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All Journal Current Biochemistry Pro-Life Majalah Kedokteran Jurnal ComunitA Servizio AJARCDE (Asian Journal of Applied Research for Community Development and Empowerment) International Journal of Health and Pharmaceutical (IJHP) Indonesian Journal of Advanced Research (IJAR) Indonesian Journal of Global Health Research
Fri Rahmawati
Universitas Kristen Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences

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Kandungan Fitokimia dan Uji Toksisitas Jamu Susut Perut Albert Jackson Yang; Fri Rahmawati; John Jackson Yang
Pro-Life Vol. 12 No. 3 (2025): November
Publisher : Program Studi Pendidikan Biologi Fakultas Keguruan dan Ilmu Pendidikan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33541/pro-life.v12i3.7079

Abstract

Jamu Susut Perut is a traditional Indonesian herbal preparation widely used as a complementary therapy to support weight loss and reduce abdominal fat. It commonly contains medicinal plants such as Guazuma ulmifolia (Jati belanda), Curcuma longa (Turmeric), Zingiber purpureum (Bangle), Murraya paniculata (Kemuning), Orthosiphon aristatus (Cat’s whiskers), Gallae (Majakanis), Areca catechu (Betel nut), and Piperis folium (Betel leaf). These plants are rich in bioactive compounds including flavonoids, polyphenols, alkaloids, and saponins, which possess lipolytic, anti-inflammatory, and hepatoprotective properties that may enhance fat metabolism and lower blood lipid levels. This study aims to identify the phytochemical compounds in Jamu Susut Perut (X) using the Harborne method and to determine its toxicity against shrimp larvae (Artemia salina Leach) through the Brine Shrimp Lethality Test (BSLT). The LC₅₀ (lethal concentration 50%) value was calculated using probit analysis in SPSS and Microsoft Excel. The phytochemical screening revealed the presence of triterpenoids, quinones, flavonoids, and saponins in the herbal formulation. The toxicity test showed that Jamu Susut Perut (X) had an LC₅₀ value of 547.92 ppm, indicating toxicity to shrimp larvae since the value is below 1000 ppm. In conclusion, Jamu Susut Perut (X) contains bioactive compounds with potential pharmacological effects but also exhibits toxic properties at certain concentrations. This research provides scientific data to ensure the safe use of Jamu Susut Perut as a traditional herbal medicine for consumers.
Bioactivity of Breadfruit Leaf Extract (Artocarpus Altilis) Fri Rahmawati; Hertina Silaban; Claudia Zenith Azriza
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.513

Abstract

Breadfruit leaves (Artocarpus altilis) contain various secondary metabolites such as flavonoids, tannins, terpenoids, and alkaloids which are potential bioactive compounds for therapeutic purposes. This study is an experimental laboratory research aimed at identifying bioactive compound groups and evaluating the antibacterial and antioxidant activities of breadfruit leaf extract. Extraction was carried out using the maceration method with 96% ethanol p.a as solvent. Identification of bioactive compounds was analyzed by Gas Chromatography Mass Spectrometry (GC-MS) method, antibacterial testing by the disc diffusion method, and antioxidant evaluation using a modified Ferric Reducing Antioxidant Power (FRAP) assay. The test bacteria used were Klebsiella pneumoniae and Staphylococcus aureus, gentamicin and chloramphenicol as positive controls. Ascorbic acid was used as the positive control for the antioxidant assay. The GC-MS analysis revealed the presence of active compounds such as Tricyclo [4.3.0.0(7,9)] nonane, trans-11-tetradecenyl acetate, ethyl tridecanoate, α-farnesol isomer, vitamin E, and β-sitosterol. The extract showed antibacterial activity against both tested bacteria, with the smallest effective concentrations of 50 mg/mL for K. pneumoniae and 25 mg/mL for S. aureus, resulting in inhibition zones of 0.3125 mm and 1.5375 mm, respectively, although these values did not meet the sensitivity criteria. The antioxidant activity test showed a potential antioxidant value of 9.84 mg AAE/g extract, using ascorbic acid as the standard curve.
Total Flavonoid, Total Phenolic Content, and Antioxidant Activity of Cardamom (Wurfbainia Compacta) Fruit Extract Fri Rahmawati; Putu Athalia Vidya Nariswari; Nur Nunu Prihantini; Romauli Lumbantobing
Indonesian Journal of Advanced Research Vol. 5 No. 9 (2026): September 2026
Publisher : PT FORMOSA CENDEKIA GLOBAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55927/ijar.v5i9.17320

Abstract

Excessive free radicals contribute to oxidative stress, highlighting the need for natural antioxidants. This study aimed to determine total flavonoid and total phenolic contents and evaluate the antioxidant activity of Wurfbainia compacta Sol. ex. Maton fruit extracts. An experimental laboratory study was conducted using sonication with 70% ethanol and 70% ethyl acetate. Total flavonoid and total phenolic contents were determined spectrophotometrically using quercetin and gallic acid as standards, respectively, while antioxidant activity was measured using the FRAP assay with Trolox as a standard. The flavonoid contents of the 70% ethanol and 70% ethyl acetate extracts were 0.651 and 0.856 mg QE/g, respectively, while phenolic contents were 46.85 and 44.56 mg GAE/g for ethanol and ethyl acetate extracts, respectively. The antioxidant capacities of the 70% ethanol and ethyl acetate extracts of cardamom fruit were 345.58 and 454.24 mg TE/g, respectively.
Co-Authors Albert Jackson Yang Antonio A. I. Tjiarwana Claudia Zenith Azriza Elferida Sormin Frisca Angreni Ganda Pariama Hazella Ishera Talakua Hertina Silaban I MADE ARTIKA Ignatia Hulukiti Irene Rumiris Bavelina Ivena S. Yanitara John Jackson Yang Louisa Ariantje Langi Lucia S. Sunarti Maria Bintang Maria Bintang Maria Bintang MARIA BINTANG Ni Made Devi Damayanti Nia Reviani Nur Nunu Prihantini Putu Athalia Vidya Nariswari Rima Yanie Romauli Lumbantobing Wija, Ida Bagus Eka Utama Zefeilyne Angelita Permata Sitorus