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Blood cadmium levels increase prostate specific antigen and insulin-like growth factor-1 among cadmium exposed workers Roestijawati, Nendyah; Maurits, Lintje Setyawati; Sugiyanto, Sugiyanto
Universa Medicina Vol 36, No 1 (2017)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2017.v36.42-48

BACKGROUNDCadmium (Cd) is a heavy metal that is classified as a human carcinogen (group IA), one of the cancers that it can cause being prostate cancer. The development of prostate cancer on a molecular basis involves oncogenes such as insuline-like growth factor-1 (IGF-1). Prostate cancer can be detected in the laboratory through the examination of prostate specific antigen (PSA). The present study aimed to determine the relationship of Cd levels with levels of PSA and IGF-1 in exposed and unexposed workers.METHODSThe study design was cross sectional. The subjects of the studycame from two groups of workers, ie. the group of Cd exposed workers who were welding shop workers and the group of unexposed workers who were office workers. The minimum samplesize was 85 people. The independent variable was blood Cd level. The dependent variables were PSA and IGF-1 levels. Blood Cd levels were measured by atomic absorption spectrometry (AAS), while PSA and IGF-1 were measured using ELISA. Data analysis was performed using the Mann-Whitney test and the Spearman correlation test.RESULTSMean blood Cd level in the exposed workers was 6.5 mg/L and in the unexposed workers 2.15 mg/L. There was a relationship between blood Cd and PSA levels (p<0.05) and between blood Cd levels and IGF-1 (p <0.05).CONCLUSIONSThere was a relationship of blood Cd with PSA and IGF-1 levels.among workers. PSA and IGF-1 could be a biochemical markers of disease control in cadmium exposed workers.

High serum iron and zinc decrease glutathione S-transferase among women with breast cancer Roestijawati, Nendyah; Ernawati, Dwi Arini; Krisnansari, Diah
Universa Medicina Vol 37, No 1 (2018)
Publisher : Faculty of Medicine, Trisakti University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2018.v37.25-30

BACKGROUNDBreast cancer in Indonesia ranks second as the most common cancer found in women after cervical cancer. Tumor cells express increased levels of antioxidant proteins to detoxify reactive oxygen species (ROS). Glutathione S-transferase (GST) is known to play a key role in the detoxification and reduction of ROS. Trace elements have nutritional benefits as essential cofactors for physiologic processes, but some can be toxic to humans. Accumulated evidence suggests that deficiency or excess of certain trace elements may be associated with risk of chronic diseases including cardiovascular diseases, diabetes and cancer. The aim of this research was to determine the correlation of the trace elements iron and zinc with the oxidative stress level of GST activity in women with breast cancer.METHODSAn observational analytic study with cross sectional design was conducted involving 35 breast cancer women. Research subjects were women with breast cancer diagnosed by biopsy. Measurements of iron and zinc levels were performed using atomic absorption spectrometry, GST activity was measured using spectrophotometry. Data analysis was done with the Pearson correlation test.RESULTSThe results showed that there was a significant relationship of serum iron with GST (r=-0.487; p<0.05) and serum zinc with GST (r=-0.409; p<0.01).CONCLUSIONOur study demonstrated that the higher zinc and iron level, the lower GST level among breast cancer women. It is recommended to use zinc, iron and GST levels as biomarkers for breast cancer and its progression.

Analisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di instalasi farmasi Rumah Sakit Margono Soekarjo Purwokerto Astuti, Nurul Istiqomah Tri; Suliyanto, Suliyanto; Roestijawati, Nendyah
Performance Vol 25 No 2 (2018): Performance
Publisher : Faculty of Economics and Business Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.986 KB)

Tujuan penelitian ini adalah untuk menganalisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di Instalasi Farmasi RS Margono Soekarjo Purwokerto. Jenis penelitian ini menggunakan survei dengan kuisioner yang diberikan kepada pasien rawat jalan RS Margono Soekarjo Purwokerto. Metode pengambilan sampel menggunakan non-probability consecutive sampling, yaitu sampel diambil dari responden yang memenuhi kriteria pemilihan sampel hingga jumlah subjek terpenuhi yaitu 110 responden. Validitas data menggunakan korelasi product moment. Teknik analisis data menggunakan path analysis dengan dibantu software SPSS 20. Hasil analisis data penelitian ini didapatkan hasil bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap waktu tunggu antrian pengambilan obat, kesalahan pemberian obat, dan komunikasi apoteker pasien. Penggunaan Computer Physician Order Entry (CPOE), waktu tunggu antrian pengambilan obat, komunikasi apoteker, dan mutu pelayanan berpengaruh terhadap kepuasan pelanggan dengan arah positif.  Kesalahan pemberian obat tidak berpengaruh terhadap kepuasan pelanggan. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap mutu pelayanan di Instalasi Farmasi RS Margono Soekarjo Purwokerto, namun berpengaruh terhadap kepuasan pelanggan di Instalasi Farmasi S Margono Soekarjo Purwokerto.

SPATIAL MODELING OF THE SPREAD OF SCABIES AND ENVIRONMENTAL SANITATION AS A RISK FACTOR AMONG SCHOOLCHILDREN: A CASE-CONTROL STUDY Wibowo, Yudhi; Roestijawati, Nendyah; Krisnansari, Diah; Purnomo, Agoes Y
Universa Medicina Vol 39, No 1 (2020)
Publisher : Faculty of Medicine, Trisakti University

BACKGROUND Scabies is a World Health Organization neglected tropical disease common in children in low-and middle-income countries. The prevalence of scabies, especially in tropical countries, is still quite high at more than 200 million cases per year. Transmission of scabies is predominantly via skin-to-skin contact. The purpose of the study was to determine the epidemiology of clinical scabies among schoolchildren and spatial modeling using geographic information systems (GIS).METHODSA study of unmatched case-control design with a ratio of 1: 1 was performed to identify specific risk factors of scabies. Cases were patients with clinical scabies and controls were healthy people in the area. A total of 100 students were involved in the study. Simple and multiple logistic regression was used to test any association between the variables. Geographical Information Systems (GIS) modeling was used to determine the spatial distribution of clinical scabies based on 69 cases.RESULTThere was a significant association between the level of environmental sanitation and the prevalence of clinical scabies (OR = 2.53;95% C.I. 1.11-5.74). Multivariate analysis showed that the level of environmental sanitation was significant (AOR = 3.05;95% C.I. 1.19-7.81). Risk factors for developing clinical scabies increased to 3 times after considering other risk factors, namely gender, age group and respondent education level. Analysis of average nearest neighbor distance showed that the spatial distribution of clinical scabies was clustered. CONCLUSIONSThe distribution of clinical scabies was spatial clustering, and prediction of transmission in a clockwise direction with Southeast and Northwest ellipses.

GANGGUAN FUNGSI PARU PADA POLISI LALU LINTAS nendyah roestijawati; Indah Rahmawati; Dwi Arini Ernawati; Khairunnisa Puspita Ayu
Kesmas Indonesia Vol 12 No 2 (2020): Jurnal Kesmas Indonesia
Publisher : Jurusan Kesehatan Masyarakat dan Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ki.2020.12.2.2427

PULMONARY FUNCTION DISORDERS IN TRAFFIC POLICE Nendyah Roestijawati1), Indah Rahmawati2), Dwi Arini Ernawati1), Khairunnisa Puspita Ayu3) 1)Departemen Kesehatan Masyarakat dan Kedokteran Komunitas 2)Departemen Ilmu Penyakit Dalam 3)Jurusan Kedokteran Fakultas Kedokteran Universitas Jenderal Soedirman Email : nendyahr@yahoo.com Traffic policemen are professions that are susceptible to pulmonary function disorders due to exposure to air pollutants. Other factors that can cause lung function disorders are age, sex, body mass index, length of work, duration of work, smoking and using personal protective equipment habits. The study aims to determine pulmonary function disorders in the traffic police of the Banyumas District Police and the factors that influence them. Cross sectional study design wa used with 50 subjects based on inclusion and exclusion criteria. Impaired pulmonary function was measured by spirometry and other variables were collected using a questionnaire by interview and measurement of body weight and height. Data analysis used the Fisher and Kolmogorov Smirnov test. The results of the study found 82% of subjects experienced a restriction disorder. Factors associated with impaired pulmonary function are body mass index, smoking and using personal protective equipment habits (p <0.05), while factors of age, sex, length and duration of works are not related to impaired lung function (p> 0.05). Keywords: pulmonary function disorder, policemen, spirometry

Analisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di instalasi farmasi Rumah Sakit Margono Soekarjo Purwokerto Nurul Istiqomah Tri Astuti; Suliyanto Suliyanto; Nendyah Roestijawati
Performance: Jurnal Personalia, Financial, Operasional, Marketing dan Sistem Informasi Vol 25 No 2 (2018): Performance
Publisher : Faculty of Economics and Business Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (587.986 KB)

Tujuan penelitian ini adalah untuk menganalisis penggunaan Computer Physician Order Entry (CPOE) terhadap mutu pelayanan dan kepuasan pelanggan di Instalasi Farmasi RS Margono Soekarjo Purwokerto. Jenis penelitian ini menggunakan survei dengan kuisioner yang diberikan kepada pasien rawat jalan RS Margono Soekarjo Purwokerto. Metode pengambilan sampel menggunakan non-probability consecutive sampling, yaitu sampel diambil dari responden yang memenuhi kriteria pemilihan sampel hingga jumlah subjek terpenuhi yaitu 110 responden. Validitas data menggunakan korelasi product moment. Teknik analisis data menggunakan path analysis dengan dibantu software SPSS 20. Hasil analisis data penelitian ini didapatkan hasil bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap waktu tunggu antrian pengambilan obat, kesalahan pemberian obat, dan komunikasi apoteker pasien. Penggunaan Computer Physician Order Entry (CPOE), waktu tunggu antrian pengambilan obat, komunikasi apoteker, dan mutu pelayanan berpengaruh terhadap kepuasan pelanggan dengan arah positif. Kesalahan pemberian obat tidak berpengaruh terhadap kepuasan pelanggan. Berdasarkan hasil tersebut, dapat disimpulkan bahwa penggunaan Computer Physician Order Entry (CPOE) tidak berpengaruh terhadap mutu pelayanan di Instalasi Farmasi RS Margono Soekarjo Purwokerto, namun berpengaruh terhadap kepuasan pelanggan di Instalasi Farmasi S Margono Soekarjo Purwokerto.

Sosialisasi Peningkatan Pengetahuan dan Praktik Pencegahan dan Penanggulangan Covid-19 Di Kelurahan Rejasari, Purwokerto Barat Yudhi Wibowo; Nendyah Roestijawati; Joko Mulyanto; Dyah Krisnansari; Siti Munfiah; M Fikri Marhadhani; Machfira Bulantrisna
The Journal of Innovation in Community Empowerment Vol 4 No 1 (2022): Journal of Innovation in Community Empowerment (JICE)
Publisher : Universitas Jenderal Achmad Yani Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30989/jice.v4i1.663

ABSTRAK Per tanggal 21 November 2020, di Kabupaten Banyumas, tercatat 1.341 kasus dan 43 kasus kematian. Di Kec. Purwokerto Barat tercatat 64 kasus dan di Rejasari tercatat 13 kasus dengan kematian 2 orang. Kelurahan Rejasari berada di Kecamatan Purwokerto Barat, terdiri dari 9 RW dan RW 3 merupakan kantong masyarakat tidak mampu yaitu 263 KK dari 391 KK termasuk keluarga pra-sejahtera. Upaya memutus rantai penularan covid-19 melalui 3M. Pengetahuan dan sikap masyarakat sangat mempengaruhi kepatuhan terhadap upaya pencegahan dan pengendalian covid-19. Tujuan kegiatan ini adalah meningkatkan pengetahun dan praktik pencegahan dan penangulangan covid-19. Metode dengan penyuluhan, simulasi dan praktik menggunakan masker dan cuci tangan menggunakan hand sanitizer yang benar sesuai ketentuan. Hasil uji Firedman dan Post Hoc Wilcoxon didapatkan peningkatan pengetahuan sebelum penyuluhan dibandingkan setelah penyuluhan, evaluasi 1 dan 2 serta berbeda signifikan secara statistik (p=0,005, p=0,032 dan p=0,043). Untuk sikap tidak berbeda signifikan secara statistik sebelum penyuluhan dengan setelah penyuluhan, evaluasi 1 dan 2 (p=0,393) dengan uji Friedman. Implikasinya bahwa penyuluhan meningkatkan pengetahuan peserta tentang covid-19. Simpulan bahwa masyarakat perlu diberi penyuluhan dan role model disiplin protokol kesehatan.

Exploring the Association Between Air Pollutant Exposure and Krebs von den Lungen-6 (KL 6) Serum Levels in Outdoor and Indoor Workers in Banyumas District, Central Java Euis Tia Istianah; Nendyah Roestijawati; Joko Mulyanto
JURNAL KESEHATAN LINGKUNGAN Vol. 14 No. 3 (2022): JURNAL KESEHATAN LINGKUNGAN
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jkl.v14i3.2022.171-177

Introduction: Indonesia ranks 8th globally in the air pollution index, with poor air quality causing premature deaths from lung ailments such as interstitial lung diseases. Krebs von den Lungen-6 (KL 6) can be used to detect lung disease caused by air pollution. However, the number of studies investigating the link between air pollutant exposure and KL-6 levels is inadequate. The present study explores the association between air pollutant exposure and KL-6 levels in workers in different settings. Methods: This cross-sectional study recruited 70 individuals who were divided into two groups. Dust levels were measured using a particle counter as a proxy for air pollutant levels. KL-6 levels were measured with ELISA. The Spearman correlation test, Mann-Whitney test, and generalized linear model were used in statistical analyses. Results and Discussion: Air pollutant exposure differed significantly between outdoor and indoor settings (p = 0.000). A significant difference was found in KL-6 serum levels between outdoor and indoor workers (p = 0.000). Air pollutant levels were inversely associated with KL-6 serum levels in outdoor (r = -0.557, p < 0.05) and indoor workers (r = -0.360, p < 0.05). Working duration did not significantly correlate with KL-6 serum levels in either group. A tendency of linear association among air pollutant exposure, overall working duration, and KL-6 serum levels was found in the multivariable model. Conclusion: Work settings were associated with varying exposures to air pollutants and KL-6 serum levels. Higher exposure to pollutants may be associated with an increase in KL-6 serum levels.

GANGGUAN FUNGSI PARU PADA POLISI LALU LINTAS nendyah roestijawati; Indah Rahmawati; Dwi Arini Ernawati; Khairunnisa Puspita Ayu
Kesmas Indonesia Vol 12 No 2 (2020): Jurnal Kesmas Indonesia
Publisher : Jurusan Kesehatan Masyarakat dan Fakultas Ilmu-Ilmu Kesehatan Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.ki.2020.12.2.2427

PULMONARY FUNCTION DISORDERS IN TRAFFIC POLICE Nendyah Roestijawati1), Indah Rahmawati2), Dwi Arini Ernawati1), Khairunnisa Puspita Ayu3) 1)Departemen Kesehatan Masyarakat dan Kedokteran Komunitas 2)Departemen Ilmu Penyakit Dalam 3)Jurusan Kedokteran Fakultas Kedokteran Universitas Jenderal Soedirman Email : nendyahr@yahoo.com Traffic policemen are professions that are susceptible to pulmonary function disorders due to exposure to air pollutants. Other factors that can cause lung function disorders are age, sex, body mass index, length of work, duration of work, smoking and using personal protective equipment habits. The study aims to determine pulmonary function disorders in the traffic police of the Banyumas District Police and the factors that influence them. Cross sectional study design wa used with 50 subjects based on inclusion and exclusion criteria. Impaired pulmonary function was measured by spirometry and other variables were collected using a questionnaire by interview and measurement of body weight and height. Data analysis used the Fisher and Kolmogorov Smirnov test. The results of the study found 82% of subjects experienced a restriction disorder. Factors associated with impaired pulmonary function are body mass index, smoking and using personal protective equipment habits (p <0.05), while factors of age, sex, length and duration of works are not related to impaired lung function (p> 0.05). Keywords: pulmonary function disorder, policemen, spirometry

PERBANDINGAN BAKTERI ASAM LAKTAT YOGHURT SINGLE DAN DOUBLE STRAIN DALAM MENGHAMBAT PERTUMBUHAN Shigella dysenteriae Bella Khoirunisa Prihandini; Anriani Puspita Karunia Ning Widhi; Nendyah Roestijawati
Mandala Of Health Vol 16 No 1 (2023): Mandala of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mandala.2023.16.1.8397

Dysentery is an infectious intestinal disease characterized by the appearance of blood in the stool. One of the prevention efforts is consuming fermented milk as yogurt. Yoghurt is a fermented milk using lactic acid bacteria (LAB). LAB used as single strains of Streptococcus thermophilus, Lactobacillus bulgaricus, and double strains of S. thermophilus and L. bulgaricus. The purpose of this study was to determine the ratio of LAB of single strain and double strain yoghurt in inhibiting the growth of Shigella dysenteriae by calculating the inhibition zone formed. This research used experimental design method with postest only with control group design. This study uses well diffusion. The total sample was 15, divided into 5 groups with 0%, 20%, 40%, 60%, dan 80% concentration respectively as controls. The experimental design in this study used the Completely Randomized Design (CRD) method. Data analysis used Kruskal Wallis test and Mann Whitney Post Hoc test. The results show that the average diameter of the LAB inhibition zone for double strains of S. thermophilus and L. bulgaricus > single strain L. blugaricus > S. thermophilus. In the Kruskal Wallis test, the p value was obtained = 0.002, it was found that the difference between the treated and untreated groups was obtained. The test results found a significant difference in the median inhibition zone diameter between groups. The conclusion of this study shows that the LAB double strains of S. thermophilus and L. bulgaricus are better at inhibiting growth S. dysenteriae compared to LAB single strains of L. bulgaricus or S. thermophilus yoghurt.

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