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All Journal Jurnal Wiyata : Penelitian Sains dan Kesehatan Darmabakti Cendekia: Journal of Community Service and Engagements Bioscientist : Jurnal Ilmiah Biologi JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Cross-border Innovative: Journal Of Social Science Research Jurnal Pharma Bhakta Folia Medica Indonesiana
Werdiningsih, Wiwik
Institut Ilmu Kesehatan Bhakti Wiyata Kediri
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Analisis Kadar Senyawa Tanin Ekstrak Etanol Daun Pepaya Jepang (Cnidoscolus aconitifolius) Menggunakan Metode Spektrofotometri UV-VIS Werdiningsih, Wiwik; Fitria, Faizatul
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 2 (2024): December
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i2.13979

Abstract

Japanese papaya plant (Cnidoscolus aconitifolius) can be used for traditional medicine such as antidiarrheal, antibacterial and antioxidant. The purpose of this study was to measure the levels of tannin compounds from the extraction of Japanese papaya leaves. This research method uses descriptive to measure the levels of tannin compounds in Japanese papaya leaf extract with UV-Vis spectrophotometry. Determination at Materia Medica Indonesia (MMI) to determine the maximum wavelength, determination of operating time, and determination of tannin content in the sample. The results showed that (1) quantitative test results with a maximum wavelength of 723 nm obtained an average tannin content of 36.782 mg TAE / g extract; (2) method validation test and the results met the requirements, namely the linearity test results obtained correlation coefficient (r2) s 0.9954; (3) accuracy test results of 98-102%; (4) precision test results RSD of 0.097%; (5) LOD and LOQ test results obtained 1.899 ppm and 5.755%.
Identifikasi Hidrokuinon Pada Produk Handbody Lotion Whitening yang Dijual Online dengan Metode Kromatografi Lapis Tipis (KLT) Werdiningsih, Wiwik
Innovative: Journal Of Social Science Research Vol. 4 No. 3 (2024): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v4i3.10606

Abstract

Handbody merupakan suatu sediaan golongan kosmetik yang banyak dimanfaatkan secara topikal untuk perawatan kulit. Handbody yang mengandung hidrokuinon perlu diwaspadai. Hidrokuinon adalah senyawa aktif mampu mengendalikan produksi pigmen yaitu dapat memperlambat proses terbentuknya melanin pada kulit serta berfungsi untuk mencegah terjadinya pigmentasi yang bekerja dengan cara menghambat enzim tirosinase yang berperan pada produksi pigmen pada kulit. Manfaat inilah sehingga hidrokuion sering ditambahkan dalam produk handbody sebagai pemutih. Adanya hidrokuionon pada produk handbody saat digunakan topikal pada kulit dapat membahayakan pada tubuh. Penggunaan produk hidrokuinon dalam jangka panjang dapat terakumulasi pada kulit sehingga dapat menyebabkan kerusakan dan mutasi seperti karsinogenik. Penelitian ini bertujuan untuk mengetahui kandungan senyawa hidrokuinon pada handbody yang dijual secara online dan tidak memiliki ijin dari BPOM. Analisa hidrokuinon pada handbody menggunakan metode Kromatografi Lapis Tipis (KLT) yang menghasilkan fluoresensi warna hitam saat dilihat di bawah sinar UV 254 nm. Pada penelitian ini dari tiga sampel handbody diberi kode sampel satu, dua, dan tiga. Hasil penelitian ini diperoleh dua sampel handbody dengan kode sampel satu dan dua hasilnya negatif atau tidak mengandung senyawa hidrokuinon sedangkan sampel dengan kode tiga memiliki potensi mengandung senyawa hidrokuinon karena diperoleh hasil selisih Rf 0,05.
IDENTIFIKASI SENYAWA FLAVONOID TERHADAP RENDEMEN EKSTRAK DAUN PEPAYA JEPANG (CNIDOSCOLUS ACONITIFOLIUS MILL) DENGAN METODE EKSTRAKSI SOKHLETASI Werdiningsih, Wiwik
JURNAL PHARMA BHAKTA Vol 3 No 2 (2023): November 2023
Publisher : FACULTY OF PHARMACY, INSTITUT ILMU KESEHATAN BHAKTI WIYATA

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Abstract

Daun pepaya jepang (Cnidoscolus aconitifolius Mill) merupakan bagian tanaman yang terdapat sejumlah senyawa metabolit sekunder guna pengobatan segala penyakit. Penelitian ini bertujuan untuk mengidentifikasi adanya senyawa flavonoid pada rendemen ekstrak daun pepaya jepang yang diekstrak menggunakan metode sokhletas. Identifikasi kandungan metabolit sekunder, serta identifikasi senyawa flavonoid menggunakan metode KLT (kromatografi lapis tipis). Metode ekstraksi pada penelitian ini menggunakan metode sokhletasi dengan pelarut etanol 70%. Analisis senyawa flavonoid serta skrining fitokimia dengan kromatografi lapis tipis dilakukan pada ekstrak daun pepaya jepang. Hasilnya memperlihatkan bahwasanya metode sokhletasi memproduksi rendemen yang cukup tinggi yakni 21,889%. Rendemen ekstrak bisa terpengaruh atas sejumlah aspek, misalanya metode dan waktu ekstraksi, serta jenis pelarut. Skrining fitokimia dengan metode ekstraksi pada daun pepaya jepang mengandung alkaloid, flavonoid, tanin, saponin, fenolik, serta terpenoid. Identifikasi senyawa flavonoid dipertegas melalui KLT memakai fase gerak n-butanol : asam asetat : air (4:1:5) dengan pembanding kuersetin. Penelitian ini juga menunjukkan hasil tidak teridentifikasi adanya senyawa kuersetin tetapi positif terdapat senyawa flavonoid yang diperlihatkan melalui kemiripan nilai Rf
COUNSELING ON THE USE OF FAMILY MEDICINAL PLANTS (TOGA) WERDININGSIH, WIWIK WERDININGSIH
Journal of Community Engagement and Empowerment Vol. 6 No. 1 (2024)
Publisher : Institut Ilmu Kesehatah Bhakti Wiyata Kediri

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Abstract

Dadapan Village is an urban area but is categorized as a disadvantaged village because its location is quite far from the center of Kediri city, so this hamlet is a hamlet that can be categorized as a rural area. Most of the people in Dadapan hamlet are housewives. The area of Dadapan hamlet is quite large and not too dense, so there are still many large yards in the hamlet. Residents in Dadapan hamlet are used to using the yards around their houses to plant various types of plants. Of the various kinds of plants that live in people's yards, many of them are plants that can be used as traditional medicinal plants. Some residents sometimes use these plants to treat health complaints, but their use is not optimal because so far the use of traditional medicinal plants has only been based on the opinions of friends or neighbors. It is feared that the use of traditional medicines that do not comply with the rules could reduce the efficacy of the medicine itself. If it is used too much, it is feared that it will also have toxic effects that will harm society. By using the method of educating the public about the TOGA utilization program at the PKK meeting on Sunday 14 January 2024, it is hoped that it will provide the public with insight into the use of TOGA to be managed into medicinal preparations to improve family health. The results of the posttest showed that 100% of the community understood and could explain the use of TOGA for family health.
"SEHATI LESTARI": STRENGTHENING HEALTH CADRES TO REALIZE A TB-FREE AND HEALTHY COMMUNITY: "SEHATI LESTARI": PENGUATAN KADER KESEHATAN WUJUDKAN MASYARAKAT BEBAS TBC DAN HIDUP SEHAT Prodyanatasari, Arshy; Pratiwi, Wahyu Nur; Astutik, Wahyu Sri; Laksono, Adi; Werdiningsih, Wiwik; Anikasari, Erni; Fernanda, jerhi Wahyu
Darmabakti Cendekia: Journal of Community Service and Engagements Vol. 7 No. 2 (2025): DECEMBER 2025
Publisher : Faculty of Vocational Studies, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/dc.V7.I2.2025.125-132

Abstract

Background: The low level of public understanding about tuberculosis (21.9%) and the limited implementation of home ventilation as a preventive measure (31.3%) prompted the launch of the “SEHATI LESTARI” program, which focuses on strengthening health cadres to create a tuberculosis-free community. Objective: This activity aimed to increase community knowledge about TB prevention, promote the adoption of healthy behaviors, and empower health cadres as agents of change at the community level. Method: The program, conducted from 16 September to 15 October 2024 with 32 participants in Tunge Village, combined interactive lectures, simulations, and field audits to ensure a comprehensive understanding. Results: Post-activity evaluations demonstrated significant improvements: participants’ knowledge of TB increased from 21.9% to 71.9%, the adoption of home ventilation practices rose from 31.3% to 68.8%, and 32 trained health cadres were successfully established. Conclusion: This community-based empowerment program through health cadres proved effective in improving knowledge and behavior related to TB prevention. To ensure program sustainability, it is recommended to establish a monthly cadre forum facilitated by the community health center (Puskesmas), integrate the TB education module into routine Posyandu activities, and develop adaptable intervention designs for other agricultural areas with similar characteristics.
Effects of Red Pitaya (Hylocereus polyrhizus) on Lipid Profile of Male White Rats (Rattus norvegicus) Receiving High Fat Diet Werdiningsih, Wiwik; Suhartati, Suhartati
Folia Medica Indonesiana Vol. 54, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Red dragon fruit (Hylocereus polyrhizus) peel contains anthocyanin, fiber and vitamin C, so it can be used to improve lipid profile in dyslipidemia. The peel of the dragon fruit is not durable, so in this study we used freeze-dried dragon fruit peel. The aim of this study was to prove that the administration of the red dragon fruit peel in a dose of 0.72 g/200 g BW, 1.08 g/200 g BW, and 1.44 g/200 g BW of rat per day for 28 days may improve lipid profile in male wistar strain white rats with high-fat diet. Lipid profiles were studied by examining of total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides. This was a pure experimental study using randomized post test only control group design. This study used experimental animal of 30 male wistar strain white rats which were divided into five groups. Measurements of total, LDL, and HDL cholesterol levels were done by CHOD-PAP method, while triglyceride level was measured with GPO-PAP method. Data were analyzed statistically by One Way Anova test. The results of this study indicated that giving the peel of red dragon fruit as much as 0.72 g lowered total cholesterol levels, 1.08 g lowered total and LDL cholesterol levels, and 1.44 g lowered total cholesterol, LDL cholesterol, triglyceride levels, and raised HDL cholesterol level. Red dragon fruit peel can be used alternatively to improve lipid profile in dyslipidemia.
Pengaruh Ekstrak Etanol Kulit Batang Duwet (Syzygium cumini L.) terhadap Pertumbuhan Staphylococcus aureus Fitria, Faizatul; Untarto Swandono, Hari; Agusti Lukis, Prima; Werdiningsih, Wiwik
Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya Vol 6 No 2 (2025): Desember 2025
Publisher : Fakultas Sains, Teknologi, dan Analsisi Institut ilmu Kesehatan Bhakti Wiyata

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56399/jst.v6i2.313

Abstract

Bacterial infections, especially those caused by Staphylococcus aureus, are a serious global health problem. This bacterium can cause a range of diseases, from mild skin infections to potentially fatal sepsis. It has also been reported to have developed resistance to antibiotics, which highlights the need for developing natural antibiotics with minimal side effects. The Duwet plant (Syzygium cumini L.), particularly its bark, is traditionally used to treat dysentery, diarrhea, and dyspepsia, and contains numerous bioactive compounds. Due to these benefits and its compounds, the bark of the duwet tree has the potential to possess beneficial antibacterial properties. The purpose of this study was to determine the extent to which the ethanol extract of duwet bark can inhibit the growth of Staphylococcus aureus in a laboratory setting (in vitro). The methods used included an extraction process where the duwet bark was soaked in 96% ethanol, followed by a phytochemical test to determine its chemical content. The extract was then tested for its ability to inhibit the growth of Staphylococcus aureus using the well diffusion method at concentrations of 20%, 40%, and 60%. The results showed that the duwet bark extract had the strongest antibacterial activity at a concentration of 60%, with an inhibition zone of 10.67 ± 2.25 mm, which falls into the moderate category.
Co-Authors Agusti Lukis, Prima Anikasari, Erni Arshy Prodyanatasari Assolychatu zahro Basuki, Dewy Faisal Akhmal Muslikh Faizatul Fitria Fita Sari, Fita Jerhi Wahyu Fernanda, Jerhi Wahyu Laksono, Adi Nahdhia, Nadhifatun Ninis Yuliati Nugroho, Septiawan Nurjanah Tia Pratiwi Pratiwi, Wahyu Nur Suhartati Suhartati Suhartati Suhartati Suryanto Susilawati, Delis Untarto Swandono, Hari Wahyu Sri Astutik