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All Journal Jurnal Keperawatan Silampari Jurnal Peduli Masyarakat Community Development Journal: Jurnal Pengabdian Masyarakat Indonesian Journal of Global Health research Humantech : Jurnal Ilmiah Multidisiplin Indonesia Jurnal Pengabdian Masyarakat Bhinneka Public Health and Safety International Journal (PHASIJ) Jurnal Keperawatan Media Pengabdian Kesehatan Indonesia Indonesian Journal of Global Health Research
Ratna Esmayanti
Universitas Bina Bangsa
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Comparison of the Effectiveness of Octenidine Dihydrochloride and Povidone-Iodine Antiseptics on Post-Circumcision Wound Healing Time Muhammad Ardi Putrawardana; Ketut Holifah; Muhammad Alghifari Budiman; Fevi Padhila; Ratna Esmayanti; Herry Octa Winarto
Indonesian Journal of Global Health Research Vol. 8 No. 1 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i1.1729

Abstract

Circumcision is a minor surgical procedure that results in an acute incision wound and requires optimal care to prevent infection and accelerate epithelialization. Povidone-iodine has long been used as a standard antiseptic, but has been reported to have potential cytotoxicity against fibroblast cells. Octenidine dihydrochloride is an alternative antiseptic with high antimicrobial efficacy and better biocompatibility. This study aims to compare the effectiveness of both antiseptics on post-circumcision wound healing time. The study used a prospective parallel randomized controlled trial (RCT) design at the Darul Khitan Clinic in Bogor City with 34 pediatric patients randomized into two groups (n = 17). The intervention group received octenidine dihydrochloride, while the control group received povidone-iodine. Wound healing was assessed on days 3 and 7 using the WINNER Scale. Data were collected through direct observation and wound assessment by trained healthcare personnel using a standardized observation form. The data were analyzed using an independent t-test (p<0.05). The results showed that the mean wound healing score of the octenidine group was higher than that of povidone-iodine (9.59±1.37 vs 7.29±1.96) with a significant difference (p<0.001; 95% CI -3.482 to -1.106). It was concluded that octenidine dihydrochloride was more effective in accelerating post-circumcision wound healing than povidone-iodine and could be considered as a more optimal antiseptic choice in clinical practice.
Co-Authors Afifah, Hurotun Agung Waluyo Agung Wisnubroto Akhdzulhijah, Akhdzulhijah Amrullah Amrullah Asep Eka Mulyanudin Asih Setyo Rini Ayadilah, Sri Ayu Trisnawati Bambang Setyo Panulisan Fadilatul Imam Ferizke, Dini Ferliyyana, Navilla Fevi Padhila Fiana, Marista Firdaus, Hifdy Gias, Muhammad Hasan, Ferdi Hasibuan, Garnis Ramitha Hernawati Herry Octa Winarto Imamudin Imamudin Irfansyah, Reinanda Aulia Ketut Holifah Kurnia, Nia Marlina Kurniazaki, Muhammad Khafidin Lestari Sukmarini Messy Marlina Misadiwana, Imoni Muhamad Ari Yanuar Muhammad Alghifari Budiman Muhammad Alghifari Budiman Muhammad Ardi Putrawardana Muhammad Efandhika Trisetya Muhammad Fadli Muhammad Faiz Muzaqi Suparman Muhammad Hidayat Nessya, Nessya Ningsih, Rastia Nova Maulana Nova Tri Handriyanto Novitalia, Dyan Popy Ramadhani Putri Kurniasih Rahman, Tubagus Irsyad Rizkia Rania Permata Rifayanti Rexi Fauzi Wijaya Riyadi, Muhammad Aditya Wiguna Rohmatillah, Fevie Roni, Roni Sari, Anita Maika Sari, Riska Imelda Setiawan, Yahmin Solihah, Maratu Sulistyowati Sulistyowati Tuti Herawati Winarto, Herry Octa Wisnubroto, Agung Prabowo Wulandari, Erina Yolla Sukma Handayani Yuarsa, Tri Agus Zakky, Betha Muhammad