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Nur Alfiah Irfayanti
universitas islam makassar
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 1 
Formulation and Activity Test of Repellent Spray Marigold Flower Essential Oil (Tagetes erecta L.) in Aedes aegypti Mosquitoes Nur Alfiah Irfayanti; Jasmiadi Jasmiadi; Alda Ta.ri
Journal Syifa Sciences and Clinical Research Vol 4, No 2 (2022): Volume 4 Edisi 2 2022
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v4i2.14161

Abstract

The purpose of this study was to determine the activity of spray preparations of marigold flower essential oil (Tagetes erecta L.) on the Aedes aegypti mosquito. Marigold flower essential oil using water distillation method using aquadest and rabbits as test animals. The study was conducted by taking five treatments, namely one negative control group K(-), three treatment groups with variations in concentration (P1) 2.5%, (P2) 5%, P(3) 10% and one positive control group K( +). The results showed that repellent spray had repulsion, control (-) was 50.67%, 2.5% concentration was 68.33%, 5% concentration was 78.67%, 10% concentration was 96% and control (+ ) by 100%. The results of the protection test showed that the repellent spray containing marigold flower essential oil had the highest activity at a concentration of 10%. Based on the results of statistical analysis showed that the calculated f is greater than f table 5% and 1% and the results of the follow-up test of SNK (Newman Keuls) showed that the concentration of 10% was not significantly different from the control (+).
Aktivitas Antihipertensi Ekstrak Etanol Daun Alpukat (Persea americana Mill.) Pada Tikus Putih (Rattus norvegicus) Sitti Fauziah Noer; Nur Alfiah Irfayanti; irpan_ muna_rahmat
Media Farmasi Vol 19 No 2 (2023): Media Farmasi
Publisher : Jurusan Farmasi Poltekkes kemenkes Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/mf.v19i2.121

Abstract

The avocado leaf plant may lower blood pressure due to its content of flavonoid compounds. These compounds prevent the enzymatic conversion from angiotensin I to angiotensin II. This study aims to assess the antihypertensive activity of ethanol extract from avocado leaves (Persea americana Mill.) on white rats (Rattus norvegicus). The powder of avocado leaf simplicia was extracted by maceration using 70% ethanol. Fifteen white rats were divided into 5 groups, each consisting of 3 rats. Blood pressure measurements were taken before induction, and then the rats were induced with 2% NaCl and 11.07 mg/kgBB prednisone. Blood pressure was measured after induction using the tail-cuff auto-pickup method and a non-invasive device (CODA). The research results were statistically analyzed using a completely randomized design (CRD). The average reduction in systolic and diastolic blood pressure in the groups was as follows: dose 125 mg/kgBB (28.01/29.79%); dose 250 mg/kgBB (41.06/38.22%); dose 375 mg/kgBB (48.47/41.12%); positive control (40.97/28.65%), and negative control (5.76/2.8%). Ethanol extract from avocado leaves (Persea americana Mill.) at 250 mg/kgBB and 375 mg/kgBB of rat body weight showed antihypertensive activity that was not significantly different from the positive control, captopril. However, at a dose of 125 mg/kgBB, there was a significant difference from the positive control and a highly significant difference from the negative control CMC 1%. For diastolic blood pressure, the extract had antihypertensive activity that was not significantly different from the positive control captopril, but there was a significant difference from the negative control CMC 1%. Tanaman alpukat dapat memiliki efek menurunkan tekanan darah karena mengandung senyawa flavonoid. Senyawa ini bekerja dengan cara mencegah pengubahan enzimatis dari angiotensin I menjadi angiotensin II. Penelitian ini bertujuan untuk mengevaluasi aktivitas antihipertensi ekstrak etanol daun alpukat (Persea americana Mill.) pada tikus putih (Rattus novergicus). Serbuk simplisia daun alpukat diekstraksi secara maserasi dengan menggunakan etanol 70%. Sebanyak 15 ekor tikus putih dibagi menjadi 5 kelompok, dengan tiap kelompok terdiri atas 3 ekor tikus. Pengukuran tekanan darah dilakukan sebelum induksi, kemudian tikus diinduksi dengan NaCl 2% dan prednison 11,07 mg/kgBB. Tekanan darah diukur setelah induksi menggunakan metode tail-cuff auto-pickup dan alat non-invasive (CODA). Hasil penelitian dianalisis secara statistik dengan rancangan acak lengkap (RAL). Rata-rata penurunan tekanan darah sistolik dan diastolik pada kelompok dosis 125 mg/kgBB (28,01/29,79%); dosis 250 mg/kgBB (41,06/38,22%); dosis 375 mg/kgBB (48,47/41,12%); kontrol positif (40,97/28,65%), dan kontrol negatif (5,76/2,8%). Ekstrak etanol daun alpukat (Persea americana Mill.) pada dosis 250 mg/kgBB dan 375 mg/kg BB tikus menunjukkan aktivitas menurunkan tekanan darah sistolik yang tidak berbeda nyata dengan kontrol positif captopril. Sementara pada dosis 125 mg/kgBB, terdapat perbedaan nyata dengan kontrol positif dan perbedaan sangat nyata dengan kontrol negatif CMC 1%. Untuk tekanan darah diastolik, ekstrak ini memiliki aktivitas menurunkan tekanan darah yang tidak berbeda nyata dengan kontrol positif captopril, namun terdapat perbedaan nyata dengan kontrol negatif CMC 1%.
Uji Toksisitas Subkronis Ekstrak Herba Suruhan (Peperomia pellucida (L.) Kunth) Terhadap Parameter Hematologi Tikus Putih (Rattus norvegicus) Nur Alfiah Irfayanti; Agus Sangka; Nurul Ayu Handayani
Jurnal Mandala Pharmacon Indonesia Vol. 9 No. 2 (2023): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v9i2.387

Abstract

Uji toksisitas subkronis dilakukan untuk mengetahui efek toksik yang dihasilkan setelah pemberian sediaan uji dosis berulang yang diberikan secara oral. Tumbuhan suruhan mengandung senyawa alkaloid, flavanoid, tanin, saponin, steroid dan terpenoid. Tujuan penelitian untuk mengetahui efek toksisitas subkronis pemberian ekstrak etanol herba suruhan (Peperomia pellucida (L.) Kunth) dosis 500 mg/kg BB, 750 mg/kg BB dan 1000 mg/kg BB dengan melihat perubahan jumlah yang terjadi dari hasil pemeriksaan hematologi (eritrosit, leukosit, dan trombosit) tikus putih (Rattus norvegicus) Jantan. Metode penelitian ini menggunakan metode ekstraksi meserasi dengan menggunakan pelarut etanol 70%. Hewan uji yang digunakan adalah tikus putih sebanyak 12 ekor, dibagi menjadi 4 kelompok. Kelompok I  kontrol negatif diberi Na-CMC 0,5%, kelompok II, III dan IV masing- masing diberi ekstrak etanol herba suruhan (EEHS) dengan dosis 500 mg/kg BB, 750 mg/kg BB dan 1000 mg/kg BB. Pemberian dilakukan dengan dosis berulang selama 28 hari. Pemeriksaan darah dilakukan menggunakan alat Hematology Analyzer. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol herba suruhan (Peperomia pellucida (L.) Kunth) dosis 500 mg/kg BB, 750 mg/kg BB dan 1000 mg/kg BB tikus tidak menimbulkan toksisitas subkronis terhadap leukosit, trombosit, dan eritrosit yang aktivitasnya sama dengan kontrol negatif Na. CMC 1% (p<0,05).
Antioksidan in vivo buah beligo (Benincasa hispida (Thunb.) Cogn.) berdasarkan penurunan kadar malondialdehid tikus jantan wistar Alim, Nur; Irfayanti, Nur Alfiah; Fajrianti, Siti; Suarni, Suarni; Jannah, Raudatul
Sasambo Journal of Pharmacy Vol. 5 No. 2 (2024): September
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/sjp.v5i2.261

Abstract

The aim is to ascertain the in vivo antioxidant activity of beligo fruit flesh ethanol extract based on the measurement of malondialdehyde levels in Wistar male rats generated by used frying oil. The procedure involves macerating 70% ethanol to extract the flesh from beligo fruit and assessing the in vivo antioxidant activity by measuring the amounts of malondialdehyde in fifty Wistar male rats split into 5 groups. Group V received vitamin C at a dose of 27 mg/kgBW, and groups II, III, and IV received an ethanol extract of beligo fruit flesh at 100, 200, and 400 mg/kg BW. Group I received 1% Na-CMC as a negative control. Using a UV-Vis spectrophotometer, malondialdehyde levels were determined using the TBARS test. Statistical data analysis by a Completely Randomized Design (CRD) and an Honestly Significant Difference (HSD) follow-up test. Malondialdehyde levels decreased in Group I (19.16%), Group II (78.70%), Group III (82.86%), Group IV (87.76%), and Group V (90.23%) according to the study's findings. The study findings demonstrated the antioxidant potential of beligo fruit flesh ethanol extract at doses of 100 mg, 200 mg/kg BW (p<0.05), and 400 mg/kg BW (p<0.01) in lowering malondialdehyde levels in Wistar male rats.
Co-Authors Agus Sangka Alda Ta.ri Fajrianti, Siti irpan_ muna_rahmat Jasmiadi, Jasmiadi Nur Alim Nurul Ayu Handayani raudatul jannah Sitti Fauziah Noer Suarni Suarni