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All Journal Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) As-syifaa Jurnal Farmasi Window of Health : Jurnal Kesehatan ad-Dawaa : Journal of Pharmaceutical Sciences Pharmaceutical Reports Journal of Multimedia Trend and Technology JURNAL PENGABDIAN MASYARAKAT YAMASI MPSJ
Irma Santi, Irma
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Arts Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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Journal : ad-Dawaa : Journal of Pharmaceutical Sciences

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Antiobesity Effect of NADES (Natural Deep Eutectic Solvent) Extract of Purslane Herb (Portulaca oleracea L.) on Male Rats (Rattus norvegicus) Azizah, Rizqi Nur; Santi, Irma; Awali, Muhammad Noer; Putra, Bayu; , Faradiba
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 8 No.1 (2025)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v8i1.56230

Abstract

Introduction: Obesity is a metabolic disorder characterized by excessive fat accumulation, leading to various health complications. One potential approach to managing obesity is through natural products, such as medicinal plants. Aims: This study evaluates the anti-obesity activity of purslane (Portulaca oleracea L.) extract obtained using the green extraction method in male rats (Rattus norvegicus). Method: A total of 18 male rats were divided into six groups: normal control, negative control (Na-CMC + NADES), positive control (orlistat), and three treatment groups receiving NADES Purslane Herb Extract (NPHE) at doses of 50, 100, and 200 mg/kg BW. The treatment groups were induced with a high-fat diet for 30 days, followed by 14 days of therapy. Result: Statistical analysis using One-Way ANOVA and Bonferroni post-hoc test showed that NADES purslane herb extract exhibited significant anti-obesity effects, with the most effective dose being 200 mg/kg BW, which reduced body weight by 13.004% and BMI by 17.935% in male rats. Conclusion: These findings suggest that purslane extract has potential as a natural anti-obesity agent. Further research is needed to explore its bioactive compounds and mechanisms of action, supporting its potential development in pharmaceutical and nutraceutical applications.
Co-Authors , Faradiba Adawiyah, Rabiyah Al Al Ishak, Andi Afifatun Nisa Amriati Syarif, Rezky Amriati, Rezki Andi Emelda Arifin, Sukmawati Ashar, Muhammad Affan Aulia Wati, Aulia Aulya, Riska Awali, Muhammad Noer Bayu Putra, Bayu Dian Dwi Aninditia, Dian Dwi Dwi Lutfiyah, Evi Eka Wahyuningsih Hativa, Hativa Husain, Nurul Fadillah Intan, Tri Rahmaputri Nur Marlian, Ayu Mochammad Imron Awalludin Muarsih, Ahmad Juniardhy Multazania, Multazania Nurul Afiah Putrisari, Nur Awaliah Rachmat Kosman, Rachmat Rahmadani, Andi Syafirah Rahmawati Rais Razak, Rais Ramadhani, Fitrah Anggun Rizqi Nur Azizah sahab, Fitria St Maryam, St sukmawati Sukmawati Sukmawati