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The Risk of Falling in Elderly Increased with Age Growth and Unaffected by Gender Susilo, Wilson; Limyati, Yenni; Gunawan, Decky
Journal of Medicine and Health Vol 1, No 6 (2017)
Publisher : Maranatha Christian University

Show Abstract | Download Original | Original Source | Check in Google Scholar

Elderly people are a group of people with age of 60 and above. Studies in United States showed one-third of elderly people experienced fall in their houses and one-forty of them need bedrest in hospital. Falling can cause physical and mental injury. Physical injury manifests as fracture, hematoma, bruises, and dislocation, and mental injury manifests as lack of self esteem. This study aimed to examine the relation between age and gender on risk of fall on elderly people. This is a cross-sectional analytical study involving 23 elderly people from Tulus Kasih Elderly Home that met the inclusion criteria. Risk of fall were checked with Timed Up and Go Test. The data acquired were analyzed with chi-square with Î± = 0,05. As results, age significantly affected risk of fall (p=0.019) but gender did not (p=0.265). We concluded the risk of falling is increased with age and unaffected by gender.Keywords : age, gender, risk of fall, timed up and go test

The Risk of Falling in Elderly Increased with Age Growth and Unaffected by Gender Susilo, Wilson; Limyati, Yenni; Gunawan, Decky
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Elderly people are a group of people with age of 60 and above. Studies in United States showed one-third of elderly people experienced fall in their houses and one-forty of them need bedrest in hospital. Falling can cause physical and mental injury. Physical injury manifests as fracture, hematoma, bruises, and dislocation, and mental injury manifests as lack of self esteem. This study aimed to examine the relation between age and gender on risk of fall on elderly people. This is a cross-sectional analytical study involving 23 elderly people from Tulus Kasih Elderly Home that met the inclusion criteria. Risk of fall were checked with Timed Up and Go Test. The data acquired were analyzed with chi-square with Î± = 0,05. As results, age significantly affected risk of fall (p=0.019) but gender did not (p=0.265). We concluded the risk of falling is increased with age and unaffected by gender.Keywords : age, gender, risk of fall, timed up and go test

Faktor-Faktor yang Memengaruhi Keberhasilan Terapi Kompresi Terhadap Perbaikan Ulkus Vena Tungkai Kronik Miguna, Landry; Jason, Daniel; Gunadi, Julia Windi; Sanjaya, Ardo; Gunawan, Decky
Jurnal Ilmu Kedokteran dan Kesehatan Vol 11, No 6 (2024): Volume 11 Nomor 6
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v11i6.15106

Ulkus vena tungkai masih merupakan masalah kesehatan yang serius karena kondisi ini masih sulit disembuhkan, seringkali menjadi kronik, dan menurunkan kualitas hidup penderitanya. Meskipun mekanisme kerja pastinya belum jelas, saat ini terapi kompresi masih menjadi pilihan utama terapi karena terbukti menurunkan angka rekurensi. Terapi kompresi memiliki variasi dalam jenis, durasi, dan tekanan yang dihasilkan. Literature review ini bertujuan untuk mengevaluasi lebih dalam tentang faktor-faktor yang memengaruhi keberhasilan terapi kompresi terhadap perbaikan ulkus vena tungkai kronik. Metode dilakukan dengan pencarian artikel dari search engine Pubmed, Google Scholar dengan kata kunci 'venous ulcer', 'compression therapy', 'chronic leg ulcer', 'pressure of compression', 'stocking compression' dan kombinasinya yang dipublikasikan dalam 20 tahun terakhir. Faktor-faktor kompresi yang diteliti yaitu jenis kompresi, durasi kompresi, dan tekanan kompresi. Indikator perbaikan yang diteliti yaitu gejala dan kondisi klinis, angka rekurensi, dan perbaikan kualitas hidup. Hasil dari 7 artikel yang ditelaah menunjukan bahwa terapi kompresi aman dan efektif di dalam mencegah rekurensi ulkus tungkai, mengurangi keluhan, dan memperbaiki kualitas hidup. Tidak ada pengaruh dari jenis dan durasi terapi kompresi terhadap keberhasilan. Derajat tekanan kompresi memengaruhi angka rekurensi, khususnya pada pengguna stoking kompresi. Sebagai simpulan, keberhasilan terapi kompresi terhadap perbaikan ulkus vena tungkai kronik terutama dipengaruhi oleh tingkat kepatuhan pasien dalam menjalani terapi yang memerlukan waktu jangka panjang.

Literature Review: Pengaruh Estrogen Terhadap Depresi Pasca Persalinan Gunawan, Decky; Camillo, Keyshia Valentine; Gunadi, Julia Windi; Sanjaya, Ardo
Health and Medical Journal Vol 7, No 1 (2025): HEME January 2025
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v7i1.1642

Depresi pasca persalinan merupakan kondisi mental yang ditunjukkan oleh perasaan yang konstan merasa rendah diri pada ibu yang baru melahirkan, dengan disertai perasaan sedih, penurunan harga diri, dan rasa putus asa. Estrogen memiliki efek indirek terhadap suasana hati melalui pengaruhnya pada fungsi endokrin, proses peradangan selama masa nifas, serta memodulasi aktivitas molekuler otak seperti brain-derived neurotrophic factor (BDNF) dan cyclic AMP response element binding protein (CREB). Perubahan hormonal yang signifikan pada ibu yang baru melahirkan memicu para peneliti untuk mengetahui pengaruh estrogen pada depresi pasca persalinan dan peluangnya dalam pengobatan. Tujuan dari telaah literatur ini adalah mengetahui pengaruh estrogen terhadap depresi pasca persalinan. Metode penelitian adalah telaah delapan artikel yang diperoleh dari PubMed dan BMJ journal dengan kata kunci “estrogen” dan “postpartum depression” dan dipilih berdasarkan kriteria inklusi seperti tahun terbit (2014-2024) dan isi artikel. Hasil telaah pada delapan artikel penelitian yang diperoleh menunjukan lima penelitian menunjukkan tidak ada pengaruh pemberian estrogen terhadap depresi pasca persalinan, sedangkan tiga penelitian menunjukan ada pengaruh. Depresi pasca persalinan bukan hanya karena faktor hormon estrogen, namun masih banyak faktor lain yang menjadi etiologinya. Kesimpulan telaah ini, sampai saat ini tidak ada bukti langsung pengaruh terapi estrogen untuk depresi pasca persalinan, namun masih memiliki potensi untuk dilakukan penelitian lebih lanjut sebagai terapi ajuvan.

Effects of dietary protein combined with high-intensity exercise in restoring skin health in male rats Gunadi, Julia Windi; Lesmana, Ronny; Kastella, Faysal; Tarawan, Vita Murniati; Goenawan, Hanna; Gunawan, Decky; Jasaputra, Diana Krisanti
Universa Medicina Vol. 44 No. 2 (2025)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2025.v44.152-161

Background Protein is essential for skin integrity, while exercise modulates cellular and molecular processes that regulate autophagy, mitochondrial biogenesis, and collagen synthesis. This study evaluates the combined effects of dietary protein restriction and varying exercise intensities on epidermal thickness, autophagy markers (LC3, p62), mitochondrial biogenesis (PGC1α), and collagen synthesis (Col1a1, Col3a1) in male Wistar rats. Methods An experimental laboratory study was conducted involving 32 male Wistar rats. They were randomized into 8 groups: control, low protein, low intensity, group IV, moderate intensity, moderate intensity low protein, high intensity, and high intensity low protein. Low protein diet (5%) compared to the control (24%) was given for 60 days, while the exercise regimen was eight weeks of treadmill exercise (low/10 m per minute, moderate/20 m per minute, and high intensity/30 m per minute) for 30 minutes a day, five days a week. Epidermal thickness, LC3, p62, PGC1α, Col1a1, and Col3a1 mRNA expression were measured at the end of the study. One-way ANOVA/Kruskal-Wallis followed by Tukey HSD/Mann–Whitney test was used to analyze the data. Results A low-protein diet significantly reduced epidermal thickness (p=0.048), increased LC3 (p=0.043) and p62 (p=0.011), indicating impaired skin regeneration and autophagy. However, exercise, especially at high intensities with low protein, mitigated this effect by increasing both LC3 (p=0.011) and PGC1α (p=0.011). Conclusions These findings highlight the compensatory role of exercise in maintaining tissue integrity under protein-deprived conditions in male rats. High-intensity exercise potentially enhances autophagy and mitochondrial biogenesis.

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