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The Immunomodulatory Activity of Cinnamomum burmanni Bark Extract on Leucocyte Differentiation of Mice (Mus musculus) In Diabetes Mellitus Model Martha Kaihena; Abdul Mahid Ukratalo; Amos Killay; Nunun Ainun Putri Sari Banun Kaliky
Jurnal Penelitian Pendidikan IPA Vol 10 No 1 (2024): January
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v10i1.5947

Abstract

Diabetes mellitus frequently coexists with infection, leading to an immunological response characterised by an elevation in leukocyte levels. This research aimed to assess the immunomodulatory activity of an extract derived from the bark of Cinnamomum burmanni on the differentiation of leukocytes in a diabetes mellitus model using mice (Mus musculus). Prior to the administration of therapy, the glucose levels of all mice were assessed. Subsequently, groups K (+), P1, P2, and P3 were administered STZ at 0.2 ml per individual. The blood glucose levels (post-STZ blood glucose) were checked once more on the seventh day. In the event of a rise in blood glucose levels over (>200 mg/dL), subjects belonging to groups P1, P2, and P3 were administered Cinnamomum burmanii extract under the prescribed dosage. The intervention was administered for 14 days, and blood glucose levels were assessed on the final day of experimentation. On the final day of the experiment, blood samples were collected from the mice's tails in order to prepare blood preparations. The findings indicate that the methanol extract derived from cinnamon bark possesses immunomodulatory properties, as evidenced by its ability to decrease the population of eosinophils, lymphocytes, and monocytes while concurrently increasing the amount of neutrophils.
Potensi Porphyra Sp. Asal Desa Allang, Pulau Ambon sebagai Sumber Pangan Fungsional Berbasis Makronutrien Lokal untuk Mendukung Kesehatan Masyarakat Abdul Mahid Ukratalo; Martha Kaihena
Quantum Wellness : Jurnal Ilmu Kesehatan Vol. 3 No. 2 (2026): Juni: Quantum Wellness : Jurnal Ilmu Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/quwell.v3i2.3306

Abstract

Porphyra sp. seaweed is a marine biological resource with significant potential as a functional food ingredient, particularly in the coastal regions of Indonesia. This study aims to analyze the macronutrient content of Porphyra sp. from Desa Allang, Ambon Island, and to evaluate its potential as a functional food source based on local nutritional resources. Protein, carbohydrate, fat, moisture, and ash contents were analyzed using the AOAC method. The results indicate that Porphyra sp. contains 13.77% protein, 15.78% carbohydrates, and 1.35% fat, reflecting a high nutritional value with low fat content, thus meeting the characteristics of functional foods that provide health benefits to the community. The moisture content obtained was 11.55%, which is relatively low and is suspected to be influenced by the drying method using an oven. Furthermore, the ash content of 21.66% indicates a relatively high mineral content, contributing additional nutritional value that supports biological functions and overall health. The macronutrient composition is influenced by environmental factors such as habitat, water depth, water quality, and the growth phase of the seaweed. With its comprehensive nutritional profile, Porphyra sp. holds promise as a raw material for functional food development that not only fulfills nutritional requirements but also supports the enhancement of public health.