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All Journal Jurnal Mandala Pharmacon Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Jurnal Farmasi Klinik dan Sains DEVOTE: Jurnal Pengabdian Masyarakat Global Jurnal Pengabdian Masyarakat Jurnal Sains dan Kesehatan
Sida, Nurramadhani A.
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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SOSIALISASI DAMPAK NEGATIF PENYALAHGUNAAN NARKOTIKA PADA SISWA SISWI SMP NEGERI 12 KENDARI Nuralifah; Sida, Nurramadhani A.; Prasetyo, Eko Juni; Maulana, Wa Ode Asriani; Purnama, Seftiawati Itha; Indiarti, Elsi; Farisyah, Astrid Risky
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 6 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Juni 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i6.1456

Abstract

Narkotika, psikotropika, dan obat-obatan terlarang yang umumnya dikenal sebagai narkoba memiliki peran penting dalam dunia medis, terutama untuk pengobatan. Namun, dewasa ini, banyak pihak yang menyalahgunakan narkoba. Penyalahgunaan narkoba pada remaja dapat menyebabkan menurunkan konsentrasi dan produktivitas belajar, menyebabkan perubahan perilaku seseorang menjadi tidak mau bersosialisasi, meningkatkan resiko penyakit, gangguan mental, serta meningkatkan tindak kriminalitas. Berdasarkan uraian tersebut, sosialisasi mengenai bahaya penyalahgunaan narkoba sangat penting untuk diberikan kepada anak-anak yang mulai memasuki usia remaja, khususnya siswa Sekolah Menengah Pertama (SMP), karena usia ini sering menjadi sasaran karena tingginya rasa ingin tahu dan kecenderungan untuk mencoba hal-hal baru. Oleh karena itu, kegiatan ini bertujuan untuk Siswa Siswi di SMP negeri 12 Kendari dapat mengetahui jenis jenis narkotika, penyebab penyalahgunaan narkoba dan memahami dampak negatif dari penyalahgunaan narkoba. Metode yang digunakan dalam kegitan ini adalah metode ceramah, agar dapat memberikan pemahaman secara langsung kepada Siswa Siswi di SMP Negeri 12 Kendari.
Profil Asam Lemak Minyak Ikan Belanak (Chelon planiceps) Sebagai Sumber Omega-3 Asal Desa Lembo Kabupaten Konawe Utara Hikmah, Nurull -; Trinovitasari, Nita; A.Sida, Nurramadhani; Sida, Nurramadhani A.; Anwar, Irvan; Fadhilah, Nurul Aliah; Irnawati
Pharmaceutical and Biomedical Sciences Journal (PBSJ) Vol. 7 No. 1 (2025)
Publisher : Pharmaceutical and Biomedical Sciences Journal (PBSJ)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/pbsj.v7i1.41029

Abstract

Ikan Belanak (Mullet) is a small pelagic fish that lives in shallow coastal waters. This type of fish lives in the coastal area of Lembo Village, North Konawe Regency. The objective of this study was to characterize physicochemicals and determine the fatty acid profile of mullet oil, which is a source of fish oil that contains unsaturated fatty acids that are beneficial to health. The reflux process is used to remove mullet flesh, which yields fish oil. The findings demonstrated that the physicochemical properties of mullet oil varied. These properties included the acid number, peroxide number, iodine number, and saponification number, which were, respectively, 0.81 mg KOH/g, 8.30 meqO2/kg, 50.98 I2/100 g, and 109.07 mg KOH/g. The fatty acid profile of mullet oil is dominated by palmitic acid, cis-9-oleic acid and DHA. Based on the test results, mullet oil can be used as edible oil according to SNI and IFOS standards. 
Uji Antiinflamasi Daun Maja (Aegle marmelos L.) Menggunakan Metode Penghambatan Denaturasi Protein Malina, Rachma; Yamin, Yamin; Anwar, Irvan; Nurul Jannah, Sitti Raodah; Sida, Nurramadhani A.; Nafiah, Afifatun
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.665

Abstract

Tubuh merespon cedera atau kerusakan jaringan dengan inflamasi, yang menyebabkan berbagai sensasi seperti rasa sakit, kemerahan, pembengkakan, panas, dan penurunan fungsi di daerah yang terluka. Daun maja (Aegle marmelos L.) secara empiris telah digunakan sebagai obat radang. Diketahui daun maja memiliki kemampuan antioksidan yang sangat kuat sehingga berpotensi sebagai antiinflamasi yang kuat. Tujuan penelitian untuk mengidentifikasi potensi antiinflamasi serta menentukan kadar total fenolik dan flavonoid daun maja. Uji aktivitas antiinflamasi dilakukan menggunakan metode penghambatan denaturasi protein, dengan mengukur persentase penghambatan denaturasi albumin serum pada konsentrasi tertentu. Analisis kadar fenolik total dilakukan menggunakan metode Folin-Ciocalteu, dengan asam galat sebagai standar, sementara kadar flavonoid total dianalisis menggunakan metode kompleksasi aluminium, menggunakan kuersetin sebagai standar. Pengukuran dilakukan menggunakan spektrofotometer UV-Vis pada panjang gelombang tertentu. Hasil skrining fitokimia daun maja mengandung alkaloid, flavonoid, saponin, tanin, dan terpenoid. Kadar fenolik dan flavonoid total tertinggi berturut-turut yaitu fraksi etil asetat sebanyak 374.17 mgEAG/g dan 394.07 mgEK/g sampel. Hasil uji aktivitas antiinflamasi menggunakan metode penghambatan denaturasi protein Bovin Serum Albumin (BSA) diperoleh nilai IC50 pada ekstrak metanol, fraksi n-heksana, fraksi etil asetat, dan fraksi air berturut-turut adalah 32.088 µg/mL, 18.361 µg/mL, 14.243 µg/mL, dan 38.894 µg/mL. Pengujian antiinflamasi menemukan bahwa fraksi etil asetat memiliki nilai IC50 tertinggi yang menunjukkan bahwa fraksi etil asetat daun Aegle marmelos L. memiliki potensi aktivitas antiinflamasi yang baik dibandingkan dengan ekstrak dan fraksi lainnya. Berdasarkan hasil tersebut menunjukkan bahwa daun Aegle marmelos L. memiliki aktivitas sebagai antiinflamasi.
PENCEGAHAN STUNTING PADA SISWA MADRASAH IBTIDAIYAAH NURUL MAGFIRAH KENDARI DENGANPEMBERIAN OBAT PENCEGAHAN MASSAL (POPM) Jabbar, Asriullah; Nasrudin, Nasrudin; Halik, Halik; Wahyuni, Wahyuni; Malik, Fadhliyah; Akib, Nur Illiyyin; Suryani, Suryani; Solo, Dian Munasari; Sida, Nurramadhani A.; Mubarak, Mubarak; Y, Muhammad Ilyas
Devote: Jurnal Pengabdian Masyarakat Global Vol. 3 No. 1 (2024): Devote : Jurnal Pengabdian Masyarakat Global, Maret 2024
Publisher : LPPM Institut Pendidikan Nusantara Global

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/devote.v3i1.2502

Abstract

Helminthiasis is a health problem that affects many children, especially elementary school. Helminthiasis can cause malnutrition because all nutrients are absorbed by worms, which will disrupt the mental and physical development of children, make children easily sick due to a decrease in their immune system, stunting or physical children become shorter and smaller than their peers, reduce children's intelligence and in some cases can also cause death in children. The purpose of this community service is the prevention and control of helminthiasis infection through the provision of mass preventive medicine for helminthiasis to prevent stunting in elementary school at Madrasah Ibtidaiyaah Nurul Magfirah Kendari. The method used, namely providing material about helminthiasis accompanied by giving deworming drugs to students. This service is in collaboration with the Health Team of Puskesmas Lepo Lepo Kendari.
An in Vitro Approach: Antibacterial Activity of Sansevieria trifasciata Prain. Leaves with Chemometric Analysis Kasmawati, Henny; Sida, Nurramadhani A.; Arfan, Arfan; Indrayanti, Wa Ode Dian; Rusman, Arman
Jurnal Sains dan Kesehatan Vol. 6 No. 1 (2024): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v6i1.2087

Abstract

Exploration the antibacterial activity of S.trifasciata Prain. is still limited, therefore this study aims to assess the antibacterial activity of extracts and ethyl acetate fractions of Sansevieria trifasciata Prain. The S.trifasciata leaves was macerated with ethanol 96%, then fractionated using the trituration method with ethyl acetate. The treatment group was divided into positive control group (PC) using ciprofloxacin, negative control (NC) using DMSO, extract, ethyl acetate fraction 5% (ET5%), 10% (ET10%), 20% (ET20%), 40% (ET40 %). Data were analyzed statistically by ANOVA and chemometrically with PCA. The inhibition zone for S.aureus bacteria in each sample is 26.69; 1.40; 23.32;2.82; 6.23; 11.11; 20.15 mm, respectively, E.coli is 26.65;0.63;22.65;3.61;7.11;11.44;21.15 mm respectively, P. aeruginosa is 27.40; 0.00; 23.23; 2.74;7.03;11.69;21.36 mm respectively. Percent inhibition of extract, ET5%, ET10%, ET20%, ET40% on S. aureus bacteria is 82.16; 5.31; 18.12; 36.39; 70.38% respectively, E.coli is 82.67; 11.13; 24.31; 40.56; 76.99% respectively, P. aeruginosa 84.85; 10.01; 25.65; 42.68; 77.98% respectively. Extract and ethyl acetate fraction have significant potential as antibacterial (p<0.05). The results of PCA chemometric analysis showed that the extract and ET40% had similar inhibition zone area to the positive control ciprofloxacin. The extract and the ethyl acetate fraction 40% are promising for development as antibacterials. Keywords:          Sansevieria trifasciata Prain., chemometric, bacterial
Evaluasi Toksisitas Akut Kulit Batang Manihot esculenta Crantz. : Pendekatan In Silico dan In Vitro Sida, Nurramadhani A.
Jurnal Farmasi Klinik dan Sains Vol 5, No 1 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i1.1649

Abstract

Manihot esculenta Crantz has been used in research focused on drug discovery and development. Although the compound content and pharmacological effects of this plant have been widely reported, it is necessary to conduct a toxicity evaluation when developing it as a potential drug candidate to determine its effectiveness and therapeutic potential. This study aims to evaluate the acute toxicity of stem bark of M. esculenta both in silico and in vitro. In-silico toxicology was conducted on 13 compounds using ProTox-II. The indicators assessed were LC50 and organ toxicity such hepatotoxic, carcinogenic, immunotoxicity, mutagenic, nephrotoxic, neurotoxic. The in vitro assay used BSLT with Artemia salina. The mortality percentage of A. salina was calculated to determine the LC50 value. The in-silico results showed five compounds Hydrocyanic acid, beta stigmasterol, 6'-Apiosyllotaustralin, Yucalexin B22, and Yucalexin B14 with a toxicity category of < 5. The in vitro results showed LC50 values for the ethanol and n-hexane fractions of 548.774 and 375.787 µg/mL, respectively. Further in vivo toxicity testing is needed to provide additional evidence of the toxicity of M. esculenta stem bark. The stem bark of M. esculenta is toxic depending on the concentration, with compounds such as hydrocyanic acid, beta stigmasterol, 6'-Apiosyllotaustralin, Yucalexin B22, and Yucalexin B14 suspected to play an important role in the toxic effects.
Co-Authors A.Sida, Nurramadhani Anwar, Irvan Arfan Arfan Fadhilah, Nurul Aliah Fadhliyah Malik Farisyah, Astrid Risky Halik, Halik Hikmah, Nurull - Indiarti, Elsi Indrayanti, Wa Ode Dian Irnawati Jabbar, Asriullah Kasmawati, Henny Malina, Rachma Maulana, Wa Ode Asriani Mubarak Mubarak Nafiah, Afifatun Nasrudin Nur Illiyyin Akib Nuralifah Nurul Jannah, Sitti Raodah Prasetyo, Eko Juni Purnama, Seftiawati Itha Rusman, Arman Solo, Dian Munasari Suryani Suryani Trinovitasari, Nita wahyuni wahyuni Y, Muhammad Ilyas Yamin, Yamin