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All Journal Journal of Applied Pharmaceutical Research International Journal of Humanities, Management, and Social Science (IJ-HuMaSS) International Journal Education and Computer Studies jes
Vikram Singh, Vikram
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Aerospace Engineering Humanities Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Control & Systems Engineering Education Electrical & Electronics Engineering Languange, Linguistic, Communication & Media Library & Information Science Mathematics Medicine & Pharmacology Social Sciences Other

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Formulation and evaluation of extended release spheroids for antidepressant drug by MUPS Kumar, Amrendra; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (183.496 KB)

Abstract

The extended release spheroids was Formulated using Ethyl Cellulose, Povidone and Triacetin as a Coating material and evaluated the effect of change in weight build up on drug release profile. Optimization of extended release coating by 19% build up of EC/PVP-K30 of formulation (F4), in which the formulation is formulated by Reservoir system and the drug release depends on coating thickness of EC/PVP-K30. As concentration of coating weight buildup increases. which increases the thickness of coating on the reservoir system hence release retarded and transformed into an extended release system.
Development and characterization of surface solid dispersion of curcumin for solubility enhancement Singh, Mahendra Vikram; Juyal, Divya; Singh, Vikram; Rawat, Geeta; Tiwari, Akhilesh
Journal of Applied Pharmaceutical Research Vol. 2 No. 4 (2014)
Publisher : Creative Pharma Assent

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Abstract

Surface solid dispersion (SSD) of curcumin was developed and characterized with purview to overcome solubility hurdle in its pharmacokinetic and pharmacodynamic performance. SSDs were prepared by co-evaporation method using polyplasdone XL, croscarmelose sodium, and silicone dioxide and polyethlene glycol 6000 as carrier. The optimized SSD (F9) was characterized using FE-SEM and XRD as an analytical tool. The formulation of modified Curcumin shows better drug release profile as compared to the natural Curcumin. Formulation F9 released more than 90% of the loaded Curcumin within 30 minutes where marketed formulations shows 90% drug only after 60 minutes.
Inspection of a novel penetration enhancer for transungual drug delivery system: Pelargonium hortorum Singh, Vikram; Chandrul , Kaushal Kishore
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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This study was to search some natural penetration enhancer and formulate them in a transungual drug delivery formulation. This natural penetration enhancer helps to overcome the main problem in front of success of transungual drug delivery system. We selected to formulate fluconazole as a model drug for the nail fungal infection treatment with extracted penetration enhancer (PE). Model drug i.e. fluconazole was formulated with the natural extracted penetration enhancer with different deigned formula. The solvent for PE extraction was methanol and that extracts were air dried. The cadaver human nail plates were used for penetration study, were collected from the same volunteer for negligence in the thickness and chemical composition concentration in the nail plate. The extracted PE (pelargonium hortorum) was selected for formulation on the basis of ethanopharmaceutical history. The human cadaver nail plates were treated with the formulation with and without the extracted PEs. Ex - vivo drug penetration was evaluated by Franz diffusion cells using cadaver human nail plate upto 36 hours. The drug filmability was found to be best with the polymer like HPMC K4M, Ethyl cellulose and hydroxyl propyle cellulose in the ratio of 1:1:1, mixture of propanol and butanol in 7:3 as solvent and 30% w/w DBP as plasticizer. The formula FT25AP4 shows total 35.67% drug penetraion i.e. near about two times of drug penetration across the nail plate when compare to the same formulation but without any penetration enhancer. The “p” value (0.0011) of drug penetration was less than 0.05.
Design and in vitro evaluation of mouth dissolving tablets olanzapine Sharma, Vivek Kumar; Singh, Vikram; Juyal, Divya; Rawat, Geeta
Journal of Applied Pharmaceutical Research Vol. 3 No. 1 (2015)
Publisher : Creative Pharma Assent

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Abstract

The purpose of this research was to design and evaluate the olanzapine fast dissolving tablets. The variable formulation of Olanzapine having challenging methodology. Olanzapine practically insoluble in water so used different polymers and superdisintigrant to make formulation. Direct compression are most desired method for preparation of mouth dissolving tablets. The tablets were evaluated for disintegration and dissolution properties of the formulation. In formulation of mouth dissolving tablet evaluate the precompression parameter and post compression parameter and after evaluation found satisfactory
Solubility enhancement of biperidine HCl by complexation with hydroxypropyl β-cyclodextrin Dubey, Amit; Singh, Vikram; Juyal, Divya; Rawat, Geet
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Oral route is the simplest and easiest way of drug administration, because of the greater stability, lesser bulk, and cheap cost of production, accurate dosage and easy process, solid oral dosage forms have several advantages over other dosage forms. All the poor water soluble drugs after oral administrations are not well absorbed and thus leads to decrease in inherent efficiency of drugs. Therefore, for oral drug delivery system the improvement of drug solubility thereby its oral bio-availability is the most important aspect of drug development process. Biperiden HCl is a potent drug (Maximum daily dose is 16mg/day), having extensive first pass metabolism resulting in poor Bioavailability. The pharmacokinetic profile of this drug showed 33±5 % Bioavailability and 18-24 hours elimination half-life (t1/2). In the present study attempt has been made to prepare and characterize inclusion complex of Biperiden HCl with Hydroxypropyl β-Cyclodextrin. The inclusion complexes prepared by different methods i.e. Physical mixture, Kneading and Solvent evaporation methods. The prepared complexes were characterized using FT-IR. The inclusion complex prepared by Kneading method exhibited greatest enhancing in solubility and faster dissolution (93.98% drug release in 60 min) of Biperiden HCl.
Subduing the nail barrier with novel herbal penetration enhancers for transungual delivery system Singh, Vikram; Gupta, R. D.; Teotia, U. V. S
Journal of Applied Pharmaceutical Research Vol. 3 No. 2 (2015)
Publisher : Creative Pharma Assent

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Abstract

Nail fungal infections are very common and also very difficult to treat because of nail morphology, deep penetrability of infectious agent inside nail plate and poor permeability of the nail plate. Transungual delivery shall be the first choice for treatment of nail infection if we get the effective penetration enhancers without causing the serious problem. In this study we tried to scanning some extracts penetration potency through the human cadaver nail plate. Five plants selected for the purpose acacia catechu, rosa hybrid, hibiscus rose-sinensis, tagetes patula, tagetes erecta. For penetration potency first defatted the nail plate with chloroform : methanol (2:1) mixture. Extracts of tagetes erecta, acacia catechu shows 100%, tagetes patula 60% and rosa hybrid 40% from dorsal side of plate. Those extracts were stable by it only. That proves that they may be used as a penetration enhancer to increase the penetration of drug
Analysis of Social Policies and Intervention Strategies for Mental Health Among Adolescents in Australia Kumari, Priya; Singh, Vikram; Harrison, Liam
International Journal of Humanities, Management and Social Science (IJ-HuMaSS) Vol 7 No 1: June 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ij-humass-0701.657

Abstract

Adolescent mental health is a growing concern in Australia, with various social, environmental, and academic pressures exacerbating anxiety, depression, and stress. This research aims to identify the key mental health challenges faced by Australian adolescents and evaluate the effectiveness of existing social policies in addressing these issues. The study focuses on factors such as social media influence, family dynamics, access to community resources, and the school environment. A mixed-methods approach was employed, including surveys from mental health organizations and interviews with policymakers and psychologists across major Australian cities like Sydney, Melbourne, and Perth, conducted between April 2023 and March 2024. Findings reveal that social media, peer pressure, and academic stress significantly contribute to adolescent mental health issues, with rural areas experiencing limited access to services and heightened stigma. Policy initiatives like Beyond Blue and Headspace are effective but show gaps in outreach to marginalized groups and lack of integration with educational systems. The study recommends improving outreach in rural areas, enhancing mental health professional training, and fostering partnerships between schools and mental health services. Future research should explore the long-term impacts of these recommendations and focus on sustainable solutions for digital health interventions, while also addressing cultural sensitivities and unique community needs in mental health service provision for adolescents.
Educational Inequality and Its Impact on Social and Economic Opportunities in Rural India Kumar, Arjun; Sharma, Priya; Patel, Ravi; Gupta, Ananya; Singh, Vikram
International Journal of Humanities, Management and Social Science (IJ-HuMaSS) Vol 7 No 2: December 2024
Publisher : Lamintang Education and Training Centre, in collaboration with the International Association of Educators, Scientists, Technologists, and Engineers (IA-ESTE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36079/lamintang.ij-humass-0702.697

Abstract

Educational inequality remains a significant challenge in rural India, with disparities in access to infrastructure, teacher quality, and technology hindering equitable learning opportunities. This study examines these inequalities in two rural regions: Barwani, Madhya Pradesh, and Kalahandi, Odisha. Using a mixed-methods approach, the research combines qualitative interviews with students, teachers, and policymakers, alongside quantitative data on enrollment, infrastructure, and learning outcomes. Findings reveal that 72% of schools in Barwani lack science laboratories, while 65% of schools in Kalahandi lack digital tools, reflecting severe infrastructural gaps. High student-to-teacher ratios of 70:1 in Barwani and 60:1 in Kalahandi further strain educational quality, exacerbated by a lack of trained teachers. Poor access to technology and unreliable internet connectivity limit digital literacy, perpetuating the digital divide. The study also evaluates government interventions such as the Sarva Shiksha Abhiyan and digital education initiatives, finding implementation inconsistencies in remote areas. The findings highlight how educational inequality restricts social mobility and economic opportunities, particularly in underdeveloped regions. Future research should focus on the effectiveness of targeted policies and explore innovative, technology-driven solutions to bridge these disparities, fostering equitable educational development and sustainable growth in rural India.
Advancing Engineering Innovation through Project-Based Learning: A Qualitative Analysis of Experimental Applications in Indian Secondary Education Singh, Vikram
International Journal Education and Computer Studies (IJECS) Vol. 5 No. 2 (2025): JULY
Publisher : Lembaga KITA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/ijecs.v5i2.4443

Abstract

Project-Based Learning (PBL) is an active and constructive approach to engineering education in which students are asked to work on problems without predetermined solutions in a problem-solving context. This paper has attempted to investigate the potential impact of PBL on the development of necessary engineering competencies in Indian school students, who constitute a crucial part of the country's potential innovative power base. Using the Hindi versions of 111 science and engineering project documents, this study qualitatively analyzed three of them to examine the projects—Building a Simple Electric Motor, Investigating Sliding Friction on an Inclined Plane, and Designing a Hydrometer Using Plastic Balls. The findings lead to the conclusion that these projects indeed embody fundamental engineering concepts such as electromagnetism, mechanics, and fluid dynamics, while fostering technical competency, creativity, and cooperative problem-solving as reflected in their design structure and projected outcomes. However, substantial barriers to implementing this reform in the Indian context exist, such as resource constraints, an exam-oriented curriculum, and inadequate teacher preparation, as demonstrated by the analysis. The study argues that PBL is a powerful pedagogical tool for transforming engineering education in developing countries, while suggesting relevant measures such as teacher training, curriculum inclusion, policy advocacy for experiential learning, and industry collaboration in these countries to address these challenges. In conclusion, this study highlights the potential of PBL to foster innovation among future engineering graduates in India, a relevant contribution to the national education agenda in the National Education Policy (NEP) 2020 as well as global discussions on experiential learning
Performance Optimization of Low-Cost DC Motors for Educational Engineering Applications Singh, Vikram
Journal of Engineering and Science Vol. 4 No. 1 (2025): June
Publisher : Yayasan Kawanad

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56347/jes.v4i1.270

Abstract

This research examines how to build and improve a basic direct current (DC) electric motor using affordable, everyday materials for classroom teaching. We constructed our motor from simple components: copper wire coils, an iron nail, permanent magnets, and standard batteries. The device effectively demonstrates electromagnetic principles and energy conversion processes that students can observe firsthand. Our experimental work concentrated on three main factors that affect motor performance: the number of wire turns in the coil, magnet strength, and battery voltage levels. We systematically tested different combinations to find the best rotational speed and energy efficiency. The results showed interesting patterns - when we increased coil turns from 50 to 100, the motor's torque improved by roughly 20%. Using stronger magnets made the rotation much more stable and consistent. The motor worked most efficiently when powered by a 9-volt battery, where energy waste dropped to minimal levels. What makes this design particularly valuable is its simplicity - teachers can easily replicate it even in schools with limited resources, especially in Indian secondary education settings where budget constraints often limit hands-on learning opportunities. To verify our physical experiments, we ran computer simulations using finite element analysis. These digital models confirmed our real-world findings and revealed that optimized coil arrangements increased magnetic flux density by 15%. The close agreement between our experimental data and simulation results strengthens confidence in the design approach. This motor design offers teachers and students a practical, affordable way to explore electromagnetism and basic engineering principles. The project has broader implications for educational programs in developing regions, where cost-effective teaching tools can make advanced concepts accessible to more students. Schools can now demonstrate complex electromagnetic theory using materials that cost less than traditional laboratory equipment while achieving comparable learning outcomes.
Co-Authors Akanksha Singh, Akanksha Akhilesh Tiwari, Akhilesh Amit Dubey, Amit Amrendra Kumar, Amrendra Chandrul , Kaushal Kishore Divya Juyal, Divya Geeta Rawat, Geeta Gupta, Ananya Harrison, Liam Kaushal Kishore Chandrul, Kaushal Kishore Kumar, Arjun Kumari, Priya Mahendra Vikram Singh, Mahendra Vikram Patel, Ravi R. D. Gupta, R. D. Rawat, Geet Sharma, Priya Teotia, U. V. S U. V. S. Teotia, U. V. S. Vivek Kumar Sharma, Vivek Kumar