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All Journal Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Syntax Literate: Jurnal Ilmiah Indonesia Jurnal Ilmiah Permas: Jurnal Ilmiah STIKES Kendal Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Pengabdian Masyarakat Medika Biomedika Jurnal Ilmiah Kesehatan Sandi Husada
Puspitasari, Metana
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Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Education Engineering Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Blood Parameters and Length of Hospitalization in Pediatric Dengue Virus Infection Patients Salsabiela, Salwa; Puspitasari, Metana; Jatmiko, Safari Wahyu
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2024: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.5539

Abstract

This research aims to evaluate the correlation between erythrocyte level, hematocrit, hemoglobin, and Hb/RDW ratio with the length of hospitalization in pediatric patients with DVI. This observational study used a cross-sectional design and analyzed secondary data from 41 pediatric DVI patients at PKU Muhammadiyah Sampangan Surakarta Hospital. The correlation between hematological parameters and length of hospitalization was analyzed using the Spearman test. Laboratory results showed a mean erythrocyte count of 5.05 million cells/nL (SD 0.61), a median hematocrit of 39.5%, hemoglobin of 13.6 g/dL, and Hb/RDW ratio of 1.03. Bivariate correlation test showed erythrocyte level (r = 0.027, p = 0.867), hematocrit (r = -0.004, p = 0.983), hemoglobin (r = 0.079, p = 0.625), and Hb/RDW ratio (r = 0.116, p = 0.472) showed no significant association with length of hospitalization. This study provides insights into the relationship between hematological parameters and the length of hospital stay in pediatric dengue patients. While no significant correlation was found, it highlights the complexity of factors influencing outcomes and the need to explore other prognostic markers. Conducted in an Indonesian endemic region, the research contributes to understanding DVI management and underscores the importance of a comprehensive, multifactorial approach to improving patient care strategies.
Aggregate Index of Systemic Inflammation is Correlated with Plasma Leakage Indicator in Dengue Virus Infection Jatmiko, Safari; Puspitasari, Metana; Aisyah, Riandini
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 02 (2025): Qanun Medika Vol 09 No 02 July 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i02.25847

Abstract

Severe dengue virus infection (DVI) is characterized by thrombocytopenia and plasma leakage (PL) due to the release of vasoactive cytokines by immune cells such as monocytes, lymphocytes, neutrophils, and platelets in response to dengue virus (DENV). This immune response triggers systemic inflammation, altering monocyte, lymphocyte, and neutrophil kinetics, which in turn affects leukocyte differentials. PL is indicated by an increase in hematocrit (Hct). This study aims to evaluate the potential use of the Aggregate Index of Systemic Inflammation (AISI) as an indicator of plasma leakage. A correlative analytical study with a cross-sectional approach was conducted on 70 pediatric DVI patients diagnosed according to the 2009 WHO criteria and confirmed by anti-DENV IgM/IgG tests. Patients with a history of malignancy, autoimmune thrombocytopenic purpura, or secondary DVI were excluded. Absolute neutrophil, monocyte, platelet, and lymphocyte counts, AISI, and Hct levels were obtained from complete blood count results using a hematology analyzer. The results showed that AISI and lymphocytes correlated with Hct, with correlation values of (r=0.410, p<0.001) and (r=0.446, p<0.001), respectively. In contrast, monocytes, neutrophils, and platelets did not correlate with Hct, with correlation values of (r=-0.009, p=0.942), (r=-0.059, p=0.628), and (r=-0.175, p=0.147), respectively. In conclusion, AISI levels in DVI were low and negatively correlated with Hct, a known indicator of PL. These findings suggest that AISI has potential as a marker for PL and disease severity in DVI.
EFEKTIVITAS PENYULUHAN KESEHATAN TERHADAP PEMAHAMAN PENYAKIT DIABETES MELITUS DAN FAKTOR RISIKONYA Puspitasari, Metana; Rahmah, Sandawi Rianda; Marchelina, Sherly
Jurnal Pengabdian Masyarakat Medika Vol 5. No. 2, September 2025
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v5i2.5866

Abstract

ABSTRAK Diabetes melitus adalah kondisi medis yang mengakibatkan peningkatan kadar gula darah akibat gangguan fungsi atau produksi insulin. Berdasarkan klasifikasi Perkeni tahun 2021, terdapat empat tipe diabetes, yaitu tipe 1, tipe 2, gestasional, dan tipe lain yang disebabkan oleh faktor spesifik. Menurut hasil SKI 2023 menunjukkan peningkatan prevalensi Diabetes Melitus tipe 2 di Indonesia meningkat menjadi 11,7% pada tahun 2023, naik dari 10,9% pada tahun 2018 pada kelompok usia ≥15 tahun. Pendekatan menyeluruh dan holistik diperlukan untuk mengelola Diabetes Melitus, melibatkan tindakan yang bersifat promotif, preventif, kuratif, dan rehabilitatif. Penyuluhan ini bertujuan untuk meningkatkan pemahaman masyarakat mengenai penyakit diabetes, sebagai langkah promotif dan preventif dalam mengatasi Diabetes Melitus. Studi ini menggunakan metode one group pre-test post-test dengan melibatkan 40 peserta dari Kelurahan Sigran, Kecamatan Geneng, Kabupaten Sukoharjo. Analisis data dilakukan dengan Wilcoxon test. Temuan dari penelitian menunjukkan adanya peningkatan skor dari rata-rata 67 pada pretest menjadi 85,25 pada posttest. Berdasarkan hasil ini dan nilai p < 0,05, dapat disimpulkan bahwa penyuluhan kesehatan telah berhasil meningkatkan pengetahuan peserta tentang diabetes melitus.   ABSTRACT Diabetes melitus is a medical condition that results in elevated blood sugar levels due to issues in insulin function or production. According to Perkeni's 2021 classification, there are four types of diabetes: Type 1, Type 2, gestational, and other types caused by specific factors. The 2023 Health Survey (SKI) indicated an increase in the prevalence of Type 2 Diabetes Melitus in Indonesia, rising to 11.7% in 2023 from 10.9% in 2018 in the age group of 15 years and older. A comprehensive and holistic approach is essential for managing Diabetes Melitus, involving promotive, preventive, curative, and rehabilitative measures. This community service activity aims to enhance public awareness and knowledge about diabetes as a preventive and promotive measure against the disease. This study applied a one-group pre-test post-test design approach. Forty participants from Sigran community in Geneng District, Sukoharjo Regency participated. Data was analyzed using the Wilcoxon test. Results showed that the average score at the pretest stage was 67, while the post-test average score was 85.25. The analysis indicates that health education significantly improved community knowledge about diabetes melitus, as evidenced by a p-value < 0.05.
Hubungan Kadar Hba1c dan Kolesterol Total dengan Kejadian Peripheral Arterial Disease pada Pasien Diabetes Mellitus Tipe 2 Puspitasari, Metana; Mahmuda, Iin Novita Nurhayati; Chandra, Ilham Edgar Fadhila; Najib, Yazid Aufa
Syntax Literate Jurnal Ilmiah Indonesia
Publisher : Syntax Corporation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-literate.v8i11.13930

Abstract

Type 2 diabetes mellitus (DMT2) is caused by the inability of pancreatic beta cells to produce insulin and tissue resistance to insulin. T2DM requires ongoing treatment to control blood sugar and prevent complications such as Peripheral Arterial Disease (PAD) and high cholesterol problems. HbA1c measurement and total cholesterol monitoring are important in diabetes management and prevention of serious complications. An observational analytical study, cross-sectional approach was conducted in September 2022 at Gatak Health Center, Sukoharjo on 65 patients with T2DM. The data were analyzed with a 2x2 chi square test table. The results of the study found that 21 (32.3%) research subjects experienced PAD. Bivariate test between total cholesterol and Hba1c with consecutive PAD incidence p = 0.377; p = 0.416. It can be concluded that there is no significant relationship between the variables total cholesterol and Hba1c with the incidence of PAD. This can be caused by lack of control over other risk factors for PAD events such as smoking, hypertension, duration of diabetes, age, and gender.
Role of laboratory examinations in the diagnosis of vasomotor rhinitis: A Review of Literature Arfiana, Nur Wisma; Jayati, Nurul Sari; Zufar, M Irvan; Putra, Kresna Aditya Nugraha; Hasmy, Alya Fauzizah; Puspitasari, Metana
Jurnal Ilmiah Kesehatan Sandi Husada Vol 14 No 2 (2025): Jurnal Ilmiah Kesehatan Sandi Husada
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Akademi Keperawatan Sandi Karsa (Merger) Politeknik Sandi Karsa

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35816/jiskh.v14i2.1302

Abstract

Introduction: Vasomotor rhinitis (VMR) is a subtype of non-allergic rhinitis characterized by chronic nasal symptoms such as congestion, rhinorrhea, and sneezing without allergic or infectious causes. The absence of specific biomarkers makes VMR difficult to distinguish from allergic rhinitis, resulting in diagnostic challenges and potentially inappropriate therapy. This review aims to assess the contribution of laboratory examinations in the differential diagnosis of VMR. Methods: A comprehensive literature search was performed using PubMed and Google Scholar databases for articles published between January 2021 and September 2025. Keywords included “non-allergic rhinitis,” “laboratory,” “IgE,” “eosinophil,” “nasal cytology,” “FeNO,” and “biomarker.” Out of 8,350 identified publications, 407 titles were relevant, and 57 full-text articles were reviewed. After applying inclusion and exclusion criteria, nine studies were selected for detailed analysis. Results: No single laboratory test can confirm the diagnosis of VMR. Total and specific IgE levels, as well as peripheral eosinophil counts, mainly serve to exclude allergic rhinitis. Nasal cytology plays a crucial role in identifying subtypes of non-allergic rhinitis, including NARES and NARNE. Measurements of nasal nitric oxide (nNO/FeNO) and newer biomarkers, including diamine oxidase (DAO), show potential as supportive indicators, though findings remain inconsistent. Conclusion: Laboratory examinations contribute primarily as adjunctive tools in differentiating VMR from allergic rhinitis. A multimodal diagnostic approach that integrates serological, cytological, and biomarker evaluations with clinical findings offers the most reliable strategy for improving diagnostic accuracy and guiding appropriate therapy.
Co-Authors Agustina, Dinda Dwi Alfajri, Asri Alim, Fika Nurul Ardhana, Regita Arfiana, Nur Wisma Chandra, Ilham Edgar Fadhila Faqihudin, Fadli Rizal Fikri, Elfin Ainul Fithriyah, Saidatul Hartia, Nabila Putri Hasmy, Alya Fauzizah Iwan Setiawan Jamiko, Safari Wahyu Jatmiko, Safari Jatmitko, Safari Wahtu Jayati, Nurul Sari Kencana, Nabila Safhira Titan kusumaningsih, dwi Listiana Masyita Dewi Mahmuda, Iin Novita Nurhayati Marchelina, Sherly Najib, Yazid Aufa Nida Faradisa Fauziyah Pambudi, Nasrurrofiq Risvana Bayu Paramadina, Izzati Putra, Kresna Aditya Nugraha Rahmah, Sandawi Rianda Retno Sintowati - Riandini Aisyah Safari Wahyu Jatmiko Salsabiela, Salwa Sulistyani Sulistyani Sulistyani, S Yamsun, Rahmat Dani Yulistina, Desita Yunitama, Alifa Agil Dhillu Zufar, M Irvan