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All Journal Journal Health & Science : Gorontalo Journal Health and Science Community Jurnal Prima Medika Sains Jurnal Kesehatan Tambusai JOURNAL LA MEDIHEALTICO Jurnal Buana Farma Jurnal EduHealth JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Locus Penelitian dan Pengabdian Nusantara Scientific Medical Research Journal PCJN Pharmaceutical and Clinical Journal of Nusantara Herbal Medicine Journal
Novriani, Erida
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Aerospace Engineering Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Electrical & Electronics Engineering Health Professions Immunology & microbiology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Formulasi dan Evaluasi Sediaan Tablet Parasetamol dengan Pati Umbi Porang (Amorphophallus muelleri Blume) Sebagai Bahan Pengisi Panjaitan, Hotma sarito; Bangar, Roy Indrianto; Novriani, Erida
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.215

Abstract

Paracetamol is a widely used analgesic–antipyretic drug; however, it exhibits poor flowability and compactibility, requiring suitable excipients in tablet formulation. This study aimed to formulate paracetamol tablets using porang tuber starch (Amorphophallus muelleri) as a filler and to evaluate the effect of its concentration on the physical properties of granules and tablets. Tablets were prepared by the wet granulation method using three concentrations of porang tuber starch: 10 mg (F1), 15 mg (F2), and 20 mg (F3). Granule evaluation showed moisture content ranging from 2.1–3.4%, flow time of 4.8–6.2 seconds, angle of repose of 25.6–30.4°, and compressibility index of 11.2–15.6%, indicating good flow and compressibility properties. Tablet evaluation demonstrated acceptable weight uniformity with deviations < 5%, hardness values of 5.1–7.8 kg, friability of 0.32–0.78%, and disintegration times of 3.4–6.8 minutes. The formulation containing 20 mg of porang tuber starch (F3) exhibited the most optimal characteristics, with the highest tablet hardness (7.8 kg) and the lowest friability (0.32%), while maintaining disintegration time within pharmacopeial limits. Therefore, porang tuber starch shows strong potential as a natural filler in paracetamol tablet formulations.
UJI AKTIVITAS ANTIOKSIDAN EKSTRAK ETANOL JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) MENGGUNAKAN METODE DPPH Raja, Hera Derliana Lumban; Simanjuntak, Nerly Juli Pranita; Novriani, Erida
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1610

Abstract

Antioxidants play an important role in warding off free radicals that can cause oxidative stress and various degenerative diseases. One potential source of natural antioxidants is red ginger leaves ( Zingiber officinale var. rubrum ). This study aims to determine the antioxidant activity of ethanol extract of red ginger leaves using the DPPH method. Extraction was carried out using ethanol solvent, then the antioxidant activity was tested at various concentrations of 20, 30, 40, and 50 ppm. The parameters observed included absorbance value, inhibition percentage, and IC ₅₀ value . The results showed that the inhibition percentage increased with increasing extract concentration. The IC₅₀ value obtained was 45.50 ppm , indicating that the ethanol extract of red ginger leaves has very strong antioxidant activity. Based on these results, it can be concluded that red ginger leaves have the potential as a source of natural antioxidants that can be developed in the fields of health and functional foods.
UJI AKTIVITAS ANTIOKSIDAN METODE DPPH DARI EKSTRAK ETANOL DAUN SUKUN (Artocarpus altilis L.) MENGGUNAKAN METODE MASERASI Sari, Cindy Kurnia; Razoki, Razoki; Novriani, Erida
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2193

Abstract

Breadfruit leaves (Artocarpus altilis L.) area plant with various health benefits due to their natural chemical compounds, one of which acts as an antioxidant. Antioxidants are compounds that can halt the oxidation process by donating electrons, there by protecting normal cells, fats, and proteins from damage caused by free radicals. The concentration of an antioxidant that causes a 50% reduction in DPPH activity is referred to as the IC50.  The objective of this study was to determine the effectiveness of ethanol extract from breadfruit leaves in combating oxidation using the DPPH method. The results showed an IC50 value of 6.66 ppm for the extract, indicating very strong antioxidant activity, although it was more effective compared to vitamin C, which served as a positive control with an IC50 value of 1.15 ppm. This difference in effectiveness is influenced by the amount of phenolic compounds present and the potential pro-oxidant effects at higher concentrations. In summary, breadfruit leaves have high potential as asource of natural antioxidants and can be used to develop pharmaceutical products to treat degenerative diseases.
Co-Authors Alwin, Nicholas Bangar, Roy Indrianto DESI NATALIA, DESI Edy Fachrial Hasibuan, Fitriah Parmadami Hendriani Djuang, Michelle irza Haicha Pratama Lubis, Razoki Merry Cisca, Anita Ndruru, Titi Marlina Neswita, Elfia Nova Riana Panjaitan, Hotma sarito Putri, Lenni Dianna Raja, Hera Derliana Lumban Randy Suryadinata, Emmanuel Razoki, Razoki Ritonga, Lestina Saragih, Maria Lady Saragih, Ria Natalia Sari, Cindy Kurnia Simanjuntak, Nerly Juli Pranita Sitorus, Christina Berliana Syahputra, Hariyadi Dharmawan