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All Journal Jurnal Ilmu Kesehatan Best Journal (Biology Education, Sains and Technology) HERBAPHARMA : Journal of Herb Farmacological Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Perak Malahayati : Pengabdian Kepada Masyarakat Jurnal Sehat Indonesia (JUSINDO) Prosiding University Research Colloquium Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Journal of Pharmaceutical and Sciences. CERATA Journal Of Medicine And Health Sciences (Medisci)
Efriani, Like
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Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary Other

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PELATIHAN PEMBUATAN NUGGET N-MUSROOM SEBAGAI ALTERNATIF MAKANAN SEHAT IBU-IBU PKK DESA PATALAGAN KABUPATEN KUNINGAN Efriani, Like; Putra, Teguh Adiyas; Gunawan, Ucha Indra
Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Vol. 2 No. 3 (2023): Ekalaya Journal
Publisher : Nindikayla Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57254/eka.v2i3.105

Abstract

Patalagan Village has various types of plants that are diverse and efficacious and can be used as home preparations that can be utilized as a source of food production and so on and can also be marketed to various regions. One of the superior potentials that can be utilized by the community as a source of income is oyster mushrooms. The purpose of this community service is to increase the knowledge of Patalagan Village residents regarding the benefits of oyster mushrooms and improve the skills of housewives in making nuggets from oyster mushrooms. The materials used are oyster mushrooms, while the methods used are socialization and counseling as well as training in making N-mushroom nuggets and product making demonstrations carried out by PKK women in Patalagan Village. The result of this training was that the participants became trained in making N-mushroom nuggets. This can be seen from the products produced by participants with good results in terms of appearance. The conclusion is that there is an increase in villagers' knowledge of the benefits of oyster mushrooms as can be seen from the results of the pretest and posttest activities given to participants where there is an increase in scores before and after the counseling and the PKK women of Patalagan Village are skilled in making "N-mushroom nuggets" products which can be seen from the quality of the products produced.
Analisis Interaksi Obat Antipsikotik pada Pasien Bipolar di Rumah Sakit Jiwa Provinsi Jawa Barat Periode Januari-Desember 2023 Efriani, Like; Putra, Teguh Adiyas; Fauzia, Hilda Nurul
Jurnal Sehat Indonesia (JUSINDO) Vol. 7 No. 1 (2025): Jurnal Sehat Indonesia (JUSINDO)
Publisher : CV. Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jsi.v7i01.178

Abstract

Bipolar merupakan gangguan mental yang ditandai dengan perubahan suasana hati yang drastis antara episode manik dan depresi. Penelitian ini bertujuan untuk menganalisis interaksi obat berdasarkan tingkat keparahan dan mekanisme interaksi obat yang terjadi pada pasien bipolar di Rumah Sakit Jiwa Provinsi Jawa Barat. Penelitian ini menggunakan desain cross-sectional (potong lintang) dengan metode retrospektif. Populasi penelitian adalah seluruh pasien di instalasi rawat jalan dengan diagnosis bipolar pada tahun 2023 sebanyak 299 pasien, dan sampel sebanyak 171 pasien dipilih menggunakan teknik purposive sampling. Data dikumpulkan melalui rekam medis pasien, mencakup informasi demografis, riwayat penggunaan obat antipsikotik, dan kejadian interaksi obat. Hasil penelitian menunjukkan bahwa interaksi obat farmakodinamik lebih banyak terjadi (87,7%) dibandingkan dengan farmakokinetik (12,3%). Kombinasi obat yang paling sering digunakan adalah risperidone-trihexyphenidyl dengan tingkat keparahan moderat. Kesimpulannya, interaksi farmakodinamik merupakan jenis interaksi yang paling umum terjadi, dengan tingkat keparahan moderat sebagai yang paling sering ditemukan. Pemantauan ketat dan penyesuaian dosis diperlukan untuk mengurangi risiko interaksi yang berbahaya pada pasien bipolar.
Potential of Several Phytochemicals of Mangrove Species (Rhizopora stylosa) as Inhibitor of Both Viral Gene Expression and Bacterial Nucleic Acid Synthesis Hadi, Ismanurrahman; Irawan, Ade; Ulfah, Mariam; Putra, Teguh Adiyas; Efriani, Like; Haq, Mailatul Ilal; Purnama, Muhamad Rifki
Jurnal Ilmu Kesehatan Vol 10 No 1 (2022): Jurnal Ilmu Kesehatan
Publisher : Universitas Muhammadiyah Kalimantan Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30650/jik.v10i1.3278

Abstract

The mangrove family (Rhizophora stylosa) has been used as traditional medicine. Due to the habitat of mangroves, they develop unique phytochemicals. Thus, they have the potential to become a source of plant-based therapeutic agents. However, many of the them remain uninvestigated. The purpose of this study was to predict the potential of some phytochemicals of the mangrove family as an inhibitor of both viral gene expression and bacterial nucleic acid. Some bioactive compounds of mangrove (taraxerol, pyrethrin, 2-Furancarboxaldehyde, and avicequinone A) were used as subject of this study. The main protease (Mpro) of SARS-Cov-2 virus (PDB ID: 6y2e), the staphylococcus aureus's proteins: topoisomerase II DNA gyrase (PDB id: 2XCT), and tyrosyl-tRNA synthetase (PDB id: 1JIJ) were used as targeted protein. The drug-likeness of compounds were analyzed using Swiss ADME based on the Lipinsky rule of five. Meanwhile, the affinity value between proteins and ligands was predicted using Autodock Vina. The root means square distance (RMSD) value (<2 A) and the binding cavity of drugs (ivermectin and ciprofloxacin) were used as validation parameters. This study resulted that only taraxerol compounds have a violation of Lipinsky's rule. Even so, out of the phytochemical compound of mangrove, the taraxerol has the highest affinity in Mpro and topoisomerase II DNA gyrase protein, although still lesser than ivermectin against Mpro; while avicequinone A has the highest affinity against tyrosyl-tRNA synthetase. This concludes that some phytochemicals of the mangrove family could be developed as an antibacterial and antiviral agents of therapy.
Analisis Drug Related Problems (DRPs) Pada Pasien Angina Pektoris RS X Kota Cirebon Tahun 2023 Efriani, Like; Irawan, Ade; Anwar, Mahfud
Jurnal Farmasi (Journal of Pharmacy) Vol. 13 No. 2 (2024): Jurnal Farmasi (Journal of Pharmacy), October 2024
Publisher : Sekolah Tinggi Ilmu Kesehatan Nasional & Pengurus Cabang Ikatan Apoteker Indonesia (IAI) Sukoharjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.373013/yfqmgz67

Abstract

Angina pectoris is one symptoms of heart disease that is a problem and a major trigger of death in Indonesia characterized by chest pain. The prevalence of angina increases every year due to various risk factors such as age, lifestyle and history diseases such as diabetes, cholesterol, and hypertension. Use of drugs in large is at risk of drug-related problems. Drug Related Problems (DRPs) are medication problems that directly or indirectly affect the results of prescribed therapy. The purpose of this study was to analyze the incidence of actual or potential DRPs in patients angina pectoris. This research is observational non-experimental. Data collection was taken from 66 medical records of angina pectoris patients from January to December 2023 who met the inclusion criteria. The incidence of DRPs was analyzed by qualitative descriptive method based on the literature. The results of the analysis showed DRPs occurred in 61 (92%) hospitalized angina pectoris patients. The presence of DRPs in the category of drug interactions (60.77%), duplication of drug groups (20.26%), underdose (12.05%), overdose (5.13%), and inappropriate drugs (1.79%). The results of the analysis did not show a significant relationship between comorbidities and polyphamidation to DRPs. It can be concluded that the incidence of DRPs in hospitalized angina pectoris patients is quite large (92%), requiring the role of pharmacists in preventing and overcoming DRPs.
PKMS Ibu-Ibu Rumah Tangga dalam Pembuatan PROPOSAL (Produk-Produk Salak) sebagai Upaya Pemanfaatan Limbah Salak Ulfah, Mariam; Efriani, Like; Sari, Vianty Mutya
Prosiding University Research Colloquium Proceeding of The 16th University Research Colloquium 2022: Bidang Pengabdian Masyarakat
Publisher : Konsorsium Lembaga Penelitian dan Pengabdian kepada Masyarakat Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

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Abstract

Salak (Salacca zalacca) merupakan buah asli Indonesia yang banyak digunakan untuk pengobatan. Kulit buah salak mengandung flavonoid yang dapat menurunkan kadar glukosa darah. Biji buah salak memiliki aktivitas antioksidan. Kulit dan buah salak selama ini tidak digunakan padahal limbah-limbah ini dapat dimanfaatkan untuk tujuan kesehatan. Desa Nanggela di Kabupaten Cirebon merupakan salah satu desa penghasil salak dengan sumber daya manusia terutama ibu-ibu rumah tangga yang memiliki keinginan yang tinggi untuk memajukan desanya dengan memanfaatkan potensi wilayah yang ada. Oleh karenanya, tujuan dari kegiatan pengabdian kepada masyarakat ini adalah membuat PROPOSAL (Produk-produk salak) yaitu teh kulit salak dan kopi biji salak untuk meningkatkan nilai guna dari limbah salak serta meningkatkan kemampuan ibu-ibu rumah tangga di Desa Nanggela untuk berwirausaha. Metode yang dilakukan dalam kegiatan pengabdian kepada masyarakat ini adalah penyuluhan manfaat kesehatan salak, pelatihan pembuatan teh kulit salak dan kopi biji salak, demo yang dilakukan oleh warga untuk membuat teh kulit salak dan kopi biji salak, pelatihan pembuatan packaging dan branding agar menarik konsumen, pelatihan perizinan bahan makanan dan pendampingan pemasaran produk. Acara pengabdian dihadiri oleh 25 hingga 30 peserta dengan rentang usia 20 hingga 40 tahun. Hasil dari pengabdian ini adalah masyarakat memahami manfaat kesehatan seluruh bagian buah salak, peserta mampu membuat teh kulit salak dan kopi biji salak, serta warga memahami proses perizinan produk rumahan. Semua hal ini tentunya dapat membantu meningkatkan perekonomian warga.
Analisis efektivitas antibiotik levofloxacin dan ceftriaxon pada pasien pneumonia di instalasi rawat inap RSD X Kota Cirebon Tahun 2023 Efriani, Like; Putra , Teguh Adiyas; Fitriyani, Fifit
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.594

Abstract

Pneumonia is inflammation caused by microorganisms such as bacteria, viruses, fungi, and foreign substances that enter the lungs. The therapeutic management of pneumonia is given antibiotics to eliminate the causative bacteria and overall healing. Conceptually, levofloxacin antibiotics are considered better for pneumonia therapy than ceftriaxone. This study aimed to determine the effectiveness of comparing levofloxacin and ceftriaxone antibiotics in pneumonia patients in the inpatient installation of RSD X Cirebon City. Parameters to determine the effectiveness of antibiotics based on body temperature and length of stay (LOS). This study used a retrospective cross-sectional research design. Patient data from medical records were 91 samples that met the inclusion criteria. Data analysis included patient characteristics, antibiotic use, and therapy effectiveness data. Data were tested statistically using Mann-Whitney. The results showed that the comparison of levofloxacin and ceftriaxon had different effectiveness as antibiotic therapy in pneumonia patients hospitalized in RSD X Cirebon City, except based on length of stay.
Uji Aktivitas Antijamur Sediaan Sabun Cair Ekstrak Daun Kencana Ungu (Ruellia tuberosa L.) Terhadap Candida albicans Dan Trychophyton rubrum. Syamsiyah, Nur; Ulfah, Mariam; Efriani, Like
BEST Journal (Biology Education, Sains and Technology) Vol 9, No 1 (2026): Juni 2026
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v9i1.13167

Abstract

Penelitian ini bertujuan untuk mengevaluasi potensi ekstrak etanol 96% daun kencana ungu (Ruellia tuberosa L.) sebagai bahan aktif dalam sediaan sabun cair yang memiliki aktivitas antijamur terhadap Candida albicans dan Trichophyton rubrum. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%, dilanjutkan dengan proses deklorofilasi. Hasil ekstraksi kemudian diformulasikan menjadi sabun cair dengan tiga variasi konsentrasi ekstrak yaitu 12%, 14%, dan 16%. Evaluasi fisik sediaan mencakup uji organoleptik, homogenitas, pH, tinggi busa, dan uji stabilitas. Uji aktivitas antijamur dilakukan dengan metode difusi sumuran. Hasil skrining fitokimia menunjukkan bahwa ekstrak mengandung senyawa alkaloid, flavonoid, saponin, tanin. Evaluasi fisik menunjukkan bahwa seluruh sediaan memenuhi parameter stabilitas fisik. Uji aktivitas antijamur menunjukkan bahwa sabun cair ekstrak daun kencana ungu memiliki aktivitas menghambat pertumbuhan Candida albicans dan Trichophyton rubrum, dengan zona hambat terbesar pada konsentrasi ekstrak 16% sebesar 15,94 mm dan 15,48mm. Hasil ini menunjukkan bahwa ekstrak daun kencana ungu berpotensi sebagai agen antijamur dalam sediaan sabun cair.Formulasi sediaan sabun cair ekstrak daun kencana ungu (Ruellia tuberosa L.) dengan konsentrasi 12%, 14%, dan 16% memiliki stabilitas fisik yang baik serta menunjukkan aktivitas antijamur terhadap Candida albicans dan Trichophyton rubrum, dengan efektivitas tertinggi ditunjukkan pada konsentrasi 16%
Co-Authors Ade Irawan Ainsani, Bela Anwar, Mahfud Ayu Puspitasari, Ayu Ayu Zakkiyah Dilla, Fatwa Fauzia, Hilda Nurul Fitriyani, Fifit Gunawan, Ucha Indra Hadi, Ismanurrahman Haq, Mailatul Ilal Muhamad Rifki Purnama Muhammad Luthfi Mutika, Indah Nabilah, Amatullah Nur Syamsiyah Nurfita, Nisa Rizki Nurhasanah Nurhasanah Purnama, Muhamad Rifki Putra , Teguh Adiyas Putra, Teguh Adiyas Sari, Vianty Mutya Sarofah, Dina Ulfah, Mariam Ulfah, Marian Vina nurul mu minah Yunita, Fina