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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Indonesian Journal of Medicine Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) Jurnal Ilmu Kefarmasian Indonesia Jurnal Ilmiah Medicamento Pharmaceutical And Biomedical Sciences Journal (PBSJ) Media Farmasi Indonesia Jurnal Ilmu Kesehatan MAKIA Jurnal Farmasi Indonesia Usadha Usadha Journal of Pharmacy
Mendra, Ni Nyoman Yudianti
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Tablet Ekstrak Daun Spondias pinnata: Pengaruh Variasi Primojel® dan Maltodekstrin terhadap Karakteristik dan Stabilitas Fisik serta Aktivitas Antioksidan Suena, Ni Made Dharma Shantini; Mayuni, Putri Diah Gita; Dewi, Ni Nyoman Ayu Pramesti; Mendra, Ni Nyoman Yudianti; Rahadi, I Wayan Surya; Wardani, I Gusti Agung Ayu Kusuma
Jurnal Ilmiah Medicamento Vol 11 No 2 (2025): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v11i2.12233

Abstract

Cemcem leaves (Spondias pinnata) are rich in phenolic and flavonoid compounds with antioxidant potential. However, their traditional beverage form lacks stability, necessitating tablet formulation to improve stability and dosing convenience. This study evaluated the effect of varying concentrations of maltodextrin (binder) and Primojel® (disintegrant) on the physical quality and antioxidant activity of cemcem leaf extract tablets. Prior to formulation, extraction temperature optimization was performed using ultrasonic-assisted maceration at 30°C and 45°C, each for 3 minutes per cycle over three cycles. Three tablet formulations were prepared using optimized extract with different maltodextrin–Primojel® ratios: F1 (3%-8%), F2 (6.5%-5%), and F3 (10%-2%). Granule evaluation included moisture content, flow rate, angle of repose, and compressibility index. Tablets were assessed on days 1, 14, and 28 under room temperature storage for organoleptic properties, weight and size uniformity, hardness, friability, and disintegration time. Data were analyzed using Repeated Measures ANOVA and the Friedman test at a 95% confidence level. Extraction at 30°C yielded superior antioxidant activity, with lower IC₅₀ values and higher total flavonoid content and was therefore selected for formulation. All granules met physical quality standards; however, among tablet parameters, only disintegration time complied with pharmacopeial requirements. Formula F3, containing the highest maltodextrin concentration (10%) and lowest Primojel® concentration (2%), demonstrated the best physical stability from day 1 to day 28 (p > 0.05) and the strongest antioxidant activity, with the lowest IC₅₀ value (23.88 µg/mL; AAI 1.68). These findings confirm a causal relationship between excipient concentration and tablet performance, supporting F3 as a promising prototype for antioxidant supplement development.
Pengaruh Pemberian Informasi Obat terhadap Kepuasan Pasien serta Faktor Pengganggu yang Terlibat di Padangsambian, Bali Sutrisnawati, Ni Komang Ayu Bintang; Agustini, Ni Putu Dewi; Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 13, No 4
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.84766

Abstract

Providing information when dispensing medicine is a pharmaceutical service that must follow applicable regulations. The best service makes patients satisfied and loyal to the pharmacy. Many things influence patient satisfaction due to varying patient perceptions regarding the quality of pharmacy services. This study aims to analyze the relationship between providing drug information and patient satisfaction, as well as confounding variables. Cross-sectional research was carried out by distributing Likert scale questionnaires and a checklist of types of drug information provided by pharmaceutical staff at the Indobat Padangsambian Pharmacy. The questionnaire was developed from literature studies and has been tested for validity and reliability. A total of 118 respondents who met the criteria were taken using convenience sampling techniques. Data were analyzed using descriptive statistics, chi-square test, and logistic regression. The chi-square test shows that the type of drug information conveyed by pharmaceutical staff is not related to patient satisfaction at the Indobat Padangsambian Pharmacy (p-value 0.580, CI 95%). All variables that are thought to be confounding variables do not have an independent effect on the dependent variable. However, it is known that occupation (health workers and non-health workers) and the patient's proximity to pharmaceutical workers interact and influence patient satisfaction. Pharmacy personnel should provide drug information according to regulations. To make patients satisfied and loyal to the pharmacy, pharmaceutical staff must pay attention to the patient's work background and personal relationship with the patient when providing drug information.
Formulasi dan Uji Mutu Fisik Masker Gel Peel Off Ekstrak Kulit Buah Naga Merah (Selenicereus costaricensis) dengan Variasi Konsentrasi PVA dan Gelatin Sebagai Gelling Agent: Formulation and Physical Quality Test of Peel Off Mask Red Dragon Fruit Peel Extract (Selenicereus costaricensis) with Various Concentrations of PVA and Gelatin as Gelling Agent Antari, Ni Putu Pina; Mendra, Ni Nyoman Yudianti; Suradnyana, I Gede Made
Jurnal Surya Medika (JSM) Vol. 10 No. 1 (2024): Jurnal Surya Medika (JSM)
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/jsm.v10i1.5516

Abstract

Antioksidan alami dapat diperoleh dari kulit buah naga merah yang mengandung vitamin C dan vitamin E yang berfungsi sebagai sumber antioksidan, sehingga digunakan sebagai perawatan kulit wajah. Masker gel peel off merupakan salah satu sediaan masker yang terbilang praktis. Ketika masker telah mengering, masker dapat langsung diangkat tanpa perlu dibilas. Penelitian ini bertujuan untuk mengetahui kesesuaian mutu fisik sediaan masker gel peel off ekstrak kulit buah naga merah (Selenicereus costaricencis) dengan sediaan sejenis yang beredar di pasaran. Pada penelitian ini dibuat formulasi sediaan masker gel peel off ekstrak kulit buah naga dengan variasi konsentrasi PVA dan gelatin sebagai gelling agent dengan perbandingan 10%:5% (F1), 12%:3% (F2), 14%:1% (F3). Parameter yang diamati yaitu mutu fisik sediaan masker gel peel off yang meliputi organoleptis, homogenitas, pH, daya sebar, daya lekat, dan waktu mengering. Berdasarkan hasil penelitian, masker gel peel off ekstrak kulit buah naga merah memenuhi persyaratan mutu fisik yang meliputi organoleptis, homogenitas, pH, daya sebar, daya lekat, dan waktu mengering. Mutu fisik ekstrak kulit buah naga merah Formula 1 (10%:5%) dan Formula 2 (12%:3%) sesuai dengan mutu fisik sediaan sejenis yang beredar di pasaran sedangkan pada formula 3 (14%:1%) tidak sesuai dengan mutu fisik pada daya sebar dan daya lekat.
The Impact of EG and DEG Cases on Sales of Over-The-Counter Syrup Mendra, Ni Nyoman Yudianti; Antari, Ni Putu Udayana; Siada, Nyoman Budiartha; Marwati, I Gusti Ayu
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 5 No. 2 (2023)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v5i2.32013

Abstract

The Indonesian Food and Drug Authority (BPOM) investigated and listed safe and unsafe syrup products in response to the contamination of Ethylene Glycol (EG) and Diethylene Glycol (DEG), causing Acute Kidney Injury in pediatric patients. Unsafe products were recalled and removed from distribution, leading to uncertainty and panic among the public and significantly impacting over-the-counter syrup sales in several pharmacies. This retrospective observational study assessed the impact of EG and DEG contamination on the sales of over-the-counter syrup in Pharmacy X in South Denpasar. Data from three months before (August to October 18th, 2022) and three months following the official instruction was published (October 19th, 2022 to December 2022) were analyzed using Wilcoxon test. The findings reveal a staggering decline in the sales of over-the-counter syrup by 35,03% (p-value of 0.03). Moreover, there was a notable increase of prescriptions in powder forms. The contamination cases caused panic, resulting in changes in behavior and consumption patterns. Despite the availability of safety information on an official website, public hesitance toward syrup products persists, indicating the need to implement a more effective strategy to address misinformation and restore public trust. Each individual must be responsible for educating the public during crises to prevent the spread of misinformation, ultimately restoring trust and normal consumer behavior. Furthermore, efficient stock management should be implemented to anticipate potential health crises in the future proactively.
POLA PERESEPAN OBAT ANTIHIPERTENSI DI POLI RAWAT JALAN RUMAH SAKIT “X” DI BALI PERIODE TAHUN 2022 Mendra, Ni Nyoman Yudianti; Puspasari, I Gusti Ayu; Siada, Nyoman Budiartha
Usadha Journal of Pharmacy Vol. 3 No. 2 (2024): Mei
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i2.311

Abstract

Hipertensi merupakan salah satu penyakit kronis dengan tingkat kejadian yang tinggi dan beresiko menyebabkan komplikasi. Pengobatan dan peresepan obat yang rasional diperlukan untuk mengontrol tekanan darah pasien serta mencegah terjadinya komplikasi. Penelitian ini bertujuan untuk mengetahui pola peresepan dan rasionalitas terapi antihipertensi pada pasien rawat jalan di salah satu rumah sakit umum di Bali tahun 2022 dengan BPJS sebagai jaminan asuransi kesehatan. Penelitian ini merupakan penelitian deskriptif dengan pengambilan data secara retrospektif dimana teknik pengambilan sampelnya menggunakan purposive sampling. Kriteria inklusi dalam penelitian ini meliputi pasien hipertensi dengan dan tanpa komorbid, telah menjalani pengobatan minimal 3 bulan terapi pada periode Januari - Desember 2022. Rasionalitas terapi meliputi tepat obat, tepat pasien, tepat dosis, dan tepat interval waktu pemberian yang dinilai berdasarkan pedoman JNC 8 dan Konsensus Penatalaksanaan Hipertensi Tahun 2021. Berdasarkan data dari 368 pasien rawat jalan, antihipertensi yang diresepkan meliputi Angiotensin receptor blocker (ARB) dengan persentase 64,13%; Calsium Channel Blocker (CCB) 59,51%; Angiotensin Converting Enzim Inhibitor (ACEI) 16,85%; Beta Blocker 15,22% dan diuretik sebesar 0,81%. Pada hasil evaluasi peresepan obat antihipertensi diperoleh tepat obat sebanyak 98,64%, tepat pasien sebanyak 96,74%, tepat dosis sebanyak 100%, dan tepat interval waktu pemberian sebanyak 100%.
Aktivitas Antioksidan Krim Hidrofilik Ekstrak Metanol Bunga Cempaka Putih (Magnolia alba) Mendra, Ni Nyoman Yudianti; Pratiwi, Dewa Ayu Yunika; Juliadi, Debby
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 18 No. 1 (2026): Jurnal Farmasi Indonesia (inpress)
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The white champaca flower (Magnolia alba) holds cultural significance for the Balinese society, being employed in religious ceremonies, adorning bridal setting, and enriching the aroma of incense. Moreover, white champaca flowers contain alkaloids, steroids, terpenoids, flavonoids, and phenols that have antioxidant activity. Therefore, it is interesting to determine the antioxidant activity of methanol extract of white champaca flowers and formulated it into an oil in water cream in this study. The extract was formulated into three cream formulas, FI, FII, and FIII with concentrations of 4, 8, and 12%, respectively.  Antioxidant activity was assessed using DPPH (2,2-Diphenyl-1-Picrylhydrazyl) assay with UV-Vis spectrophotometer at a wavelength of 516 nm. The antioxidant activity based on IC50 values for FI, FII, and FIII were 29.72, 25.50, and 25.05 µg/ml, respectively, with IC50 value of vitamin C was 2.93 µg/ml as a standard comparison. The research findings indicate that the methanol extract of white champaca flower o/w cream exhibit a very strong antioxidant activity in vitro. Further research is imperative to investigate the ability of the formulations to delaying the photoaging mechanism through in vivo studies.
PENGARUH PENGETAHUAN TERHADAP PERILAKU SWAMEDIKASI MAAG PADA PELAJAR SEKOLAH MENENGAH ATAS NON KESEHATAN DI KABUPATEN BANGKA Salasa, Dian Oktarizka; Gumay, Burhanudin; Mendra, Ni Nyoman Yudianti; Hardiyanti, Ttirahmi
Jurnal Ilmu Kesehatan MAKIA Vol 16 No 1 (2026): Jurnal Ilmu Kesehatan MAKIA
Publisher : LPPM ISTeK ICsada Bojonegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37413/zj2n1e20

Abstract

Swamedikasi merupakan pengobatan diri sendiri tanpa harus berkonsultasi dengan tenaga Kesehatan professional. Swamedikasi dapat dilakukan untuk mengobati penyakit ringan seperti batuk, demam, diare, nyeri ringan, maag dan penykit kulit. Menurut data World Health Organization (WHO) Indonesia masuk kedalam 3 besar negara dengan Tingkat kejadian maag paling tinggi yakni sebesar 40,80%. Penelitian ini bertujuan untuk melihat hubungan pengetahuan terhadap perilaku swamediaksi maag pada pelajar sekolah menengah atas negeri non kesehatan Kabupaten Bangka. Penelitian ini merupakan penelitian observasional dengan rancangan penelitian cross sectional yang bersifat deskriptif. Pengambilan data dilakukan dengan teknik purposive sampling menggunakan alat bantu berupa kuesioner di Sekolah Menengah Atas Negri Non Kesehatan Kabupaten Bangka. Hasil penelitian menunjukkan sebanyak 54,7% rsponden berpengetahuan cukup dan 56,6% responden memiliki perilaku positif. Berdasarkan analisis gamma didapatkan hasil nilai p value sebesar 0,032 yang berarti terdapat pengaruh antara pengetahuan terhadap perilaku swamedikasi maag pada pelajar sekolah menengah atas negeri non Kesehatan Kabupaten Bangka
Chemical and DPPH Free Radical Scavenging Stability of Avocado Seed Acetone Extract Against pH Changes Suradnyana, I Gede Made; Juliadi, Debby; Mendra, Ni Nyoman Yudianti; Suena, Ni Made Dharma Shantini
Jurnal Ilmiah Medicamento Vol 12 No 1 (2026): Jurnal Ilmiah Medicamento (In progress)
Publisher : Fakultas Farmasi Universitas Mahasaraswati Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36733/medicamento.v12i1.12213

Abstract

Background: Avocado seeds contain phenol, flavonoid, and anthocyanidin compounds that have antioxidant activity. The stability of phenolic compounds depends on the pH of the solution. A decrease in total phenolic levels causes a decrease in antioxidant activity. The chemical stability and DPPH free radical scavenging activity of avocado seed extract against pH are not yet known.Objective: This study aimed to determine the effect of pH on the chemical stability and DPPH free radical scavenging activity of avocado seed extract.Methods: Chemical stability was observed from changes in total phenolic levels, and stability of DPPH free radical scavenging activity was observed from the difference in the percentage of DPPH reduction of the extract solution in phosphate-citrate buffer at pH 3.24, 5.52, and 7.44 before and after being heated at 60°C for 2 hours.Results: The average decrease in total phenolic levels of the extract in buffer pH 3.24, 5.52, and 7.44 before and after being heated was 5.76%, 3.89%, and 22.08%, respectively. The decrease in DPPH free radical scavenging activity of the extract in buffer pH 3.24, 5.52, and 7.44 before and after heating was 24.78%, 1.96%, and 56.09%, respectively. There is a significant difference in the total phenolic content and DPPH free radical scavenging activity of the acetone extract solution in phosphate–citrate buffer at pH 3.24 and 7.44 before and after heating, but there is no significant difference at pH 5.52.Conclusion: Therefore, in the development of formulations containing acetone extract of avocado seeds, buffering at a pH close to 5.22 is required.
Co-Authors Ade Irma Suryani Agustini, Ni Putu Dewi Antari, Ni Putu Pina Buana, Komang Dirga Mega Candraningrat, I Dewa Agung Ayu Diva Debby Juliadi Dewi, Ni Nyoman Ayu Pramesti Dwi Arymbhi Sanjaya Fridayana, Ni Luh Gede Erica Givanda, Jesi Dyah Ayu Gumay, Burhanudin Hardiyanti, Ttirahmi Hastama, Ryo Intansari, Ni Putu Ocha Indira Ketut Agus Adrianta Marwati, I Gusti Ayu Mayuni, Putri Diah Gita Megawati, Fitria Ni Made Dharma Shantini Suena Ni Made Puspayanti, Ni Made Ni Nyoman Wahyu Udayani Ni Putu Udayana Antari Nyoman Budiartha Siada Pebriani, Ni Luh Gede Wiwin Pratiwi, Dewa Ayu Yunika Puspasari, I Gusti Ayu Puspawati, Made Putra, Made Agus Sunadi Rahadi , I Wayan Surya Rahadi, I Wayan Surya Salasa, Dian Oktarizka Sasadara, Maria Malida Vernandes Sukamto, Ika Sumiyarsi Suradnyana, I Gede Made Sutrisnawati, Ni Komang Ayu Bintang Wardani, I Gusti Agung Ayu Kusuma