Garuda - Garba Rujukan Digital

p-Index From 2020 - 2025

1.829

P-Index

This Author published in this journals

All Journal CHEMISTRY PROGRESS e-Journal Pustaka Kesehatan STOMATOGNATIC- Jurnal Kedokteran Gigi Al-Kimia Jurnal Kimia Terapan Indonesia Eksakta : Berkala Ilmiah Bidang MIPA Dedication : Jurnal Pengabdian Masyarakat BERNAS: Jurnal Pengabdian Kepada Masyarakat Indonesian Community Journal Jurnal ABDI MERCUSUAR Dedication : Jurnal Pengabdian Masyarakat Jurnal Sains dan Kesehatan

Dwi Koko Pratoko

Fakultas Farmasi Universitas Jember

Author-ID : 6363551

Religion Agriculture, Biological Sciences & Forestry Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

Published : 21 Documents Claim Missing Document

Claim Missing Document

Articles

1 2 3

MOLECULAR DOCKING SENYAWA FITOKIMIA PIPER LONGUM (L.) TERHADAP RESEPTOR SIKLOOKSIGENASE-2 (COX-2) SEBAGAI ANTIINFLAMASI Pratoko, Dwi Koko
CHEMISTRY PROGRESS Vol 5, No 1 (2012)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/cp.5.1.2012.651

Pratoko, 2012. Molecular docking senyawa fitokimia Piper longum (L.) terhadap reseptor siklooksigenase-2(COX-2) sebagai antiinflamasi. Piper longum (L.) memiliki aktivitas antiinflamasi dengan mekanisme penghambatan enzim siklooksigenase-2(COX-2). Penelitian ini melakukan penambatan (docking) molekul senyawa fitokimia yang terkandung dalamPiper longum (L.) terhadap reseptor siklooksigenase-2 (COX-2) untuk menguji energi docking yang seringkalidihubungkan dengan afinitas ikatan antara ligan dengan reseptor. Dari penelitian ini, didapatkan 2 senyawayang memiliki energy paling rendah diantara senyawa fitokimia yang lain, seperti pipericide dan sylvetin. Kelimasenyawa ini memiliki afinitas ikatan antara ligan dan reseptor yang kuat dan stabil. Berdasarkan energi daninteraksi yang terjadi antara senyawa dan reseptor dapat disimpulkan bahwa senyawa-senyawa ini diprediksimemberikan pengaruh yang signifikan terhadap aktivitas.Kata kunci : docking, Piper longum (L.), reseptor siklooksigenase-2, COX-2, antiinflamasiPratoko, 2012. Molecular docking of phytochemical compound from Piper longum (L.) on siklooksigenase-2(COX-2) receptor as anti inflamation. Piper longum (L.) has anti-inflammatory activity with a mechanism of inhibition of the enzyme cyclooxygenase-2(COX-2). This study did docking phytochemical compounds that contained in Piper longum (L.) to the receptorof cyclooxygenase-2 (COX-2). These docking studies to determine the docking energy associated with thebinding affinity between the ligand and receptor. From this study, obtained 2 compounds that have the lowestenergy among other phytochemical compounds, such as pipericide and sylvetin. These compounds have abinding affinity between ligand and receptor are strong and stable. Based on the energy and the interactionsbetween compounds and receptors can be concluded that these compounds are predicted have a significantinfluence on the activity.Keywords : docking, Piper longum (L.), cyclooxygenase-2 receptor, COX-2, anti-inflammatory

Pelatihan Pembuatan Souvenir Sabun Kepada Kelompok Ibu-Ibu Rumah Tangga Kecamatan Kaliwates Kabupaten Jember Dalam Rangka Meningkatkan Perekonomian Masyarakat Dwi Koko Pratoko; Nia Kristiningrum; Adelia A Devi Devi; Regol S Raudiah Raudiah
Dedication : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2019)
Publisher : LPPM IKIP Jember

Sasaran dari kegiatan pengabdian masyarakat ini adalah kelompok ibu-ibu rumah tangga di Kecamatan Kaliwates Jember. Metode pelaksanaan dari kegiatan ini dibagi menjadi beberapa tahap yaitu persiapan, pelaksanaan pelatihan pembuatan souvenir sabun dan pelatihan pembuatan toko daring. Peserta dibagi menjadi kelompok-kelompok kecil sehingga sangat efektif dalam meningkakan pemahaman dan keterampilan kerja peserta. Adanya kegiatan ini diharapkan dapat memberikan ide, pengetahuan dan keterampilan bagi kelompok ibu rumah tangga tersebut sehingga mempunyai rumah produksi souvenir sabun dan harapannya bisa meningkatkan perekonomian keluarganya.

Upaya Pencegahan Stunting dengan Optimalisasi Peran Posyandu Melalui Program Kemitraan Masyarakat Ika Norcahyanti; Antonius N. W. Pratama; Dwi Koko Pratoko
Dedication : Jurnal Pengabdian Masyarakat Vol 3 No 2 (2019)
Publisher : LPPM IKIP Jember

Permasalahan gizi yang penting dan perlu mendapat perhatian khusus di Indonesia adalah stunting. Kasus stunting juga ditemukan di Kabupaten Jember, Jawa Timur. Meskipun penanganan stunting membutuhkan waktu yang panjang, intervensi gizi-sensitif dan gizi-spesifik perlu untuk diperkenalkan kepada masyarakat. Kegiatan pengabdian masyarakat ini bertujuan untuk memfasilitasi warga di Posyandu Aster 138A Jember berkaitan dengan upaya pencegahan stunting melalui kegiatan penyuluhan dan budidaya tanaman hidroponik, penyediaan sarana bermain ramah anak serta pelatihan pembuatan makanan tambahan. Kegiatan yang dilakukan selama kurun waktu Juli-September 2019 telah memberikan dampak dan hasil positif berupa peningkatan pengetahuan dan pengalaman dari para kader dan juga anggota Posyandu Aster 138A tentang urban farming melalui budidaya tanaman hidroponik serta pembuatan makanan tambahan dalam bentuk kukis dan nugget yang kaya akan zat besi. Selain itu, pada kegiatan pendirian sarana bermain anak yang dapat merangsang aktivitas motorik juga disambut baik oleh anak-anak yang berada di lingkungan Posyandu Aster 138A. Sebagai kesimpulan, program-program yang mendukung intervensi gizi-sensitif dan gizi spesifik dapat diterima dengan baik oleh masyarakat sasaran. Program seperti ini diharapkan dapat dilakukan berkelanjutan untuk membantu mencegah stunting di Indonesia.

Kadar Fenolat dan Flavonoid Total serta Kapasitas Antioksidan Ekstrak Etanol dan Fraksi Jahe Merah (Zingiber officinale var. Rubrum) Dwi Koko Pratoko; Firdha Aprillia Wardhani; Nia Kristiningrum; Fifteen Aprila Fajrin; Dian Agung Pangaribowo
Al-Kimia Vol 6 No 2 (2018): December
Publisher : Study Program of Chemistry - Alauddin State Islamic University of Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/al-kimia.v6i2.6316

Determination of total phenolic, total flavonoid, and antioxidant capacity of ethanolic extract and fractions from red ginger (Zingiber officinale var. Rubrum) has been done. Red gingers contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contributing to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143.9 ± 0.9 µmol/g (CUPRAC) and 4526.4 ± 3.0 (DPPH), GAE 229.9 ± 1.3 mg/g, and QE 46,6 ± 1,8 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation. Determination of total phenolic, total flavonoid, antioxidant capacity from ethanolic extract and fractions of red ginger (Zingiber officinale var. Rubrum) has been done.Red ginger contain the highest oleoresins among other ginger varieties. Oleoresins are component that had the most responsibility for pharmacological effect of red ginger, one of them is as antioxidant. Phenolic and flavonoid are highly contribute to the antioxidant effect of red ginger. The aim of this research is to determine the antioxidant capacity of extract and fractions of red ginger, and to investigate the correlation between antioxidant capacity with both total phenolic and total flavonoid. Ethanolic extracts are fractinationed with n-hexane, chloroform, ethyl acetate, n-butanol, and methanol solvent. Antioxidant capacity, total phenolic, and total flavonoid of all the samples are measured. Highest antioxidant capacity, total phenolic, and total flavonoid obtained from ethyl acetate fraction with TEAC 2143,893 ± 0,890 µmol/g, GAE 229,878 ± 1,330 mg/g, and QE 46,564 ± 1,804 mg/g. One way ANOVA and post hoc analysis show significant result with p value <0,01. Pearson correlation shows high positive correlation.

Pengembangan Sensor Kloramfenikol Berbasis Bovine Serum Albumin menggunakan Spektrofotometri UV (The Development of Chloramphenicol Sensor Based on Bovine Serum Albumin using Spectrophotometry UV) Sarah Aisha; Bambang Kuswandi; Dwi Koko Pratoko
Pustaka Kesehatan Vol 6 No 1 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i1.6609

Misuse of antibiotics has been discovered in shrimp exported from Indonesia, one of them is chloramphenicol, therefore it is necessary to develop methods for chloramphenicol detection. In this study, the chemical sensor for chloramphenicol detection has been developed. The sensor developed by immobilized bovine serum albumin (BSA) onto cellulose acetate membrane. The sensor has linear range of 6-16 μg/ml chloramphenicol with r 0.999 and limit of detection (LOD)-limit of quantification (LOQ) value of 0.74-2.21 μg/ml. The RSD value of repeatability and intermediet precision were 2.41% and 2.31%, where the recovery was 100.29%. Three of the five samples of tiger shrimp on the market containing chloramphenicol at level of 1.03; 2.48; and 3 μg/ml. The result also shown in good agreement with conventional spectrophotometry UV-Vis method. Keywords: shrimp, chloramphenicol, BSA, cellulose acetate

Sintesis dan Uji Aktivitas Antibakteri Senyawa N-fenil-4-klorobenzamida Elok Dea Orens Ubung Wisnu; Indah Purnama Sary; Dwi Koko Pratoko
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7569

N-phenylbenzamide is benzamide derivatives, which is potential as an antibacterial agent. N-phenyl-4-chlorobenzamide is N-phenylbenzamide derivative that substitued by chloro to the para position and it was expected to enhance the antibacterial activity. N-phenyl-4-chlorobenzamide was synthesized by reacting 1,3-diphenyilthiourea and 4-chlorobenzoil chloride. This compound has been purified and provided 53% of product with crystal shape, white color, and melting point of 195-197 oC. The purification of this compound was confirmed by TLC and the structure was identified by 1H-NMR, 13C-NMR, and FTIR spectroscopy. This compound was tested for its activity against gram positive bacteria Staphylococcus aureus and gram negative bacteria Pseudomonas aeruginosa, evaluated by well diffusion method and the result showed no activity against both Staphylococcus aureus and Pseudomonas aeruginosa. Keywords: N-phenyl-4-chlorobenzamide, synthesis, antibacterial activity

Sintesis dan Uji Aktivitas Antibakteri Senyawa N-Fenil-4-Bromobenzamida (Synthesis and Antibacterial Activity Assay of N-Phenyl-4-Bromobenzamide) Nazilatul Maghfiroh; Indah Purnama Sary; Dwi Koko Pratoko
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i2.5868

Infectious diseases are contagious disease caused by pathogenic microorganisms and can be spread directly or indirectly from one person to another. The aim of this research was to synthesized N-phenyl-4-bromobenzamide as a new antibacterial agent. Thereaction was carried out by reacting 1,3-diphenylthiourea with 4-bromobenzoyl chloride by nucleophilic substitution. The purification of this compound was confirmed by TLC and the structure was identified by UV, IR, 1H-NMR and 13C-NMR. The newly synthesized compound was screened for its antibacterial activity against gram-positive and gram-negative bacteria, Staphylococcus aureus ATCC 6538 and Pseudomonas aeruginosa ATCC 27853 using well diffusion method. The concentration of the test solution used were 31.25; 62.5; 125; 250; 500; 1,000; 2,000; 4,000; 8,000; and 10,000 μg/ml with levofloxacin as positive control. The synthesized product did not show any antibacterial activity which characterized by the absence of inhibition zone.Keywords: 1,3-diphenylthiourea, N-phenyl-4-bromobenzamide, nucleophilic substitution, antibacterial activity.

Pengembangan Bromfenol Biru dan Bromtimol Biru pada Label Pintar Sensor Kematangan Buah Naga Merah (Hylocereus polyrhizus) (The Development of Bromophenol Blue and Bromothymol Blue on Ripeness Sensor Smart Label on Red Dragon Fruit (Hylocereus polyrhizu Raden Ayu Rifqa Zainatul Hurriyah; Bambang Kuswandi; Dwi Koko Pratoko
Pustaka Kesehatan Vol 5 No 3 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i3.5890

The novel on-package color indicator label has been fabricated based on bromophenol blue and mixture between bromophenol blue and bromothymol blue, and tests have been conducted to assess the ripeness of red dragon fruit (Hylocereus polyrhizus). Bromophenol blue (BPB) and mixture between bromophenol blue and bromothymol blue (BTB) were immobilized onto acetate cellulose membrane via adsorption method. The BPB and mixture between BPB and BTB/acetate cellulose membrane as color indicator work based on pH decrease as the volatile organic compounds (e.g. acetic acid). They produced gradually in the package headspace during developing of red dragon fruit. Subsequently, the color of the indicator will change from blue to green for over-ripe indication, which can be visible visually. The results showed that the color indicator could be used to determine the state of ripeness of the red dragon at ambient condition (25±2oC) and chiller condition (4±2oC). The color change of the indicators reflects the pH of headspace of the red dragon packaging. Furthermore, it also in similar trends to the change of several parameters (soluble solids content, pH, texture, sensory evaluation and weight loss) that normally used to characterize the ripeness of red dragon, therefore the indicator can be used for real time visual monitoring of ripeness state of packaged red dragon fruit. Keywords: ripeness indicator, BPB, BTB, red dragon fruit, acetate cellulose membrane

Pengembangan Sensor Kloramfenikol Berbasis Imobilisasi Bovine Serum Albumin (BSA) pada Selulosa Asetat dengan Metode Spektroflorometri (The Development of Chloramphenicol Sensor Based on Bovine Serum Albumin (BSA) Immobilization on Cellulose Acetate using Spectrofluorometry Method) Dhany Alghifari; Bambang Kuswandi; Dwi Koko Pratoko
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v5i1.3947

The chloramphenicol usage in shrimp cultivation is an example of antibiotics abuse that have adverse effects for health. According to Indonesian Drug and Food Agency (BPOM) survey, it showed that from 14 samples of shrimp test, entirely contain residues of chloramphenicol. In this context, the sensor has been developed base on cellulose acetate membrane immobilized with bovine serum albumin (BSA). The chloramphenicol sensor has a linearity range of 2-12 μg/ml and the r value of -0.997. The value of limit of detection is 0.157 μg/ml and limit of quantification is 0.472 μg/ml. The RSD value of repeatability is 1.542 % and the value of intermediate precision is 1.058%. The average value of recovery as the parameter an accuracy test of 95.338 ± 0.636% and this sensor has a good selectivity tests to erythromycin, pellets and shrimp meat. The result also shown in good agreement with the conventional spectrofluorometry method Keywords: shrimp, chloramphenicol, BSA, sensor, spectrofluorometry

Pengembangan Biosensor Berbasis Plastik Zona Mikro untuk Skrining Aktivitas Antidiabetes pada Ekstrak Tanaman Obat Indri Firma Wati; Bambang Kuswandi; Dwi Koko Pratoko
Pustaka Kesehatan Vol 9 No 1 (2021): Volume 9 No.1, 2021
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v9i1.20423

Research on the diabetes mellitus (DM) treatment has recently been carried out, especially on discovering antidiabetic agents derived from plants. This study aims to determine the fabrication of microzone plastic-based biosensors, determine the optimal sensor conditions, analysis characteristics, and compare the biosensor with the UV-Vis spectrophotometric method. The results showed that the response time was 15 minutes, the linear range was 500-40000 µg / mL (R = 0.9989). The limit of detection (LOD) was 1109.6 µg / mL, and the limit of quantification (LOQ) was 3698.8 µg / mL. Biosensor filled up the precision parameters with an RSD value of less than 3.7% and an accuracy with recovery in the range of 95-105%. The biosensor is stable in storage at 25 ° C for 270 minutes and at chiller temperature for three days. The antidiabetic activity of the biosensor was compared with the UV-Vis spectrophotometer using the Independent Sample T-test and showed insignificant differences between the two methods.

Co-Authors Adelia A Devi Devi Antonius N. W. Pratama Ari Satia Nugraha Asia Asia Bambang Kuswandi Dhany Alghifari Dian Agung Pangaribowo Dian Agung Pangaribowo Dina Trianggaluh Fauziah Dyan Wigati Edi Susanto Elok Dea Orens Ubung Wisnu Faizah oktaviana Fifteen Aprila Fajrin Gani Asri Muharam Ika Norcahyanti Indah Purnama Sary Indah Purnama Sary Indri Firma Wati Iski Weni Pebrianti lindawati setyaningrum Lindawati Setyaningrum Muhammad Zainul Arifin Nazilatul Maghfiroh Nia Kristinigrum Nia Kristiningrum Raden Ayu Rifqa Zainatul Hurriyah Rahmadania Affelia Dianto Rahmadaniah Affelia Dianto Regol S Raudiah Raudiah Saeful Akhmad Tauladani Sarah Aisha Seftyani, Mita Shinta Mayasari Wanda Tri Agustin Wanda Tri Agustin Wardhani, Firdha Aprillia Wilda Nur Rohmatillah

Title

Found 21 Documents
Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title Search

Found 21 Documents Search

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Title

Found 21 Documents
Search