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All Journal Jurnal SOLMA Indonesian Journal of Cancer INCOME: Indonesian Journal of Community Service and Engagement
Analysa, Analysa
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Humanities Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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The Correlation of PD-L1 Overexpression With Tumor Budding In Cervical Carcinoma Lestari, Desak Putu Oki; Analysa, Analysa; Armerinayanti, Ni Wayan; Riasa, I Nyoman Putu; Artha, I Gusti Alit
Indonesian Journal of Cancer Vol 18, No 3 (2024): September
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v18i3.1103

Abstract

Background: Several studies have proven the relationship between PD-L1, which is known as an immunotherapy target, and poor prognosis. The presence of a tumor budding (TB) group tumor outside the main tumor is also associated with a poor prognosis. The purpose of this study was to determine the relationship between PD-L1 and the grade of TB in cervical carcinoma. Methods: The design of this research is a case-control study with a retrospective approach. The sample is from a paraffin block of the primary cervical cancer tumor from the results of surgery in Balimed Denpasar Hospital between 2020 and 2023. From the statistical formula for the case-control study, a minimum sample of 15 is obtained for the case group with the criteria of high-grade TB, while 15 people were in the control group with low-grade TB. Immunohistochemistry (IHC) PD-L1 is positive if the membrane or cytoplasm is brown, and is negative if there is no brown color on the membrane or cytoplasm. Inferential statistics were used to evaluate the relationship between PD-L1 overexpression and low- and high-grade TB in cervical carcinoma using a chi-square test. Results: The results of this research revealed (p = 0.273) that there was no correlation between PD-L1 expression and high- and low-grade TB. Overexpression of PD-L1 was associated with a 2.250-fold increased risk of high-grade TB (OR = 2.250 with a 95% confidence interval of 0.103–1.915). Conclusions: The severity of TB does not correlate with PD-L1 expression. The functions of PD-L1 and other variables in the carcinogenesis of TB development are the cause of this weak association.
Peningkatan Peran OSIS Dalam Pencegahan Kanker Serviks Dan Vaksinasi HPV Pada Siswi SMP di Bali Lestari, Desak Putu Oki; Analysa, Analysa; Kerans, Fransiscus Anthony; Winata, I Gde Sastra; Riasa, I Nyoman Putu
INCOME: Indonesian Journal of Community Service and Engagement Vol 4 No 3 (2025)
Publisher : EDUPEDIA Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56855/income.v4i3.1496

Abstract

Kanker serviks merupakan jenis kanker tertinggi ke-2 di Bali dan Indonesia, dengan infeksi virus HPV high risk sebagai faktor risiko utama. Meskipun vaksinasi HPV efektif menurunkan insiden kanker serviks, implementasinya di Indonesia, khususnya Bali masih baru dimulai dan tingkat pengetahuan remaja tentang kanker serviks masih rendah. Kegiatan pengabdian kepada masyarakat (PKM) ini bertujuan untuk meningkatkan pengetahuan, sikap, dan perilaku siswi SMP, khususnya pengurus OSIS terkait pencegahan kanker serviks dan vaksinasi HPV, serta mendorong peran aktif OSIS sebagai agen edukasi di lingkungan sekolah. Program dilakukan melalui penyuluhan aktif, pelatihan, dan pendampingan kepada pengurus OSIS di tiga SMP di Bali. Evaluasi dilakukan menggunakan pre-test dan post-test untuk mengukur perubahan pengetahuan, sikap, dan perilaku, serta pemantauan capaian vaksinasi HPV. Terdapat peningkatan signifikan pada nilai pengetahuan (dari rata-rata 3,47 menjadi 8,74), sikap (4,12 menjadi 9,32), dan perilaku (3,54 menjadi 9,01) setelah intervensi (p < 0,05). Cakupan vaksinasi HPV mencapai lebih dari 95%. Sebanyak 75% siswa mampu melakukan edukasi di kelompok kecil, dan 25% mampu melakukan penyuluhan di kelas besar. Intervensi berbasis OSIS efektif meningkatkan pengetahuan, sikap, perilaku, dan cakupan vaksinasi HPV pada siswa SMP. Peran OSIS sebagai duta kesehatan perlu terus didukung untuk memperluas dampak edukasi pencegahan kanker serviks di lingkungan sekolah.
Peningkatan Peran Tokoh Desa Dalam Pengenalan Faktor Resiko, Gejala Klinis Dan Deteksi Dini Kanker Kolorektum di Desa Candikuning Tabanan Analysa, Analysa; Primadi, Putu; Oki Lestari, Desak Putu; I Gusti, Alit Artha; I Nym, Putu Riasa; Yusuf, M. Yusuf
Jurnal SOLMA Vol. 13 No. 2 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v13i2.15076

Abstract

Background: Dalam 5 tahun ini terdapat 15/6.324 orang atau 30/100.000 penduduk yang menderita kanker kolon dan rektum di kecamatan Baturiti, Tabanan. Tingginya angka kematian disebabkan sebagian besar 11/15 (73,33%) datang pada stadium lanjut yaitu stadium III dan IV. Tujuan kegiatan ini untuk meningkatkan peran kepala desa dan tokoh masyarakat untuk mensosialisasikan faktor resiko, gejala klinis dan deteksi dini kanker kolorektal di masyarakat. Metode: Mitra kegiatan yaitu kepala desa dan tokoh adat Desa Candikuning, Bali beserta 40 penduduk setempat. Metode yang dilakukan, pertemuan dengan masyarakat, sistem belajar bersama dengan cara praktik langsung, melakukan sosialisasi dan penyuluhan, dan evaluasi kemampuan Mitra serta evaluasi hasil pada masyarakat. Pengambilan data dilakukan dengan observasi berupa ceklis, kuesioner berupa pretest dan posttest.  Hasil: Kegiatan ini menunjukkan bahwa terjadi peningkatan pengetahuan para tokoh dan masyarakat terhadap pengetahuan serta gejala klinis sebesar 99,1%, peningkatan sikap dalam pencegahan kanker kolorektal sebesar 90,8%. Kesimpulan: Disimpulkan bahwa peran kepala desa dan tokoh masyarakat dapat meningkatkan pengetahuan dan sikap terhadap gejala klinis dan pencegahan kanker kolorektal pada masyarakat.
Correlation of Overexpression of PDL-1 With Lymph Node Metastasis in Penile Carcinoma Witari, Ni Putu Diah; Analysa, Analysa; Lestari, Putu Oki
Indonesian Journal of Cancer Vol 20, No 1 (2026): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i1.1360

Abstract

Background: Penile cancer cases are rarely found, but in the Bali area, the case is higher than in other regions in Indonesia. The death rate of penile cancer is still high, and 80% of cancer deaths are related to metastasis. As immunotherapy in cancer develops, PDL-1 is becoming one of the targets for immune therapies that promise to replace conventional therapies or serve as adjunct therapies. This study aims to see the correlation between the overexpression of PDL-1 and lymph node metastasis, which is one indicator of the poor prognosis of a cancer.Methods: This study used a case-control study design with a retrospective approach. The sample was 70 primary squamous type penile cancer formalin-fixed paraffin-embedded (FFPE) specimens with complete clinical data from several Anatomic Pathology laboratories in Bali, 2015-2023. FFPE sections that were damaged and did not have complete data were excluded. The case is 35 with lymph node metastasis, and 35 without lymph node metastasis as a control. In this study, the correlation between PDL-1 overexpression and tumor grading and lymph node metastasis in penile carcinoma will be explored. Data analysis with Chi-square using SPSS. The p-value for the significance test was less than 0.05. The accuracy of the data is determined by a 95% confidence interval (CI). The research was conducted from February 2024 to August 2024 Results: This study showed a significant correlation between PDL-1 overexpression and lymph node metastasis, p 0.05. There was a significant correlation of PDL-1 overexpression with lymph node metastasis (p = 0.001). There was a correlation between overexpression of PDL-1 and tumor size (p = 0.035), tumor grading (p = 0.027), and lymphatic invasion (p = 0.038). There was no correlation between PDL-1 overexpression with age (P = 0.424)Conclusions: This study demonstrates a significant correlation between PDL-1 overexpression and lymph node metastasis in penile carcinoma patients. Furthermore, PDL-1 overexpression is significantly associated with larger tumor size, higher tumor grade, and lymphatic invasion. These results suggest that PDL-1 serves as a critical prognostic biomarker for predicting disease aggressiveness and metastatic potential.
Co-Authors Artha, I Gusti Alit Desak Putu Oki Lestari I Gusti, Alit Artha I Ketut Suwiyoga I Nym, Putu Riasa Kerans, Fransiscus Anthony Lestari, Putu Oki M. Yusuf Yusuf, M. Yusuf Ni Wayan Armerinayanti, Ni Wayan Oki Lestari, Desak Putu Primadi, Putu Riasa, I Nyoman Putu Witari, Ni Putu Diah