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All Journal Jurnal Biotek Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Kolaboratif Sains Jurnal Pijar MIPA Jurnal Ilmu Kesehatan dan Farmasi Jurnal Ilmiah Pengabdian dan Inovasi Jurnal Pengabdian kepada Masyarakat IPTEKS
Novitarini
Universitas Bumigora
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Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review Novitarini; Jason Merari P.; Dian Marlina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.591

Abstract

Antibiotic resistance This causes the performance of synthetic antibiotics to decrease, so it is necessary to search for natural antibiotics. Moringa plant (Moringa oleifera Lam.) has antibacterial activity proven to inhibit and kill pathogenic bacteria and Multi-Drug Resistance (MDR)article review aims to collect data related to testing the antibacterial activity of Moringa plants as an effort to overcome antibiotic resistance. The method follows the PRISMA-2020 protocol by searching data on PubMed and ScienceDirect media using the keywords: "Antibacterial activity" and "Moringa oleifera". The data selection uses the Rayyan application by considering the inclusion and exclusion criteria that have been set. The final results obtained are 95 data which are experimental journals of the Randomized Control Trial (RCT) type published in 1981-2021. Moringa plants began to be investigated for their activity against MDR bacteria in 2012 and became a sign that research was already in the direction of finding solutions. Antibacterial testing was carried out in vitro (10 studies) and in vivo (1 study). The leaves have been thoroughly tested for their activity against Methicillin-Resistant Staphylococcus aureus (MRSA). The results of in vitro study obtained the range of zone of inhibition, minimum inhibitory concentration, and minimum kill concentration, respectively: 8.3-12 mm; 0.25-20 mg/ml; 0.50-20 mg/ml study in vivo showed that there was the healing of MRSA infection wounds in test animals.
Aktivitas Antibakteri Ekstrak Daun Kelor (Moringa oleifera Lam.) terhadap Staphylococcus epidermidis Penyebab Jerawat: Antibacterial Activites Cream Extracts of Kelor Leaves (Moringa oleifera Lam.) against Staphyloccus Epidermidis Cause of Acne Novitarini; Muhammad Eka Putra Ramandha; Baiq Yulia Hasni Pratiwi
Jurnal Kolaboratif Sains Vol. 7 No. 5: MEI 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i5.5075

Abstract

Prevalensi jerawat dalam masa remaja dan resistensi antibiotik yang tinggi mendorong eksplorasi alternatif antibiotik berbasis herbal. Daun kelor (Moringa oleifera Lam.) merupakan tanaman yang memiliki aktivitas antibakteri karena mengandung senyawa flavonoid, alkaloid, tanin, dan saponin yang dapat dijadikan sebagai antibiotik berbasis herbal. Penelitian ini bertujuan untuk menguji aktivitas antibakteri dari ekstrak daun kelor (5, 10, dan 15%) terhadap Staphylococcus epidermidis penyebab jerawat. Pengujian ini menggunakan metode difusi sumuran untuk melihat aktivitas antibakteri (zona hambat) dari ekstrak daun kelor berbagai konsentrasi terhadap Staphylococcus epidermidis. Data dianalisis menggunakan One Way ANOVA dengan program SPSS. Hasil yang diperoleh berupa diameter zona hambat ekstrak etanol daun kelor konsentrasi 5, 10, 15% yaitu: 23,01 mm, 23,34 mm dan 23,68 mm. Pengujian ini mempunyai nilai Sig = 0,000 yang berarti rata rata antar kelompok terdapat perbedaan yang signifikan. Dapat disimpulkan bahwa zona hambat ekstrak daun kelor tergolong mempunyai daya hambat kuat terhadap Staphylococcus epidermidis.
Ekstraksi Etanol Daun Inggu (Ruta Angustifolia [L.] Pers) sebagai Analgesik dan Antiinflamasi dengan Metode Tail Flick dan Induksi Karagenan: Ethanol Extraction of Inggu Leaves (Ruta Angustifolia [L.] Pers) as an Analgesic and Anti-Inflammatory Method using the Tail Flick Method and Carrageenan Induction Busyairi, Lalu; Mia Ariasti; Novitarini
Jurnal Kolaboratif Sains Vol. 7 No. 6: Juni 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i6.5394

Abstract

Inflamasi atau radang didefinisikan sebagai respon lokal jaringan mamalia yang mengalami luka akibat agen merugikan seperti bakteri, virus, trauma mekanik, keracunan organik, anorganik serta benda asing lainnya. Tanda peradangan meliputi kemerahan, nyeri serta kehilangan fungsi. Sedangkan nyeri merupakan suatu gejala penyakit yang timbul karena disebabkan oleh rangsangan mekanis, termal, kimia, atau listrik yang dapat menyebabkan kerusakan pada jaringan dengan pembebasan mediator nyeri seperti bradikinin dan prostaglandin, kemudian prostaglandin tersebut menimbulkan hiperalgesia, sehingga mediator nyeri seperti bradikinin dan histamin menimbulkan rasa nyeri. Daun dan batang inggu mengandung minyak atsiri yang terdiri dari metil nonilketon mencapai 90%, pinen. Dari hasil uji kualitatif skrining fitokimia daun inggu (Ruta angustifolia) terdapat kandungan senyawa kimia yaitu flavonoid, steroid, alkaloid, saponin, tanin, kuinon dan triterpenoid. Uji efek antiinflamasi dilakukan dengan metode edema kaki tikus dengan menginduksikan ?-karagenan 0,8 % sebanyak 0,2 ml. Metode induksi karagenan ini merupakan salah satu metode pengujian aktivitas antiinflamasi. daya aktivitas analgesik pada sediaan uji ditunjukkan dengan persentase hambatan nyeri yang diberikan lebih besar atau sama dengan 50% dari kelompok kontrol negatif, maka dianggap efektif sebagai analgesik. Hasil uji statistik menunjukkan persentase hambatan nyeri terdistribusi normal dengan nilai signifikan 0,651(>0,05) dan homogen dengan nilai signifikan 0,152(>0,05) Hasil uji statistik menunjukkan bahwa ekstrak etanol daun inggu dosis 10 mg dan 20 mg / 200 g BB berbeda bermakna dengan kontrol negatif CMC Na, sehingga membuktikan bahwa pada ekstrak daun inggu mempunyai efek sebagai analgesik
Perbandingan Kecepatan Disolusi Intrinsik (Absorpsi) Tablet Asetosal Menggunakan Pelarut Etanol 95% dengan Pelarut Kloroform Mia Ariasti; Lalu Busyairi Muhsin; Novitarini Novitarini
JIKF Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan dan Farmasi
Publisher : Fakultas Ilmu Kesehatan Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51673/jikf.v12i1.2246

Abstract

Disolusi didefinisikan sebagai proses dimana suatu zat padat masuk ke dalam pelarut menghasilkan suatu larutan secara sederhana. Penelitian ini ertujuan untuk mengetahui kecepatan instrisik suatu sedeiaan tablet. Kecepatan intrisik berpengaruh pada absorpsi tubuh pada tablet obat.Disolusi merupakan proses dimana zat padat melarut secara prinsip dikendalikan oleh afinitas antara zat padat dan pelarut. Karakteristik fisik sediaan, proses pembasahan sediaan kemampuan penetrasi media disolusi ke dalam sediaan, proses pengembangan, proses integrasi dan degadrasi. Sediaan merupakan sebagian dari faktor yang mempengaruhi karakteristik disolusi obat dari sediaan. Uji Disolusi yaitu melakukan rekristalisas asetosal dengan pelarut etanol 95% dan chloroformMencetak hasil rekristalisasi menjadi tablet A (Hasil rekristalisasi dengan pelarut chloroform) dan tablet B (hasil rekristalisasi dengan pelarut etanol 95%).. Sampel ditentukan kadarnya dengan spektrofotometer pada λ= 265 nm dengan blangko dapar asetat. (replikasi 3 kali). Pembuatan kurva baku asetosal dimulai dengan menimbang dengan seksama 140 mg asetosal, melarutkan asetosal dengan alkohol 95% beberapa tetes dalam labu takar 50 ml, menambahkan dapar asetat ada tanda batas (larutan stok). Tablet A 0,319mg/menit.mm, Tablet B 0,182 mg/menit.mm. Terdapat perbedaan antara tablet A dan tablet B pada nilai DE dan kecepatan disolusinya. Dilihat dari efisiensi disolusinya, tablet asetosal dengan pelarut kloroform memiliki nilai DE yang lebih besar daripada tablet asetosal dengan pelarut etanol 95%.
Ekstrak Buah Lerak (Sapindus rarak) sebagai Sabun Antibakteri yang Ramah Lingkungan Novitarini, Novitarini; Kresnapati, I Nyoman Bagus Aji; Akmi, Alfarizi Muzaifa
Jurnal Biotek Vol 12 No 2 (2024): DESEMBER
Publisher : Department of Biology Education of Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jb.v12i2.51245

Abstract

Synthetic surfactants contribute to environmental pollution and can cause skin irritation, highlighting the need for natural biosurfactants. Lerak fruit (Sapindus rarak) shows promise as a biosurfactant due to its 28% saponin content and potential antibacterial activity. This study aimed to evaluate the antibacterial activity of lerak fruit extract using three parameters: inhibition zone, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) against Staphylococcus aureus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative). The research utilized a Posttest Only Control Group Design to test the antibacterial activity of lerak fruit extract against skin-surface normal flora, specifically Staphylococcus aureus and Pseudomonas aeruginosa. All antibacterial activity results were analyzed using One-Way ANOVA in SPSS IBM version 22. The study found the MIC to be 6.25% for Gram-positive bacteria and 1.56% for Gram-negative bacteria. The MBC was determined to be 25% for Gram-positive bacteria and 50% for Gram-negative bacteria. At a 50% concentration, the inhibition zones against Gram-positive and Gram-negative bacteria were 21.53 mm and 22.13 mm, respectively. These results demonstrate that lerak fruit extract possesses strong antibacterial activity against both Gram-positive and Gram-negative bacteria. This research provides a foundation for developing environmentally friendly antibacterial soap formulations using lerak fruit extract.
Penyuluhan Pentingnya Cuci Tangan Yang Baik dan Benar Dalam Upaya Pencegahan Infeksi Cacing di SDN 15 Cakranegara Mia Ariasti; Lalu Busyairi Muhsin; Salsabila Yunita Kurniawan; Sri Winarni Sofya; Ayudia Cipta khaerani; Novitarini
Jurnal Pengabdian kepada Masyarakat IPTEKS Vol. 2 No. 1 (2024)
Publisher : Rajawali Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Abstract: Worm infestation is a parasitic infection that can affect the health, nutrition, intelligence and productivity of patients, especially in primary school-aged children. The disease often occurs due to unsanitary lifestyles and poor sanitation, with a high prevalence in Indonesia, especially in West Nusa Tenggara Province. Children aged 5-14 years, especially in areas with low economic levels, are particularly vulnerable to worms due to a lack of knowledge about clean and healthy living behaviors (PHBS). One solution that can be implemented is to provide counseling to children on how to wash their hands properly to prevent worm infections. This counseling activity was conducted at SDN 15 Cakranegara using a participatory approach, in collaboration with the school and local community. The results of this activity show that counseling can increase children's understanding of the importance of washing hands with soap and running water, which is expected to prevent the spread of worm infections and other related diseases. The success of this counseling is an important step in efforts to increase health awareness among children and communities.
Anthelmintic Potential of Annona muricata Leaf Extract against Parasitic Nematode Haemonchus contortus Pratiwi, Baiq Yulia Hasni; Novitarini, Novitarini
Jurnal Pijar Mipa Vol. 20 No. 1 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i1.8220

Abstract

Gastrointestinal infections caused by the parasitic worm Haemoncus contortus are the main cause of economic losses in the agricultural sector. H. contortus causes small ruminants such as goats to experience acute anemia and diarrhea, weight loss, decreased productivity, and eventually mortality, which impacts economic losses. Synthetic antiparasitics have been used extensively around the world to combat haemonchosis. However, the emergence of resistance to anthelmintics, accompanied by the unavailability of an effective vaccine, results in difficulties in controlling this disease. Because of the high cost of treatment and the emergence of resistance and toxicity due to the residue of antiparasitic drugs, it is necessary to develop natural anthelmintics that are easy to obtain, economical, and have minimal risk. This study aims to determine the anthelmintic effect of Annona muricata leaf extract on mice infected with H. contortus larvae. First, an in vitro study was conducted to see if the soursop leaf extract from Lombok would show a different effect from the previous research. In the in vivo test, the impact of A. muricata leaf extract was measured from the number of H. contortus eggs found in the feces and the percent reduction of adult worms collected from mice's stomachs. The result shows that the higher the concentration of soursop leaf extract, the higher the inhibition effect on larvae motility. The combination of A. muricata and albendazole had the strongest antiparasitic effect, shown by the lowest amount of eggs in feces and the highest reduction of adult worms in the stomach. However, administering A. muricata leaf extract can also reduce the number of eggs and adult worms in the stomach. Therefore, it can be concluded that A. muricata is a potential anthelmintic candidate for overcoming the H. contortus infection.
Edukasi Pemanfaatan Bahan Alam sebagai Asi Booster pada Ibu Hamil dan Menyusui Novitarini; Muhammad Eka Putra Ramandha; Baiq Yulia Hasni Pratiwi; Lalu Busyairi Muhsin; Mia Ariasti; Sri Winarni Sofya
Jurnal Ilmiah Pengabdian dan Inovasi Vol. 2 No. 4 (2024): Jurnal Ilmiah Pengabdian dan Inovasi (Juni)
Publisher : Insan Kreasi Media

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57248/jilpi.v2i4.399

Abstract

Low levels of exclusive breastfeeding will increase the risk of stunting and susceptibility to disease in the future. One of the reasons for this low supply is that breast milk production is not smooth, so it is necessary to facilitate the production of breast milk from natural ingredients. This service aims to educate about using natural ingredients to enable breast milk for pregnant and breastfeeding mothers. This service method has 4 stages: namely approach, preparation, delivery of material, and discussion. The results of the service showed that the village community understood the natural ingredients that could be used to facilitate breast milk, namely katuk leaves, turi, spinach and banana blossoms. Apart from that, in the service, proper processing is demonstrated so that the content is not lost or reduced. The conclusion of this service is that the community of Preparation Reban Madani village will utilize natural ingredients with proper processing to facilitate breast milk so that they can carry out exclusive breastfeeding. The implication of community service is that village knows how to process local plants to facilitate breast milk.
Co-Authors Akmi, Alfarizi Muzaifa Ayudia Cipta Khairani Baiq Yulia Hasni Pratiwi Busyairi, Lalu Jason Merari Peranginangin Kresnapati, I Nyoman Bagus Aji Marlina, Dian Mia Ariasti Muhammad Eka Putra Ramandha Muhsin, Lalu Busyairi Salsabila Yunita Kurniawan Sri Winarni Sofya