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All Journal VALENSI Indonesian Journal of Applied Sciences STOMATOGNATIC- Jurnal Kedokteran Gigi Insisiva Dental Journal : Majalah Kedokteran Gigi Insisiva Dentino: Jurnal Kedokteran Gigi Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia B-Dent, Jurnal Kedokteran Gigi Universitas Baiturrahmah Jurnal Kreativitas PKM Jurnal Review Pendidikan dan Pengajaran (JRPP) JPP Jurnal Kesehatan Poltekkes Palembang Indonesia Berdaya Jurnal Pengabdian Masyarakat Kebidanan Jurnal Kesehatan Gigi dan Mulut (JKGM) Denta: Jurnal Kedokteran Gigi Indonesian Journal of Dentistry Molekul: Jurnal Ilmiah Kimia Prosiding Seminar Kesehatan Masyarakat
Risyandi Anwar
Herbal Medicine Research, Department Of Pediatric Dentistry, Faculty Of Dental Medicine, University Of Muhammadiyah Semarang, Semarang
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Dentistry Economics, Econometrics & Finance Education Energy Environmental Science Health Professions Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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24-Methylenecycloartanol Isolated from The Fruit Peel of Matoa (Pometia pinnata) and Its Activity as an Antibacterial against Staphylococcus aureus and Escherichia coli Anwar, Risyandi; Arnov, Steffi Triany; Putri, Ghesta Alifka; Sinaga, Siska Elisahbet; Naini, Al Arofatus; Supratman, Unang
Chimica et Natura Acta Vol 12, No 3 (2024)
Publisher : Departemen Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/cna.v12.n3.55682

Abstract

Triterpenoids are compounds with highly diverse chemical structures and exhibit interesting biological activities such as antiviral, antibacterial, anti-inflammatory, and anticancer properties. The matoa plant (Pometia pinnata), belonging to the genus Pometia from the family Sapindaceae, has been used in traditional medicine and shows potential as an antibacterial agent. The purpose of this research was to isolate and determine the chemical structure of triterpenoids from the peel of the matoa fruit (P. pinnata) and to evaluate their antibacterial activity against Staphylococcus aureus and Escherichia coli. The ethyl acetate extract from the peel of P. pinnata demonstrated significant antibacterial activity. In this study, a triterpenoid compound was identified, and its chemical structure was determined using spectroscopic methods, including UV, IR, MS, 1H-NMR, 13C-NMR, and 2D-NMR, as well as by comparing data from the literature. The compound was identified as a cycloartane-type triterpenoid known as 24-methylenecycloartanol. The compound was then tested for antibacterial activity against S. aureus and E. coli. The test results showed a minimum inhibitory concentration (MIC) of 500 μg/mL for both bacteria, which was categorized as very weak
THE POWER OF RED SHOOT LEAF EXTRACT: HOW SOLVENT VARIATIONS AFFECT BONE HEALING AFTER TOOTH EXTRACTION IN RATS Rachmawati, Ika; Anwar, Risyandi; Prajarini, Megawati; Asti, Salma Mei; Febriyani, Ita
Indonesian Journal of Dentistry Vol 5, No 1 (2025): February 2025
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v5i1.17127

Abstract

Background: A popular medicinal plant in Indonesia, red shoot leaves (Syzygium myrtifolium Walp) have been extensively explored for their biological activity and potential to promote hard tissue healing in tooth sockets after extraction. However, few studies have examined this potential. Analyzing the impact of red leaf extract with different solvents on alveolar bone repair in the post-extraction socket in Wistar rats was the aim of this investigation.Method: This study aimed to determine differences in the healing process of bone after tooth extraction. Conducted on 15 male Wistar rats (12 weeks old, weighing 150 – 200 grams). The experiment includes three groups: Group A (5 animals received a gel base as a negative control group), Group B: (5 animals received 2% n-hexane gel treatment of red shoot leaves) and Group C (5 animals received 2% extract ethanol gel of red shoot leaves, based on designated observation days 30. The assessment involves bone remodeling area o from radiograph.Outcome: The average alveolar bone density varies greatly, as indicated by the study's p value of 0.000 (p < 0.005). The group that had 2% n-hexane gel treatment for red shoot leaves had the highest average alveolar bone density. According to the results of the phytochemical screening test, the n-hexane extract included triterpenoid and steroids, but the ethanol extract contained flavonoids, tannins, and alkaloids. The findings of this study demonstrate that the use of solvents with varying polarity can have an impact on bone remodeling.Conclusion: The alveolar bone mineral density of Wistar rats following tooth extraction was increased by 2% n-hexane gel treatment of red shoot leaves.
ACTIVITY OF WATER AND ETHANOL Syzygium myrtifolium Walp. AS ANTIBACTERIAL Aggregatibacter actinomycetemcomitans Deviana Adinda Nurfatimah; Risyandi Anwar; Puspito Ratih Hardhani
Denta Journal Kedokteran Gigi Vol 19 No 1 (2025): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/denta.v19i1.1

Abstract

Background: One of the pathological conditions in the mouth that affects periodontal tissue is periodontitis. Aggregatibacter actinomycetemcomitans is a potential trigger of periodontal disease if allowed to settle, multiply, and express virulence factors. The pharmacological activity of Syzygium myrtifolium based on solvent extract has several functions, one of which is antibacterial. Solvents function to attract compounds or active ingredients in natural materials, and solvents are distinguished based on their polarity. Water is very polar, so it will attract compounds or active ingredients that are very polar, while ethanol is polar, so it will attract active substances/compounds that are polar. So that later it can be known how both perform. Objective: This study aims to determine the activity of water and ethanol extracts of Syzygium myrtifolium Walp. 10%, 20%, 40%, and 80% in inhibiting the growth of Aggregatibacter actinomycetemcomitans bacteria. Materials and Methods: This study is a laboratory experiment. Ethanol extract of Syzygium myrtifolium Walp. was partitioned to obtain a water extract of Syzygium myrtifolium Walp. A  disc diffusion method on Mueller Hinton Agar (MHA) media was the antibacterial test method used in this study (n=4). Metronidazole 50 µg was used as a positive control and DMSO 2% as a negative control. Results: The average inhibition zone of ethanol extract was 9.11 mm, 11.475 mm, 13.625 mm, and 15.2875 mm, respectively, while the water extract was 10.3125 mm, 13.25 mm, 14.725 mm, and 16.725 mm, respectively. Positive control 22.975 mm and negative control 0 mm. Conclusion: Water and ethanol extracts of Syzygium myrtifolium Walp. have antibacterial activity against Aggregatibacter actinomycetemcomitans.
KAJIAN LITERATUR: STRATEGI OPTIMALISASI CRM DALAM MENINGKATKAN DAYA SAING RUMAH SAKIT DI ERA DIGITAL Risyandi Anwar; Fitri Anisdyasarathi
Jurnal Review Pendidikan dan Pengajaran Vol. 8 No. 1 (2025): Volume 8 No. 1 Tahun 2025
Publisher : LPPM Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jrpp.v8i1.42456

Abstract

Transformasi digital telah mendorong perubahan signifikan dalam sektor kesehatan, membuka peluang bagi rumah sakit untuk meningkatkan efisiensi, kualitas layanan, dan hubungan dengan pasien. Customer Relationship Management (CRM) telah diakui sebagai strategi penting dalam menciptakan keunggulan kompetitif melalui pengelolaan data pasien yang efisien dan personalisasi layanan. Penelitian ini bertujuan untuk menganalisis manfaat, tantangan, dan strategi optimalisasi CRM di rumah sakit dalam konteks transformasi digital. Penelitian ini menggunakan pendekatan systematic literature review (SLR) dengan menganalisis artikel akademik dan penelitian empiris yang diterbitkan antara tahun 2018–2024. Proses analisis dilakukan secara tematik untuk mengidentifikasi pola, manfaat, tantangan, dan rekomendasi implementasi CRM. CRM terbukti meningkatkan loyalitas dan kepuasan pasien melalui integrasi teknologi seperti Big Data Analytics, Artificial Intelligence (AI), dan sistem berbasis cloud. Namun, implementasi CRM menghadapi kendala seperti biaya investasi tinggi, resistensi organisasi, dan isu privasi data. Dengan strategi yang tepat, CRM dapat menjadi alat yang efektif dalam meningkatkan daya saing rumah sakit, terutama melalui dukungan manajemen yang kuat, pelatihan staf, dan adopsi teknologi modern.
POTENSI EKSTRAK ETANOL DAN N-HEKSAN KULIT BUAH MATOA (Pometia pinnata) SEBAGAI ANTIBAKTERI TERHADAP Streptococcus mutans Sulistyorini, Ratna; Tripermata, Anita Novia; Anwar, Risyandi
Jurnal Kesehatan Gigi dan Mulut (JKGM) Vol 7 No 1 (2025): Jurnal Kesehatan Gigi dan Mulut (JKGM)
Publisher : Jurusan Kesehatan Gigi, Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jkgm.v7i1.2760

Abstract

Latar Belakang: Karies gigi merupakan permasalahan dalam bidang kesehatan gigi dan mulut yang sering kali dihadapi masyarakat Indonesia. Salah satu bakteri yang dapat menyebabkan karies gigi adalah Streptococcus mutans Pada tanaman matoa ditemukan senyawa tanin, flavonoid, tapenoid, saponin, alkaloid dan glikosida. Tujuan dari penelitian ini adalah untuk mengetahui potensi ekstrak metanol dan n-heksan kulit buah Pometia pinnata sebagai antibakteri Streptococcus mutans pada konsentrasi 25%, 50%, 75%, 100%. Metode: Metode penelitian adalah eksperimental laboratorium. Ekstrak metanol kulit buah matoa dibuat dengan metode maserasi kemudian dilakukan partisi untuk mendapat ekstrak n-heksan kulit buah matoa. Uji antibakteri dilakukan dengan metode difusi cakram pada media Brain Heart Infusion Agar (BHIA) dengan 4 kali pengulangan sampel. Pepsodent herbal mouthwash digunakan sebagai kontrol positif dan DMSO 2% digunakan sebagai kontrol negatif. Hasil: Hasil penelitian menunjukkan rerata zona hambat ekstrak metanol masing-masing 1,625 mm, 0,8625 mm, 0 mm, dan 0 mm, kontrol positif 3,375 mm dan kontrol negatif 0 mm, sedangkan ekstrak n-heksan pada semua konsentrasi memiliki rerata zona hambat 0 mm. Kesimpulan: Dapat disimpulkan bahwa ekstrak metanol kulit buah Pometia pinnata konsentrasi 100% dan 75% berpotensi sebagai antibakteri Streptococcus mutans dengan rerata zona hambat masing-masing 1,625 mm dan 0,8625 mm dengan kategori lemah, sedangkan ekstrak n-heksan kulit buah Pometia pinnata tidak berpotensi antibakteri Streptococcus mutans.
Efektivitas Ekstrak Daun Pucuk Merah pada Penyembuhan Luka Pasca Pencabutan Gigi Tikus Nikmaturrizqi, Nada; Anwar, Risyandi; Amiza Zam, Syarifah Nova
JPP JURNAL KESEHATAN POLTEKKES PALEMBANG Vol 20 No 1 (2025): JPP (Jurnal Kesehatan Poltekkes Palembang)
Publisher : Poltekkes Kemenkes Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36086/jpp.v20i1.2804

Abstract

Background: Tooth extraction is a procedure that involves removing the tooth from the tooth socket. The wound healing process after tooth extraction ranges from 3 to 14 days. Wound healing can be treated with povidone iodine, but excessive use has side effects. Another alternative is red shoot leaves Methods: Experimental research with posttest only control group design. The sample was 30 male wistar rats, divided into 5 groups, namely positive control given povidone iodine, negative control base, 2% of Syzygium myrtifolium walp leaves extract, 4% of Syzygium myrtifolium walp leaves extract, and 6% of Syzygium myrtifolium walp leaves extract.. Results: Obtained a p value of 0.048 (p <0.05), indicating that there is a significant difference in the amount of epithelial thickness of all groups and the administration of Syzygium myrtifolium walp extract gel with a concentration of 6% on day 14 is thicker. Conclusion: Giving Syzygium myrtifolium walp leaves extract effect on wound healing after tooth extraction in male wistar rats.
THE INHIBITORY EFFECT OF BAMBOO CHARCOAL EXTRACT ON THE GROWTH OF STREPTOCOCCUS MUTANS Sekarningrum, Galih Prawesty Ayu; Aminah, Siti; Jayanti, Lira Wiet; Anwar, Risyandi
Indonesian Journal of Dentistry Vol 5, No 2 (2025): August 2025
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v5i2.17549

Abstract

ABSTRACTBackground: Streptococcus mutans is the primary cause of dental caries due to its acidogenic and aciduric properties. Natural antibacterial agents, such as bamboo charcoal extract, have been explored as potential alternatives to synthetic antimicrobial agents. However, the effectiveness of bamboo charcoal extract in inhibiting Streptococcus mutans remains uncertain. This study aimed to evaluate the antibacterial potential of bamboo charcoal extract at various concentrations.Methods: This research was conducted using a laboratory experimental method. The number of samples per group was determined using the Federer formula (t−1)(n−1)≥15, where t is the number of treatment groups and n the number of replications. With seven groups (six concentrations of bamboo charcoal extract and one positive control), a minimum of three replications per group was required, resulting in 21 samples in total. Bamboo charcoal extract was prepared through maceration using 96% ethanol and tested at concentrations of 0%, 12.5%, 25%, 37.5%, 50%, and 62.5% against Streptococcus mutans using the disk diffusion method. A 0.2% chlorhexidine solution served as the positive control. Inhibition zones were measured after a 24-hour incubation at 37°C.Results:  Statistical analysis using descriptive analysis showed no significant difference in inhibition zones. None of the bamboo charcoal extract concentrations demonstrated antibacterial activity against Streptococcus mutans. In contrast, the positive control (0.2% chlorhexidine) produced a significant inhibition zone of 12.56 mm.Conclusion:  Bamboo charcoal extract at concentrations of 12.5%, 25%, 37.5%, 50%, and 62.5% did not show any inhibitory effect on the growth of Streptococcus mutans.
Aktivitas Repelensi Ekstrak Etil Asetat dan Metanol Rimpang Lengkuas Terhadap Nyamuk Aedes aegypti dan Aedes albopictus Sarni; Anwar, Risyandi; Sayono
PROSIDING SEMINAR KESEHATAN MASYARAKAT Vol 1 No Oktober (2023): Seminar (NiCe-PHResComS - 1)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/pskm.v1iOktober.233

Abstract

Latar Belakang: DBD ditularkan melalui gigitan nyamuk Aedes aegypti dan Aedes albopictus yang telah terinfeksi virus dengue. Sampai saat ini belum ditemukan pengobatan dan vaksinasi yang tepat bagi penderita DBD, sehingga upaya yang diandalkan adalah pengendalian vektor. Penggunaan repellent berbahan dasar kimia seperti malathion, diethyltoluamide (DEET), parathion, diclorovinil dimethyl phospat (DDP) dan lain-lain dapat berdampak buruk terhadap kesehatan. Sehingga diperlukan bahan aktif lain yang efektif, aman dan ramah lingkungan terutama dari bahan alami yang dapat digunakan sebagai alternatif pengendalian vektor nyamuk. Penelitian ini bertujuan untuk mengetahui daya proteksi repellent ekstrak etil asetat dan metanol dalam memberikan perlindungan terhadap gigitan nyamuk Ae. aegypti dan Ae. albopictus. Metode: Penelitian eksperimen dengan rancangan penelitian yaitu post-test dengan kelompok kontrol (The Postest-Only Control Group Design), repellent ekstrak etil asetat dan metanol rimpang lengkuas dibuat empat konsentrasi yaitu 5%, 10%, 15% dan 25%. Subjek penelitian adalah 25 ekor nyamuk betina Ae. aegypti dan 25 ekor nyamuk betina Ae. albopictus yang dimasukkan ke dalam chamber uji selama 30 detik dengan 5 jam pengamatan. Hasil: repellent ekstrak etil asetat rimpang lengkuas memiliki daya proteksi lebih baik dari pada repellent ekstrak metanol rimpang lengkuas. Repellent esktrak etil asetat terhadap nyamuk Ae. albopictus pada konsentrasi 15% dapat memberikan perlindungan pada jam ke-5 sampai 95,45%. Kesimpulan: Repellent ekstrak etil asetat dan metanol rimpang lengkuas menujukkan perbedaan rata-rata daya proteksi terhadap nyamuk Ae. aegypti dan Ae. albopictus
Aktivitas Larvasida Ekstrak N-Heksan Rimpang Kencur Terhadap Larva Aedes aegypti Dewi, Anisa Candra; Anwar, Risyandi; Sayono
PROSIDING SEMINAR KESEHATAN MASYARAKAT Vol 1 No Oktober (2023): Seminar (NiCe-PHResComS - 1)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/pskm.v1iOktober.239

Abstract

Latar Belakang: Demam Berdarah Dengue (DBD) ditularkan melalui gigitan nyamuk Aedes, baik Ae. aegypti maupun Ae. albopictus. Obat antivirus belum ada dan vaksin belum efektif maka penanggulangan DBD mengandalkan pemberantasan vektor. Masyarakat lebih memilih metoda kimia yang berakibat terjadinya resistensi dalam jangka panjang. Masyarakat daerah endemis lebih memilih metode kimia termasuk larvasida temepos sehingga dalam jangka panjang timbul resistensi, dan perlu bahan aktif pengganti yang lebih aman. Penelitian ini bertujuan untuk menguji efektivitas ekstrak n-Heksan rimpang kencur (kaemferia galanga Linn.) terhadap kematian larva Ae. aegypti dan menentukan konsentrasi ekstrak yang efektif. Metode: Ekperiment ini menguji coba 5 tingkatan pada konsentrasi 30, 40, 50, 60, dan 70 ppm ekstrak N-heksan kencur terhadap larva Ae. aegypti instar III yang susceptible temepos. Setiap konsentrasi direplikasi 5 kali dan tiap replikat dipaparkan terhadap 20 ekor larva selama 24 jam. Mortalitas larva ditentukan setelah 24 jam paparan dan sekaligus penghitungan konsentrasi efektif (LC50 dan LC90) dengan analisis probit. Hasil: Mortalitas terendah dan tertinggi masing-masing pada konsentrasi 30 dan 70 ppm, di mana kematian larva seiring peningkatan konsentrasi. LC50 dan LC90 pada pengaamatan 24 jam adalah 55.444 dan 62.099 ppm. Kesimpulan: Ekstrak N-heksan rimpang kencur memiliki aktivitas larvasida yang tinggi dimana konsentrasi 70 ppm setara dengan temephos 0,02ppm.
Aktivitas Larvasida N-Heksan Rimpang Kencur Terhadap Larva Aedes albopictus: Studi Pendahuluan Mastura, Nurul Izzah; Anwar, Risyandi; Sayono
PROSIDING SEMINAR KESEHATAN MASYARAKAT Vol 1 No Oktober (2023): Seminar (NiCe-PHResComS - 1)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/pskm.v1iOktober.247

Abstract

Latar belakang: Aedes albopictus merupakan vektor primer Chikungunya dan sekunder untuk Dengue dan Zika. Cara pengendalian spesies ini masih mengandalkan metode kimia seperti fogging dan larvasida. Kondisi ini telah berlangsung lama, sehingga muncul status resisten pada populasi Aedes dan menghambat upaya pengendalian penyakit-penyakit tersebut sehingga perlu dicari bahan aktif larvasida yang aman, mudah dan ramah lingkungan. Penelitian ini bertujuan untuk mengetahui aktivitas larvasida ekstrak n – heksan kencur terhadap larva Aedes albopictus. Metode: Penelitian eksperimen ini menerapkan Posttest Only Control Group Design dengan 5 konsentrasi ekstrak n-heksan kencur yaitu 10, 25, 50, 75, dan 100 ppm. Sebanyak 500 larva instar III Aedes albopictus instar menjadi subjek penelitian yang dibagi menjadi 5 kelompok perlakukan dan masing-masing direplikasi 5 kali sehingga setiap perlakuan berisi 20 larva. Analisis data menggunakan uji Kruskal-Wallis dan probit. Hasil: Kematian larva Ae. albopictus berkisar antara 3-100 % dengan konsentrasi efektif larvasida ekstrak n–heksan kencur (LC50 dan LC90) masing-masing 32,051 (29,741–34,419), dan 46,145 (42,395–51,531) ppm. Kesimpulan: Ekstrak n–heksan kencur dapat menjadi kandidat bahan aktif larvasida terhadap larva Aedes albopictus dengan tingkat efektivitas yang tinggi (LC50< 50 ppm).
Co-Authors Al Arofatus Naini Amiza Zam, Syarifah Nova Anjari, Intan Hawina Aprillia, Zita Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Setiawan Arlette Suzy Puspa Pertiwi Arnov, Steffi Triany Asti, Salma Mei Darwati Darwati Delia Ilfani Desi Harneti Desi Harneti Putri Huspa Deviana Adinda Nurfatimah Dewi, Anisa Candra Erina Hilmayanti Etny Dyah Harniati Faizah Maira Farabi, Kindi Faridia Puspita Lestari Febriyani, Ita Fitri Anisdyasarathi Jayanti, Lira Wiet Khalijah Awang Kindi Farabi Lilis Siti Aisyah Lisa Oktaviana Mayasari Mastura, Nurul Izzah Mayasari, Lisa Oktaviana Muhamad Nurul Azmi Naini, Al Arofatus Nikmaturrizqi, Nada Nisma Dinastiti Nisma Dinastiti Nurhidayah, Rizky Nurlelasari Nurlelasari Nurlelasari Nurlelasari Pebrian Diki Prestya Prajarini, Megawati Puspito Ratih Hardhani Putri, Ghesta Alifka Rachmawati, Ika Rani Maharani Rani Maharani Ratna Sulistyorini, Ratna Rizky Nurhidayah Samuel San Parulian Sarni Sayono Sekarningrum, Galih Prawesty Ayu Sinaga, Siska Elisahbet Siti Aminah Sofa Fajriah Steffi Triany Arnov Suaeni Kurnia Wirda Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Supriatno Sutiyono, Triagus Nursasongko Tri Mayanti Tri Mayanti Tripermata, Anita Novia Tyas Nurfadlilah Amaliah Unang Supratman Vidia Afina Nuraini Yenny Febriani Yun Yoshihito Shiono