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All Journal JURNAL PHARMASCIENCE Pharmascience SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Pendidikan Hayati Bioscientiae, Jurnal ilmu ilmu Biologi
Budi Prayitno
Universitas Balikpapan
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Pharmascience

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Penentuan Kadar Flavonoid Total dan Aktivitas Antioksidan Ekstrak Etanol Daun Kajajahi (Leucosyke capitellata Wedd.) Irvan Ipand; Liling Triyasmono; Budi Prayitno
Jurnal Pharmascience Vol 3, No 1 (2016): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5839

Abstract

ABSTRAK  Tumbuhan kajajahi (Leucosyke capitellata Wedd.) merupakan tumbuhan yang berkhasiat sebagai obat tradisional seperti penurun panas dan anti diare. Tumbuhan kajajahi telah diketahui mengandung senyawa flavonoid dengan sifat sebagai penangkal radikal bebas. Penelitian ini bertujuan untuk menentukan kadar flavonoid total dan aktivitas antioksidan dari ekstrak etanol daun kajajahi. Penelitian ini bersifat eksperimental. Sampel yang digunakan adalah daun kajajahi yang berasal dari desa Hulu Banyu Kecamatan Loksado Kabupaten Hulu sungai Selatan. Penentuan kadar flavonoid total dilakukan secara spektrofotometri didasarkan pada kemampuan flavonoid membentuk kompleks dengan AlCl3 sedangkan Aktivitas antioksidan ditentukan menggunakan metode DPPH (2,2-difenil-1-pikrilhidrazil). Hasil penelitian diperoleh kadar flavonoid total ekstrak etanol daun kajajahi sebesar 6,14 ± 0,193 mg/g kuersetin dan aktivitas antioksidan sebesar  IC50  455,570 ppm. Sehingga dapat digolongkan sebagai antioksidan lemah.Kata kunci : Leucosyke capitellata Wedd, Antioksidan, DPPH,Flavonoid Total ABSTRACT Kajajahi Plant (Leucosyke capitellata Wedd.) a potent plant that may act as a traditional medicine such as antifever and anti-diarrhea. Kajajahi plant known contain flavonoid compounds that have properties as free-radical scavengers. The Purpose of this study was to determine the total flavonoid content and antioxidant activity of kajajahi leaves ethanol extract. The design of this research is experimental. The sample were kajajahi leaves from Hulu Banyu, Loksado, Hulu sungai Selatan.  The determination of total flavonoids done by spectrophotometry based on the ability of flavonoids to form complexes with AlCl3 while The antioxidant activity determined using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method. Results of this study showed the total flavonoid content of kajajahi leaves ethanol extract was 6.14  ± 0,193 mg/g of  quercetin and antioxidant of IC50 455.570 ppm. Which, may be classified as weak antioxidant. Keywords: Leucosyke capitellata Wedd, Antioxidant, DPPH, Total Flavonoids
Uji Antioksidan Senyawa Terpenoid Dari Fraksi M-17 Ekstrak Metilena Klorida Kulit Batang Tumbuhan Kasturi (Mangifera casturi) Budi Prayitno; Kholifatu Rosyidah; Maria Dewi Astuti
Jurnal Pharmascience Vol 3, No 1 (2016): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v3i1.5832

Abstract

 ABSTRAK  Penelitian tentang isolasi senyawa dari ekstrak metilen klorida telah dilakukan. Hasil analisis diduga senyawa tersebut adalah senyawa (23-E)-27-nor-3β-hidroksisikloart-23-en-25-on. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antioksidan terhadap radikal DPPH. Uji aktivitas antioksidan dilakukan dengan metode DPPH (1,1-difenil-2-pikril hidrazil). Vitamin C digunakan sebagai kontrol positif. Senyawa 1 memiliki nilai IC50 sebesar 6.751 ppm dan IC50 vitamin C sebesar 2,98 ppm, sehingga senyawa ini tidak aktif antioksidan.  Kata kunci: Mangifera  casturi., antioksidan, triterpenoid  ABSTRACT Research on the isolation of compounds from the fraction of M 17 of methylene chloride extract has been done. The suspected compound is (23-E)-27-nor-3β-hydroxycycloart-23-ene-25-one. The aims of this study were to determine the antioxidant activity against DPPH radical fraction isolates extracts of plants kasturi to DPPH. The antioxidant activity assay was conducted by DPPH (1,1-diphenyl-2-picryl hydrazyl) method, vitamin C using as a positive control. Compound 1 has an IC50 value of 6.751 ppm while the value of IC50 for vitamin C was 2,98 ppm, so the compound is not an active antioxidant compounds.  Key words: Mangifera casturi, Antioxidant, triterpenoid 
Co-Authors Bayu Hari Mukti Dede Mahdiyah Djalu Sakti Agiyaka Erlya Yunita Larasati Fina Ainil Martia Firly Eryun Desita Safitri Irvan Ipand Irvan Ipandi, Irvan Janlemi Prahara Pamungkas Kholifatu Rosyidah Liling Triyasmono Maria Dewi Astuti Muhammad Abdul Azis Musyarofah Musyarofah Rini Helvi Novita Sari Rizky Ramadhani Sastrawan, Febrian Dedi Syarifah Husnul Khatimah