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All Journal Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Kreativitas PKM Jurnal Ilmiah Ecosystem HERBAPHARMA : Journal of Herb Farmacological Journal of Holistic and Health Sciences (Jurnal Ilmu Holistik dan Kesehatan) Jurnal Buana Farma JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Pijar MIPA Journal of Pharmaceutical and Sciences. Parapemikir Jurnal Ilmiah Farmasi Journal of Pharmaceutical Science and Clinical Pharmacy (PSCP) Jurnal Medika Farmaka Kartika : Jurnal Ilmiah Farmasi
Syumillah Saepudin
Program Studi Farmasi, Fakultas MIPA Universitas Al Ghifari, Bandung, Jawa Barat Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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An KRIM ANTIJERAWAT EKSTRAK ETANOL DAUN KESUM (Polygonum minus Huds) Saepudin, Syumillah; Hartono, Kusdi; Wasih, Efriliya Andila
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i2.14707

Abstract

Kesum (Polygonum minus Huds) memiliki potensi sebagai antibakteri dan dapat dikembangkan menjadi sediaan krim untuk pengobatan jerawat. Salah satu eksipien krim, asam stearat, merupakan emulgator yang dapat mempengaruhi sifat fisik sediaan. Tujuan penelitian ini untuk melihat pengaruh konsentrasi asam stearat 6% (F1), 12% (F2), dan 18% (F3) terhadap sifat fisik sediaan krim. Ekstraksi daun kesum dilakukan menggunakan metode maserasi dengan pelarut etanol 70%. Konsentrasi ekstrak daun kesum yang diformulasikan menjadi krim adalah 5%. Evaluasi sifat fisik sediaan krim meliputi pengamatan organoleptik, uji nilai pH, homogenitas, dan daya sebar. Aktivitas antibakteri dari tiap formula dilakukan terhadap bakteri Propionibacterium acnes. Hasil menujukkan krim ekstrak daun kesum terdistribusi secara homogen, kisaran pH krim yang diperoleh adalah 4­6, kemampuan penyebaran krim adalah 5,2­6,2 cm. Hasil uji antibakteri formula krim F1, F2, dan F3 memiliki aktivitas yang kuat dalam menghambat pertumbuhan bakteri P. acnes. Sediaan krim ekstrak daun kesum dengan variasi konsentrasi asam stearat 6%,12%, dan 18% memiliki sifat fisik yang meliputi bentuk, warna dan bau yang stabil, sediaan yang homogen, nilai pH dan daya sebar yang telah memenuhi syarat evaluasi fisik sediaan krim.
Uji Aktivitas Antibakteri dan Analisis KLT-Bioautografi Ekstrak Etanol Daun Situduh Langit (Erigeron sumatrensis Retz) Terhadap Bakteri Escherichia coli Saepudin, Syumillah; Kartikawati, Endah; Herliyani, Widya
Jurnal Medika Farmaka Vol 2 No 1 (2024): Jurnal Medika Farmaka
Publisher : LP4M STIKes Karsa Husada Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33482/jmedfarm.v2i1.31

Abstract

Introduction: Situduh langit (Erigeron sumatrensis Retz.) is a plant with medicinal benefits for mouthwash, headaches, muscle pain, canker sores, blood pressure regulation, and acne treatment. It also has antimicrobial activity. Secondary metabolites like saponins and flavonoids in situduh langit can treat diarrhea. Method: This study aims to determine the concentration and TLC-Bioautography profile of ethanol extract from situduh langit leaves for inhibiting Escherichia coli. The leaves were extracted using the maceration method with 70% ethanol. The antibacterial activity of the ethanol extract at concentrations of 6.5%, 12.5%, 25%, and 50% was tested using the disc diffusion method. TLC-Bioautography identified the compounds with antibacterial activity. Results: ANOVA analysis showed normal and homogeneous data with a significance value of 0.000 < 0.05. The 6.5% concentration had an average inhibition of 6.0±0.00; 12.5% had 6.23±0.24; 25% had 6.77±0.89. These showed the smallest effect on inhibiting Escherichia coli growth. The 50% concentration had an average inhibition of 7.71±1.17, showing the greatest effect. TLC-Bioautography showed Rf values of 0.97; 0.92; 0.67; 0.60; 0.31; 0.21 and 0.14, with no clear zones forming around the media. Conclusion: The leaf extract of situduh langit has antibacterial activity against Escherichia coli at a 50% concentration with a moderate category, and TLC-Bioautography analysis of the ethanol extract did not form clear zones around the media.
An Analysis of Total Flavonoid Content in Extracts of Bandotan, Ketul, and Kirinyuh Leaves with Various Solvents Saepudin, Syumillah; Hidayat, Taufik Septiyan; Destiati, Yinyin; Al-Azzahra, Yunita; Kartikawati, Endah
HERBAPHARMA : Journal of Herb Farmacological Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Desember 2024
Publisher : STIKes Muhammadiyah Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55093/herbapharma.v6i2.579

Abstract

Bandotan (Ageratum conyzoides (L.) L.), Ketul (Bidens pilosa L.), dan Kirinyuh (Chromolaena odorata (L.)) merupakan tanaman invasif yang mudah ditemui di pekarangan rumah. Akan tetapi, belum dimanfaatkan secara optimal karena tanaman ini dianggap sebagai gulma, walaupun dianggap sebagai gulma tetapi masyarakat menggunakan tanaman ini sebagai bahan pengobatan untuk penyakit sakit kepala, sakit perut, penyembuh luka, diabetes, dan obat kumur. Salah satu senyawa metabolit sekunder yang terkandung didalam tanaman tersebut yaitu flavonoid. Penelitian ini dilakukan untuk menentukan kadar flavonoid total pada ekstrak daun bandotan, daun ketul, dan daun kirinyuh yang diekstraksi menggunakan metode maserasi dengan pelarut etanol 96%, etil asetat, dan akuades. Penetapan kadar flavonoid total dilakukan dengan menggunakan spektrofotometer UV-Vis. Pengujian analisis kualitatif menunjukkan seluruh sampel mengandung senyawa flavonoid. Hasil penetapan kadar flavonoid total paling rendah diperoleh pada ekstrak etil asetat daun bandotan sebesar 2,678 mg QE/g dan kadar flavonoid total paling tinggi diperoleh pada ekstrak etanol 96% daun kirinyuh sebanyak 78,229 mg QE/g.
ANALISIS KUALITATIF DAN KUANTITATIF SENYAWA BIOAKTIF EKSTRAK KERANG MATA LEMBU (Turbo setosus) El Viera, Baiq Vera; Sari, Dea Permata; Widiyawati, Ida Erna; Saepudin, Syumillah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 10 No 1 (2025): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v10i1.2343

Abstract

The rough turban snail (Turbo setosus) is a marine mollusk species often utilized as a traditional food source due to its high protein content and its empirically believed aphrodisiac properties. However, limited information is available on its bioactive compound content, so this study aims to be a preliminary study to analyze the bioactive compound content of the rough turban snail extract using qualitative and quantitative tests. Qualitative tests of bioactive compounds were carried out by adding various reagents that produce color changes or precipitate formation, while quantitative tests were carried out using UV-Vis spectrophotometry. The results of qualitative tests showed that the ethanol extract of the rough turban snail contains alkaloids, flavonoids, phenolics, steroids, and tannins. Quantitative tests gave results for phenolic content, flavonoid content, alkaloid content, and tannin content of 34.749 mg GAE/g extract, 11.6226 mg QE/g extract, 3.365 mg CE/g extract, and 332.79 mg TAE/g extract, respectively. The results of this study provide information on the bioactive compound content of T. setosus, which can be further developed as a natural product with pharmacological properties.
Analysis of antioxidant and standardization of ethanol extract of rumput mutiara (Oldelandia corymbosa L.) Herawati, Irma Erika; Saepudin, Syumillah
Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i2.27939

Abstract

The majority of traditional medicinal plants in Indonesia lack scientific validation. Scientific assessment, in conjunction with traditional knowledge, is crucial for acquiring effective pharmaceuticals for commercial use. Rumput mutiara (Oldelandia corymbosa L) is a member of the Rubiaceae family and has been utilized as a traditional medicinal plant for the treatment of various ailments. The objective of this research was to assess the quality of both specific and non-specific parameters and to investigate the antioxidant potential of rumput mutiara. Antioxidant activity was evaluated with 2,2-diphenyl-1-picrylhydrazy (DPPH). The findings for non-specific parameters indicated that the shrinkage drying of the extract and the water content were 18.00 ± 0.000% and 12.20 ± 0.000%, respectively. Simultaneously, particular parameters indicate that the extracts possess a distinct odor, exhibit a blackish-brown hue, and display a viscous consistency. Microscopic parameters of rumput mutiara simplicia showed fragments such as anthers, leaf mesophyll, epidermis and stomata, transport bundles, stem parenchym, and sclerenchyma. Spesific parameters, such as the water-soluble content, and ethanol-soluble compounds were 72.00 ± 0.000 % and 35.00± 0.000 % , respectively. In addition, TLC profiles showed that secondary metabolites of extract  were 6 alkaloids, 5 phenolics, 5 flavonoids, 5 tanins, 3 saponins, 5 steroid, and 5 glycosides. The extract has strong antioxidant activity with IC50 value of 14.11 ±0.008 µg/mL.
Pengaruh Perbedaan Metode Ekstraksi Terhadap Kadar Senyawa Bioaktif Ekstrak Daun Sirih Hutan Piper aduncum L. Nuur Hanifah, Hesty; Saepudin, Syumillah; Octaviani, Anindita
Jurnal Ilmiah Ecosystem Vol. 25 No. 2 (2025): Ecosystem Vol. 25 No 2, Mei - Agustus Tahun 2025
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35965/eco.v25i2.6327

Abstract

Piper aduncum L., dikenal sebagai sirih hutan, merupakan tanaman dari famili Piperaceae yang secara tradisional dimanfaatkan untuk mengobati luka bakar, bisul, batuk, sariawan, dan gangguan saluran cerna. Tanaman ini diketahui mengandung senyawa metabolit sekunder seperti fenolik, flavonoid, dan alkaloid. Penelitian bertujuan mengevaluasi pengaruh metode ekstraksi maserasi dan refluks terhadap kadar senyawa fenolik, flavonoid, dan alkaloid menggunakan spektrofotometer UV-Vis. Hasil analisis menunjukkan bahwa metode refluks menghasilkan kadar fenolik dan alkaloid yang lebih tinggi (60,686 mg GAE/g dan 4,628 mg PE/g) dibandingkan maserasi (42,134 mg GAE/g dan 3,678 mg PE/g). Sebaliknya, kadar flavonoid lebih tinggi pada metode maserasi (30,726 mg QE/g) dibandingkan refluks (26,368 mg QE/g). Perbedaan metode ekstraksi berpengaruh terhadap komposisi metabolit sekunder dalam ekstrak daun sirih hutan. Piper aduncum L., commonly known as forest betel, is a plant from the Piperaceae family that has traditionally been used to treat burns, boils, coughs, mouth ulcers, and digestive disorders. This plant is known to contain secondary metabolites such as phenolics, flavonoids, and alkaloids. This study aimed to evaluate the effect of maceration and reflux extraction methods on the levels of phenolic, flavonoid, and alkaloid compounds using a UV-Vis spectrophotometer. The results showed that the reflux method produced higher levels of phenolics and alkaloids (60.686 mg GAE/g and 4.628 mg PE/g, respectively) compared to the maceration method (42.134 mg GAE/g and 3.678 mg PE/g). Conversely, the maceration method yielded a higher flavonoid content (30.726 mg QE/g) than the reflux method (26.368 mg QE/g). The differences in extraction methods significantly influenced the composition of secondary metabolites in the forest betel leaf extract.
Penyuluhan Rasionalisasi Penggunaan Antibiotik sebagai Strategi Pencegahan Resistensi di RW 08 Desa Cikadut Saepudin, Syumillah; Dewi, Anisya; Wulansari, Wulansari; Salsabila, Alifia; Diani, Riski; Indria, Nefha
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 8, No 11 (2025): Volume 8 No 11 (2025)
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v8i11.22568

Abstract

ABSTRAK Penggunaan antibiotik yang tidak rasional merupakan penyebab utama meningkatnya resistensi antimikroba di Indonesia. Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan pengetahuan dan mengubah sikap warga terkait penggunaan antibiotik melalui penyuluhan berbasis komunitas. Program dilaksanakan selama satu minggu dari tanggal 15–21 Juni 2025 di RW 08 Desa Cikadut, Kabupaten Bandung, dengan melibatkan mahasiswa sebagai pelaksana utama. Metode yang digunakan adalah pra-eksperimental dengan desain one group pre-test and post-test yang melibatkan 80 responden dari berbagai latar belakang. Kegiatan penyuluhan dilakukan secara door to door dengan pendekatan edukatif partisipatif, menggunakan media leaflet dan materi yang mengacu pada prinsip DAGUSIBU (Dapatkan, Gunakan, Simpan, dan Buang). Instrumen evaluasi berupa kuesioner pre-test dan post-test digunakan untuk mengukur perubahan pengetahuan dan sikap peserta. Peneliti menganalisis data dengan metode uji paired t-test untuk membandingkan hasil sebelum dan sesudah intervensi dengan bantuan aplikasi SPSS versi 25. Hasil menunjukkan peningkatan signifikan pada skor pengetahuan setelah penyuluhan (p < 0,05), serta perubahan sikap positif dalam penggunaan antibiotik secara bijak. Kegiatan ini membuktikan bahwa pendekatan edukatif yang humanis, partisipatif, dan kontekstual efektif dalam meningkatkan kesadaran masyarakat serta memperkuat kontribusi institusi pendidikan tinggi dalam pembangunan kesehatan berbasis komunitas. Kata Kunci: Penyuluhan, Antibiotik, Resistensi, Cikadut  ABSTRACT The irrational use of antibiotics is a major contributing factor to the rise of antimicrobial resistance in Indonesia. This community service activity aimed to improve public knowledge and attitudes regarding the rational use of antibiotics through a community-based educational intervention. The program was conducted over one week June periode from 15–21, 2025 in RW 08, Cikadut Village, Bandung Regency, with university students serving as the primary implementers. A pre-experimental one-group pre-test and post-test design was applied, involving 80 respondents from diverse demographic backgrounds. The counseling was delivered door to door using a participatory and contextual educational approach, guided by the DAGUSIBU principles (Get, Use, Store, and Dispose). Evaluation instruments included structured questionnaires administered before and after the intervention. Data analysis was performed using a paired t-test to evaluate differences between pre- and post-intervention results, assisted by SPSS version 25. The results showed a significant increase in participants’ knowledge scores after the intervention (p < 0.05), along with improved attitudes toward the safe and responsible use of antibiotics. This activity demonstrates that a humanistic and locally adapted educational strategy is effective in increasing public awareness and highlights the strategic role of higher education institutions in translating scientific knowledge into community health practice. Keywords : Counseling, Antibiotics, DAGUSIBU, Resistance, Cikadut
Preparation and Evaluation of Capsule Shell Films Formulated from Brown Seaweed Alginate (Sargassum crassifolium) El Viera, Baiq Vera; Saepudin, Syumillah; As Saidah, Luthfiyah Irbah
Jurnal Pijar Mipa Vol. 21 No. 1 (2026)
Publisher : Department of Mathematics and Science Education, Faculty of Teacher Training and Education, University of Mataram. Jurnal Pijar MIPA colaborates with Perkumpulan Pendidik IPA Indonesia Wilayah Nusa Tenggara Barat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jpm.v21i1.10824

Abstract

Brown seaweed (Sargassum crassifolium) grows a lot along the coast of Indonesia, especially in the Pangandaran area. Brown seaweed may serve as a viable natural source of sodium alginate, a biopolymer extensively utilized in pharmaceutical dosage forms. Most capsule shells are made of gelatin, but as more people seek alternatives to animal products, alginate-based materials are being explored. This study aimed to extract sodium alginate from Sargassum crassifolium and fabricate capsule-shell films, subsequently evaluating their physicochemical properties. To obtain sodium alginate powder, the extraction process involved the following steps: acid pretreatment, alkaline immersion, sodium carbonate extraction, bleaching, precipitation, and drying. The extracted material had a moisture content of 12% and a yield of 26.21%. FTIR spectroscopy confirmed the structure of the extracted material by showing that its functional groups, such as hydroxyl, carbonyl, C–O–H, and C–O–C, were the same as those of standard sodium alginate. Capsule-shell films were prepared by varying the alginate concentration in the casting volume to 3%, 4%, and 5%. Organoleptic testing showed that all formulations produced films that were slightly brown, opaque, and felt like paper. Tests on thickness and weight showed that films with higher alginate concentrations were thicker and heavier. F3-1 had a thickness value that was closest to what is needed for commercial hard capsules, and F1-2 had a moisture content range that was acceptable for commercial capsule shells. The moisture content of the formulations ranged from 8% to 24%, depending on the temperature, humidity, and length of time they were dried. All formulations produced films that could be used, but F3-1 had the best thickness, and F1-2 had the correct moisture content, supporting their potential application as non-gelatin capsule-shell alternatives.
An Pengaruh Perlakuan Dekolorisasi Karbon Aktif terhadap Intensitas Warna dan Kadar Fenolik Total dari Ekstrak Daun Okra (Abelmoschus esculentus L.) Saepudin, Syumillah; Hartono, Kusdi; Khoerunnisa, Annisa; Rahmayanti , Nurul; Febriani, Raihani
Journal of Pharmaceutical and Sciences JPS Volume 9 Nomor 1 (2026)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v9i1.1156

Abstract

Background: Okra leaves (Abelmoschus esculentus L.) are a potential natural source of phenolic compounds with antioxidant activity and prospective applications in pharmaceutical and cosmetic formulations. However, the dark green color of the extract, mainly due to chlorophyll pigments, may negatively affect the aesthetic quality of the final product. Decolorization using activated carbon is therefore required to improve visual appearance without reducing bioactive compounds. Objective: This study aimed to evaluate the effect of activated carbon decolorization on color intensity and total phenolic content of okra leaf extract. Methods: Okra leaf extract was prepared by maceration using 70% ethanol. Decolorization was performed using activated carbon at various concentrations (0.5–8%) and contact times (2–72 hours). Color intensity was measured using a UV–Vis spectrophotometer at 663.50 nm. Total phenolic content was determined using the Folin–Ciocalteu method and expressed as mg gallic acid equivalent (GAE)/g extract. Statistical analysis was conducted using one-way ANOVA at a significance level of 0.05. Results: Activated carbon effectively reduced color intensity through adsorption mechanisms. Variation in activated carbon concentration did not significantly affect total phenolic content (p = 0.71), whereas contact time had a significant effect (p = 0.0014). The optimum condition was observed at 24 hours of contact time, showing reduced color intensity while maintaining phenolic content. No significant correlation was found between absorbance reduction and total phenolic content (ρ = 0.102; p = 0.555), indicating selective adsorption. Conclusion: Activated carbon decolorization effectively improves the visual appearance of okra leaf extract without significantly reducing its total phenolic content. The optimum contact time was 24 hours, suggesting its potential application in enhancing the quality of natural-based pharmaceutical and cosmetic preparations.
Co-Authors Ade Cahyati Ajeng, Nurtina Dwi Al-Azzahra, Yunita Alifia Salsabila As Saidah, Luthfiyah Irbah Dadan Rohdiana Destiati, Yinyin Dewi, Anisya Dewi, Lisna Diani, Riski Dini Febrianty El Viera, Baiq Vera Febriani, Raihani Herawati, Sinta Oktaviani Herliyani, Widya Hidayat, Taufik Septiyan inayah, ita Indria, Nefha Irma Erika Herawati Kartikawati, Endah Khoerunnisa, Annisa Kusdi Hartono, Kusdi Marni, Aulia Mudrikah Ramdhani, Humairo Nuur Hanifah, Hesty Octaviani, Anindita Rahayu, Iseu Rahmayanti , Nurul Sari, Dea Permata Septiyan, Taufik Wasih, Efriliya Andila Widiyaningrum, Eva Mutba Widiyawati, Ida Erna Wulansari Wulansari Yasmiwar Susilawati Yunita Al-Azzahra