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All Journal MEDIA MEDIKA INDONESIANA Jurnal NERS agriTECH Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Universa Medicina Jurnal Gizi Klinik Indonesia Jurnal Gizi dan Pangan Soedirman (JGPS) Media Pertanian Biomedika
Diah Krisnansari
Universitas Jenderal Soedirman
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Universa Medicina

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High serum iron and zinc decrease glutathione S-transferase among women with breast cancer Roestijawati, Nendyah; Ernawati, Dwi Arini; Krisnansari, Diah
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.25-30

Abstract

BACKGROUNDBreast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.METHODSAn observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.RESULTSThe results showed that there was a significant relationship of serum iron with GST (r=-0.487; p<0.05) and serum zinc with GST (r=-0.409; p<0.01).CONCLUSIONOur study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.
SPATIAL MODELING OF THE SPREAD OF SCABIES AND ENVIRONMENTAL SANITATION AS A RISK FACTOR AMONG SCHOOLCHILDREN: A CASE-CONTROL STUDY Wibowo, Yudhi; Roestijawati, Nendyah; Krisnansari, Diah; Purnomo, Agoes Y
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.625 KB) | DOI: 10.18051/UnivMed.2020.v39.55-62

Abstract

BACKGROUND Scabies is a World Health Organization neglected tropical disease common in children in low-and middle-income countries. The prevalence of scabies, especially in tropical countries, is still quite high at more than 200 million cases per year. Transmission of scabies is predominantly via skin-to-skin contact. The purpose of the study was to determine the epidemiology of clinical scabies among schoolchildren and spatial modeling using geographic information systems (GIS).METHODSA study of unmatched case-control design with a ratio of 1: 1 was performed to identify specific risk factors of scabies. Cases were patients with clinical scabies and controls were healthy people in the area. A total of 100 students were involved in the study. Simple and multiple logistic regression was used to test any association between the variables. Geographical Information Systems (GIS) modeling was used to determine the spatial distribution of clinical scabies based on 69 cases.RESULTThere was a significant association between the level of environmental sanitation and the prevalence of clinical scabies (OR = 2.53;95% C.I. 1.11-5.74). Multivariate analysis showed that the level of environmental sanitation was significant (AOR = 3.05;95% C.I. 1.19-7.81). Risk factors for developing clinical scabies increased to 3 times after considering other risk factors, namely gender, age group and respondent education level. Analysis of average nearest neighbor distance showed that the spatial distribution of clinical scabies was clustered. CONCLUSIONSThe distribution of clinical scabies was spatial clustering, and prediction of transmission in a clockwise direction with Southeast and Northwest ellipses.
Co-Authors A.A. Ketut Agung Cahyawan W Agus Prastowo Amilia Ramadhani Ariadne Tiara Hapsari Christiana Cahyani Prihastuti Ernawati, Dwi Arini Evy Sulistyoningrum Fitranto Arjadi Fitri Diah Oktadewi Haris Budi Widodo HERY WINARSI Hidayah Dwiyanti Hidayah Dwiyanti Hidayat Sulistyo M. Zaenuri Syamsu Hidayat Mahindra Awwaludin Romdlon Martha Irene Kartasurya MM Rudi Prihatno, MM Rudi Mohammad Zen Rahfiludin Nendyah Roestijawati Nendyah Roestijawati Purnomo, Agoes Y Retno Setyawati Retno Setyawati Siswantoro Siswantoro Siswantoro Siswantoro Wahyu Dwi Kusdaryantoi Yudhi Wibowo Yudhi Wibowo, Yudhi