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All Journal JAAF (Journal of Applied Accounting and Finance) Innovative: Journal Of Social Science Research Jurnal Pharmacia Mandala Waluya Jurnal Wicara Desa
Lestari, Nur Ayu
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Agriculture, Biological Sciences & Forestry Humanities Computer Science & IT Economics, Econometrics & Finance Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Public Health Social Sciences Other

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Skrining Virtual Berbasis Farmakofor Dari Database Bahan Alam Sebagai Inhibitor Alosterik Mutan T790M/C797 EGFR Untuk Penemuan Obat Kanker Paru Lestari, Nur Ayu; Isrul, Muhammad; Ramadhan, Dwi Syah Fitrah; Fatahu
Jurnal Pharmacia Mandala Waluya Vol. 3 No. 3 (2024): Jurnal Pharmacia Mandala Waluya
Publisher : Prodi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54883/jpmw.v3i3.102

Abstract

Virus korona merupakan penyakit menular berbahaya yang disebabkan oleh virus baru (SARS-CoV-2). Usaha untuk mengeksplorasi bahan-bahan alam aktif sebagai anti-virus terus dilakukan. Salah satu tanaman lokal Indonesia yang dapat menghambat SARS-CoV-2 protein spike yaitu herba sambiloto (Andrographis paniculata) secara in silico, akan tetapi aktivitasnya terhadap mutan D614G SARS-CoV-2 belum diketahui. Tujuan dari penelitian ini yaitu untuk mengkaji aktivitas metabolit andrographolide dan turunannya dalam herba sambiloto (Andrographis paniculata) terhadap mutasi D614G SARS-CoV-2 protein spike secara in silico.Penelitian ini menggunakan metode in silico yaitu penambatan molekul. Penambatan molekul dilakukan menggunakan Autodock Tools 1.5.6 dan dianalisis interaksi ikatannya menggunakan BIOVIA Discovery Studio 2017, kemudian diprediksi ADME menggunakan software Swiss ADME dan sofware PASS online untuk mengetahui toksisitasnya.Hasil penelitian menunjukkan bahwa diperoleh dari 23 senyawa turunan andrographolide yang memiliki stabilitas ikatan lebih baik dari pada senyawa andrographolide yaitu senyawa 14-Acetyl-3,19-isopropylideneandrographolide yang dapat menghambat reseptor non-mutasi (6VSB) dengan energi ikatan -5.34 kcal/mol dan mutan D614G (7KDL) dengan energi ikatan -5.72 kcal/mol dengan hasil prediksi ADME memenuhi aturan lipinski dan tidak menunjukan adanya aktivitas toksisitas hepatotoksik dan nefrotoksik yang bermakna.
Karakteristik Malformasi Anorektal di RSUP Dr. Tadjuddin Chalid Makassar Tahun 2021-2024 Rahman, Muhammad Fatur; Gani, Aziz Beru; Darma, Sidrah; Purnamasari, Reeny; Lestari, Nur Ayu
Innovative: Journal Of Social Science Research Vol. 5 No. 1 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i1.17316

Abstract

This study aims to analyze the characteristics of anorectal malformation (AMR) patients treated at Dr. Tadjuddin Chalid General Hospital, Makassar City in the period 2021 to 2024. Using univariate analysis methods with medical record data, this study presents an overview of gender, initial age at surgery, anorectal malformation variants, and types of surgery performed on patients. The results showed that male patients dominated MAR cases with a proportion of 74.6%, while the other 25.4% were female. The initial age of surgery in most patients was ≤ 2 days (44.4%). The most common type of malformation found was the type without fistula (87.3%), followed by several types of rectovaginal, rectovesical, and other fistulas. Colostomy was the most common first surgical procedure performed, with 69.8% of patients undergoing the procedure. These findings are consistent with previous studies showing a male predominance in the incidence of MAR and a tendency to perform colostomy in the early stages of treatment. This study is expected to provide a clearer picture of the characteristics of MAR patients in Indonesia and the importance of early diagnosis and treatment to prevent complications.
Tax planning implementation on income tax article 21 of permanent employees for efficient payment of tax burden at PT. SC Lestari, Nur Ayu; Siringoringo, Whereson
JAAF (Journal of Applied Accounting and Finance) Vol 8, No 2 (2024): JAAF (Journal of Applied Accounting and Finance)
Publisher : President University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33021/jaaf.v8i2.4595

Abstract

This research aims to understand the application of tax planning for Income Tax Article 21 at PT. SC and to determine the effect of applying each method used in the implementation of tax planning for Income Tax Article 21 related to the efficiency of paying the company's tax expense. This research uses a qualitative descriptive research method. Data sources were obtained through interviews and documentation. The results obtained through this research show that the policy of PT. SC in the application of Gross Up is implemented to reduce the expense on corporate income tax and so that employees are motivated to increase their productivity without worrying about the taxes that must be paid. However, tax planning for Income Tax Article 21 implemented by PT. SC is not yet efficient regarding the taxes that must be paid because the application of the Gross Up calculation causes the payment of the tax expense during one financial year to be greater than with other methods.
PEMANFAATAN AQUAPONIK SEBAGAI TEKNOLOGI BUDIDAYA IKAN NILA DAN SAYURAN YANG MENDUKUNG PERTANIAN BERKELANJUTAN DI DESA KAYANGAN, KECAMATAN KAYANGAN, KABUPATEN LOMBOK UTARA Azis, M Abdul; Widianti, Heny; Sanhuri, Sanhuri; Ranesa, Sulhan Salma; Anggraini, Syarifa Ayu; Mizwar, Zulham; Berliana, Cok Gea; Lestari, Nur Ayu; Kalia, Ragil Alfarizi; Sahrani, Rani; Sriasih, Made
Jurnal Wicara Vol 1 No 3 (2023): Jurnal Wicara Desa
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/wicara.v1i3.2447

Abstract

This introduction to aquaponic planting techniques aims to provide examples of the application of advanced and sustainable agricultural technology to the people in Kayangan village, Kayangan sub-district, North Lombok district (KLU). This activity was carried out from December 2022 to February 2023 at the Bagek Kembar hamlet, Kayangan. The fish used were 60 days old fish seeds with a size of 10 cm x 5 cm which were reared in a 4x3 m tarpaulin container. The plant growth media used is in the form of used foam taken from one of the residents' houses with a size of 5 cm. Placement of the planting media uses used plastic cups and used bottles as containers for placing plastic cups. The vegetables used in making this aquaponics are mustard greens, lettuce and pakcoy. The nutrients used to support plant growth are in the form of fish manure and some additional organic nutrients which are made independently using organic waste from the kitchen. The results of using aquaponic technology as a cultivation technology show that the plants grow but the leaves of the plants turn yellow and the fish in the pond can grow large.
Co-Authors Anggraini, Syarifa Ayu Azis, M Abdul Berliana, Cok Gea Darma, Sidrah Fatahu Gani, Aziz Beru Kalia, Ragil Alfarizi Made Sriasih, Made Mizwar, Zulham Muhammad Isrul Purnamasari, Reeny Rahman, Muhammad Fatur Ramadhan, Dwi Syah Fitrah Ranesa, Sulhan Salma Sahrani, Rani Sanhuri, Sanhuri Siringoringo, Whereson Widianti, Heny