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Journal : Jurnal Farmasi Sains dan Praktis

STUDY OF THE SEVERITY AND EARLY ANTIVIRAL TREATMENT FOR THE DURATION OF THE RECOVERY COVID-19 PATIENTS Susilo, Rinto; _, Tomi; Hidayati, Nur Rahmi; Asmarandani, Deani; Fadhilah, Daffa
Jurnal Farmasi Sains dan Praktis Vol 9 No 1 (January-April 2023)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v9i1.7916

Abstract

Late antiviral treatment can potentially cause the Covid-19 virus to replicate very quickly, so it is necessary to understand antiviral drugs and optimize treatment for Covid-19 patients. The study aimed to determine the correlation between the severity, speed of administration of antivirals, and the recovery time of Covid-19 patients. This type of research is an observational study with retrospective data collection on 94 Covid-19 medical records at “X” Hospital Cirebon from 316 populations in June-July 2021 according to inclusion criteria. The data analysis used was univariate and bivariate using Spearman's Rho. The 55–59-year age group (28.7%) was the most infected with Covid-19. There are more males than females (52.1% vs 47.9%). Favipiravir therapy (43.6%) was given the most. Moderate severity (74.5%) had the highest proportion. The speed of administration of antivirals was most initiated at 5-8 days (42.6%) after the onset of symptoms. The maximum recovery time for Covid-19 patients is 13-18 days (58.5%). A strong positive correlation between the speed of giving antivirals to the recovery time of Covid-19 patients (sig. 0.000) and the correlation coefficient of 0.659. Does not show a correlation between the severity of recovery time (sig. 0.113) and speed of antiviral administration to the severity of Covid-19 patients (sig. 0.297). There is a correlation between the early antiviral treatment and the recovery time of Covid-19 patients; the earlier antiviral therapy is given, the faster it will heal.
STUDY OF ADVERSE DRUG REACTIONS OF LINEZOLID IN DRUG RESISTANT TUBERCULOSIS PATIENTS Susilo, Rinto; Sundhani, Elza; Setyaningsih, Indah; Retnaningsih, Ririn; Nurjanah, Ucu; Endang Ayu Prihatini, Nok
Jurnal Farmasi Sains dan Praktis Vol 11 No 2 (May-August 2025)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v11i2.12472

Abstract

The estimated number of DR TB patients in Indonesia is increasing. High adverse drug reactions have the potential to affect the success of DR TB patient treatment. Linezolid is one of the drugs in combination with DR TB therapy that has the potential to cause adverse drug reactions in the form of hematological disorders and visual impairment. This study aims to determine the incidence of Linezolid ADRs, including the incidence, severity, and risk factors associated with the occurrence of ADRs. This type of study is observational with a cross-sectional design conducted retrospectively in DR TB patients at the lung clinic of Hospital 'X" and Hospital "Y" in Indonesia. The results of the study showed that the incidence of ADRs suspected of Linezolid that met the criteria was 70 patients out of a total of 215. The most common type of ADRs was hematological disorders at 89%, the rest were visual impairment. The type of regimen and type of ADRs correlate with the severity of ADRs. It is necessary to monitor drug levels in the blood in order to monitor and prevent the potential for more severe ADRs so that therapy can be individualized.
Co-Authors Aan Kunaedi Adrian A. Kaptein Aeni, Markhamatul Afiah, Nida Nur Agus Kurniawan Agus Kurniawan Ahmad Alfateh Rahanyamtel Aida Maftuhah Aida Maftuhah Ajeng Diantini Andriana Anggraeni, Mila Anisa Putri Anoez, Nawaal Hilmy Aris Slamet Widodo Arista Maulana Arsyad Bachtiar Asmarandani, Deani Bachtiar, Arsyad bayu pamungkas Choerunnisa, Sari Della Pariska Deni Fajarudin Derriawan Derriawan Dewi Kartika Dhia Salsabila Didi Rohadi Didin Ahidin Dyah A. Perwitasari Dyah Aryani Perwitasari Endang Ayu Prihatini, Nok Endang Yuniarti Fadhilah, Daffa Fadila, Fasiha Nur Fajarudin, Deni Fathiyah Putri Alifia Febrianti, Hellen Gufron Amirullah Hana Syifaun Nufus Hayatun Nega Amna Hellen Febrianti Hidayah Karuniawati Hulman Taufik Azhar Ibnu Mas’ud IIN INDAWATI Imaniar Noor Faridah Indah Setyaningsih Indyati, Retno Iqbal Bagus Prayogo Jafar Izzudin Johan Kaptein, Adrian A. Khofifah Khofifah KHOFIFAH Kiki Lukman Lala Komalasari Lediyana, Riska Lestari, Trisna Listiyani, Lilis M. Agung Miftahuddin Maftuhah, Aida Markhamatul Aeni Mila Anggraeni Mila Zainatul Milhah Milhah, Mila Zainatul Milla, Muayyadah Muayyadah Milla Muh Yani Zamzam Muh. Yani Zamzam Muhamad Kusnendar Muhammad Fikri Fanillah Nanda Riandita Rizky Kinanti Nenden Anindya Koesmaedhy Nida Nur Afiah Nisa Dwi Nurindah Nufus, Hana Syifaun Nur Azizah Nur Rahmi Hidayati, Nur Rahmi Nurcholisah Nurcholisah Nurcholisah Nurdiansyah, Iid Nurjanah, Ucu Perwitasari, Dyah A. Pransiska, Siska Puspita Afriliani Putri Dwi Jayanti Regar N Dhea Renny Amelia Renny Amelia Retnaningsih, Ririn Retno Indyati Rizky Fitra Ramadhan Rizqah Sely Salsabil Sampurno Sampurno Santana, Salma Audhita Sapitri Hikmatul Aziz Sarah Diah Maharani Setyaningsih, Indah Sidik Lingga Kusuma Sidik Lingga Kusuma Siska Pransiska Suharyani, Ine Sulistiorini Indriaty Sundhani, Elza Suwarno Suwarno Syifa Imelda Tomi . Tri Septiyati Trisna Lestari Unggul Nirwikoro Prihadmoko Woro Supadmi Yadi Supriyadi Yadi Supriyadi Yayan Rizkiyan Yuni Rahmasari Zamzam, Muh. Yani _, Tomi