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All Journal Science and Technology Indonesia Jurnal Penelitian Pendidikan IPA (JPPIPA) ad-Dawaa : Journal of Pharmaceutical Sciences
Yusnita Rifai, Yusnita
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Physics

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Antioxidant Activity of Zerumbone and Its Pharmacological Prospects in Oxidative Stress Conditions: A Narrative Review Doloking, Haeria; Lallo, Subehan; Manggau, Marianti A; Rifai, Yusnita
Ad-Dawaa: Journal of Pharmaceutical Sciences Vol. 6 No. 2 (2023)
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v6i2.39968

Abstract

Introdiction: Oxidative stress is a condition caused by an imbalance between the level of oxidants in cells and tissues and the ability of the biological system to detoxify these reactive products. To compensate for the excess oxidant molecules, the human body requires the intake of antioxidant compounds through diet or medicinal plants to overcome the deficiency of these endogenous antioxidants. Zerumbone is the main bioactive compound of the Zingiber zerumbet L. Smith rhizome that was reported to have antioxidant activity and different pharmacological effects, like anti-inflammatory, anti-cancer, antidiabetic, immunomodulatory, anti-neurodegenerative disease, hepatoprotective, and gastroprotective. Aims: This review aims to gather available scientific research data regarding the antioxidant activity of zerumbone and its pharmacological prospects under conditions of oxidative stress. This paper is an overview of previous research on the various pharmacological activities of zerumbone and studies of its mechanism of action related to oxidative stress at the molecular level. The selected articles are related research reports for the 2010–2022 period, which can be accessed online through NCBI, Science Direct, MDPI, and Google Scholar. Result: The research results mentioned in this review paper can summarize knowledge to explain the pharmacological potential of zerumbone so that it can be used as a starting point or comparison in designing further research. Conclusion: The results of the reviews show that the various pharmacological prospects of zerumbone are related to oxidative stress conditions through various modes of action.
Validated Chromatography Method for Analysis of Formaldehyde Migration Levels in Bottled Drinking Water Ramadhani, Nur; Yulianty, Risfah; Rifai, Yusnita; Aswad, Muhammad; Alam, Gemini; Naid, Tadjuddin; Kasim, Athia Kurnia
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.660-668

Abstract

Polyethylene terephthalate (PET) is utilized in the containment of potable water, nonetheless, it is susceptible to impairment due to temperature and duration of storage. Migration of formaldehyde from PET arises as a consequence of thermal deterioration. This study aims to ascertain the extent of formaldehyde transference in PET-contained drinking water of varying condition, subjected to diverse temperature setting and storage durations. An examination into the levels of formaldehyde migration in polyethylene terephthalate (PET) bottled drinking water was effectively carried out employing a validated high-performance liquid chromatography (HPLC) technique. A total of 162 water samples from three different PET bottled water brands sourced from supermarkets in Palu City, Central Sulawesi, Indonesia, underwent analysis. The formaldehyde assessment was executed utilizing a mobile phase composition of methanol:acetonitrile:water (48:12:40 v/v) for 12.97 minutes at a flow rate of 0.8 mL/minute on the 1st day, the 14th day, and the 42nd day while stored at room temperature and exposed to sunlight. Formaldehyde, lacking effective chromophoric entities and not readily ionizable, necessitated derivatization with 2,4-dinitrophenylhydrazine before HPLC analysis. The findings of the study demonstrated exceptional method linearity within the concentration span of 0.5 to 1321 µg/mL, exhibiting a commendable correlation coefficient of 0.999. The limit of detection (LOD) and quantification (LOQ) were determined to be 17.33 and 57.76 µg/mL, correspondingly. Precision evaluations displayed average intraday and interday values of 128.46±3.48% and 103.19±0.12%, respectively (%RSD < 2/3 CV Horwitz ratio). The intraday and interday %recovery values were computed at 97.22±3.48% and 96.83±0.14% (n = 6). The scrutiny of formaldehyde concentrations in the water samples unveiled the absence of formaldehyde migration.
In Silico Evaluation of the Glioma Activity of Reported Compounds from the Extract Rhodomyrtus tomentosa (Aiton) Hassk.) Marwati, Marwati; Alam, Gemini; Yulianty, Risfah; Sami, Fitriyanti J.; Nur, Syamsu; Nursamsiar; Rifai, Yusnita
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10809

Abstract

The plant Rhodomyrtus tomentosa is empirically treated and can be developed in vitro as an anticancer. To see the interaction and evaluate the compound of Rhodomyrtus tomentosa as glioma inhibition, especially on Smoothened receptor by using the in silico. 44 compounds from Rhodomyrtus tomentosa leaf plants obtained from previous studies and native ligands and target proteins were generated through PubChem and RSCB protein database. In silico analysis was performed using various, absorption, distribution, toxicity prediction, and molecular tethering of compounds to smoothened (SMO) target proteins. Drug similarity showed that most of the compounds conformed to Lipinski's rule. The absorption and Distribution analysis of the compounds for each parameter gave different pharmacokinetic profiles according to the physicochemical properties of the compounds. Quercetin, β-sitosterol, and Quercetrin are prediction mutagenic, and Rhodomyrtoxin C and β-amyrenonol compounds are What follows is a prediction genotoxic carcinogenic. The results of docking analysis showed that the leaf compounds of Rhodomyrtus tomentosa leaf compounds that can interact with SMO receptors with the best interaction shown by compound 13 (Rhodomyrtoxin C) with a free bond energy of -9.29 kcal/mol, Quercitrin of-12.72 kcal/mol, 2-(4-hydroxyphenyl)acetic acid -14.24 kcal/mol and β-Sitosterol of -11,61 kcal/mol and has the same key amino acid residues as the native ligand LY2940680 (4-fluro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazine-1yl]piperidin-4-yl} 2 (trifluoromethyl) benzamide )namely Arg400, Asp473 and Glu518. His470, and Asn521. Specific compounds from Rhodomyrtus tomentosa are predicted to be developed as candidates for glioma inhibitors predicted to have the same mechanism of action as Smoothened inhibitors and further research is needed.
Co-Authors Doloking, Haeria Gemini Alam Kasim, Athia Kurnia Lallo, Subehan Marianti A Manggau Marwati - Muhammad Aswad Nursamsiar Ramadhani, Nur Risfah Yulianty Sami, Fitriyanti J. Syamsu Nur, Syamsu Tadjuddin Naid