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Journal : Cermin Dunia Kedokteran

Sindrom Chorea Hiperglikemia Ganglia Basalis: Laporan Kasus Puspita, Amelia; Sumada, I Ketut; Wiratni, Ni Ketut Candra; Yuliani, Desie; Jayanthi, Ni Made Kurnia Dwi
Cermin Dunia Kedokteran Vol 51 No 7 (2024): Kedokteran Umum
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v51i7.963

Abstract

Background: Chorea hyperglycemia basal ganglia (C-H-BG) syndrome is an uncommon manifestation of diabetes mellitus seen in patients with poor glycemic control. Case: A 74-year-old poorly controlled diabetic women with acute onset of movement disorder in the form of uncontrolled choreiform movements of her left upper and lower extremity. Her initial glucose level was 289 mg/dL and HbA1C was 9.5%. Discussion: Most C-H-BG patients are older Asian female. Female predisposition is probably related to the estrogen decline during menopause, resulting in gamma-aminobutyric acid (GABA) depletion or dopamine receptors hypersensitivity and enhancement of dopaminergic system. Its pathophysiology has not been entirely defined. Conclusion: C-H-BG is a rare manifestation of poorly controlled diabetes. Early recognition and treatment of elevated blood glucose levels appear to lead to total resolution.