anggoro, RM Suryo Annisa, Firda Aulia Rizka, Aulia Aulia, Devi Mailinda N Budi Wiati, Catur C. Martin Rumende, C. Martin Ceva W. Pitoyo Dono Antono Edwin Wijaya, Edwin Erni J Nelwan, Erni J Evy Yunihastuti Findy Prasetyawaty, Findy Gurmeet Singh Herikurniawan, Herikurniawan Jasirwan, Chyntia OM Kamiliah Wilda Karmilasanti Khairul Amri Khie Chen Kuntjoro Harimurti Leonard Nainggolan Luthfie, Setiawan Muhammad Maksum, Maradewi Muzdalifah Muzdalifah Nilam Sari Noto Dwimartutie Pratiwi Putri, Intan Suari Adidarma Robert Sinto Satrio, Trian Suhardjono Suhardjono Triapritasyari, Aulya Triyani Kresnawan, Triyani Wicaksana, Bramantya Widayat Djoko Santoso, Widayat Djoko Yatimah, Yatimah Yusmerita Yusmerita