This article examines the establishment and role of Indonesia’s Majelis Profesi Nakes (MPN) under Health Law No. 17 of 2023, addressing the legal and institutional challenges of professional health governance. The study identifies the gap between Indonesia’s emerging regulatory framework and mature international models, such as the United Kingdom’s General Medical Council, the United States’ Federation of State Medical Boards, and Australia’s Medical Board. Using a qualitative normative legal approach combined with comparative analysis, the research analyzes statutory provisions, institutional designs, and governance practices to assess MPN’s legitimacy, regulatory capacity, and alignment with global standards. The findings indicate that while MPN is statutorily mandated to oversee ethics, discipline, and multi-professional coordination, its operational capacity is constrained by pending implementing regulations, limited transparency mechanisms, and incomplete integration of continuing professional development into its regulatory processes. Comparative insights demonstrate the importance of independent governance, public accountability, and integrated CPD and revalidation systems in strengthening institutional legitimacy and professional oversight. The study concludes that MPN can achieve effective and credible governance by embedding responsive regulatory strategies, formalizing participatory procedures, ensuring independence, and establishing mechanisms for international cooperation. The article contributes a novel integrative perspective, combining doctrinal, comparative, and theoretical analyses, and offers recommendations for legal refinement and future empirical research to monitor MPN’s implementation and effectiveness.