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All Journal Majalah Obat Tradisional Science and Technology Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Unnes Journal of Public Health Health Information : Jurnal Penelitian Narra J Jurnal Kedokteran Hewan Jurnal Farmasi Indonesia

Risfah Yulianty

Bagian Klinik Hewan, Fakultas Kedokteran Hewan, Universitas Udayana, Bali

Author-ID : 424939

Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Veterinary

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Articles

SKRINING DAN ANALISIS KLT-BIOAUTOGRAFI SENYAWA ANTIMIKROBA BEBERAPA EKSTRAK SPONS ASAL PERAIRAN LAUT PULAU BARRANG LOMPO, SULAWESI SELATAN Yulianty, Risfah; Rante, Herlina; Alam, Gemini; Tahir, Akbar
Majalah Obat Tradisional Vol 16, No 2 (2011)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Spons merupakan salah satu invertebrata filum Porifera yang menghasilkan senyawa aktif dengan berbagai variasi struktur dan salah satu aktivitas biologinya adalah sebagai antimikroba. Penelitian ini bertujuan untuk mengetahui ekstrak spons yang dapat menghambat pertumbuhan mikroba dan potensi senyawa aktif antimikroba dari spons asal perairan Pulau Barrang Lompo. Mikroba uji yang digunakan adalah Escherichia coli, Salmonella typhii, Staphylococcus aureus, dan Candida albicans. Bahan uji diperoleh dengan maserasi 14 buah sampel spons dengan metanol yang dilanjutkan dengan partisi berturut-turut menggunakan kloroform dan metanol, selanjutnya dilakukan uji KLT-bioautografi terhadap ekstrak yang aktif. Hasil penelitian menunjukkan bahwa ekstrak metanol dari sampel spons dengan kode BRLP-009 dan BRLP-010 mempunyai aktivitas paling potensial sebagai antimikroba.

Effectiveness of Soursop Leaf Extract (Annona muricata l.) on IL-6 Levels in Mammary Sprague dawley Female Rats Induced by Staphylococcus aureus Purnamasari, Feby; Yulianty, Risfah; Latief, Syamsa
Unnes Journal of Public Health Articles in Press
Publisher : Universitas Negeri Semarang in cooperation with Association of Indonesian Public Health Experts (Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI))

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ujph.v0i0.30904

  Research this aiming for analyze effectiveness extract leaf soursop could take effect to IL-6 levels at mammae rat female Sprague Dawley induced Staphylococcus aureus. Research this use type research Experiment Moot or quasi-experimental design with the design of the Post-test Only Control Group Design by looking at the 3th and 6th day IL-6 levels after induction bacteria Staphylococcus aureus and giving treatment on mammae rat female Sprague Dawley. Taking sample blood done at eye rat 2 times with examination elisa kit. Data analyzed with use Hock and Post test followed by the Mann Whitney test . Research results to show that not there is difference IL-6 levels at group control (?=0,062 > ? =0,05) and group antibiotics (?=0,0514 > ? =0,05). On group leaf soursop (?=0.037 < ? =0,05) and group antibiotics + leaves soursop and on group control (?=0.030 < ? =0,05) to show there is difference levels IL-6. Value mean on group soursop 7.50 ± 1.74 pg/ml day to3, and 7.50 ± 1.74 1 pg/ml day 6. Value mean on group soursop + antibiotics 7.46 ± 26t.66 pg/ml Day 3, and 4.73 ± 1.36 pg/ml day 6. The implication of this study is that soursop leaf extract or combination of antibiotic + soursop leaf extract can be as a complementary therapy for mastitis caused by the bacteria Staphylococcus aureus. Keywords: Extract Leaf Soursop, Levels IL-6, Rat Sprague Dawley Females

Validated Chromatography Method for Analysis of Formaldehyde Migration Levels in Bottled Drinking Water Ramadhani, Nur; Yulianty, Risfah; Rifai, Yusnita; Aswad, Muhammad; Alam, Gemini; Naid, Tadjuddin; Kasim, Athia Kurnia
Science and Technology Indonesia Vol. 9 No. 3 (2024): July
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2024.9.3.660-668

Polyethylene terephthalate (PET) is utilized in the containment of potable water, nonetheless, it is susceptible to impairment due to temperature and duration of storage. Migration of formaldehyde from PET arises as a consequence of thermal deterioration. This study aims to ascertain the extent of formaldehyde transference in PET-contained drinking water of varying condition, subjected to diverse temperature setting and storage durations. An examination into the levels of formaldehyde migration in polyethylene terephthalate (PET) bottled drinking water was effectively carried out employing a validated high-performance liquid chromatography (HPLC) technique. A total of 162 water samples from three different PET bottled water brands sourced from supermarkets in Palu City, Central Sulawesi, Indonesia, underwent analysis. The formaldehyde assessment was executed utilizing a mobile phase composition of methanol:acetonitrile:water (48:12:40 v/v) for 12.97 minutes at a flow rate of 0.8 mL/minute on the 1st day, the 14th day, and the 42nd day while stored at room temperature and exposed to sunlight. Formaldehyde, lacking effective chromophoric entities and not readily ionizable, necessitated derivatization with 2,4-dinitrophenylhydrazine before HPLC analysis. The findings of the study demonstrated exceptional method linearity within the concentration span of 0.5 to 1321 µg/mL, exhibiting a commendable correlation coefficient of 0.999. The limit of detection (LOD) and quantification (LOQ) were determined to be 17.33 and 57.76 µg/mL, correspondingly. Precision evaluations displayed average intraday and interday values of 128.46±3.48% and 103.19±0.12%, respectively (%RSD < 2/3 CV Horwitz ratio). The intraday and interday %recovery values were computed at 97.22±3.48% and 96.83±0.14% (n = 6). The scrutiny of formaldehyde concentrations in the water samples unveiled the absence of formaldehyde migration.

Efektivitas Biskuit Beras Merah (Oryza nivara) dan Kedelai (Glycine max L) terhadap Kadar Hemoglobin Remaja Putri Anemia Dewiyana, Srigita; Hafsah, Amir Mahmud; Arsyad, Aryadi; Yulianty, Risfah; Ahmad, Mardiana; Usman, Andi Nilawati
Health Information : Jurnal Penelitian Content Digitized
Publisher : Poltekkes Kemenkes Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Latar Belakang: Anemia merupakan masalah kesehatan di seluruh dunia terutama di negara berkembang. Remaja merupakan kelompok yang rentan terhadap anemia karena dalam masa pertumbuhan dan perkembangan. Pemerintah melakukan upaya suplementasi tablet tambah darah selain itu pemanfaatan pangan lokal yang kaya akan zat besi. Tujuan: Penelitian ini bertujuan untuk mengetahui efektivitas biskuit beras merah dan kedelai terhadap kadar hemoglobin remaja putri anemia. Metode: Jenis penelitian quasi experiment (nonequivalent control group design). Penelitian ini dilakukan selama 30 hari dengan sampel sebanyak 36 sampel. Sampel dibagi menjadi 4 kelompok yaitu Kelompok Beras Merah (6 orang), Kedelai (6 orang), Beras Merah dan Kedelai (6 orang) dan Kontrol (18 orang). Instrumen yang digunakan Hematologi Analyzer. Analisis yang digunakan One Way Anova dan Post Hoc Test. Hasil: Hasil analisis menunjukkan bahwa rata-rata kadar hemoglobin kelompok Beras Merah, Kedelai, Beras Merah dan Kedelai, Kontrol sebelum intervensi adalah 11,40 g/dl, 10,85 g/dl, 10,68 g/dl, 11,34 g/dl dengan nilai p=0,037. Setelah dilakukan intervensi didapatkan rata-rata kadar hemoglobin kelompok Beras Merah, Kedelai, Beras Merah dan Kedelai, Kontrol yaitu 11,90 g/dl, 12,51 g/dl, 11,95 g/dl, 11,72 g/dl dengan nilai p=0,001. Rata-rata selisih kadar hemoglobin adalah 0,5 g/dl, 1,66 g/dl, 1,27 g/dl, 0,38 g/dl dengan nilai p=0,001. Dapat disimpulkan, pemberian biskuit beras merah (Oryza Nivara) dan Kedelai (Glycine Max L) efektif meningkatkan kadar hemoglobin remaja putri.

Chemical fingerprinting and antioxidant properties of Glochidion philippicum Khairuddin, Khairuddin; Manggau, Marianti A.; Rante, Herlina; Hardiyanti, Widya; Latada, Nadila P.; Umar, Abdul H.; Nur, Syamsu; Wahyudin, Elly; Rahman, Latifah; Yulianty, Risfah; Nainu, Firzan
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1886

Glochidion philippicum has been suggested to exhibit considerable pharmacological potential, yet its chemical composition and bioactivity remain inadequately explored. The aim of this study was to investigate the chemical fingerprint and antioxidant properties of G. philippicum leaf extracts using Fourier-transform infrared spectroscopy (FTIR) with chemometric analyses, and in vitro and in vivo evaluations. Four extraction methods (maceration, reflux, ultrasound-assisted extraction (UAE), and microwave-assisted extraction (MAE)) were optimized with water, 70% ethanol, ethyl acetate, and n-hexane as solvents. FTIR profiles were analyzed with principal component analysis (PCA), hierarchical cluster analysis, and orthogonal partial least squares discriminant analysis. An in vitro study assessing the free radical scavenging capacity was conducted using the 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric-reducing antioxidant power (FRAP) methods, while in vivo evaluations were conducted using Drosophila melanogaster to measure antioxidant enzyme activity and expression of endogenous antioxidant-related genes. FTIR profiles identified functional groups contributing to antioxidant activity. In vitro assays using ABTS and FRAP methods revealed that extracts obtained with 70% ethanol and water exhibited the highest antioxidant activity, attributed to key functional groups such as C=C (aromatic), O−H (acidic), N=O (nitro), and C−O (ester). In vivo studies showed that ethanol-based MAE extracts (MAEEO) significantly improved the survival of autoinflammatory PGRP-LBΔ mutant larvae exposed to heat-killed Escherichia coli. Real-time quantitative PCR analysis indicated this effect was dependent on endogenous antioxidant gene activation. The study highlights that G. philippicum leaf extracts as a natural source of bioactive compounds with exogenous antioxidant properties, offering potential for therapeutic applications.

Eksplorasi efek etanol terhadap survival dan status imunitas Drosophila melanogaster Rosa, Reski Amalia; Latada, Nadila Pratiwi; Asbah, Asbah; Mu'arif, Ahmad; Yulianty, Risfah; Nainu, Firzan
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 13 No. 2 (2021): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

: High doses of ethanol in the body can elicit damage to organs including the brain, liver and kidneys. In addition, ethanol can trigger the formation of reactive oxygen species (ROS), where excess levels of ROS in the body can promote cell death through the apoptotic pathway. Apoptotic cells that are not phagocytosed will undergo necrosis. In the process of necrosis, cells release DAMPs, endogenous pro-inflammatory molecules and induce the core immune system in Drosophila that are homologues to humans, namely Toll, IMD (Immune Deficiency), and JAK-STAT (Janus Tyrosine Kinase-Signal Transducer and Activator of Transcription). The aim of this research is to investigate how ethanol exposure influences gene expression in the Toll, Imd, and JAK-STAT pathways. The results showed that ethanol could affect the survival rate of male and female Drosophila melanogaster w1118. Exposure to ethanol at high concentrations (85%) caused a decrease in the expression of Drs, but not the expression of the Dpt. In addition, TotA expression, but not Upd3, was amplified significantly as the ethanol concentration increased. In conclusion, Drosophila experienced a decrease in the survival rate due to ethanol exposure which might be related to the stress response and the immune system which is mediated by certain pathways.

Modifikasi Serat Limbah Kubis Menjadi Nanokristalin Selulosa Melalui Metode Hidrolisis Asam: Waste Cabbage Fibers Modification Into Nano-Crystalline Cellulose Via Acid Hydrolysis Method Arjuna, Andi; Natsir, Selva; Khumaerah, Andi Amelia; Yulianty, Risfah
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 4 No. 2 (2018): (October 2018)
Publisher : Universitas Tadulako

As one of vegetable plants in South Sulawesi, cabbage (Brassica oleracea L.) crops has generated cellulose fibers biomass which is potentially modified into nano-crystalline cellulose, a valuable material in the pharmaceutical formula. Therefore, this study aims to manipulate the natural cellulose fibers of cabbage biomass through acid hydrolysis method within product preliminary evaluation through FT-IR and XRD. The fibers were modified through the bleaching process produce micro crystalline cellulose, which was then hydrolyzed with 65% sulfuric acid to obtain nanocrystalline cellulose. The products have yellow pale to brown colour, with a yield of 10.06% and 31.16% respectively. Based on FT-IR spectra, both products inherit cellulose characteristics, C-O (1232.16 cm-1); C = O (1743.65 cm-1); -OH (1625.99 cm-1); C-H (2920.23 cm-1); O-H (3414 cm-1). The increasing trend of crystallinity index during the process was also observed in XRD diffractogram. It is identifiable from 7.41% for natural fiber, 69.68% for crystalline microcrystalline, and 78.01% for nano crystalline cellulose. Through MatchÂ®, the estimated crystalline product size reaches 58.91 nm.

In Silico Evaluation of the Glioma Activity of Reported Compounds from the Extract Rhodomyrtus tomentosa (Aiton) Hassk.) Marwati, Marwati; Alam, Gemini; Yulianty, Risfah; Sami, Fitriyanti J.; Nur, Syamsu; Nursamsiar; Rifai, Yusnita
Jurnal Penelitian Pendidikan IPA Vol 11 No 6 (2025): June
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i6.10809

The plant Rhodomyrtus tomentosa is empirically treated and can be developed in vitro as an anticancer. To see the interaction and evaluate the compound of Rhodomyrtus tomentosa as glioma inhibition, especially on Smoothened receptor by using the in silico. 44 compounds from Rhodomyrtus tomentosa leaf plants obtained from previous studies and native ligands and target proteins were generated through PubChem and RSCB protein database. In silico analysis was performed using various, absorption, distribution, toxicity prediction, and molecular tethering of compounds to smoothened (SMO) target proteins. Drug similarity showed that most of the compounds conformed to Lipinski's rule. The absorption and Distribution analysis of the compounds for each parameter gave different pharmacokinetic profiles according to the physicochemical properties of the compounds. Quercetin, β-sitosterol, and Quercetrin are prediction mutagenic, and Rhodomyrtoxin C and β-amyrenonol compounds are What follows is a prediction genotoxic carcinogenic. The results of docking analysis showed that the leaf compounds of Rhodomyrtus tomentosa leaf compounds that can interact with SMO receptors with the best interaction shown by compound 13 (Rhodomyrtoxin C) with a free bond energy of -9.29 kcal/mol, Quercitrin of-12.72 kcal/mol, 2-(4-hydroxyphenyl)acetic acid -14.24 kcal/mol and β-Sitosterol of -11,61 kcal/mol and has the same key amino acid residues as the native ligand LY2940680 (4-fluro-N-methyl-N-{1-[4-(1-methyl-1H-pyrazol-5-yl)phthalazine-1yl]piperidin-4-yl} 2 (trifluoromethyl) benzamide )namely Arg400, Asp473 and Glu518. His470, and Asn521. Specific compounds from Rhodomyrtus tomentosa are predicted to be developed as candidates for glioma inhibitors predicted to have the same mechanism of action as Smoothened inhibitors and further research is needed.

EFEKTIVITAS PENTAGAMAVUNON-0 TERHADAP PENGHAMBATAN EKSPRESI SIKLOOKSIGENASE-2 PADA MODEL KANKER KOLON TIKUS Yulianty, Risfah; Hakim, Lukman; S, Sardjiman; Alam, Gemini; Nufika, Riska; Widyarini, Sitarina
Jurnal Kedokteran Hewan Vol 6, No 2 (2012): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v6i2.344

Penelitian ini bertujuan menentukan efektivitas pentagamavunon-0 (PGV-0) terhadap penghambatan ekspresi siklooksigenase-2 (COX-2) pada kanker kolon tikus Wistar. Pada penelitian ini digunakan 20 ekor tikus Wistar jantan yang dibagi secara acak dalam 4 kelompok perlakuan. Kelompok I merupakan kontrol negatif, kelompok II kontrol positif, kelompok III diberi PGV-0 40 mg/kg BB selama 15 minggu, dan kelompok IV diberi PGV-0 40 mg/kg BB selama 25 minggu. Pemberian PGV-0 dilakukan secara oral dua kali seminggu. Induksi kanker kolon dilakukan dengan cara injeksi subkutan DMH 60 mg/kg BB, satu kali seminggu selama 15 minggu. Pada minggu ke-26, semua hewan coba dieutanasia, kolon difiksasi dalam formalin 10% untuk selanjutnya diamati perubahan makroskopik dan mikroskopik. Penilaian ekspresi COX-2 dilakukan dengan menggunakan metode Dukes stage dan skor imunoreaktivitas (IRS). Hasil penelitian ini memperlihatkan pemberian PGV-0 selama 25 minggu menurunkan jumlah nodul kanker kolon dari 5 ke 2 (berkurang 60%); diameter kanker kolon (pxl) dari 0,712 mm ke 0,0043 mm (berkurang 99,31%). Pemberian PGV-0 selama 15 minggu hanya menurunkan jumlah nodul 10% dan area kanker kolon dari 0,712 mm ke 0,0062 mm (99,07%). Skor imunoreaktivitas COX-2 diekspresikan oleh kelompok III dan IV adalah 4 dan 5. Gambaran histologis dari kolon mendukung hasil di atas. Pemberian PGV-0 efektif menurunkan jumlah dan area nodul kanker kolon melalui penghambatan ekspresi COX-2.

Co-Authors Ahmad, Mardiana Akbar Tahir, Akbar Andi Nilawati Usman Arjuna, Andi Arsyad, Muhammad Aryadi Asbah, Asbah Dewiyana, Srigita Elly Wahyudin Firzan Nainu Gemini Alam Hafsah, Amir Mahmud Hardiyanti, Widya Herlina Rante Kasim, Athia Kurnia Khairuddin - Khumaerah, Andi Amelia Latada, Nadila P. Latada, Nadila Pratiwi Latief, Syamsa Latifah Rahman Lukman Hakim Marianti A Manggau Marwati Marwati Mu'arif, Ahmad Muhammad Aswad Natsir, Selva Nursamsiar Purnamasari, Feby Ramadhani, Nur Riska Nufika Rosa, Reski Amalia Sami, Fitriyanti J. Sardjiman S Sitarina Widyarini Syamsu Nur, Syamsu Tadjuddin Naid Umar, Abdul H. Yusnita Rifai, Yusnita

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