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All Journal Padjadjaran Journal of Dentistry Narra J Preventif : Jurnal Kesehatan Masyarakat
Harun Achmad, Harun
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Anti-tumor agent celecoxib activity towards SP-C1 tongue cancer cells invasion (in vitro) Achmad, Harun; Satari, Mieke Hemiawati; Oewen, Roosje Rosita; Supriatno, S.
Padjadjaran Journal of Dentistry Vol 23, No 1 (2011): March
Publisher : Faculty of Dentistry Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1465.155 KB) | DOI: 10.24198/pjd.vol23no1.14053

Abstract

Invasion is a characteristic of the occurrence of cancer and indicates the cancer cells capability to destroy and degrade the border between the epithet and basal membrane to further spread into the surrounding extra-cellular matrix. The purpose of this research was to find the existence of impediment at the SP-C1 tongue cancer cell using celecoxib chemopreventive medication. The SP-C1 tongue cancer cells were treated in vitro using celecoxib medication as a research subject at the following concentrations 5, 10, 25, 50, 75, 100, 125%; and 0 as control group (only DMEM growth medium treatment). Pure experimental testing was carried out for 24 and 48 hours, with observation and calculation of an average number of SP-C1 tongue cancer cells. The data collected were analyzed using the ANOVA test with Newman Keuls paired range test or t-test. Research results indicated that the average number of SP-C1 tongue cancer cells invasion after administration of celecoxib medication based on administration concentration and time statistically yielded significant results. The ANOVA test results were statistically significant, that is, average occurrence of the number of SP-C1 tongue cancer cells due to the use of celecoxib at certain concentrations compared to that without celecoxib was different. At celecoxib of zero (control) concentration was 24.4 with celecoxib concentration starting at 5 up to 125% experienced a decline from its average 11 to become 2.3. The conclusion of the research was that the greater the celecoxib concentration administered, the greater the effect on the impediment of SP-C1 tongue cancer cell invasion.
Cryotherapy on exfoliative cytological changes for oral mucositis in cancer patients undergoing chemotherapy: A randomized control trial Erika, Kadek A.; Mulhaeriah, Mulhaeriah; Miskad, Upik A.; Zuraida, Eli; Sangkala, Moh S.; Magfirah, Ika; Achmad, Harun
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1644

Abstract

Oral mucositis is a common complication of chemotherapy that significantly impacts quality of life and may reduce treatment efficacy. While oral cryotherapy has been widely studied as a preventive intervention due to its cost-effectiveness, safety, and ease of use, most research focused on clinical outcomes without incorporating objective cytological assessments of mucosal changes. The aim of this study was to evaluate the effectiveness of oral cryotherapy in managing chemotherapy-induced mucositis using exfoliative cytology to monitor oral mucosal changes. A single-blinded, randomized controlled trial was conducted involving 50 cancer patients undergoing chemotherapy, who were randomly assigned to either the intervention or control group. The control group (n=25) received standard oral hygiene care, while the intervention group (n=25) received oral cryotherapy in addition to routine oral hygiene. A 20-minute oral cryotherapy was administered twice daily after breakfast (09:00 A.M.) and lunch (01:00 P.M.) for 14 days. This study found a significant reduction in mucositis scores was observed in both groups (p<0.05). However, post-hoc analysis indicated that mucositis severity declined earlier in the cryotherapy group, whereas improvement in the control group was noted only after 14 days. Serial oral mucosal smears analyzed via exfoliative cytology revealed a reduction in inflammatory cells and the absence of coccus microorganisms by days 7 and 14 in the intervention group. In conclusion, this study demonstrated that oral cryotherapy effectively reduces the severity and duration of mucositis and accelerates recovery in cancer patients undergoing chemotherapy. Oral cryotherapy can be applied as a viable alternative to mitigate the severity of oral mucositis in this patient population.
Karakteristik Kesehatan Terkait Perkawinan Anak di Sulawesi Selatan: Fertilitas, Mortalitas dan Kesehatan Reproduksi Putri, Nike Dwi; Pulubuhu, Dwia Aries Tina; Achmad, Harun
Preventif : Jurnal Kesehatan Masyarakat Vol. 13 No. 2 (2022): Volume 13 No. 2 (2022)
Publisher : Tadulako University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/preventif.v13i2.401

Abstract

Salah satu dampak perkawinan anak adalah permasalahan kesehatan. Artikel ini bertujuan untuk memeriksa keterkaitan permasalahan fertilitas, mortalitas, dan kesehatan reproduksi dari perempuan yang menikah pada usia anak-anak. Penelitian ini merupakan jenis penelitian kuantitatif dengan menggunakan analisis deksriptif. Data yang digunakan berasal dari Badan Pusat Statistik hasil Survei Sosial Ekonomi Nasional pada bulan Maret 2017. Merujuk pada metadata indikator perkawinan anak SDGs, maka unit penelitian pada artikel ini adalah perempuan berumur 20-24 tahun yang menikah. Terdapat 899 unit penelitian yang kemudian diperiksa terkait indikator fertilitas, mortalitas, dan kesehatan reproduksi. Hasil penelitian mengindikasikan bahwa pada aspek fertilitas, perempuan berumur 20-24 tahun yang menikah sebelum umur 18 tahun memiliki peluang 8 kali lipat dalam melahirkan 3 atau lebih anak lahir hidup dibandingkan mereka yang menikah di usia dewasa. Pada umur melahirkan pertama didominasi pada kelompok umur 15-19 tahun yang merupakan kelompok umur dengan peluang yang tinggi pada kematian ibu. Terdapat sekitar 18 persen bayi yang lahir dengan berat badan lahir rendah dilahirkan dari perempuan yang menikah di usia anak. Pada aspek kesehatan reproduksi, masih terdapat 26,3 persen dari perempuan yang menikah sebelum umur 18 tahun tidak menggunakan alat KB. Kesimpulan yang didapatkan dari penelitian ini adalah bahwa perkawinan anak dapat meningkatkan resiko terhadap permasalahan fertilitas, mortalitas, dan kesehatan reproduksi.
Co-Authors Erika, Kadek A. Magfirah, Ika Mieke Hemiawati Satari Mulhaeriah, Mulhaeriah Pulubuhu, Dwia Aries Tina Putri, Nike Dwi Roosje Rosita Oewen, Roosje Rosita Sangkala, Moh S. Supriatno Upik A. Miskad, Upik A. Zuraida, Eli