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All Journal International Journal of Public Health Science (IJPHS) Indonesian Journal of Pharmaceutical Science and Technology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Berkala Kedokteran Jurnal Farmasi Sains dan Komunitas BERDIKARI : Jurnal Inovasi dan Penerapan Ipteks JSFK (Jurnal Sains Farmasi & Klinis) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) Community Empowerment Journal of Fundamental and Applied Pharmaceutical Science Prosiding Seminar Nasional Program Pengabdian Masyarakat Jurnal Medika: Medika
Salmah Orbayinah
Universitas Muhammadiyah Yogyakarta
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Dentistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Journal of Fundamental and Applied Pharmaceutical Science

 1 
Antibacterial Activity of Fractions from Extract Ethanolic of Hylocereus Polyrhizus Peel Against E. Coli and S. aureus Tsania Khusnul Khotimah; Annisa Krisridwany; Salmah Orbayinah; Sabtanti Harimurti
Journal of Fundamental and Applied Pharmaceutical Science Vol 1, No 2 (2021): February
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v1i2.11001

Abstract

Peel of red dragon fruit (Hylocereus polyrhizus) is one of the plants used as an antibacterial agent as it contains saponin triterpenoid compounds, flavonoid compounds, and alkaloid compounds which can have antibacterial activity. This research aims to determine the antibacterial effect of n-hexane, ethyl acetate, and ethanol fraction of red dragon fruit’s peel against Escherichia coli and Staphylococcus aureus by the concentration of 10mg/ml, 20mg/ml, 40mg/ml, 80mg/ml dan 160mg/ml. This research was conducted by using laboratory experiments. The simplicia was macerated with 96% ethanol and fractionated by n-hexane and ethyl acetate. The phytochemical screening of the fraction was n-hexane fraction containing saponin and alkaloid, while the ethyl acetate fraction contained saponin and flavonoid. Kanamycin was used as a positive control, while DMSO was used as a negative control. According to this research, the MIC value of ethanol fraction, n-hexane fraction, and ethyl acetate fraction were 80mg/ml, 20mg/ml, and 80mg/ml, respectively, for E. coli and all fractions were 10mg/ml for S. aureus. Based on the average diameter of the inhibition zone, the largest diameter zone in E. coli was ethyl acetate fraction with 160mg/ml concentration  that was  10,33mm. Meanwhile, in S. aureus n-hexane fraction, it was 160mg/ml, which was 11,20mm. This result showed that the n-hexane fraction has good gram-positive activity while the ethyl acetate fraction has good activity on gram-negative.
Potential of Binahong Leaf Ethanol Extract (Anredera cordifolia (Ten.) Steenis) against Elevated HDL Levels (Rattus corvegious) Streptozonic-Induced Wistar Strain Orbayinah, Salmah; Auliya, Rizqa
Journal of Fundamental and Applied Pharmaceutical Science Vol 5, No 1 (2024): August
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/jfaps.v5i1.22496

Abstract

Diabetes mellitus is frequently associated with decreased levels of high-density lipoprotein (HDL), which are prevalent cardiovascular disease risk factors. The use of synthetic drugs substantially increases the risk of atherosclerosis since they often have severe side effects, require high costs, and have poor prescription adherence. Anredera cordifolia (Ten.) Steenis, often known as the binahong plant, is a potentially effective complementary therapy for increasing HDL levels. Flavonoid compounds present in the ethanol extract of Binahong leaf have the potential to increase HDL levels. This work aims to evaluate the action of an ethanol extract from binahong leaves in raising HDL levels in rats of the Streptozotocin-induced Wistar strain (Rattus norvegicus). In this research, the Pretest-Posttest Control Group Design was used. The study involved the grouping of five Wistar strain rats (n=5) into five distinct groups: one received binahong leaf ethanol extract at concentrations of 25 mg/kg BW, 50 mg/kg BW, and 100 mg/kg BW, which served as the positive control group and received a negative control group supplemented with atorvastatin at 0.9 mg/kg BW. The CHOD-PAP method was applied to measure HDL levels. SPSS software was used to run the normality test, Wilcoxon test, one-way ANOVA test, and paired sample t-test. No statistically significant difference in HDL levels was found between treatment groups. The 50 mg/kg BW binahong leaf extract group had significantly higher HDL levels (p-value 0.05). As a result, the ethanol extract obtained from binahong leaves presumably raises HDL levels in streptozotocin-induced Wistar rats.
Co-Authors - Restu Abidin, Ghaida Rahmani Putri Adhe Filiyahtri Mohdar Ardi Pramono Auliya, Rizqa Dewi, Yunita P. Dina Khoirin Wahidah Dini, Riyanti Raf’al Faizah Nurul Latifah Fathinah Hanun Fitra Korniawan Hari Widada Hari Widada Hari Widada Hari Widada, Hari Haryono, Dedy Hasna Nuansa Sasadara Indardi Indardi Indriastuti Cahyaningsih Ingenida Hadning Kartyanto, Adhita Krisridwany, Annisa Kurnia Eka Permana, Kurnia Eka Kurniawan, Fariez Laksmi Putri Utami Lilis Suryani Lilis Suryani Lukluk Purbaningrum, Lukluk Muhammad Thesa Ghozali Nanang Kurniawan Nosa Septiana Anindita Nurul Maziyyah Nurul Maziyyah Pinasti Utami Pinasti Utami R. Sapto Hendri Boedi Soesatyo Sabtanti Harimurti Supono Supono Surria Dwiwahyu Suryani, Lilis Tri Wulandari Kesetyaningsih Tsania Khusnul Khotimah Utami, Inta Resty Vella Lailli Damarwati Wiwik Kusumawati