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All Journal Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Kreativitas PKM Jurnal Ilmiah Ecosystem Pharma Xplore : Jurnal Sains dan Ilmu Farmasi HERBAPHARMA : Journal of Herb Farmacological Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Journal of Fundamental and Applied Pharmaceutical Science Jurnal Buana Farma JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences. Organisms: Journal of Biosciences Parapemikir Jurnal Ilmiah Farmasi Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) Jurnal Medika Farmaka Kartika : Jurnal Ilmiah Farmasi
Syumillah Saepudin
Program Studi Farmasi, Fakultas MIPA Universitas Al Ghifari, Bandung, Jawa Barat Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary

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An KRIM ANTIJERAWAT EKSTRAK ETANOL DAUN KESUM (Polygonum minus Huds) Syumillah Saepudin; Kusdi Hartono; Efriliya Andila Wasih
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.14707

Abstract

Kesum (Polygonum minus Huds) memiliki potensi sebagai antibakteri dan dapat dikembangkan menjadi sediaan krim untuk pengobatan jerawat. Salah satu eksipien krim, asam stearat, merupakan emulgator yang dapat mempengaruhi sifat fisik sediaan. Tujuan penelitian ini untuk melihat pengaruh konsentrasi asam stearat 6% (F1), 12% (F2), dan 18% (F3) terhadap sifat fisik sediaan krim. Ekstraksi daun kesum dilakukan menggunakan metode maserasi dengan pelarut etanol 70%. Konsentrasi ekstrak daun kesum yang diformulasikan menjadi krim adalah 5%. Evaluasi sifat fisik sediaan krim meliputi pengamatan organoleptik, uji nilai pH, homogenitas, dan daya sebar. Aktivitas antibakteri dari tiap formula dilakukan terhadap bakteri Propionibacterium acnes. Hasil menujukkan krim ekstrak daun kesum terdistribusi secara homogen, kisaran pH krim yang diperoleh adalah 4­6, kemampuan penyebaran krim adalah 5,2­6,2 cm. Hasil uji antibakteri formula krim F1, F2, dan F3 memiliki aktivitas yang kuat dalam menghambat pertumbuhan bakteri P. acnes. Sediaan krim ekstrak daun kesum dengan variasi konsentrasi asam stearat 6%,12%, dan 18% memiliki sifat fisik yang meliputi bentuk, warna dan bau yang stabil, sediaan yang homogen, nilai pH dan daya sebar yang telah memenuhi syarat evaluasi fisik sediaan krim.
Standardization, Quantification of Total Phenolics, Flavonoid Content, and Antibacterial Activity of Yellow Root (Arcangelisia flava (L.) Merr.) Herawati, Irma Erika; Dewi, Lisna; Kartikawati, Endah; Saepudin, Syumillah
Journal of Fundamental and Applied Pharmaceutical Science Vol. 7 No. 1 (2026): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v7i1.29746

Abstract

Yellow root (Arcangelisia flava (L.) Merr.) has been used empirical in West Sumatra, Indonesia, for stomach disease, anti-malaria, and tumors. The present study aims to characterize non-specific and specific parameters, total phenolic content (TPC), total flavonoid content (TFC), and antibacterial activity of yellow root. Standardization of yellow root extract tests was carried out in accordance with the Indonesian Herbal Pharmacopeia. TPC was determined by the Folin-Ciocalteu colorimetric method. TFC was calculated using an aluminum chloride colorimetric assay, and antibacterial activity was evaluated against Propionibacterium acnes ATCC 1223 by the agar diffusion method using the extract and fractions. The results for non-specific parameters showed the water content of the extract (10.1%) and the shrinkage-dried extract (12%). Specific parameters revealed that the extract had a distinct odor, a bitter taste, a brownish-yellow color, and a thick consistency. Microscopic parameters revealed fragments including fibrous sclerotic cells, parenchymal cells, exocarpic stone cells, stone cells, essential oil cells, and tracheal cells. The value of water-soluble compounds was 5.25%, and the value of the ethanol-soluble compounds was 19.75%. Thin-layer chromatography from the extract showed the presence of spots of alkaloids, phenolics, flavonoids, and saponins. The yellow root extract contained total phenolic and flavonoid contents of 87.37 mg GAE/g and 73.80 mg QE/g, respectively. At 800 ppm, the ethanolic extract and fractions, with an inhibition zone of 20.53±0.58 mm, approached the value for clindamycin phosphate (21.90±0.40 mm). Overall, these findings demonstrate that the standardized ethanolic extract of Arcangelisia flava (L.) Merr. roor possesses promising antibacterial activity against P. acnes, supporting its potential as a source of bioactive compounds for further development as a natural anti-acne agent.
Co-Authors Ade Cahyati Ajeng, Nurtina Dwi Al-Azzahra, Yunita Alifia Salsabila Annisa Khoerunnisa Baiq Vera El Viera Dadan Rohdiana Destiati, Yinyin Dewi, Anisya Dewi, Lisna Diani, Riski Dini Febrianty Efriliya Andila Wasih El Viera, Baiq Vera Ginayanti Hadisoebroto Henny Setiawati Herawati, Sinta Oktaviani Herliyani, Widya Hidayat, Taufik Septiyan inayah, ita Indria, Nefha Irma Erika Herawati Irma Erika Herawati Ita Inayah Kartikawati, Endah Kusdi Hartono Kusdi Hartono Lisna Dewi Luthfiyah Irbah As Saidah Marni, Aulia Mudrikah Ramdhani, Humairo Nurul Rahmayanti Nuur Hanifah, Hesty Octaviani, Anindita Rahayu, Iseu Raihani Febriani Sari, Dea Permata Septiyan, Taufik Syulastri Effendi Widiyaningrum, Eva Mutba Widiyawati, Ida Erna Wulansari Wulansari Yasmiwar Susilawati Yunita Al-Azzahra Yus Hargono Cahyaning Yudi