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All Journal VALENSI Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat EduChemia: Jurnal Kimia dan Pendidikan Jurnal Ilmiah Arena Tekstil Indonesian Journal of Science and Technology The Indonesian Biomedical Journal Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Akta Kimia Indonesia Molekul: Jurnal Ilmiah Kimia Molekul: Jurnal Ilmiah Kimia
Euis Julaeha
Departemen Kimia Fakultas Matematikda Dan Ilmu Pengetahuan Alam Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Public Health

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Journal : Indonesian Journal of Science and Technology

 1 
In-Vitro Anticancer Activity of Chemical Constituents from Etlingera alba Poulsen against Triple Negative Breast Cancer and in silico Approaches towards Matrix metalloproteinase-1 Inhibition W. Wahyuni; Ajeng Diantini; Mohammad Ghozali; Anas Subarnas; Euis Julaeha; Riezki Amalia; Adryan Fristiohady; Andini Sundowo; Sofa Fajriah; Yuni Elsa Hadisaputri; Raden Maya Febrianti; Fauzia Azzahra; Agung W.M. Yodha; I. Sahidin
Indonesian Journal of Science and Technology Vol 7, No 2 (2022): IJOST: VOLUME 7, ISSUE 2, September 2022
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/ijost.v7i2.50547

Abstract

Etlingera alba (EA) is one of the endemic plants grown in Sulawesi. We determined the cytotoxic and anti-metastatic activity of isolates obtained from EA rhizome extract. IC50 value for 1,7-diphenyl-6-heptene-3-one, sitostenone, sinapyl alcohol diacetate, and sinapyl alcohol acetate were 134.59; 170 ; 128.11; and 161.96 μg/mL, respectively. The compounds also had anti-migration activity. 200-μg/mL Sitostenon exhibited the lowest migration rate (3.32%). The free bond energies of sitostenon, 1,7-diphenyl-6-heptene-3-one, sinapyl alcohol acetate, and sinapyl alcohol diacetate were -11.81; -8.25; -6.64; and -6.28 kcal/mol, respectively. All compounds were more effective in stabilizing the Matrix metalloproteinase 1 complex. Isolation from EA rhizomes have the potential to be developed as anti-metastatic for Triple-Negative Breast Cancer.
Co-Authors Ace Tatang Hidayat Achmad Zainuddin Ade Akbar Abdilla Ade Kania Ningsih Aditya Seiza Wibisono Adryan Fristiohady Agung W.M. Yodha Agus Surya Mulyawan Agus Surya Mulyawan Ahmad Kurniawan Ajeng Diantini, Ajeng Almas Widyana Anas Subarnas Andini Sundowo Ari Hardianto Arif Rahman Hakim Arif Rahman Hakim Chantika Azka Hunafa Cica Kasipah Darwati Darwati Desi Harneti Putri Huspa Dewa Gede Katja Diana Rakhmawaty Eddy Dinda Dede Nabila Doni Sugiyana Dwi Nur Indah Sari Fauzia Azzahra, Fauzia Hanna Goenawan I. Sahidin Iman Permana Maksum Jakariya Nugraha Jamaluddin Al Anshori Kasipah, Cica Khalijah Awang Kindi Farabi Kindi Farabi Kristin Shinta Dewi Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah Luthfia Pratiwi Miftah Andiani Lestari Mohammad Ghozali Muhammad Hanafi Mulyawan, Agus Surya Nani Suryani Nila Sari Pandiangan Nova Sylviana Nurlelasari Nurlelasari Ois Nurcahyanti Prayudie, Untung Purwoko, Agus Raden Maya Febrianti Rani Maharani Retna Nurkhotimah Riezki Amalia Riza Yulisar Ronny Lesmana Sandra Puspita Sandra Puspita Sari Purbaya Shabarni Gaffar Sofa Fajriah Supriatno Salam Susianti Susianti Sylvia Rachmawati Meilanie Tarso Rudiana, Tarso Tatang Wahyudi Tatang Wahyudi Tatang Wahyudi Tatang Wahyudi Tatang Wahyudi Tati Herlina Tati Herlina Tri Mayanti Tri Mayanti Tri Reksa Saputra Tri Reksa Saputra Unang Supratman Untung Prayudie W. Wahyuni Wahyudi, Tatang Yenny Febriani Yun Yenny Febriani Yun Yenny Febriani Yun, Yenny Febriani Yuni Elsa Hadisaputri Yuni Susanti Pratiwi