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STUDI EFFEKTIVITAS NANOEMULSI PURWOCENG PADA PERBAIKAN FUNGSI REPRODUKSI TIKUS PUTIH JANTAN PASCA INDUKSI SLEEP DEPRIVATION: Study of the Effectiveness of Purwoceng Ethanol Extract Nanoemulsion on Improvement of the Reproductive Function of Male White Rats Post Sleep Deprivation Induction Denok Tri Hardiningsih; Tuti Sri Suhesti; Dody Novrial; Fitranto Arjadi
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.594

Paradoxical sleep deprivation (PSD) or sleep disorders can affect sexual function and potentially reduce fertility rates. The active substance of Purwoceng (Pimpinella pruatjan Molk.), namely flavonoid and tannin compounds can improve the quality of function. Drug nanoemulsion is expected to increase the therapeutic effect and reduce toxicity. This study aims to determine the effect of purwoceng nanoemulsion on serum testosterone levels, testicular volume and testicular histopathology of male Wistar rats after stress induction of paradoxical sleep deprivation for 96 hours. This research is an experimental study with a post-test only design with a control group. A total of 24 rats were divided into 6 treatment groups. Group A was given PSD, group B was given PSD and sleep recovery, group C was given PSD and purwoceng extract 25 mg/300 gBW/day, group D was given PSD and purwoceng nanoemulsion 25 mg/300 gBW/day, group E was given PSD and purwoceng nanoemulsion. 50 mg/300 gBW/day, and group F was given PSD and purwoceng nanoemulsion 75 mg/300 gBW/day. Serum testosterone levels were measured by the ELISA method, testicular volume and histopathology determined using Image J software and data were analyzed by One Way ANOVA test and followed by Post Hoc Bonferroni test. Statistical analysis showed that there were significant differences in serum testosterone levels, testicular volume and testicular histopathology (p<0.005). Administration of purwoceng nanoemulsion affects serum testosterone levels, testicular volume, and testicular histopathology after PSD induction

PENINGKATAN PENGETAHUAN MASYARAKAT MENGENAI HIPERTENSI DI PUSKESMAS OLAK KEMANG, DANAU TELUK KOTA JAMBI Attiya Istarini; Lipinwati; Hasna Dewi; Wulandari, Putri Sari; Samsirun Halim; Amatullah, Afifah; Hafizah; Denok Tri Hardiningsih
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 7 No. 2 (2024): MEDIC. Medical dedication
Publisher : Universitas Jambi

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Hypertension significantly increases the risk of heart, brain and kidney diseases, and is one of the top causes of death and disease throughout the world. One of the global targets for noncommunicable diseases is to reduce the prevalence of hypertension by 33% between 2010 and 2030. This Community Service Activity (CSA) was conducted at the Olak Kemang Health Center. The purpose of this Community Service is the prevention and control of Hypertension by increasing the participation and level of knowledge of the community in Danau Teluk Village through health education and blood pressure checks. The activity was attended by 66 participants, participants were given pretest and posttest questions to measure knowledge about hypertension. The results showed an increase in the knowledge of community service participants after being given counseling about hypertension (p-value 0.000).

DEVELOPMENT OF ENTREPRENEURSHIP SKILLS AMONG MEDICAL STUDENTS: OPENING BUSINESS OPPORTUNITIES IN THE HEALTH SECTOR Ayudia, Esa Indah; Denok Tri Hardiningsih; Suzan, Raihanah; Miftahurrahma, Miftahurrahma; Justitia, Budi; Hafizah, Hafizah
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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In the era of globalization and rapid technological advancement, the healthcare sector in Indonesia faces various challenges, including the need for innovation and more effective services. Medical students possess significant potential to contribute to creating relevant solutions for public health issues. However, many of them lack adequate entrepreneurial skills. Conventional teaching methods often fall short in providing students with the practical skills necessary.Therefore, the implementation of Project-based Learning (PjBL) in entrepreneurship courses becomes essential. Through PjBL, students not only learn theory but also engage directly in projects related to current health issues. This allows them to develop practical skills such as market research and business planning. The program involved 119 first-semester medical students, beginning with a Pre-Test to assess their initial knowledge about Community Service, followed by presentation sessions and a Post-Test to evaluate their understanding. Results showed that 60% of students were interested in entrepreneurship within the healthcare sector; 52.5% recognized its importance; however, 70% still lacked an understanding of business concepts in healthcare. A significant increase was observed after the Post-Test was conducted. The application of PjBL needs to be conducted continuously to further enhance students' knowledge about entrepreneurship. Keywords: Entrepreneurship, Project-based Learning (PjBL), Medicine

EVALUATION OF BLOOD PRESSURE, CHOLESTEROL, GLUCOSE, AND URIC ACID LEVELS IN PATIENTS AT THE OLAK KEMANG HEALTH CENTRE IN JAMBI CITY Attiya Istarini; Lipinwati; Hasna Dewi; Wulandari, Putri Sari; Samsirun Halim; Amatullah, Afifah; Hafizah; Denok Tri Hardiningsih
Medical Dedication (medic) : Jurnal Pengabdian kepada Masyarakat FKIK UNJA Vol. 8 No. 1 (2025): MEDIC. Medical dedication
Publisher : Universitas Jambi

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ABSTRACT Hypertension is a chronic elevation of systemic arterial pressure beyond a level that may damage the endothelium. Individuals with hypertension typically demonstrate increased levels of blood glucose, cholesterol, and uric acid. Hyperlipidemia, age, and hypertension exhibit a complicated interplay that profoundly influences cardiovascular risk. Inadequate management of blood pressure and insufficient public awareness regarding the early detection of metabolic syndrome continue to significantly worsen the global prevalence of cardiovascular disease.This community service initiative assessed blood pressure and blood chemistry to identify early risk factors for cardiovascular disease. Olak Kemang Health Centre, affiliated with Jambi University's Faculty of Medicine and Health Sciences, conducts community service projects. Patients of the Regular Olak Kemang Health Center engaged in this research. Following an 8-hour fasting period, all individuals underwent assessments of their blood pressure, cholesterol levels, glucose, and uric acid concentrations. This study evaluated the blood pressure and clinical chemistry of 44 subjects. Seven patients (15.9%) exhibited pre-hypertension, twelve (27.3%) presented with stage 1 hypertension, and eleven (25%) were diagnosed with stage 2 hypertension. The majority of individuals with hypertension were aged 46 to 55 years. In the community service, 4 participants exhibited elevated uric acid levels, 9 had elevated glucose levels, and 7 had elevated cholesterol levels. Eight patients with stage 1 hypertension exhibited higher blood chemistry levels. Considering that glucose, cholesterol, and uric acid are associated with cardiovascular disease risk, it is advisable for patients with hypertension to have their levels regularly monitored. Their connection highlights the need for integrated management strategies to improve patient care and prevent complications. Keywords: Elderly, Hypertension, Hyperlipidemia, Hyperglicemia, Hyperuricemia. ABSTRAK Hipertensi adalah peningkatan kronis tekanan arteri sistemik di atas level yang dapat merusak endotelium pembuluh darah. Individu dengan hipertensi biasanya menunjukkan peningkatan kadar glukosa darah, kolesterol, dan asam urat. Hiperlipidemia, usia, dan hipertensi menunjukkan interaksi yang meningkatkan resiko kejadian penyakit kardiovaskular. Manajemen tekanan darah yang tidak memadai dan kurangnya kesadaran publik mengenai deteksi dini sindrom metabolik terus memperburuk prevalensi penyakit kardiovaskular global secara signifikan. Kegiatan pengabdian masyarakat ini bertujuan untuk pemeriksaan tekanan darah dan kimia darah untuk mengidentifikasi lebih awal faktor risiko penyakit kardiovaskular. Kegiatan ini diinisiasi oleh Fakultas kedokteran dan Ilmu Kesehatan Universitas Jambi bekerja sama dan dilaksanakan di Puskesmas Olak Kemang Kota Jambi. Pasien Puskesmas Reguler Olak Kemang terlibat dalam kegiatan ini. Setelah puasa selama 8 jam, semua individu menjalani penilaian tekanan darah, kadar kolesterol, glukosa, dan konsentrasi asam urat. Studi ini mengevaluasi tekanan darah dan kimia klinis dari 44 peserta. Tujuh orang (15,9%) menunjukkan pra-hipertensi, dua belas orang (27,3%) menunjukkan hipertensi stadium 1, dan sebelas orang (25%) didiagnosis hipertensi stadium 2. Mayoritas individu dengan hipertensi berusia 46 hingga 55 tahun. Dalam pengabdian masyarakat, empat orang menunjukkan peningkatan kadar asam urat, sembilan orang memiliki peningkatan kadar glukosa, dan tujuh orang memiliki peningkatan kadar kolesterol. Delapan pasien dengan hipertensi stadium 1 menunjukkan kadar kimia darah yang lebih tinggi. Mengingat bahwa glukosa, kolesterol, dan asam urat berhubungan dengan risiko penyakit kardiovaskular, disarankan bagi pasien hipertensi untuk memantau kadar kimia darah secara teratur. Hubungan antara hipertensi dan sindrom metabolik menunjukkan perlunya strategi manajemen terpadu untuk meningkatkan perawatan pasien dengan hipertensi dan mencegah komplikasi. Kata kunci: Lansia, Hipertensi, Hiperlipidemia, Hiperglikemia, Hiperurisemia

Pengaruh Pemberian Ekstrak Kulit Buah Cempedak ( Artocarpus Integer ) terhadap Pencegahan Penurunan Kadar Hemoglobin Pada Tikus Putih Jantan yang Dipapar Asap Rokok Indah Ayudia, Esa; Tri Hardiningsih, Denok; Iksan, Pahrul; Harahap, Huntari; Putra Agung, Rhonaz
Jurnal Kesehatan Qamarul Huda Vol. 13 No. 1 (2025): Juni 2025
Publisher : Universitas Qamarul Huda Badaruddin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37824/jkqh.v13i1.2025.739

The negative influence of the environment caused by smoking is free radicals. Cempedak plants contain active substances flavonoids, phenols, and tannins which are active substances that can function as antioxidants that can prevent free radicals. The purpose of the research was to find out the effect of cempedak fruit peel extract (Artocarpus integer) on the prevention of the decrease in hemoglobin levels in male white rats exposed to cigarette smoke. This type of research is quantitative analysistrue experimental using a completely randomized design withpretest and Posttest Control Group Design. The groups were divided into 6, namely the treatment group of 50 mg/kg, 100 mg/kg, 200/kg, the positive control of Vitamin E, the negative control, and the normal group. In several treatment groups there was no significant reduction in hemoglobin levels (p<0.05). The most significant increase in blood hemoglobin levels occurred in the treatment group with a dose of 200 mg/kgBW. The results of the study concluded that the giving of cempedak fruit peel extract (Artocarpus integer) is effective in preventing the decrease in hemoglobin levels in male white rats exposed to cigarette smoke.

Sinergi Edukasi Gizi Dan Pemanfaatan Bahan Lokal Dalam MPASI Untuk Cegah Stunting Pada Balita Esa Indah Ayudia; Hafizah, Hafizah; Mirna Marhami Iskandar; Patrick Wiliam Gading; Zahra Frizki Asty; Dea Anenta Veonika; Denok Tri Hardiningsih; Miftahurrahmah, Miftahurrahmah
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 1: November 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i1.12278

Stunting merupakan masalah kesehatan masyarakat yang serius dengan prevalensi yang masih tinggi di Indonesia, termasuk peningkatan di Provinsi Jambi pada tahun 2024. Periode 1.000 Hari Pertama Kehidupan (HPK), terutama masa Pemberian Makanan Pendamping ASI (MPASI) sejak usia 6 bulan, menjadi jendela kritis pencegahan. Kesenjangan pengetahuan ibu mengenai praktik MPASI yang tepat dan kurangnya optimalisasi pemanfaatan bahan pangan lokal yang bergizi dan terjangkau menjadi kendala. Program pengabdian ini bertujuan untuk mendukung percepatan penurunan stunting di wilayah kerja Puskesmas Olak Kemang, Kota Jambi, dengan meningkatkan pengetahuan dan keterampilan ibu serta kader kesehatan tentang gizi seimbang, stunting, dan praktik MPASI berbasis pangan lokal. Metode yang digunakan adalah penyuluhan interaktif, pre-test, post-test, dan identifikasi bahan lokal. Hasil menunjukkan adanya peningkatan signifikan pada skor pengetahuan ibu balita setelah penyuluhan, dengan rata-rata peningkatan sebesar 27,35% (rata-rata skor pre-test 71 menjadi post-test 98). Program ini berhasil meningkatkan literasi gizi dan keterampilan praktis ibu dalam menyiapkan MPASI bergizi berbasis sumber daya lokal, yang merupakan pendekatan strategis dan efektif biaya dalam pencegahan stunting.

Pengembangan Obat Nyamuk Berbasis Kulit Buah Lansium domesticum sebagai Inovasi creative healthpreneur Berbasis Sumber Daya Alam Lokal di wilayah kerja Puskesmas Olak Kemang, Kota Jambi Miftahurrahmah, Miftahurrahmah; Tri Hardiningsih, Denok; Justitia, Budi; Imam Taufiq Siregar, Mara; Susan, Raihanah; Indah Ayudia, Esa; Hafizah, Hafizah; Wida Ekaputri Hz, Tia
Joong-Ki : Jurnal Pengabdian Masyarakat Vol. 5 No. 1: November 2025
Publisher : CV. Ulil Albab Corp

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56799/joongki.v5i1.12292

Abstract: Pengembangan produk antinyamuk berbasis kulit buah Lansium domesticum merupakan upaya inovatif pemanfaatan sumber daya alam lokal yang ramah lingkungan sekaligus mendukung konsep healthpreneurship. Kegiatan pengabdian masyarakat ini bertujuan untuk mensosialisasikan cara pembuatan lilin aromaterapi antinyamuk berbahan dasar kulit duku kepada masyarakat dan tenaga kesehatan di wilayah kerja Puskesmas Olak Kemang, Kota Jambi dengan memanfaatkan media video ajar. Metode yang digunakan berupa sosialisasi, penayangan video pengajaran, diskusi interaktif, dan praktik langsung pembuatan produk oleh peserta. Evaluasi pemahaman dan keterampilan dilakukan melalui pre–post test pada 25 responden. Hasil menunjukkan peningkatan skor rata-rata dari 4,12 menjadi 4,88 dengan penurunan simpangan baku dari 0,726 menjadi 0,332 yang menandakan peningkatan signifikan dan pemerataan pemahaman peserta. Kegiatan ini terbukti efektif dalam meningkatkan keterampilan peserta dalam menghasilkan produk inovatif berbasis sumber daya alam lokal, memberikan wawasan baru tentang insektisida nabati, serta membuka peluang healthpreneurship masyarakat. Model sosialisasi berbasis media digital ini berpotensi untuk direplikasi di wilayah lain dengan karakteristik serupa.

STUDI EFFEKTIVITAS NANOEMULSI PURWOCENG PADA PERBAIKAN FUNGSI REPRODUKSI TIKUS PUTIH JANTAN PASCA INDUKSI SLEEP DEPRIVATION: Study of the Effectiveness of Purwoceng Ethanol Extract Nanoemulsion on Improvement of the Reproductive Function of Male White Rats Post Sleep Deprivation Induction Denok Tri Hardiningsih; Tuti Sri Suhesti; Dody Novrial; Fitranto Arjadi
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.594

Paradoxical sleep deprivation (PSD) or sleep disorders can affect sexual function and potentially reduce fertility rates. The active substance of Purwoceng (Pimpinella pruatjan Molk.), namely flavonoid and tannin compounds can improve the quality of function. Drug nanoemulsion is expected to increase the therapeutic effect and reduce toxicity. This study aims to determine the effect of purwoceng nanoemulsion on serum testosterone levels, testicular volume and testicular histopathology of male Wistar rats after stress induction of paradoxical sleep deprivation for 96 hours. This research is an experimental study with a post-test only design with a control group. A total of 24 rats were divided into 6 treatment groups. Group A was given PSD, group B was given PSD and sleep recovery, group C was given PSD and purwoceng extract 25 mg/300 gBW/day, group D was given PSD and purwoceng nanoemulsion 25 mg/300 gBW/day, group E was given PSD and purwoceng nanoemulsion. 50 mg/300 gBW/day, and group F was given PSD and purwoceng nanoemulsion 75 mg/300 gBW/day. Serum testosterone levels were measured by the ELISA method, testicular volume and histopathology determined using Image J software and data were analyzed by One Way ANOVA test and followed by Post Hoc Bonferroni test. Statistical analysis showed that there were significant differences in serum testosterone levels, testicular volume and testicular histopathology (p<0.005). Administration of purwoceng nanoemulsion affects serum testosterone levels, testicular volume, and testicular histopathology after PSD induction

Acute Toxicity Test of Tamarillo Fruit Ethanol Extract (Solanum betaceum Cav.) on the Levels of Liver Transaminase Enzymes in Male Wistar Rats Amalia, Ary Nahdiyani; Yulianti, Rini Dwi; Khumaeni, Eko Hidayaturrohman; Hardiningsih, Denok Tri
Medical and Health Journal Vol 5 No 2 (2026): February
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2026.5.2.19413

Indonesians traditionally utilize tamarillo for its various health benefits. However, the lipophilic compounds it contains have the potential to cause hepatotoxicity and increase transaminase enzymes, namely SGPT and SGOT enzymes. The study aimed to test the toxicity of tamarillo ethanol extract acutely on SGPT and SGOT levels in male Wistar white rats. The study used a post-test only experimental design with a control group design. Fifteen rats were randomly divided into five treatment groups. Group K1 as a control was given distilled water, group K2 was given paracetamol 2.5 g/kgBW, while groups K3, K4, and K5 were each given tamarillo ethanol extract in single doses of 200, 400, and 600 mg/kgBW. After 24 hours, rat blood serum samples were taken through the orbital sinus to measure SGPT and SGOT levels using the UV test method. The results showed that the average SGPT levels increased in the K2 group by 295.34±13.31 U/L and K5 by 93.67±19.03 U/L. Meanwhile, the average SGOT levels increased in the K2 group by 874±25.06 U/L, K4 by 164.67±7.57 U/L and K5 by 213.34±13.50 U/L. The One-Way ANOVA test showed a significance value of p=0.000 in the K2 and K5 groups for SGPT, while SGOT in the K2, K4 and K5 groups. Administration of tamarillo ethanol extract can cause liver damage at doses of 400 mg/kgBW and 600 mg/kgBW.

DUKU PEEL INNOVATION: EFFORTS TO IMPROVE CREATIVE HEALTHPRENEURS THROUGH THE DEVELOPMENT OF PLANT-BASED INSECTICIDES Miftahurrahma Miftahurrahma; Tengku Arief Buana Perkasa; Huntari Harahap; Hafizah Hafizah; Denok Tri Hardiningsih; I Made Dwi Mertha Adnyana
BUDIMAS : JURNAL PENGABDIAN MASYARAKAT Vol. 8 No. 1 (2026): BUDIMAS : Jurnal Pengabdian Masyarakat
Publisher : LPPM ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/budimas.v8i1.19448

Duku peel is an underutilized agricultural byproduct in Talang Duku Village, a major center of duku production, and is commonly discarded as waste. The community’s heavy reliance on synthetic chemical insecticides presents environmental and health risks, compounded by limited knowledge regarding the processing of agricultural waste into value-added products. This community service program aimed to empower the “A. Khalik Duku Plantation” Farmers Group by converting duku peel waste into a high-value plant-based insecticide in the form of aromatherapy candles, thereby fostering a new generation of creative healthpreneurs. The program applied a participatory community empowerment approach through education, hands-on training, and continuous mentoring. The stages included needs assessment, production and business management training, and evaluation using pre-test and post-test data analyzed with the Wilcoxon and Chi-Square tests. The results showed a significant improvement in participants’ knowledge (P < 0.001), with the median score increasing from 70% to 80% and the number of participants achieving the ≥80% competency threshold rising from 13 to 49. Furthermore, the program successfully facilitated the production of insect-repellent aromatherapy candles and the establishment of the “KUB Duku Lestari” Joint Business Group, which sold more than 50 units within the first three months. In conclusion, this program effectively transformed agricultural waste into a valuable product, promoted sustainable entrepreneurship, and contributed to improving community welfare. It is recommended that the business group standardize product packaging to enhance market competitiveness and that future studies focus on optimizing extraction techniques to improve product efficacy.

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