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Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review Novitarini; Jason Merari P.; Dian Marlina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.591

Antibiotic resistance This causes the performance of synthetic antibiotics to decrease, so it is necessary to search for natural antibiotics. Moringa plant (Moringa oleifera Lam.) has antibacterial activity proven to inhibit and kill pathogenic bacteria and Multi-Drug Resistance (MDR)article review aims to collect data related to testing the antibacterial activity of Moringa plants as an effort to overcome antibiotic resistance. The method follows the PRISMA-2020 protocol by searching data on PubMed and ScienceDirect media using the keywords: "Antibacterial activity" and "Moringa oleifera". The data selection uses the Rayyan application by considering the inclusion and exclusion criteria that have been set. The final results obtained are 95 data which are experimental journals of the Randomized Control Trial (RCT) type published in 1981-2021. Moringa plants began to be investigated for their activity against MDR bacteria in 2012 and became a sign that research was already in the direction of finding solutions. Antibacterial testing was carried out in vitro (10 studies) and in vivo (1 study). The leaves have been thoroughly tested for their activity against Methicillin-Resistant Staphylococcus aureus (MRSA). The results of in vitro study obtained the range of zone of inhibition, minimum inhibitory concentration, and minimum kill concentration, respectively: 8.3-12 mm; 0.25-20 mg/ml; 0.50-20 mg/ml study in vivo showed that there was the healing of MRSA infection wounds in test animals.

Antibacterial Activity of Moringa Plants (Moringa oleifera Lam.) to Overcome Antibiotic Resistance: A Systematic Review Novitarini; Jason Merari P.; Dian Marlina
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 10 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i10.591

Antibiotic resistance This causes the performance of synthetic antibiotics to decrease, so it is necessary to search for natural antibiotics. Moringa plant (Moringa oleifera Lam.) has antibacterial activity proven to inhibit and kill pathogenic bacteria and Multi-Drug Resistance (MDR)article review aims to collect data related to testing the antibacterial activity of Moringa plants as an effort to overcome antibiotic resistance. The method follows the PRISMA-2020 protocol by searching data on PubMed and ScienceDirect media using the keywords: "Antibacterial activity" and "Moringa oleifera". The data selection uses the Rayyan application by considering the inclusion and exclusion criteria that have been set. The final results obtained are 95 data which are experimental journals of the Randomized Control Trial (RCT) type published in 1981-2021. Moringa plants began to be investigated for their activity against MDR bacteria in 2012 and became a sign that research was already in the direction of finding solutions. Antibacterial testing was carried out in vitro (10 studies) and in vivo (1 study). The leaves have been thoroughly tested for their activity against Methicillin-Resistant Staphylococcus aureus (MRSA). The results of in vitro study obtained the range of zone of inhibition, minimum inhibitory concentration, and minimum kill concentration, respectively: 8.3-12 mm; 0.25-20 mg/ml; 0.50-20 mg/ml study in vivo showed that there was the healing of MRSA infection wounds in test animals.

Ekstraksi Etanol Daun Inggu (Ruta Angustifolia [L.] Pers) sebagai Analgesik dan Antiinflamasi dengan Metode Tail Flick dan Induksi Karagenan: Ethanol Extraction of Inggu Leaves (Ruta Angustifolia [L.] Pers) as an Analgesic and Anti-Inflammatory Method using the Tail Flick Method and Carrageenan Induction Busyairi, Lalu; Mia Ariasti; Novitarini
Jurnal Kolaboratif Sains Vol. 7 No. 6: Juni 2024
Publisher : Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jks.v7i6.5394

Inflamasi atau radang didefinisikan sebagai respon lokal jaringan mamalia yang mengalami luka akibat agen merugikan seperti bakteri, virus, trauma mekanik, keracunan organik, anorganik serta benda asing lainnya. Tanda peradangan meliputi kemerahan, nyeri serta kehilangan fungsi. Sedangkan nyeri merupakan suatu gejala penyakit yang timbul karena disebabkan oleh rangsangan mekanis, termal, kimia, atau listrik yang dapat menyebabkan kerusakan pada jaringan dengan pembebasan mediator nyeri seperti bradikinin dan prostaglandin, kemudian prostaglandin tersebut menimbulkan hiperalgesia, sehingga mediator nyeri seperti bradikinin dan histamin menimbulkan rasa nyeri. Daun dan batang inggu mengandung minyak atsiri yang terdiri dari metil nonilketon mencapai 90%, pinen. Dari hasil uji kualitatif skrining fitokimia daun inggu (Ruta angustifolia) terdapat kandungan senyawa kimia yaitu flavonoid, steroid, alkaloid, saponin, tanin, kuinon dan triterpenoid. Uji efek antiinflamasi dilakukan dengan metode edema kaki tikus dengan menginduksikan ?-karagenan 0,8 % sebanyak 0,2 ml. Metode induksi karagenan ini merupakan salah satu metode pengujian aktivitas antiinflamasi. daya aktivitas analgesik pada sediaan uji ditunjukkan dengan persentase hambatan nyeri yang diberikan lebih besar atau sama dengan 50% dari kelompok kontrol negatif, maka dianggap efektif sebagai analgesik. Hasil uji statistik menunjukkan persentase hambatan nyeri terdistribusi normal dengan nilai signifikan 0,651(>0,05) dan homogen dengan nilai signifikan 0,152(>0,05) Hasil uji statistik menunjukkan bahwa ekstrak etanol daun inggu dosis 10 mg dan 20 mg / 200 g BB berbeda bermakna dengan kontrol negatif CMC Na, sehingga membuktikan bahwa pada ekstrak daun inggu mempunyai efek sebagai analgesik

Perbandingan Kecepatan Disolusi Intrinsik (Absorpsi) Tablet Asetosal Menggunakan Pelarut Etanol 95% dengan Pelarut Kloroform Mia Ariasti; Lalu Busyairi Muhsin; Novitarini Novitarini
JIKF Vol 12 No 1 (2024): Jurnal Ilmu Kesehatan dan Farmasi
Publisher : Fakultas Ilmu Kesehatan Universitas Nahdlatul Wathan Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51673/jikf.v12i1.2246

Disolusi didefinisikan sebagai proses dimana suatu zat padat masuk ke dalam pelarut menghasilkan suatu larutan secara sederhana. Penelitian ini ertujuan untuk mengetahui kecepatan instrisik suatu sedeiaan tablet. Kecepatan intrisik berpengaruh pada absorpsi tubuh pada tablet obat.Disolusi merupakan proses dimana zat padat melarut secara prinsip dikendalikan oleh afinitas antara zat padat dan pelarut. Karakteristik fisik sediaan, proses pembasahan sediaan kemampuan penetrasi media disolusi ke dalam sediaan, proses pengembangan, proses integrasi dan degadrasi. Sediaan merupakan sebagian dari faktor yang mempengaruhi karakteristik disolusi obat dari sediaan. Uji Disolusi yaitu melakukan rekristalisas asetosal dengan pelarut etanol 95% dan chloroformMencetak hasil rekristalisasi menjadi tablet A (Hasil rekristalisasi dengan pelarut chloroform) dan tablet B (hasil rekristalisasi dengan pelarut etanol 95%).. Sampel ditentukan kadarnya dengan spektrofotometer pada λ= 265 nm dengan blangko dapar asetat. (replikasi 3 kali). Pembuatan kurva baku asetosal dimulai dengan menimbang dengan seksama 140 mg asetosal, melarutkan asetosal dengan alkohol 95% beberapa tetes dalam labu takar 50 ml, menambahkan dapar asetat ada tanda batas (larutan stok). Tablet A 0,319mg/menit.mm, Tablet B 0,182 mg/menit.mm. Terdapat perbedaan antara tablet A dan tablet B pada nilai DE dan kecepatan disolusinya. Dilihat dari efisiensi disolusinya, tablet asetosal dengan pelarut kloroform memiliki nilai DE yang lebih besar daripada tablet asetosal dengan pelarut etanol 95%.

Ekstrak Buah Lerak (Sapindus rarak) sebagai Sabun Antibakteri yang Ramah Lingkungan Novitarini, Novitarini; Kresnapati, I Nyoman Bagus Aji; Akmi, Alfarizi Muzaifa
Jurnal Biotek Vol 12 No 2 (2024): DESEMBER
Publisher : Department of Biology Education of Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jb.v12i2.51245

Synthetic surfactants contribute to environmental pollution and can cause skin irritation, highlighting the need for natural biosurfactants. Lerak fruit (Sapindus rarak) shows promise as a biosurfactant due to its 28% saponin content and potential antibacterial activity. This study aimed to evaluate the antibacterial activity of lerak fruit extract using three parameters: inhibition zone, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) against Staphylococcus aureus (Gram-positive) and Pseudomonas aeruginosa (Gram-negative). The research utilized a Posttest Only Control Group Design to test the antibacterial activity of lerak fruit extract against skin-surface normal flora, specifically Staphylococcus aureus and Pseudomonas aeruginosa. All antibacterial activity results were analyzed using One-Way ANOVA in SPSS IBM version 22. The study found the MIC to be 6.25% for Gram-positive bacteria and 1.56% for Gram-negative bacteria. The MBC was determined to be 25% for Gram-positive bacteria and 50% for Gram-negative bacteria. At a 50% concentration, the inhibition zones against Gram-positive and Gram-negative bacteria were 21.53 mm and 22.13 mm, respectively. These results demonstrate that lerak fruit extract possesses strong antibacterial activity against both Gram-positive and Gram-negative bacteria. This research provides a foundation for developing environmentally friendly antibacterial soap formulations using lerak fruit extract.

Penyuluhan Pentingnya Cuci Tangan Yang Baik dan Benar Dalam Upaya Pencegahan Infeksi Cacing di SDN 15 Cakranegara Mia Ariasti; Lalu Busyairi Muhsin; Salsabila Yunita Kurniawan; Sri Winarni Sofya; Ayudia Cipta khaerani; Novitarini
Jurnal Pengabdian kepada Masyarakat IPTEKS Vol. 2 No. 1 (2024)
Publisher : Rajawali Media Utama

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract: Worm infestation is a parasitic infection that can affect the health, nutrition, intelligence and productivity of patients, especially in primary school-aged children. The disease often occurs due to unsanitary lifestyles and poor sanitation, with a high prevalence in Indonesia, especially in West Nusa Tenggara Province. Children aged 5-14 years, especially in areas with low economic levels, are particularly vulnerable to worms due to a lack of knowledge about clean and healthy living behaviors (PHBS). One solution that can be implemented is to provide counseling to children on how to wash their hands properly to prevent worm infections. This counseling activity was conducted at SDN 15 Cakranegara using a participatory approach, in collaboration with the school and local community. The results of this activity show that counseling can increase children's understanding of the importance of washing hands with soap and running water, which is expected to prevent the spread of worm infections and other related diseases. The success of this counseling is an important step in efforts to increase health awareness among children and communities.

Anthelmintic Potential of Annona muricata Leaf Extract against Parasitic Nematode Haemonchus contortus Pratiwi, Baiq Yulia Hasni; Novitarini, Novitarini
Jurnal Pijar Mipa Vol. 20 No. 1 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i1.8220

Gastrointestinal infections caused by the parasitic worm Haemoncus contortus are the main cause of economic losses in the agricultural sector. H. contortus causes small ruminants such as goats to experience acute anemia and diarrhea, weight loss, decreased productivity, and eventually mortality, which impacts economic losses. Synthetic antiparasitics have been used extensively around the world to combat haemonchosis. However, the emergence of resistance to anthelmintics, accompanied by the unavailability of an effective vaccine, results in difficulties in controlling this disease. Because of the high cost of treatment and the emergence of resistance and toxicity due to the residue of antiparasitic drugs, it is necessary to develop natural anthelmintics that are easy to obtain, economical, and have minimal risk. This study aims to determine the anthelmintic effect of Annona muricata leaf extract on mice infected with H. contortus larvae. First, an in vitro study was conducted to see if the soursop leaf extract from Lombok would show a different effect from the previous research. In the in vivo test, the impact of A. muricata leaf extract was measured from the number of H. contortus eggs found in the feces and the percent reduction of adult worms collected from mice's stomachs. The result shows that the higher the concentration of soursop leaf extract, the higher the inhibition effect on larvae motility. The combination of A. muricata and albendazole had the strongest antiparasitic effect, shown by the lowest amount of eggs in feces and the highest reduction of adult worms in the stomach. However, administering A. muricata leaf extract can also reduce the number of eggs and adult worms in the stomach. Therefore, it can be concluded that A. muricata is a potential anthelmintic candidate for overcoming the H. contortus infection.

Hepatoprotector Edible Flower in Indonesia: A Review Kresnapati, I Nyoman Bagus Aji; Kurniawan, Salsabila Yunita; Novitarini, Novitarini; Pratiwi, Baiq Yulia Hasni
Jurnal Pijar Mipa Vol. 20 No. 3 (2025)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v20i3.8983

Hepatotoxicity is an agent that causes damage to human liver function, and every year, cases of liver damage are increasing. Agents that cause liver damage, such as drugs (Paracetamol), chemicals, Carbon Tetrachloride (CCL4), cause liver damage, which is characterized by an increase in the liver enzymes Serum Glutamic Oxaloacetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT). Giving natural ingredients such as edible flower extracts (hepatoprotectors) can reduce SGOT and SGPT levels in liver damage (Hepatoxicity). Indonesia is a country rich in biodiversity, including edible flowers. Therefore, the purpose of this study was to analyze edible flowers that grow in Indonesia and have hepatoprotective activity. This research method is based on a Google Scholar search for the last 5 years (2024-2020) with a keyword search for herbal plants that grow in Indonesia, then selected edible flowers, and a search for edible flowers, then selected edible flowers that act as hepatoprotective. From the search results, edible flowers that act as hepatoprotectors were obtained, namely, Rosella Flower (Hibiscus sabdariffa), Pagoda Flower (Clerodendrum paniculatum L.), Water Hyacinth Flower (Eichhornia crassipes), French Marigold Flower (Tagetes Patula) and Butterfly Pea Flower (Clitoria ternatea), which grow abundantly in Indonesia. Based on the content of active edible compounds, namely flavonoids, anthocyanins, tannins, alkaloids, saponins, terpenoids, phenolic acids and carotenoids, with flavonoids being the most dominant found in all edible flowers. And among the 5 edible flowers as hepatoprotective, only 2 are the most familiar in Indonesia, namely Rosella Flower (Hibiscus sabdariffa) and Butterfly Pea Flower (Clitoria ternatea), so it can be concluded that the most familiar hepatoprotective edible flowers in Indonesia are Rosella Flower (Hibiscus sabdariffa) and Butterfly Pea Flower (Clitoria ternatea).

Penyuluhan Pentingnya Cuci Tangan Yang Baik dan Benar Dalam Upaya Pencegahan Infeksi Cacing di SDN 15 Cakranegara Ariasti, Mia; Muhsin, Lalu Busyairi; Kurniawan, Salsabila Yunita; Sofya, Sri Winarni; Khaerani, Ayudia Cipta; Novitarini, Novitarini
Jurnal Pengabdian Pada Masyarakat IPTEKS Vol. 2 No. 1: Jurnal Pengabdian Pada Masyarakat IPTEKS, Desember 2024
Publisher : CV. Global Cendekia Inti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71094/jppmi.v2i1.80

Worm infestation is a parasitic infection that can affect the health, nutrition, intelligence and productivity of patients, especially in primary school-aged children. The disease often occurs due to unsanitary lifestyles and poor sanitation, with a high prevalence in Indonesia, especially in West Nusa Tenggara Province. Children aged 5-14 years, especially in areas with low economic levels, are particularly vulnerable to worms due to a lack of knowledge about clean and healthy living behaviors (PHBS). One solution that can be implemented is to provide counseling to children on how to wash their hands properly to prevent worm infections. This counseling activity was conducted at SDN 15 Cakranegara using a participatory approach, in collaboration with the school and local community. The results of this activity show that counseling can increase children's understanding of the importance of washing hands with soap and running water, which is expected to prevent the spread of worm infections and other related diseases. The success of this counseling is an important step in efforts to increase health awareness among children and communities.

Uji Zona Hambat Antibakteri Ekstrak Etanol Bunga Kamboja Cendana (Pulmeria alba L.) terhadap bakteri Escheria coli dan Staphylococcus aureus indriyani, dwi windi; novitarini, novitarini novitarini; Muhsin, Lalu Busyairi
Jurnal Ilmiah Pharmacy Vol 12, No 2 (2025)
Publisher : Sekolah Tinggi Kesehatan Al-Fatah Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52161/jiphar.v12i2.754

Tingginya angka infeksi bakteri dan meningkatnya resistensi antibiotik memicu kebutuhan akan alternatif pengobatan berbasis herbal. Bunga kamboja cendana (Plumeria alba L.) diketahui memiliki kandungan senyawa bioaktif seperti flavonoid, alkaloid, tanin, dan saponin yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk menguji zona hambat antibakteri ekstrak etanol bunga kamboja cendana terhadap bakteri Staphylococcus aureus dan Escherichia coli dengan variasi konsentrasi 25%, 50%, 75%, dan 100%. Metode yang digunakan adalah difusi sumuran dengan media Mueller Hinton Agar, serta dilakukan uji statistik Kruskal-Wallis dan Mann-Whitney. Hasil penelitian menunjukkan bahwa zona hambat terhadap Staphylococcus aureus dari ekstrak pekat adalah 14,9 mm, 16,3 mm, 17,1 mm, dan 17,5 mm, sedangkan terhadap Escherichia coli sebesar 7,6 mm, 9,1 mm, 10,4 mm, dan 11,3 mm. Uji statistik menunjukkan hasil signifikan (p = 0,000) pada kedua jenis bakteri, menandakan adanya perbedaan antar konsentrasi. Dapat disimpulkan ekstrak etanol bunga kamboja cendana memiliki zona hambat yang signifikan, terutama lebih efektif terhadap bakteri gram positif Staphylococcus aureus.Kata kunci: Antibakteri alami; Escherichia coli; Plumeria alba L; Staphylococcus aureus; Zona hambat.

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