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All Journal Majalah Kesehatan FKUB Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Medfarm: Jurnal Farmasi dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Pengabdian Masyarakat Medika JHeS (Journal of Health Studies) Biomedika Jurnal Ilmiah Kesehatan Sandi Husada
Puspitasari, Metana
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Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Blood Parameters and Length of Hospitalization in Pediatric Dengue Virus Infection Patients Salsabiela, Salwa; Puspitasari, Metana; Jatmiko, Safari Wahyu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5539

Abstract

This research aims to evaluate the correlation between erythrocyte level, hematocrit, hemoglobin, and Hb/RDW ratio with the length of hospitalization in pediatric patients with DVI. This observational study used a cross-sectional design and analyzed secondary data from 41 pediatric DVI patients at PKU Muhammadiyah Sampangan Surakarta Hospital. The correlation between hematological parameters and length of hospitalization was analyzed using the Spearman test. Laboratory results showed a mean erythrocyte count of 5.05 million cells/nL (SD 0.61), a median hematocrit of 39.5%, hemoglobin of 13.6 g/dL, and Hb/RDW ratio of 1.03. Bivariate correlation test showed erythrocyte level (r = 0.027, p = 0.867), hematocrit (r = -0.004, p = 0.983), hemoglobin (r = 0.079, p = 0.625), and Hb/RDW ratio (r = 0.116, p = 0.472) showed no significant association with length of hospitalization. This study provides insights into the relationship between hematological parameters and the length of hospital stay in pediatric dengue patients. While no significant correlation was found, it highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. Conducted in an Indonesian endemic region, the research contributes to understanding DVI management and underscores the importance of a comprehensive, multifactorial approach to improving patient care strategies.
Aggregate Index of Systemic Inflammation is Correlated with Plasma Leakage Indicator in Dengue Virus Infection Jatmiko, Safari; Puspitasari, Metana; Aisyah, Riandini
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25847

Abstract

Severe dengue virus infection (DVI) is characterized by thrombocytopenia and plasma leakage (PL) due to the release of vasoactive cytokines by immune cells such as monocytes, lymphocytes, neutrophils, and platelets in response to dengue virus (DENV). This immune response triggers systemic inflammation, altering monocyte, lymphocyte, and neutrophil kinetics, which in turn affects leukocyte differentials. PL is indicated by an increase in hematocrit (Hct). This study aims to evaluate the potential use of the Aggregate Index of Systemic Inflammation (AISI) as an indicator of plasma leakage. A correlative analytical study with a cross-sectional approach was conducted on 70 pediatric DVI patients diagnosed according to the 2009 WHO criteria and confirmed by anti-DENV IgM/IgG tests. Patients with a history of malignancy, autoimmune thrombocytopenic purpura, or secondary DVI were excluded. Absolute neutrophil, monocyte, platelet, and lymphocyte counts, AISI, and Hct levels were obtained from complete blood count results using a hematology analyzer. The results showed that AISI and lymphocytes correlated with Hct, with correlation values of (r=0.410, p<0.001) and (r=0.446, p<0.001), respectively. In contrast, monocytes, neutrophils, and platelets did not correlate with Hct, with correlation values of (r=-0.009, p=0.942), (r=-0.059, p=0.628), and (r=-0.175, p=0.147), respectively. In conclusion, AISI levels in DVI were low and negatively correlated with Hct, a known indicator of PL. These findings suggest that AISI has potential as a marker for PL and disease severity in DVI.
EFEKTIVITAS PENYULUHAN KESEHATAN TERHADAP PEMAHAMAN PENYAKIT DIABETES MELITUS DAN FAKTOR RISIKONYA Puspitasari, Metana; Rahmah, Sandawi Rianda; Marchelina, Sherly
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.5866

Abstract

ABSTRAK Diabetes melitus adalah kondisi medis yang mengakibatkan peningkatan kadar gula darah akibat gangguan fungsi atau produksi insulin. Berdasarkan klasifikasi Perkeni tahun 2021, terdapat empat tipe diabetes, yaitu tipe 1, tipe 2, gestasional, dan tipe lain yang disebabkan oleh faktor spesifik. Menurut hasil SKI 2023 menunjukkan peningkatan prevalensi Diabetes Melitus tipe 2 di Indonesia meningkat menjadi 11,7% pada tahun 2023, naik dari 10,9% pada tahun 2018 pada kelompok usia ≥15 tahun. Pendekatan menyeluruh dan holistik diperlukan untuk mengelola Diabetes Melitus, melibatkan tindakan yang bersifat promotif, preventif, kuratif, dan rehabilitatif. Penyuluhan ini bertujuan untuk meningkatkan pemahaman masyarakat mengenai penyakit diabetes, sebagai langkah promotif dan preventif dalam mengatasi Diabetes Melitus. Studi ini menggunakan metode one group pre-test post-test dengan melibatkan 40 peserta dari Kelurahan Sigran, Kecamatan Geneng, Kabupaten Sukoharjo. Analisis data dilakukan dengan Wilcoxon test. Temuan dari penelitian menunjukkan adanya peningkatan skor dari rata-rata 67 pada pretest menjadi 85,25 pada posttest. Berdasarkan hasil ini dan nilai p < 0,05, dapat disimpulkan bahwa penyuluhan kesehatan telah berhasil meningkatkan pengetahuan peserta tentang diabetes melitus.   ABSTRACT Diabetes melitus is a medical condition that results in elevated blood sugar levels due to issues in insulin function or production. According to Perkeni's 2021 classification, there are four types of diabetes: Type 1, Type 2, gestational, and other types caused by specific factors. The 2023 Health Survey (SKI) indicated an increase in the prevalence of Type 2 Diabetes Melitus in Indonesia, rising to 11.7% in 2023 from 10.9% in 2018 in the age group of 15 years and older. A comprehensive and holistic approach is essential for managing Diabetes Melitus, involving promotive, preventive, curative, and rehabilitative measures. This community service activity aims to enhance public awareness and knowledge about diabetes as a preventive and promotive measure against the disease. This study applied a one-group pre-test post-test design approach. Forty participants from Sigran community in Geneng District, Sukoharjo Regency participated. Data was analyzed using the Wilcoxon test. Results showed that the average score at the pretest stage was 67, while the post-test average score was 85.25. The analysis indicates that health education significantly improved community knowledge about diabetes melitus, as evidenced by a p-value < 0.05.
Hubungan Kadar Hba1c dan Kolesterol Total dengan Kejadian Peripheral Arterial Disease pada Pasien Diabetes Mellitus Tipe 2 Puspitasari, Metana; Mahmuda, Iin Novita Nurhayati; Chandra, Ilham Edgar Fadhila; Najib, Yazid Aufa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13930

Abstract

Type 2 diabetes mellitus (DMT2) is caused by the inability of pancreatic beta cells to produce insulin and tissue resistance to insulin. T2DM requires ongoing treatment to control blood sugar and prevent complications such as Peripheral Arterial Disease (PAD) and high cholesterol problems. HbA1c measurement and total cholesterol monitoring are important in diabetes management and prevention of serious complications. An observational analytical study, cross-sectional approach was conducted in September 2022 at Gatak Health Center, Sukoharjo on 65 patients with T2DM. The data were analyzed with a 2x2 chi square test table. The results of the study found that 21 (32.3%) research subjects experienced PAD. Bivariate test between total cholesterol and Hba1c with consecutive PAD incidence p = 0.377; p = 0.416. It can be concluded that there is no significant relationship between the variables total cholesterol and Hba1c with the incidence of PAD. This can be caused by lack of control over other risk factors for PAD events such as smoking, hypertension, duration of diabetes, age, and gender.
Role of laboratory examinations in the diagnosis of vasomotor rhinitis: A Review of Literature Arfiana, Nur Wisma; Jayati, Nurul Sari; Zufar, M Irvan; Putra, Kresna Aditya Nugraha; Hasmy, Alya Fauzizah; Puspitasari, Metana
Jurnal Ilmiah Kesehatan Sandi Husada Vol 14 No 2 (2025): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v14i2.1302

Abstract

Introduction: Vasomotor rhinitis (VMR) is a subtype of non-allergic rhinitis characterized by chronic nasal symptoms such as congestion, rhinorrhea, and sneezing without allergic or infectious causes. The absence of specific biomarkers makes VMR difficult to distinguish from allergic rhinitis, resulting in diagnostic challenges and potentially inappropriate therapy. This review aims to assess the contribution of laboratory examinations in the differential diagnosis of VMR. Methods: A comprehensive literature search was performed using PubMed and Google Scholar databases for articles published between January 2021 and September 2025. Keywords included “non-allergic rhinitis,” “laboratory,” “IgE,” “eosinophil,” “nasal cytology,” “FeNO,” and “biomarker.” Out of 8,350 identified publications, 407 titles were relevant, and 57 full-text articles were reviewed. After applying inclusion and exclusion criteria, nine studies were selected for detailed analysis. Results: No single laboratory test can confirm the diagnosis of VMR. Total and specific IgE levels, as well as peripheral eosinophil counts, mainly serve to exclude allergic rhinitis. Nasal cytology plays a crucial role in identifying subtypes of non-allergic rhinitis, including NARES and NARNE. Measurements of nasal nitric oxide (nNO/FeNO) and newer biomarkers, including diamine oxidase (DAO), show potential as supportive indicators, though findings remain inconsistent. Conclusion: Laboratory examinations contribute primarily as adjunctive tools in differentiating VMR from allergic rhinitis. A multimodal diagnostic approach that integrates serological, cytological, and biomarker evaluations with clinical findings offers the most reliable strategy for improving diagnostic accuracy and guiding appropriate therapy.
Larvicidal Activity of Ethanol Extracts of Bidara (Ziziphus mauritiana) Leaves and Fruits Against Aedes aegypti Bestari, Rochmadina Suci; Fikri, Muhammad Ihsanul; Aisyah, Riandini; Puspitasari, Metana; Wahyuni, Sri; Porusia, Mitoriana
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.586

Abstract

Dengue fever vector control uses abate chemicals can harm the ecosystem. One of the plants that can be used as a natural larvicide is bidara. Bidara leaves and fruits easily available and contains flavonoids, saponins, alkaloids, and tannins. The compound have an impact on the mortality of Aedes aegypti mosquito larvae. Contains study design, subject, methods, data collection and data analysis. Research on ethanol extract of bidara leaves and bidara fruit with Poly Ethylene Glycol (PEG) was experimental laboratory design with post-test only controlled group design. The technique of extraction is maseration. The larvae of Aedes aegypti instar III-IV are used, 800 in total, divided into 8 groups. At 6, 12, 18, and 24 hours, the number of dead larvae was counted .Normality and homegenity tests obtained the results of data not normally distributed and not homogeneous, so it is necessary to do the Kruskall-Wallis non-parametric test followed by Mann-Whitney post hoc .The result is bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour, meanwhile bidara fruit extract with concentration of 1.5% + 3% PEG resulted 70% larval death in 24th hour. Ethanol extract of bidara leaves has better effectiveness than bidara fruit extract in its ability as a larvicide, where bidara leaf extract with a concentration of 1.5% + 3% PEG resulted in 100% larval death in the 24th hour.
RASIO EOSINOFIL-MONOSIT TIDAK BERKORELASI DENGAN MARKER DERAJAT PENYAKIT INFEKSI VIRUS DENGUE PADA ANAK Jatmiko, Safari Wahyu; Puspitasari, Metana; Widyastuti, Noor Hafida; Aisyah, Riandini
Majalah Kesehatan Vol. 0 No. 00 (2026): Article in Press
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Rasio Eosinofil-Monosit (REM) telah digunakan sebagai marker inflamasi yang berhubungan dengan derajat penyakit seperti stroke iskemik akut, gagal jantung, dan Grave’s disease, namun belum pernah dilakukan pada infeksi virus dengue (IVD). Eosinofil dan monosit berperan dalam patogenesis IVD dan terdapat laporan bahwa jumlah monosit berbanding terbalik dengan jumlah eosinofil pada kondisi inflamasi. Di sisi lain, platelet dan hematokrit merupakan bagian dari marker derajat penyakit pada IVD. Semakin berat derajat IVD semakin tinggi hematokrit dan semakin rendah platelet. Maka, penelitian mengenai REM dan penyusun REM yang dikaitkan dengan platelet dan hematokrit perlu dilakukan. Tujuan penelitian untuk mengetahui korelasi antara monosit dengan hematokrit, sel esoinofil dengan hematokrit dan platelet, dan REM dengan hematokrit dan platelet pada IVD anak. Metode penelitian observasional dengan desain cross-sectional. Penelitian dilakukan di RS PKU Muhammadiyah Sampangan Surakarta dari Desember 2023-2024 terhadap populasi pasien IVD di bawah 15 tahun, sesuai kriteria IVD WHO 2009, dan terkonfirmasi melalui tes antibodi anti-dengue. Pasien dengan riwayat gangguan homeostasis, komorbid, riwayat vaksinasi dengue, alergi, malignansi, kecacingan, atau sedang mengalami infeksi lainnya dikecualikan dari penelitian. Berdasarkan rumus besar sampel untuk uji korelasi Pearson  menggunakan transfor-masi Fisher’s Z didapatkan jumlah sampel sebanyak 50. Analisis monosit, eosinofil, REM, hematokrit, dan platelet dilakukan menggunakan Hematology Analyzer. Hasil penelitian ditemukan bahwa terdapat korelasi antara monosit dengan Hct (r = 0,361, p = 0,001), namun tidak ada korelasi yang signifikan secara statistik antara eosinofil dan REM dengan platelet dan hematokrit. Kesimpulan menunjukkan monosit berpotensi sebagai indikator derajat keparahan IVD, namun tidak dengan eosinofil dan REM.  
Relationship of acid–base imbalance with hemorrhage volume and mortality in intracerebral stroke hemorrhage Mukti, Gavin; Setiawan, Iwan; Puspitasari, Metana; Sulistyani, Sulistyani
JHeS (Journal of Health Studies) Vol. 10 No. 1 (2026): Maret
Publisher : Universitas 'Aisyiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31101/jhes.4008

Abstract

This study aimed to evaluate the relationship between acid-base balance disturbances and intracerebral hemorrhage volume with mortality rates in hemorrhagic stroke cases. The research used an observational analytic design with a cross-sectional approach and was conducted at Dr. Soeratno Gemolong General Hospital, Sragen, from September to November 2024. The study population consisted of medical records of patients diagnosed with hemorrhagic stroke at the hospital between August 2021 and August 2024 who met the inclusion criteria. A total of 50 samples were selected using a purposive sampling technique. Data analysis included univariate analysis, bivariate analysis using the Chi-Square test, and multivariate analysis using logistic regression. The results showed a significant relationship between acid–base balance disturbances and intracerebral hemorrhage volume with mortality in hemorrhagic stroke cases (p=0.001). In addition, intracerebral hemorrhage volume was significantly associated with mortality (p=0.007). Multivariate analysis confirmed that both acid–base imbalance and hemorrhage volume significantly influence mortality outcomes. These findings indicate that acid–base imbalance and intracerebral hemorrhage volume greater than 30 ml are strong predictors of mortality in hemorrhagic stroke patients. Therefore, strict monitoring of arterial blood gases, neurological status, and hemodynamic stability is essential during the acute phase of care. Early detection of physiological deterioration and prompt intervention may help reduce the risk of adverse outcomes. Future research is recommended to use prospective multicenter designs with larger sample sizes to further clarify causal relationships and evaluate whether early correction of acid–base disturbances can improve mortality outcomes in hemorrhagic stroke patients.
Co-Authors Agustina, Dinda Dwi Alfajri, Asri Alim, Fika Nurul Ardhana, Regita Arfiana, Nur Wisma Chandra, Ilham Edgar Fadhila Faqihudin, Fadli Rizal Fikri, Elfin Ainul Fikri, Muhammad Ihsanul Fithriyah, Saidatul Hartia, Nabila Putri Hasmy, Alya Fauzizah Iwan Setiawan Jamiko, Safari Wahyu Jatmiko, Safari Jatmitko, Safari Wahtu Jayati, Nurul Sari Kencana, Nabila Safhira Titan kusumaningsih, dwi Listiana Masyita Dewi Mahmuda, Iin Novita Nurhayati Marchelina, Sherly Mitoriana Porusia Mukti, Gavin Najib, Yazid Aufa Nida Faradisa Fauziyah Noor Hafida Widyastuti Pambudi, Nasrurrofiq Risvana Bayu Paramadina, Izzati Putra, Kresna Aditya Nugraha Rahmah, Sandawi Rianda Retno Sintowati - Riandini Aisyah Rochmadina Suci Bestari Safari Wahyu Jatmiko Salsabiela, Salwa Sri Wahyuni Sulistyani Sulistyani Sulistyani, S Yamsun, Rahmat Dani Yulistina, Desita Yunitama, Alifa Agil Dhillu Zufar, M Irvan